Atazanavir

Umxholo

• Ngaphambi kokuba uthathe i-atazanavir,
• I-Atazanavir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Ukuba uhlakulela ukukhawuleza okukhulu kunye naziphi na iimpawu ezilandelayo, yeka ukuthatha i-atazanavir uze ubize ugqirha wakho ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Atazanavir isetyenziswa kunye namanye amayeza, anje nge-ritonavir (i-Norvir), ukunyanga usulelo lwe-immunodeficiency virus (HIV) kubantu abadala nasebuncinaneni ubuncinci iinyanga ezintathu ubudala kwaye inobunzima obungama-22 lb (10 kg). U-Atazanavir ukwiklasi yamayeza abizwa ngokuba zii-protease inhibitors. Isebenza ngokunciphisa inani le-HIV egazini. Nangona i-atazanavir ingayinyangi i-HIV, inokuwanciphisa amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezinje ngezifo ezomeleleyo okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokudlulisela intsholongwane kagawulayo kwabanye abantu.

I-Atazanavir iza njengecapsule nanjengomgubo wokuwuthatha ngomlomo. I-capsule kunye ne powder zihlala zithathwa kanye ngosuku kunye nesidlo okanye i-snack. Thatha i-atazanavir malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-atazanavir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Uya kuthatha amanye amayeza e-HIV ngelixa uthatha i-atazanavir. Ugqirha wakho uza kukuxelela ukuba la mayeza kufuneka athathwe ngaxeshanye ne-atazanavir, okanye iiyure ezininzi ngaphambi okanye emva kokuba uthathe i-atazanavir. Landela le shedyuli ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba unemibuzo malunga namaxesha ekufuneka uwathathe amayeza akho.

I-Atazanavir powder kufuneka ithathwe kunye ne-ritonavir (Norvir). Musa ukuthatha i-atazanavir powder ngaphandle kwe-ritonavir (Norvir).

Ginya zonke iifomsile; sukuwahlula-hlula, okanye uwavule. Ukuba awukwazi ukugwinya iicapsule, xelela ugqirha wakho okanye usokhemesti.

I-Atazanavir powder inokongezwa ekutyeni okunjengeapilesauce okanye iyogathi, okanye ulwelo njengamanzi, ubisi, okanye ubisi olungumgubo lweentsana. Hlanganisa kakuhle, kwaye uthabathe wonke umxube kwangoko ukuze uthathe idosi epheleleyo. Ukuba uxutywe namanzi, yitya i-snack okanye utye kwangoko emva kokuba uthathe umxube we powder. Kwiintsana (ezindala kuneenyanga ezintathu ubudala) ezingakwaziyo ukusela kwikomityi, umgubo lowo ungaxutywa nefomula yobisi inikwe nesirinji yomlomo; musa ukunika umxube kusana olusebhotileni yosana. Ukuba umxube awuthathwanga kwangoko kufuneka ugcinwe kubushushu begumbi kwaye uthathwe ngaphakathi kweyure e-1. Yifunde ngononophelo imiyalelo yomenzi echaza indlela yokuxuba kunye nokuthatha idosi ye-atazanavir. Qiniseka ukuba ubuza usokhemesti okanye ugqirha ukuba unayo nayiphi na imibuzo malunga nendlela yokuxuba okanye ukuthatha la mayeza.

Thetha nogqirha malunga nokuba wenzeni xa umntwana wakho egabha, etshica, okanye ethatha kuphela inxenye yedosi ye-atazanavir.

I-Atazanavir iyanceda ukulawula usulelo lwe-HIV, kodwa ayiyinyangi. Qhubeka nokuthatha i-atazanavir nokuba uziva uphilile. Sukuyeka ukuthatha i-atazanavir ngaphandle kokuthetha nogqirha wakho. Xa unikezelo lwakho lwe-atazanavir luqala ukuba phantsi, fumana ngakumbi kugqirha wakho okanye kwikhemesti. Ukuba uyeka ukuthatha i-atazanavir okanye ukweqa idosi, imeko yakho kunokuba nzima ukunyanga.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana. Funda olu lwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo.

