IMifepristone (Mifeprex)

Umxholo

• Ngaphambi kokuba uthathe i-mifepristone,
• I-Mifepristone inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Iimpawu libanda kungaquka oku kulandelayo:

Ukopha okunobuzaza okanye okusongela ubomi kwilungu lobufazi kusenokwenzeka xa ukukhulelwa kugqitywa kukusweleka okanye kukhupha isisu ngonyango okanye ngotyando. Ayaziwa ukuba ukuthatha i-mifepristone kuyonyusa umngcipheko wokufumana ukopha kakhulu. Tshela ugqirha wakho ukuba ukhe wanengxaki yokopha, i-anemia (ngaphantsi kwenani eliqhelekileyo leeseli ezibomvu zegazi), okanye ukuba uthatha ii-anticoagulants ('igazi elincinci') njenge-aspirin, apixaban (Eliquis), dabigatran (Pradaxa) , Dalteparin (Fragmin), edoxaban (Savaysa). enoxaparin (Lovenox), Fondaparinux (Arixtra), heparin, rivaroxaban powder (Xarelto), okanye warfarin (Coumadin, Jantoven). Ukuba kunjalo, ugqirha wakho uya kukuxelela ukuba ungathathi i-mifepristone. Ukuba uva ukopha okunzima kakhulu kwilungu lobufazi, njengokuntywila kwimilinganiselo emibini yococeko egcwele ubungakanani obugcweleyo ngeyure nganye iiyure ezimbini eziqhubekayo, tsalela umnxeba kwangoko okanye ufune unyango olukhawulezileyo.

Usulelo olunobuzaza okanye olusongela ubomi lunokwenzeka xa ukukhulelwa kugqitywa kukusweleka okanye ngokukhupha isisu ngonyango okanye ngotyando. Inani elincinci lezigulana lisweleke ngenxa yosulelo abaye bakhula emva kokusebenzisa i-mifepristone kunye ne-misoprostol ukuphelisa ukukhulelwa kwabo. Ayaziwa ukuba i-mifepristone kunye / okanye i-misoprostol ibangele olu sulelo okanye ukusweleka. Ukuba uhlaselwa sisifo esibi, awunakuba neempawu ezininzi kwaye iimpawu zakho zisenokungabi qatha. Kuya kufuneka ubize ugqirha wakho kwangoko okanye ufumane unyango olukhawulezileyo ukuba ufumana ezinye zeempawu ezilandelayo: umkhuhlane ongaphezulu kwe-100.4 ° F (38 ° C) ohlala ngaphezulu kweeyure ze-4, iintlungu eziqatha okanye ukuthamba kwindawo engezantsi kwesinqe, Ukugodola, ukubetha kwentliziyo okukhawulezayo, okanye ukuphelelwa ngamandla.

Kuya kufuneka ubize ugqirha wakho kwangoko okanye ufumane unyango olungxamisekileyo ukuba uneempawu eziqhelekileyo zokugula ezinje ngobuthathaka, isicaphucaphu, ukugabha, urhudo, okanye ukuziva ugula ngaphezulu kweeyure ezingama-24 emva kokuthatha i-mifepristone nokuba awunomkhuhlane okanye iintlungu. kwindawo engezantsi kwesinqe sakho.

Ngenxa yomngcipheko weengxaki ezinzulu, i-mifepristone ifumaneka kuphela ngenkqubo ethintelweyo. Inkqubo phantsi kwenkqubo ebizwa ngokuba yi-Mifeprex Risk Evaluation and Mitigation Strategies (REMS) seyimiselwe bonke abaguli ababhinqileyo abayalelwe i-mifepristone. Ugqirha wakho uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) ukuze ulifunde ngaphambi kokuba uqale unyango kunye ne-mifepristone. Kuya kufuneka usayine isivumelwano sesigulana ngaphambi kokuba uthathe i-mifepristone. Xelela ugqirha wakho ukuba unemibuzo malunga nonyango lwe-mifepristone okanye ukuba awukwazi ukulandela izikhokelo kwisivumelwano sesigulana. I-Mifepristone ifumaneka kuphela kwiiklinikhi, kwiiofisi zonyango, nasezibhedlele kwaye ayihanjiswa ngevenkile zentengiso.

