Iprotheyini esebenzayo yeC

Iprotein esebenzayo ye-C (CRP) iveliswa sisibindi. Inqanaba leCRP lenyuka xa kukho ukudumba emzimbeni wonke. Lelinye leqela leeproteni ezibizwa ngokuba zii-reactants phase phase eziya ziphendula ukudumba. Amanqanaba ama-reactants phase phase reactants ayenyuka ekuphenduleni iiprotheni ezithile ezivuthayo ezibizwa ngokuba yi-cytokines. Ezi proteni ziveliswa ziiseli ezimhlophe zegazi ngexesha lokudumba.

Eli nqaku lixoxa ngovavanyo lwegazi olwenziwe ukulinganisa isixa seCRP egazini lakho.

Isampulu yegazi iyafuneka. Oku kuhlala kuthathwa emthanjeni. Inkqubo ibizwa ngokuba yi-venipuncture.

Akukho manyathelo akhethekileyo afunekayo ukulungiselela olu vavanyo.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye banokuziva ngathi batyhafile okanye batyhafile. Emva koko, kunokubakho ukuthotywa okuthile.

Uvavanyo lweCRP luvavanyo ngokubanzi lokujonga ukudumba emzimbeni. Ayiluvavanyo oluthile. Oko kuthetha ukuba inokubonisa ukuba unokudumba kwenye indawo emzimbeni wakho, kodwa ayinakukhomba eyona ndawo sikuyo. Uvavanyo lweCRP luhlala lusenziwa nge-ESR okanye uvavanyo lwenqanaba lokulinganisa elijonga ukuvuvukala.

Unako ukuluvavanya:

• Jonga ukuqhambuka kwezifo ezikruthayo ezinje nge-rheumatoid arthritis, lupus, okanye vasculitis.
• Chonga ukuba ngaba iyeza elichasayo liyasebenza ukunyanga isifo okanye imeko.

Nangona kunjalo, inqanaba eliphantsi leCRP alisoloko lithetha ukuba akukho kukudumba kukhoyo. Amanqanaba e-CRP ayinakonyuswa kubantu abane-rheumatoid arthritis kunye ne-lupus. Isizathu soku asaziwa.

Uvavanyo lwe-CRP olubuthathaka ngakumbi, olubizwa ngokuba yiprotein esebenzayo ye-C-reactive protein (hs-CRP), iyafumaneka ukumisela umngcipheko womntu wesifo sentliziyo.

Amaxabiso aqhelekileyo eCRP ayahluka ngokwelabhoratri. Ngokubanzi, kukho amanqanaba asezantsi eCRP anokufunyanwa egazini. Amanqanaba ahlala enyuka kancinci ngobudala, isini sabasetyhini nakuma-Afrika aseMelika.

Ukonyuka kwe-serum CRP kunxulumene nemeko yomngcipheko wentliziyo kunye nokubonisa indima yezi zinto zibangela umngcipheko wokudumba kwemithambo.

Ngokwe-American Heart Association, iziphumo ze-hs-CRP ekumiseleni umngcipheko wesifo sentliziyo zinokuchazwa ngolu hlobo lulandelayo:

• Usemngciphekweni ophantsi wokukhula kwesifo sentliziyo ukuba inqanaba lakho le-hs-CRP lingaphantsi kwe-1.0 mg / L.
• Ubungozi bokufumana isifo sentliziyo ukuba amanqanaba akho aphakathi kwe-1.0 mg / L kunye no-3.0 mg / L.
• Usemngciphekweni omkhulu wesifo sentliziyo ukuba inqanaba lakho le-hs-CRP liphezulu kune-3.0 mg / L.

Qaphela: Uluhlu lwamaxabiso aqhelekileyo luyahluka kancinci phakathi kweelebhu ezahlukeneyo. Thetha nomboneleli wakho wezempilo malunga nentsingiselo yeziphumo zakho zovavanyo.

Imizekelo engentla ibonisa imilinganiselo eqhelekileyo yeziphumo zolu vavanyo. Ezinye iilabhoratri zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo.

Uvavanyo oluqinisekileyo luthetha ukuba unokudumba emzimbeni. Oku kunokuba ngenxa yeemeko ezahlukeneyo, kubandakanya:

• Umhlaza
• Izifo ezinxulumene nezihlunu
• Ukuhlaselwa yintliziyo
• Usulelo
• Isifo sesibindi sokuvuvukala (IBD)
• ILupus
• Ukukrala kwemiphunga
• Irheumatoid Arthritis
• Umkhuhlane wamathambo
• Isifo sephepha

Olu luhlu alubandakanyi konke.

Qaphela: Iziphumo ezilungileyo zeCRP zikwenzeka nakwisiqingatha sokugqibela sokukhulelwa okanye kusetyenziswe iipilisi zolawulo lokuzalwa (izinto zokucwangcisa ngomlomo).

Iingozi ezinxulunyaniswa nokutsalwa kwegazi zincinci, kodwa zinokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

CRP; Ubuntununtunu obuphezulu beC-protein esebenzayo; hs-CRP

• Uvavanyo lwegazi

IChernecky CC, iBerger BJ. C. Kwi: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 266-432.

Ukutya DJ. Ii-amino acid, iipeptides, kunye neeproteni. Ku: Rifai N, ed. I-Tietz yeNcwadi yeKlinikhi yeKhemistry kunye neDiagnostics yeMolekyuli. Umhla wesi-6. ISt Louis, MO: Elsevier; I-2018: isahluko 28.

Ridker PM, Libby P, Buring JE. Iimpawu zomngcipheko kunye nothintelo lokuqala lwezifo zentliziyo. Ku: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, ii-eds. Isifo sentliziyo seBraunwald: Incwadi yesifundo seMpilo yeNtliziyo. Ngomhla we-11. IPhiladelphia, PA: Elsevier; I-2019: isahluko 45.