I-Atazanavir ngamanye amaxesha isetyenziselwa ukuthintela usulelo kubasebenzi bokhathalelo lwempilo okanye abanye abantu abachanabeke ngengozi kwi-HIV. Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-atazanavir,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-atazanavir, nawaphi na amanye amayeza, okanye nasiphi na isithako esikuyo Ugqirha wakho unokukuxelela ukuba ungathathi i-atazanavir. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba ngaba uthatha nawaphi na amayeza alandelayo okanye iimveliso zamayeza: i-alfuzosin (i-Uroxatral); i-cisapride (iPropulsid; ayifumaneki e-US); elbasvir kunye negrazoprevir (Zepatier); I-ergot alkaloids ezinje nge-dihydroergotamine (i-DHE 45, iMigranal), i-ergonovine, i-ergotamine (i-Ergomar, eCafergot, eMigergot), okanye i-methylergonovine (Methergine); glecaprevir kunye nepibrentasvir (Mavyret); indinavir (iCrixivan); irinotecan (Camptosar); I-lovastatin (Altoprev); ilurasidone (iLatuda); midazolam ngomlomo; nevirapine (Viramune), pimozide (Orap); irifampin (Rimactane, Rifadin, eRifater, eRifamate); sildenafil (kuphela uphawu lweRevatio olusetyenziselwa isifo semiphunga); isimvastatin (iZocor, eVytorin); I-wort yaseSt. kunye netriazolam (Halcion). Ugqirha wakho uya kukuxelela ukuba ungathathi i-atazanavir ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhaliswanga, iivithamini, iimveliso zamayeza esintu, kunye nezongezo zesondlo ozithathayo okanye oceba ukuzithatha.Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-anticoagulants ('i-blood thinner') efana ne-warfarin (Coumadin, Jantoven); i-antidepressants (’mood elevators’) ezinje nge-amitriptyline, desipramine (Norpramin), doxepin (Silenor, Zonalon), imipramine (Tofranil, Surmontil), protriptyline (Vivactil), trazodone, kunye ne-trimipramine (Surmontil); ii-antifungals ezithile ezinje nge-itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), kunye ne-voriconazole (Vfend); bepridil (Vascor) (ayifumaneki e-US); iibhloko ze-beta ezinjengelebetalol (iTrandate), i-nadolol (iCorgard, eCorzide), kunye nepropranolol (IHemangeol, i-Inderal, i-Innopran XL, kwi-Inderide); i-boceprevir (ayisafumaneki e-US; iVictrelis); i-bosentan (iTracleer); i-buprenorphine (iBuprenex, iButrans, kwiBunavail, eSuboxone, eZubsolv); iicalcium block blockers ezinjenge diltiazem (Cardizem, Cartia, Tiazac, abanye), felodipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia), kunye ne-verapamil (Calan, Verelan, eTarka, abanye); amayeza athile athoba i-cholesterol (ii-statins) ezinjenge-atorvastatin (Lipitor, eCaduet), kunye ne-rosuvastatin (Crestor); i-clarithromycin (i-Biaxin, kwi-Prevpac); icolchicine (iiColcrys, iMitigare); idigoxin (Lanoxin); i-fluticasone (iFlonase, iFlovent, eAdvair); amayeza okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Cordarone, Nexterone, Pacerone), lidocaine (Octocaine, Xylocaine), kunye nequinidine (eNuedexta); amayeza athintela amajoni omzimba anje ngecyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), kunye netacrolimus (Astagraf, Prograf); amanye amayeza e-HIV okanye i-AIDS kubandakanya i-efavirenz (Sustiva, e-Atripla), ritonavir (Norvir, e-Kaletra, e-Viekira Pak), saquinavir (Invirase), kunye ne-tenofovir (Viread, e-Atripla, eSribild, eTruvada, ezinye); midazolam ngenaliti; iPaclitaxel (Abraxane, iTaxol); ezithile ze-phosphodiesterase inhibitors (PDE-5 inhibitors) ezisetyenziselwa ukungasebenzi kakuhle kwe-erectile njenge-sildenafil (Viagra), tadalafil (Cialis), kunye ne-vardenafil (Levitra, Staxyn); repaglinide (Prandin, kwi Prandimet); iquetiapine (iSeroquel); irifabutin (Mycobutin); isalmeterol (iSerevent, eAdvair); isofosbuvir, velpatasvir, kunye ne-voxilaprevir (Sovaldi, Epclusa, Vosevi); kunye neTadalafil (Adcirca, Cialis). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-atazanavir, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha ii-antacids, i-didanosine yokulibaziseka-yokukhupha iicapsule (iVidex EC), okanye nawaphi na amanye amayeza angasebenziyo anjenge-aspirin (Bufferin), thatha i-atazanavir kwiiyure ezi-2 ngaphambi okanye kwiyure enye emva kokuba uthathe amayeza. Buza ugqirha wakho okanye usokhemesti ukuba awuqinisekanga ukuba ngaba nawaphi na amayeza owathathayo alungisiwe.
