Inaliti engaphezulu

Umxholo

• Ngaphambi kokusebenzisa inaliti engaphezulu,
• Eli yeza linokubangela utshintsho kwiswekile yegazi lakho. Kuya kufuneka uyazi iimpawu zeswekile esezantsi kunye ephezulu yegazi kwaye wenzeni ukuba unayo le miqondiso.
• Inaliti ye-Exenatide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo okanye ezo zidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, yeka ukusebenzisa ixesha elingaphezulu kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

Inaliti ye-Exenatide inokuwonyusa umngcipheko wokuba ube nezihlunu ze-thyroid, kubandakanya i-medullary thyroid carcinoma (MTC; uhlobo lomhlaza wedlala lengqula). Izilwanyana zaselebhu ezazinikwe amathumba angaphezulu, kodwa ayaziwa ukuba eli yeza lonyusa umngcipheko wamathumba ebantwini. Tshela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho une-MTC okanye i-Multiple Endocrine Neoplasia syndrome yohlobo lwesibini (i-MEN 2; imeko ebangela amathumba kwilungu elinye emzimbeni). Ukuba kunjalo, ugqirha wakho uya kukuxelela ukuba ungasebenzisi inaliti engaphezulu. Ukuba unazo naziphi na kwezi mpawu zilandelayo, biza ugqirha ngoko nangoko: iqhuma okanye ukudumba entanyeni; ukudakumba; ubunzima bokugwinya; okanye ukuphefumla okufutshane.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngenaliti eyandisiweyo yokukhululwa kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga neengozi zokusebenzisa inaliti engaphezulu.

I-Exenatide isetyenziswa kunye nokutya kunye nokuzilolonga ukunyanga uhlobo lwe-2 yeswekile (imeko apho umzimba ungasebenzisi i-insulin ngokwesiqhelo kwaye ngenxa yoko awukwazi ukulawula ubungakanani beswekile egazini). I-Exenatide ikwiklasi yamayeza abizwa ngokuba yi-incretin mimetics. Isebenza ngokukhuthaza i-pancreas ukukhupha i-insulin xa amanqanaba eshukela egazi ephezulu. I-insulin inceda ukuhambisa iswekile egazini iye kwezinye izicwili zomzimba apho isetyenziselwa khona amandla. Ukugqithisa kwakhona kunciphisa ukukhutshwa kwesisu kwaye kubangele ukwehla kokutya. I-Exenatide ayisetyenziswanga ukunyanga isifo seswekile sokuqala (imeko apho umzimba ungayivelisi khona i-insulin kwaye ngenxa yoko ayinakho ukulawula ubungakanani beswekile esegazini). I-Exenatide ayisetyenziswanga endaweni ye-insulin ukunyanga abantu abanesifo seswekile abafuna i-insulin.

Ixesha elingaphezulu, abantu abanesifo seswekile kunye neswekile ephezulu yegazi banokuba neengxaki ezinzulu okanye ezisongela ubomi, kubandakanya isifo sentliziyo, ukubetha, iingxaki zezintso, ukonakala kwemithambo-luvo kunye neengxaki zamehlo. Sebenzisa amayeza, ukwenza utshintsho kwindlela yokuphila (umzekelo, ukutya, ukwenza umthambo, ukuyeka ukutshaya), kunye nokujonga iswekile yegazi rhoqo kunokunceda ukulawula isifo seswekile kunye nokuphucula impilo yakho. Olu nyango lunokunciphisa amathuba akho okuhlaselwa sisifo sentliziyo, ukubetha, okanye ezinye iingxaki ezinxulumene nesifo seswekile ezinje ngokusilela kwezintso, ukulimala kwentliziyo (ukubindeka, imilenze ebandayo okanye iinyawo; ukunciphisa amandla ezesondo kumadoda nabasetyhini), iingxaki zamehlo, kubandakanya notshintsho okanye ukulahleka kombono, okanye isifo seentsini. Ugqirha wakho kunye nabanye ababoneleli ngempilo bayakuthetha nawe ngeyona ndlela yokulawula isifo sakho seswekile.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seMithi) xa uqala unyango ngokungaphaya kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.

Ukukhutshwa kwangoko (i-Byetta^®) iza njengesisombululo (ulwelo) kwipenisi yedosi ekhethiweyo yokufaka inaliti (phantsi kolusu). Ukukhutshwa okwandisiweyo okwandisiweyo (ukusebenza ixesha elide) (Bydureon^®) iza njengomgubo oxutywe nolwelo kwi-vial okanye ipeni yedosi ekhethiweyo yokujova ngendlela engeyiyo. Isisombululo esiphuma ngokukhawuleza esivela ngokukhawuleza sihlala sitofwe kabini ngemini kwisithuba semizuzu engama-60 ngaphambi kokutya kwasekuseni nangokuhlwa; sukuyitofa emva kokutya. Ugqirha wakho uya kukuqala ngedosi esezantsi yokufumana inaliti yokukhupha kwangoko kwaye unokukutshintshela usiba ngephepha elinedosi ephezulu ukuba ulawulo lweswekile yegazi aluphuculanga emva kokuba usebenzise ixesha elingaphezulu kwinyanga e-1. Isisombululo esandisiweyo sokukhutshwa sikhutshiwe kanye ngeveki nangaliphi na ixesha losuku ngaphandle kokutya. Sebenzisa ukukhutshwa okwandisiweyo okwandisiweyo ngosuku olunye ngeveki ngalo naliphi na ixesha losuku. Ungalutshintsha usuku lweveki oyisebenzisayo xa ukhupha i-exenatide eyandisiweyo ukuba ibiyi-3 okanye ngaphezulu kweentsuku okoko usebenzise idosi yakho yokugqibela. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Sebenzisa inaliti ye exenatide ngokuchanekileyo njengoko kuyalelwe. Sukuyisebenzisa ngaphezulu okanye ngaphantsi okanye uyisebenzise rhoqo kunokuyalelwa ngugqirha.

