Uvavanyo lwegazi lwe-ACTH

Uvavanyo lwe-ACTH lilinganisela inqanaba lehomoni ye-adrenocorticotropic (ACTH) egazini. I-ACTH yincindi yedlala ephuma kwilungu lengqondo ebuchotsheni.

Isampulu yegazi iyafuneka.

Ugqirha wakho uya kucela ukuba uvavanyo lwenziwe kwasekuseni. Oku kubalulekile, kuba inqanaba le-cortisol liyahluka yonke imihla.

Unokuxelelwa nokuba uyeke ukuthatha amayeza anokuchaphazela iziphumo zovavanyo. La mayeza abandakanya i-glucocorticoids efana ne-prednisone, i-hydrocortisone, okanye i-dexamethasone. (Musa ukuwayeka la mayeza ngaphandle kokuba uyalelwe ngumboneleli wakho.)

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukutyumza kancinci. Oku kuya kuhamba kungekudala.

Owona msebenzi uphambili we-ACTH kukulawula i-glucocorticoid (steroid) hormone cortisol. I-Cortisol ikhutshwa yi-adrenal gland. Ilawula uxinzelelo lwegazi, iswekile yegazi, amajoni omzimba kunye nokuphendula koxinzelelo.

Olu vavanyo lunokunceda ekufumaneni oonobangela beengxaki ezithile zehomoni.

Amaxabiso aqhelekileyo esampulu yegazi ethathwe kwakusasa nge-9 ukuya kwi-52 pg / mL (2 ukuya ku-11 pmol / L).

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo. Thetha nogqirha wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Inqanaba eliphezulu kuneliqhelekileyo le-ACTH linokubonisa:

• Izibilini ze-Adrenal azivelisi i-cortisol eyaneleyo (isifo se-Addison)
• Amadlala eadrenal angavelisi iihomoni ezaneleyo (i-adrenal hyperplasia)
• Enye okanye ngaphezulu kwamadlala endocrine asebenza kakhulu okanye enze ithumba (uninzi lwe-endocrine neoplasia yohlobo I)
• Ubume besimo benza i-ACTH kakhulu (isifo seCushing), esihlala sibangelwa yithumba elingengomhlaza kwilungu lobudoda.
• Uhlobo oluqhelekileyo lwethumba (imiphunga, idlala lengqula, okanye ipancreas) elenza kakhulu i-ACTH (ectopic Cushing syndrome)

Inqanaba elisezantsi kuneliqhelekileyo le-ACTH linokubonisa:

• Amayeza eglucocorticoid acinezela imveliso ye-ACTH (exhaphake kakhulu)
• Idlala lengqula alivelisi iihormoni ezaneleyo, ezinje nge-ACTH (hypopituitarism)
• Ithumba le-adrenal gland evelisa kakhulu i-cortisol

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye nakwelinye icala lomzimba liye kwelinye. Ukuthatha igazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko enxulumene nokutsalwa kwegazi incinci kodwa inokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

I-serum adrenocorticotropic hormone; Iadrenocorticotropic hormone; Kakhulu-ethe ACTH

• Amadlala endocrine

IChernecky CC, iBerger BJ. Ihomoni yeAdrenocorticotropic (ACTH, corticotropin) -iserum. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 107.

I-Melmed S, i-Kleinberg D. Ubunzima bePituitary kunye nezihlunu. IMelmed S, iPolonsky KS, iLarsen PR, iKronenberg HM, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 9.

Stewart PM, Newell-Price JDC. I-adrenal cortex. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 15.