Ukunqongophala kwehomoni yokukhula - abantwana

Ukukhula kwehomoni yokukhula kuthetha ukuba i-pituitary gland ayenzi ngokwaneleyo ukukhula kwehomoni.

Idlala lengqula libekwe emazantsi engqondo. Eli dlala lilawula ukulingana komzimba wehomoni. Kwakhona kwenza ukukhula kwehommone. Le hormone ibangela ukuba umntwana akhule.

Ukusilela kwehomoni yokukhula kunokuba khona xa kuzalwa. Ukunqongophala kwehomoni yokukhula kunokuba sisiphumo sempilo. Ukulimala kakhulu kwengqondo kunokubangela nokusilela kwehomoni.

Abantwana abaneziphene ebusweni nasokhakhayini, ezinje ngomlomo ococekileyo okanye inkalakahla ecandekileyo, banokuhla kwinqanaba lokukhula kwehomoni.

Uninzi lwexesha, unobangela wokukhula kwehomoni ayaziwa.

Ukukhula kancinci kunokuqala kuqatshelwe ebusaneni kwaye kuqhubeke kubuntwana. Ugqirha wabantwana uya kuhlala ezothula ukukhula komntwana kwitshathi yokukhula. Abantwana abanentswelo yokukhula kwehomoni banokukhula kancinci okanye okuthe tyaba kokukhula. Ukukhula kancinci kunokungabonakali de umntwana abe neminyaka emi-2 okanye emithathu ubudala.

Umntwana uya kuba mfutshane kunoninzi lwabantwana abakwiminyaka efanayo kunye nesini. Umntwana usaya kuba nemilinganiselo eqhelekileyo yomzimba, kodwa abe chubby. Ubuso bomntwana buhlala bubonakala buncinci kunabanye abantwana abakwiminyaka efanayo. Umntwana uya kuba nengqondo eqhelekileyo kwiimeko ezininzi.

Kubantwana abadala, ukufikisa kunokufika emva kwexesha okanye kungafiki kwaphela, kuxhomekeke kwisizathu.

Uvavanyo lomzimba, kubandakanya ubunzima, ukuphakama, kunye nokulingana komzimba, kuya kubonisa iimpawu zokukhula okucothayo. Umntwana akazukulandela amanqanaba okukhula okuqhelekileyo.

Isandla x-ray sinokumisela ubudala bethambo. Ngokwesiqhelo, ubungakanani kunye nokumila kwamathambo kuyatshintsha njengoko umntu ekhula. Olu tshintsho lunokubonwa kwi-x-reyi kwaye zihlala zilandela ipateni njengoko umntwana ekhula.

Uvavanyo luhlala lusenziwa emva kokuba ugqirha wabantwana ejonge kwezinye izizathu zokungakhuli kakuhle. Uvavanyo olunokwenziwa lunokubandakanya:

• Ukukhula okufana ne-insulin 1 (IGF-1) kunye nokukhula okufana ne-insulin okubopha iprotein 3 (IGFBP3). Ezi zizinto ezikhulisa iihomoni ezibangela ukuba umzimba wenziwe. Uvavanyo lunokulinganisa iimeko zokukhula. Ukuvavanywa kokuchaneka kokuchaneka kwehomoni kubandakanya uvavanyo lokukhuthaza. Olu vavanyo luthatha iiyure ezininzi.
• I-MRI yentloko inokubonisa i-hypothalamus kunye ne-pituitary gland.
• Uvavanyo lokulinganisa amanye amanqanaba ehomoni lunokwenziwa, kuba ukunqongophala kokukhula kwehomoni akunakuba yingxaki kuphela.

Unyango lubandakanya i-hormone yokukhula (inaliti) enikezwe ekhaya. Iimbumbulu zihlala zinikwa kanye ngemini. Abantwana abadala bahlala befunda indlela yokuzinikela.

Unyango ngehommone yokukhula ihlala ixesha elide, ihlala ihlala iminyaka eliqela. Ngeli xesha, umntwana kufuneka abonwe rhoqo ngugqirha wabantwana ukuqinisekisa ukuba unyango luyasebenza. Ukuba kuyimfuneko, umboneleli wezempilo uyakutshintsha idosi yeyeza.

Iziphumo ebezingalindelekanga ezinzulu zokunyanga kwehomoni kunyango zinqabile. Iziphumo eziqhelekileyo zibandakanya:

• Intloko ebuhlungu
• Ukugcina ulwelo
• Imisipha kunye namalungu adibeneyo
• Ukutyibilika kwamathambo esinqe

Ukuqala kokunyangwa kwale meko, kulithuba elingcono lokuba umntwana akhule aye kubude obuqhelekileyo obuqhelekileyo. Uninzi lwabantwana lufumana ii-intshi ezi-4 okanye nangaphezulu (malunga neesentimitha ezili-10) kunyaka wokuqala, kunye nee-intshi ezi-3 okanye nangaphezulu (malunga neesentimitha ezi-7.6) kwiminyaka emi-2 ezayo. Izinga lokukhula liyehla kancinci.

Unyango lokukhula kwehomoni alusebenzi kubo bonke abantwana.

Ukushiya kunganyangwa, ukunqongophala kwehomoni kunokukhokelela kufutshane kwaye kulibazise ukufikisa.

Ukusilela kwehomoni yokukhula kunokwenzeka ngokusilela kwezinye iihomoni ezinje ngezo zilawulayo:

• Ukuveliswa kwehomoni yedlala lengqula
• Ukulinganisela kwamanzi emzimbeni
• Ukuveliswa kwehomoni zesini samadoda nabasetyhini
• Amadlala adrenal kunye nemveliso yawo yecortisol, DHEA, kunye nezinye iihormone

Shayela umnikezeli wakho ukuba umntwana wakho ubonakala emfutshane ngokungaqhelekanga kwiminyaka yakhe.

Uninzi lweziganeko alunakuthintelwa.

Ukuphonononga itshathi yokukhula komntwana wakho nogqirha wabantwana kuvavanyo ngalunye. Ukuba kukho inkxalabo malunga nenqanaba lokukhula komntwana wakho, kuvavanywa yingcali kuyacetyiswa.

Ubuncinci be-pituitary; Ukunqongophala kokukhula kwehommone yokukhula; Ukusilela kokukhula kwehomoni; Ukunqongophala kokukhula kokuzalwa kwehomoni; IPanhypopituitarism; Umthamo omfutshane-ukukhula kwehomoni ekukhuleni

• Amadlala endocrine
• Ubude / itshathi yobunzima

UCooke DW, iDivall SA, uRadovick S. Ukukhula kwesiqhelo kunye nokuchaphazeleka kwabantwana. Ku: UMelmed S, uAuchus RJ, uGoldfine AB, uKoenig RJ, uRosen CJ, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-14. IPhiladelphia, PA: Elsevier; 2020: isahluko 25.

IGrimberg A, iDiVall SA, iPolychronakos C, et al. Izikhokelo zokukhula kwehommone kunye ne-insulin-efana nokukhula kwento-unyango kunyana nakwishumi elivisayo: ukukhula kwe-hormone yokukhula, ukukhula okufutshane kwe-idiopathic, kunye ne-insulin ephambili efana nokukhula kwento-ndiyasilela. IHorm Res Paediatr. Ngo-2016; 86 (6): 361-397. IINKCUKACHA: 27884013 www.ncbi.nlm.nih.gov/pubmed/27884013.

IPatterson BC, iFelner EI. Hypopituitarism. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, ii-eds. Incwadi kaNelson yeNcwadi yePediatrics. Umhla wama-21. IPhiladelphia, PA: Elsevier; 2020: isahluko 573.