Uvavanyo lwegazi lwe-TBG

Uvavanyo lwegazi lwe-TBG lulinganisa inqanaba leprotein ehambisa idlala lengqula emzimbeni wakho wonke. Le protein ibizwa ngokuba yi-thyroxine binding globulin (TBG).

Kuthathwa isampulu yegazi ize ithunyelwe elebhu ukuvavanywa.

Amachiza athile kunye namayeza anokuchaphazela iziphumo zovavanyo. Umboneleli wakho wezempilo angakuxelela ukuba uyeke ukuthatha iyeza elithile ixesha elifutshane ngaphambi kovavanyo. Ungaze uyeke ukuthatha naliphi na iyeza ungakhange uqale uthethe nomboneleli wakho.

La mayeza kunye neziyobisi zinokunyusa inqanaba le-TBG:

• I-Estrogens, efumaneka kwiipilisi zokulawula ukuzalwa kunye nonyango lwe-estrogen
• IHeroin
• Imethadone
• I-Phenothiazines (iziyobisi ezithile ezichasene nengqondo)

La mayeza alandelayo anokunciphisa amanqanaba e-TBG:

• Idepakote okanye idepakene (ekwabizwa ngokuba yi-valproic acid)
• I-Dilantin (ekwabizwa ngokuba yi-phenytoin)
• Amanani aphezulu e-salicylates, kubandakanya i-aspirin
• Amadoda ehomoni, kubandakanya i-androgens kunye ne testosterone
• IPrednisone

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukutyumza kancinci. Oku kuya kuhamba kungekudala.

Olu vavanyo lunokwenziwa ukufumanisa iingxaki kwi-thyroid yakho.

Uluhlu oluqhelekileyo zii-micrograms ezili-13 ukuya kwezingama-39 kwidesilitha nganye (mcg / dL), okanye ii-nanomoles ezili-150 ukuya kwezingama-360 kwilitha nganye (nmol / L).

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Inqanaba le-TBG elonyukayo linokubangelwa:

• I-porphyria ene-intermittent intermittent (isifo esingaqhelekanga sokuphazamiseka komzimba)
• I-Hypothyroidism (i-thyroid engasebenzi)
• Isifo sesibindi
• Ukukhulelwa (amanqanaba e-TBG ahlala enyuka ngexesha lokukhulelwa)

Qaphela: Amanqanaba e-TBG ahlala ephezulu kubantwana abasandul 'ukuzalwa.

Ukuhla kwenqanaba le-TBG kunokubangelwa:

• Ukugula kakhulu
• I-Acromegaly (ingxaki ebangelwa kukukhula kakhulu kwehomoni)
• Hyperthyroidism (idyroid esebenzayo)
• Ukungondleki
• I-Nephrotic syndrome (iimpawu ezibonisa umonakalo wezintso zikhona)
• Uxinzelelo koqhaqho

Amanqanaba aphezulu okanye asezantsi e-TBG achaphazela ubudlelwane phakathi kwe-T4 iyonke kunye novavanyo lwegazi lwe-T4 yasimahla. Utshintsho kumanqanaba egazi le-TBG anokutshintsha idosi efanelekileyo yokutshintshwa kwe-levothyroxine yabantu abane-hypothyroidism.

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye nakwelinye icala lomzimba liye kwelinye. Ukufumana isampulu yegazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko yokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi elakhiweyo phantsi kolusu)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

I-serum thyroxine ebopha i-globulin; Inqanaba le-TBG; Inqanaba le-TBG yeSerum; IHypothyroidism - TBG; Hyperthyroidism - TBG; I-thyroid engasebenziyo - i-TBG; Idlala lengqula eligqithisileyo - TBG

• Uvavanyo lwegazi

UGuber HA, uFarag AF. Uvavanyo lomsebenzi we-endocrine. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 24.

UKruse JA. Iingxaki ze-thyroid. Ku: Parrillo JE, Dellinger RP, ii-eds. Unyango oluKhathalelayo oluBalulekileyo: Imigaqo yokuchongwa kunye noLawulo kuLuntu oluDala. Umhla we-5. IPhiladelphia, PA: Elsevier; I-2019: isahluko 57.

USalvatore D, uCohen R, uKopp PA, uLarsen PR. I-thyroid pathophysiology kunye novavanyo lokuqonda isifo. Ku: UMelmed S, uAuchus RJ, uGoldfine AB, uKoenig RJ, uRosen CJ, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-14. IPhiladelphia, PA: Elsevier; 2020: isahl 11.