Thetha nogqirha wakho kwaye uthathe isigqibo sokuba ubize bani kwaye wenzeni xa kukho imeko kaxakeka emva kokuthatha i-mifepristone. Xelela ugqirha wakho ukuba awucingi ukuba uza kukwazi ukulandela esi sicwangciso okanye ufumane unyango ngokukhawuleza kwimeko engxamisekileyo kwiiveki ezimbini zokuqala emva kokuba uthathe i-mifepristone. Thatha umkhombandlela wakho xa usiya kwigumbi likaxakeka okanye ufuna unyango olungxamisekileyo ukuze oogqirha abakunyangayo baqonde ukuba ukhupha isisu.

Gcina lonke ixesha lokudibana nogqirha wakho. Oku kuqeshwa kuyimfuneko ukuze uqiniseke ukuba ukukhulelwa kwakho kuphelile kwaye awukhange ube neengxaki ezinzima zokukhupha isisu ngonyango.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-mifepristone.

I-Mifepristone isetyenziswa ngokudibeneyo ne-misoprostol (Cytotec) ukuphelisa ukukhulelwa kwangethuba. Ukukhulelwa kwangoko kuthetha ukuba sele kuneentsuku ezingama-70 okanye ngaphantsi ukusukela kwixesha lokuya esikhathini. I-Mifepristone ikudidi lwamayeza abizwa ngokuba yi-antiprogestational steroids. Isebenza ngokuthintela umsebenzi weprogesterone, into eyenziwa ngumzimba wakho ukunceda ukuqhubeka nokukhulelwa.

I-Mifepristone ikwafumaneka njengenye imveliso (i-Korlym), esetyenziselwa ukulawula i-hyperglycemia (iswekile ephezulu yegazi) kubantu abanohlobo oluthile lwe-Cushing's Syndrome apho umzimba wenza i-hormone ye-cortisol kakhulu. Le monograph inika kuphela ulwazi malunga ne-mifepristone (Mifeprex), esetyenziswa sodwa okanye ngokudibeneyo nelinye iyeza lokuphelisa ukukhulelwa kwangoko. Ukuba usebenzisa i-mifepristone ukulawula i-hyperglycemia ebangelwa yi-Cushing's syndrome, funda i-monograph enesihloko esithi mifepristone (Korlym) ebhaliweyo malunga nale mveliso.

I-Mifepristone iza njengecwecwe lokuthatha ngomlomo. Uya kuthatha ipilisi enye ye-mifepristone kanye ngosuku lokuqala. Kwisithuba seeyure ezingama-24 ukuya kwezingama-48 emva kokuthatha i-mifepristone, uya kufaka iipilisi ezine lilonke elinye iyeza elibizwa ngokuba yi-misoprostol buccally (phakathi kwentsini nesidlele) ngokubeka iipilisi ezimbini kwisingxobo ngasinye esidleleni imizuzu engama-30, emva koko uginye umxholo oseleyo ngamanzi okanye enye ulwelo. Qiniseka ukuba ukwindawo efanelekileyo xa uthatha i-misoprostol kuba ukopha kwilungu lobufazi, iicramps, isicaphucaphu, kunye norhudo luqala kwisithuba seeyure ezi-2 ukuya kwezi-24 emva kokulusebenzisa kodwa lungaqala kwisithuba seeyure ezi-2.Ukopha kwilungu lobufazi okanye ukubonwa kuhlala kuhlala iintsuku ezili-9 ukuya kwezi-16 kodwa kunokuhlala iintsuku ezingama-30 okanye ngaphezulu. Kuya kufuneka ubuyele kugqirha wakho ukuze enze uviwo okanye i-ultrasound iintsuku ezi-7 ukuya kwezi-14 emva kokuthatha i-mifepristone ukuqinisekisa ukuba ukukhulelwa kuphelile kwaye ujonge inani lokopha. Thatha i-mifepristone ngokuchanekileyo njengoko kuyalelwe.

