Uvavanyo lomchamo lwe-17-hydroxycorticosteroids

Uvavanyo lwe-17-hydroxycorticosteroids (17-OHCS) lilinganisa inqanaba le-17-OHCS kumchamo.

Isampuli yomchamo weeyure ezingama-24 iyafuneka. Uya kudinga ukuqokelela umchamo wakho ngaphezulu kweeyure ezingama-24. Umboneleli wakho wezempilo uya kukuxelela ukuba ungakwenza njani oku. Landela imiyalelo ngokuchanekileyo.

Umboneleli uya kukuyalela, ukuba kukho imfuneko, uyeke amayeza anokuphazamisa uvavanyo. Oku kunokubandakanya:

• Iipilisi zolawulo lokuzalwa ziqukethe i-estrogen
• Iintsholongwane ezithile
• Iiglucocorticoids

Uvavanyo lubandakanya kuphela ukuchama okuqhelekileyo. Akukho buhlungu.

I-17-OHCS yimveliso eyenziweyo xa isibindi kunye nezinye izihlunu zomzimba zisaphula i-steroid cortisol.

Olu vavanyo lunokunceda ekuchongeni ukuba ngaba umzimba uvelisa kakhulu i-cortisol. Uvavanyo lunokusetyenziselwa ukufumanisa isifo seCushing. Esi sisifo esenzeka xa umzimba unenqanaba eliphezulu lecortisol rhoqo.

Umthamo womchamo kunye nomchamo we-creatinine uhlala usenziwa ngovavanyo lwe-17-OHCS ngaxeshanye. Oku kunceda umboneleli atolike uvavanyo.

Olu vavanyo alwenziwa rhoqo ngoku. Uvavanyo lomchamo wasimahla we-cortisol luvavanyo olungcono lokujonga isifo seCushing.

Amaxabiso aqhelekileyo:

• Indoda: 3 ukuya kwi-9 mg / iiyure ezingama-24 (8.3 ukuya kuma-25 olmol / iiyure ezingama-24)
• Abasetyhini: 2 ukuya kwi-8 mg / iiyure ezingama-24 (5.5 ukuya kuma-22 µmol / iiyure ezingama-24)

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye ukuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Inqanaba eliphezulu kuneliqhelekileyo le-17-OHCS linokubonisa:

• Uhlobo lwe-Cushing syndrome olubangelwa yithumba kwi-adrenal gland evelisa i-cortisol
• Uxinzelelo
• Unyango lweHydrocortisone
• Ukungondleki
• Ukutyeba kakhulu
• Ukukhulelwa
• Unobangela wehomoni yoxinzelelo lwegazi oluphezulu
• Uxinzelelo olukhulu lomzimba okanye lweemvakalelo
• Ithumba kwilungu le-pituitary okanye kwenye indawo emzimbeni ekhupha ihomoni ebizwa ngokuba yi-adrenocorticotropic hormone (ACTH)

Inqanaba elingaphantsi kweqhelekileyo le-17-OHCS linokubonisa:

• Amadlala eadrenal akavelisi ngokwaneleyo iihomoni zawo
• Idlala lengqula alivelisi ngokwaneleyo iihomoni zalo
• Ukusilela kwe-enzyme yelifa
• Utyando lwangaphambili lokususa i-adrenal gland

Ukuchama ngaphezulu kweelitha ezi-3 ngosuku (i-polyuria) kunokwenza iziphumo zovavanyo lube phezulu nangona imveliso ye-cortisol iqhelekile.

Akukho bungozi kolu vavanyo.

I-17-OH corticosteroids; I-17-OHCS

IChernecky CC, iBerger BJ. 17-hydroxycorticosteroids (17-OHCS) - umchamo weeyure ezingama-24. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 659-660.

UJuszczak A, uMorris DG, uGrossman AB, uNieman LK. Isifo sikaCushing. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, ii-eds. Endocrinology: Abantu abadala kunye nabantwana. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 13.