• xelela ugqirha wakho ukuba uthatha amayeza okugaya isisu, isilungulela, okanye izilonda ezinje nge-cimetidine, esomeprazole (Nexium, eVimovo), i-famotidine (Pepcid, e-Duexis), i-lansoprazole (Prevacid, e-Prevpac), i-nizatidine (Axid), omeprazole (Prilosec, eZegerid), pantoprazole (Protonix), rabeprazole (AcipHex), okanye ranitidine (Zantac). Ugqirha wakho unokukuxelela ukuba ungawathathi amayeza okanye uthathe idosi encinci yamayeza. Ukuba uza kuqhubeka nokuthatha amayeza, ugqirha wakho uya kukuxelela ukuba lingakanani ixesha ekufuneka ulivumele phakathi kokuthatha amayeza kunye nokuthatha i-atazanavir.
• xelela ugqirha wakho ukuba ngaba ubukhe wanesifo sentliziyo esingaqhelekanga, isifo seswekile okanye iswekile ephezulu yegazi, ihemophilia (imeko apho igazi lingagqumi ngesiqhelo) okanye nakuphi na ukuphazamiseka kokopha, hepatitis (usulelo lwentsholongwane esibindini) okanye esinye isifo sesibindi, izintso okanye isifo sentliziyo.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ukhulelwa ngelixa uthatha i-atazanavir, tsalela ugqirha wakho. Akufanelanga ukuncancisa xa wosulelwe yi-HIV kwaye uthatha i-atazanavir.
• Kuya kufuneka uyazi ukuba i-atazanavir inokunciphisa ukusebenza kwezicwangcisi zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa kunye nenaliti). Thetha nogqirha wakho malunga neendlela zolawulo lokuzalwa eziza kukusebenzela ngelixa uthatha i-atazanavir.
• ukuba uyenziwa utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-atazanavir.
• Kuya kufuneka uyazi ukuba unokufumana i-hyperglycemia (inyuka kwiswekile esegazini lakho) ngelixa uthatha eli yeza, nokuba awukabinaso isifo seswekile. Xelela ugqirha wakho kwangoko ukuba unayo kwezi mpawu zilandelayo ngelixa uthatha i-atazanavir: ukunxanwa okugqithisileyo, ukuchama rhoqo, indlala egqithisileyo, umbono ophuthileyo, okanye ubuthathaka. Kubaluleke kakhulu ukubiza ugqirha wakho nje ukuba ube nazo naziphi na ezi mpawu, kuba iswekile ephezulu yegazi enganyangekiyo inokubangela imeko embi ebizwa ngokuba yi ketoacidosis. I-Ketoacidosis inokuba sengozini yobomi ukuba ayinyangwa kwangoko. Iimpawu zeketoacidosis zibandakanya: umlomo owomileyo, isicaphucaphu kunye nokugabha, ukuphefumla kancinci, umphefumlo onuka iziqhamo, kunye nokwehla kwengqondo.
• Kuya kufuneka uyazi ukuba ngelixa uthatha i-atazanavir amanqatha omzimba wakho anganyuka okanye ahambele kwiindawo ezahlukeneyo zomzimba wakho njengasemva kwentamo yakho kunye namagxa aphezulu ('inyathi i-hump'), isisu, namabele. Ungaphulukana namanqatha ezingalweni, emilenzeni, ebusweni nasezimpundu. Thetha nogqirha wakho ukuba uphawula naluphi na olu tshintsho kumanqatha akho emzimbeni.
• ukuba unayo i-phenylketonuria (PKU, imeko ezuzwe njengelifa apho ukutya okukhethekileyo kufuneka kulandelwe ukuthintela ukudodobala kwengqondo), kuya kufuneka wazi ukuba i-atazanavir powder umgubo uswiti kunye ne-aspartame eyenza i-phenylalanine.
• Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho. Oku kunokubangela ukuba ube neempawu zolu sulelo. Ukuba uneempawu ezintsha okanye eziba mandundu nangaliphi na ixesha kunyango lwakho nge-atazanavir, qiniseka ukuxelela ugqirha wakho.