I-Mifepristone ngamanye amaxesha isetyenziselwa ukuphelisa ukukhulelwa xa sele kudlule iintsuku ezingama-70 ukusukela kwixesha lokugqibela lokuya exesheni komfazi; njengothintelo lokuthintela ukukhulelwa emva kokuba neentlobano zesini ezingakhuselekanga ('ipilisi yasemva kwentsasa'); ukunyanga amathumba engqondo, i-endometriosis (ukukhula kwesicu sesibeleko ngaphandle kwesibeleko), okanye i-fibroids (amathumba angenasifo esibelekweni); okanye ukukhuthaza abasebenzi (ukunceda ukuqala inkqubo yokuzalwa komfazi okhulelweyo). Thetha nogqirha wakho malunga neengozi zokusebenzisa eli chiza kwimeko yakho.

Ngaphambi kokuba uthathe i-mifepristone,

• xelela ugqirha wakho ukuba ngaba uxabisa i-mifepristone (urhashalala, irhashalala, ukurhawuzelela, ukudumba kobuso, amehlo, umlomo, umqala, izandla, ukuphefumla nzima okanye ukugwinya); i-misoprostol (iCytotec, kwiArthrotec); ezinye ii-prostaglandin ezinje ngealprostadil (Caverject, Edex, Muse, ezinye), carboprost tromethamine (Hemabate), dinoprostone (Cervidil, Prepidil, Prostin E2), epoprostenol (Flolan, Veletri), latanoprost (Xalatan), treprostinilod (Orenitram, Orenitram ); nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-mifepristone. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha ii-corticosteroids ezinje nge-beclomethasone (Beconase, QNASL, QVAR), betamethasone (Celestone), budesonide (Entocort, Pulmicort, Uceris), cortisone, dexamethasone, fludrocortisone, flunisolide (Aerospan HFA), Fluticasone , Veramyst, abanye), hydrocortisone (Cortef, Solu-Cortef, U-Cort, abanye), methylprednisolone (Medrol, Depo-Medrol), prednisolone (Omnipred, Prelone, abanye), prednisone (Rayos), kunye ne-triamcinolone (Kenalog, abanye ). Ugqirha wakho uya kukuxelela ukuba ungathathi i-mifepristone.
• xelela ugqirha wakho ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo. Qiniseka ukuba ukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zilandelayo: i-benzodiazepines efana ne-alprazolam (Xanax), diazepam (Diastat, Valium), midazolam, okanye triazolam (Halcion); buspirone; iicalcium block blockers ezinje ngeamlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, nifedipine (Adalat, Afeditab CR, Procardia), nisoldipine (Sular), okanye verapamil (Calan, Verelan, in Tarka); carbamazepine (Equetro, Tegretol, Teril, nabanye); I-chlorpheniramine (antihistamine ekukhwehleleni nakwimveliso ebandayo); ukunciphisa amayeza e-cholesterol (ii-statins) ezinjenge-atorvastatin (iLipitor, eCaduet), i-lovastatin (i-Altoprev, kwi-Advicor), okanye i-simvastatin (Simcor, Zocor, eVytorin); i-clarithromycin (i-Biaxin, kwi-Prevpac); icyclosporine (Gengraf, Neoral, Sandimmune); erythromycin (EES, Erythrocin, abanye); haloperidol; furosemide; I-HIV protease inhibitors efana ne-indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, eKaletra, ezinye), okanye i-saquinavir (i-Invirase); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); imethadone (iDolophine, iMethadose); nefazodone; phenobarbital; phenytoin (iDilantin, iPhenytek); ipimozide (Orap); ipropranolol (IHemangeol, Inderal, i-Innopran); quinidine (kwiNuedexta); irifampin (Rifadin, Rimactane, eRifamate, eRifater); irifabutin (Mycobutin); itacrolimus (Astagraf, Prograf, Protopic, nabanye); tamoxifen (Soltamox); ithenda okanye i-vincristine (Marqibo Kit). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wakhulelwa yi-ectopic ('tubal pregnancy' okanye ukukhulelwa ngaphandle kwesibeleko), ukusilela kwe-adrenal (iingxaki nge-adrenal gland), okanye i-porphyria (isifo segazi esizuzwe njengelifa esinokubangela ulusu okanye iingxaki kwinkqubo yovalo. ). Ugqirha wakho uya kukuxelela ukuba ungathathi i-mifepristone. Kwakhona xelela ugqirha wakho ukuba ufake i-intrauterine device (IUD). Kuya kufuneka isuswe ngaphambi kokuba uthathe i-mifepristone.
• Kuya kufuneka uyazi ukuba kungenzeka ukuba i-mifepristone ayizukuphelisa ukukhulelwa kwakho. Ugqirha wakho uya kujonga ukuze aqiniseke ukuba ukukhulelwa kwakho kuphelile xa ubuyela kulungiselelo lwakho lokulandela emva kokuba uthathe i-mifepristone. Ukuba ukhulelwe emva kokuba uthathe i-mifepristone, kukho ithuba lokuba usana lwakho luzalwe luneziphene. Ukuba ukukhulelwa kwakho akuphelanga ngokupheleleyo, ugqirha wakho uya kuxoxa ngezinye iindlela onokuthi uziqwalasele. Unokukhetha ukulinda, uthathe elinye idosi le-misoprostol okanye wenze utyando ukuphelisa ukukhulelwa. Ukuba uthatha idosi ephindiweyo ye-misoprostol, kuya kufuneka undwendwele kunye nogqirha wakho kwiintsuku ezisi-7 emva kwethamo ukuze uqiniseke ukuba ukukhulelwa kwakho kuphelile.

