Iserum globulin electrophoresis

Uvavanyo lwe-serum globulin electrophoresis lilinganisa amanqanaba eeproteni ezibizwa ngokuba ziiglobulin kwindawo yolwelo yesampulu yegazi. Olu lwelo lubizwa ngokuba yi-serum.

Isampulu yegazi iyafuneka.

Kwilebhu, igcisa libeka isampuli yegazi kwiphepha elikhethekileyo kwaye lifaka umbane. Iiproteni zihamba ephepheni kwaye zenze iibhendi ezibonisa inani leprotein nganye.

Landela imiyalelo yokuba ufuna ukukhawuleza okanye hayi ngaphambi kolu vavanyo.

Amayeza athile anokuchaphazela iziphumo zolu vavanyo. Umboneleli wakho wezempilo uya kukuxelela ukuba ngaba ufuna ukuyeka ukuthatha nawaphi na amayeza. Sukuyeka nawaphi na amayeza ngaphambi kokuba uthethe nomboneleli wakho.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukukrala kancinci. Oku kuya kuhamba kungekudala.

Olu vavanyo lwenziwa ukujonga iiproteni ze-globulin egazini. Ukuchonga iintlobo zeglobulin kunokunceda ekuchongeni iingxaki ezithile zonyango.

Iiglobulin zihlukaniswe ngamaqela amathathu: i-alpha, i-beta, kunye ne-gamma globulins. I-Gamma globulins ibandakanya iintlobo ezahlukeneyo zeentsholongwane ezinjenge-immunoglobulins (Ig) M, G, kunye no-A.

Izifo ezithile zinxulunyaniswa nokuvelisa ii-immunoglobulin ezininzi. Umzekelo, iWaldenstrom macroglobulinemia ngumhlaza weeseli ezithile ezimhlophe zegazi. Inxulunyaniswa nokuvelisa ii-antibodies ezininzi ze-IgM.

Amaxabiso aqhelekileyo ngala:

• I-serum globulin: i-2.0 ukuya kwi-3.5 gram kwidesilitha nganye (g / dL) okanye kwi-20 ukuya kwi-35 yeegramu kwilitha nganye (g / L)
• Icandelo le-IgM: i-75 ukuya kwi-300 milligrams ngedesilitha (mg / dL) okanye i-750 ukuya kwi-3,000 milligrams kwilitha nganye (mg / L)
• Icandelo le-IgG: 650 ukuya kwi-1,850 mg / dL okanye kwi-6.5 ukuya kwi-18.50 g / L
• Icandelo le-IgA: 90 ukuya kwi-350 mg / dL okanye i-900 ukuya kwi-3,500 mg / L

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye ukuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Ukunyuka kweeproteni ze-gamma globulin kunokubonisa:

• Usulelo olubi
• Umhlaza wegazi kunye nomongo wethambo kubandakanya uninzi lwe-myeloma, kunye nezinye i-lymphomas kunye ne-leukemias
• Ukuphazamiseka komzimba
• Ixesha elide (elingapheliyo) isifo esivuthayo (umzekelo, i-rheumatoid arthritis kunye ne-systemic lupus erythematosus)
• IWaldenström macroglobulinemia

Mncinci umngcipheko obandakanyekayo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye, kwaye ukusuka kwelinye icala lomzimba ukuya kwelinye. Ukuthatha igazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko enxulumene nokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi elakhiweyo phantsi kolusu)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

Ubungakanani beemunoglobulin

• Uvavanyo lwegazi

IChernecky CC, iBerger BJ. Immunoelectrophoresis - serum kunye nomchamo. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 667-692.

UDominiczak MH, uFraser WD. Iiproteni zegazi kunye neplasma. Ku: Baynes JW, Dominiczak MH, ii-eds. Unyango ngamachiza. Umhla we-5. IPhiladelphia, PA: Elsevier; I-2019: isahluko 40.