Thetha nogqirha wakho malunga nokutya igrapefruit okanye ukusela ijusi yegrapefruit ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Atazanavir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• isisu esibuhlungu
• urhudo
• intloko ebuhlungu
• ukudakumba
• ifiva
• ubunzima bokulala okanye ukulala
• iintlungu zemisipha
• irhashalala ethambileyo
• ukuba ndindisholo, ukutshisa, iintlungu, okanye ukurhawuzelelwa kwezandla okanye iinyawo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukubetha kwentliziyo ngokungaqhelekanga
• isiyezi
• ndiziva ndidiniwe okanye ndinentloko elula
• utshintsho lombono
• ubumthubi besikhumba okanye amehlo (ngakumbi kwiintsana ezisandul 'ukuzalwa)
• iintlungu emqolo okanye ecaleni
• intlungu okanye ukutshisa ngokuchama
• igazi kumchamo
• ukugabha
• Ukuphelelwa ngumdla wokutya
• ukudumba kwezandla, iinyawo, imilenze, okanye amaqatha
• ukuncipha kokuchama
• umchamo omnyama-mnyama
• intshukumo ekhanyayo emathunjini
• ulwakhiwo oluhlala ixesha elide kuneeyure ezingama-4

Ukuba uhlakulela ukukhawuleza okukhulu kunye naziphi na iimpawu ezilandelayo, yeka ukuthatha i-atazanavir uze ubize ugqirha wakho ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukugula ngokubanzi okanye 'iimpawu zomkhuhlane'
• ifiva
• izihlunu okanye amalungu ngokudibeneyo
• amehlo abomvu okanye adumbileyo
• i-blisters okanye i-peeling skin
• izilonda zomlomo
• ukudumba kobuso bakho okanye intamo
• iqhuma elibuhlungu, elifudumeleyo, okanye elibomvu phantsi kolusu lwakho

I-Atazanavir inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina la mayeza kwisitya okanye ipakethi engenile, ivaliwe ngokuqinileyo, kwaye ingafikeleleki kubantwana nakwizilwanyana zasekhaya. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• mthubi ulusu okanye amehlo

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-atazanavir.

Gcina unikezelo lwe-atazanavir ngesandla. Sukulinda de uphelelwe ngamayeza ukuze uphinde uzalise amayeza akho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Reyataz^®

• Evotaz^® (Equlathe iAtazanavir, iCobicistat)

• I-ATZ