• xelela ugqirha wakho ukuba uncelisa.

• ukuba uyenziwa utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthathe i-mifepristone.
• Kuya kufuneka uyazi ukuba emva kokuphelisa ukukhulelwa kunye ne-mifepristone, unokuphinda ukhulelwe kwakhona kwangoko, nangaphambi kokuba kubuye ixesha lakho. Ukuba awufuni kuphinda ukhulelwe kwakhona, kuya kufuneka uqale ukusebenzisa ulawulo lokuzalwa kwangoko xa kuphela okukhulelweyo okanye ngaphambi kokuba uphinde ulale kwakhona.

Musa ukuthatha i-mifepristone ngejusi yeziqhamo. Thetha nogqirha wakho malunga nokusela ijusi yamagilebhisi emva kokuthatha eli yeza.

Uya kuthatha kuphela i-mifepristone kwiofisi kagqirha okanye eklinikhi, ke awunakukhathazeka ngokulibala ukuthatha idosi ekhaya.

I-Mifepristone inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukopha kwilungu lobufazi okanye ukubonwa
• iicampu
• iintlungu zangasese
• ukutshisa kwelungu lobufazi, ukurhawuzelela, okanye ukukhupha
• intloko ebuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na iimpawu ezichazwe kwicandelo LESILUMKISO ESIBALULEKILEYO, tsalela ugqirha wakho ngokukhawuleza.

I-Mifepristone inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Ugqirha wakho uya kugcina amayeza eofisini yakhe.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• isiyezi
• isiqaqa
• ukungaboni kakuhle
• isicaphucaphu
• ukudinwa
• ubuthathaka
• ukuqhawukelwa ngumphefumlo
• ukubetha kwentliziyo ngokukhawuleza

Kuya kufuneka ufumane i-mifepristone kuphela kugqirha oqinisekisiweyo kwaye usebenzise la mayeza kuphela ngelixa ugcinwe ngugqirha. Akufanele uthenge i-mifepristone kweminye imithombo, njenge-Intanethi, kuba ungagqitha kwizikhuselo ezibalulekileyo ukukhusela impilo yakho.

Musa ukuvumela nabani na ukuba athathe amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Sifumpa^®

• RU-486