Ukuba utshintsha ukusuka kukhululo olukhawulezileyo ukongeza ukukhutshwa okwandisiweyo, amanqanaba eswekile yakho (iswekile) anokunyuka okwethutyana iiveki ezi-2 ukuya kwezi-4 emva kolu tshintsho.

Ulawulo lwangaphandle lwesifo seswekile kodwa alusinyangi. Qhubeka nokusebenzisa ngaphandle nokuba uziva uphilile. Sukuyeka ukusebenzisa ngaphandle ngaphandle kokuthetha nogqirha wakho.

Ukuba usebenzisa i-exenatide-release-release (Byetta^®) Iipeni zeedosi ezifakiweyo, kuyakufuneka uthenge iinaliti ngokwahlukeneyo. Buza ugqirha wakho okanye usokhemesti ukuba loluphi uhlobo lweenaliti oza kuzidinga ukujova amayeza akho. Qiniseka ukuba uyayiqonda kwaye uyayiqonda imiyalelo yomvelisi yokutofa ngaphandle usebenzisa ipeni. Qiniseka ukuba uyazi ukuba uyicwangcisa njani kwaye nini ipeni entsha. Buza ugqirha wakho okanye usokhemisti akubonise indlela yokusebenzisa usiba. Landela izikhokelo ngononophelo. Ungaze uyisuse iCartridge ebuhlanti okanye uzame ukongeza naluphi na olunye uhlobo lwamayeza kwikhatriji.

Ngalo lonke ixesha jonga kwisisombululo sakho sangaphambi kokuba usitofe. Kufuneka icace gca, ingenambala, kwaye inamanzi njengamanzi. Sukusebenzisa indawo exenatide ukuba inombala, inamafu, iyajiya, okanye iqulethe amasuntswana aqinileyo, okanye ukuba umhla wokuphelelwa kwebhotile udlulile. Musa ukudibanisa i-exenatide ne-insulin kwisitofu esinye.

Ungaze uphinde usebenzise iinaliti kwaye ungaze wabelane ngeenaliti okanye iipeni. Soloko uyisusa inaliti emva kokuba utofile idosi yakho. Lahla iinaliti kwisitya esinganyangekiyo. Buza ugqirha wakho okanye usokhemesti ngendlela yokusilahla isikhongozeli esinganyangekiyo.

I-Exenatide inokulawulwa kwithanga (umlenze ongasentla), isisu (isisu), okanye ingalo ephezulu. Sebenzisa indawo eyahlukileyo ngenaliti nganye, malunga ne-intshi enye (2.5 iisentimitha) kude nenaliti yangaphambili kodwa kwindawo enye efanayo (umzekelo, ithanga). Sebenzisa zonke iisayithi ezikhoyo kwindawo efanayo ngaphambi kokutshintshela kwindawo eyahlukileyo (umzekelo, ingalo ephezulu). Sukusebenzisa indawo efanayo yenaliti rhoqo ngaphezu kwenyanga nganye.

Unokufaka i-exentadine kunye ne-insulin eyandisiweyo kwindawo efanayo yomzimba, kodwa iinaliti akufuneki zinikezwe kanye ecaleni kwenye.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokusebenzisa inaliti engaphezulu,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba u-aleji ukuya exenatide, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-exenatide injection. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Kubaluleke ngakumbi ukuxelela ugqirha wakho malunga nawo onke amayeza owathatha ngomlomo kuba i-exenatide inokutshintsha indlela umzimba wakho owabamba ngayo la mayeza. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-angiotensin-converting enzyme (ACE) inhibitors enjenge benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipcil Un ( , perindopril, (Aceon), quinapril (Accupril), ramipril (Altace), kunye trandolapril (Mavika); umchamo ('iipilisi zamanzi'); i-aspirin kunye nezinye iziyobisi ezichasayo (i-NSAIDs) ezifana ne-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve, Naprosyn); i-lovastatin (Altoprev, kwiGqwetha); amayeza kuxinzelelo lwegazi; I-insulin okanye amanye amayeza ukunyanga isifo seswekile njenge-sulfonylureas enjenge-chlorpropamide (Diabinese), glimepiride (Amaryl, e-Avandaryl, e-Duetact), glipizide (Glucotrol), glyburide (DiaBeta, e-Glucovance), tolazamide, kunye ne-tolbutamide, kunye ne-warfarin (Coumadin , Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• ukuba uthatha izinto zokucwangcisa ngomlomo (iipilisi zolawulo lokuzalwa) okanye ii-antibiotics, zithathe okungenani iyure enye ngaphambi kokuba usebenzise inaliti ye-exenatide. Ukuba uxelelwe ukuba uthathe la mayeza kunye nokutya, thatha ngesidlo okanye ukutya okutyayo ngexesha ongasebenzisi ngalo.
• xelela ugqirha wakho ukuba uyasela okanye wakha wasela izixa ezikhulu zotywala, kwaye ukuba unesicaphucaphu, ukugabha, urhudo okanye ucinga ukuba unokuphelelwa ngamanzi emzimbeni, okanye ucinga ukuba ezi mpawu uzenza nangaliphi na ixesha kunyango lwakho. Xelela ugqirha wakho ukuba ukhe wafakelwa izintso okanye ukuba ukhe okanye wakha wanengxaki ezinzima zesisu, kubandakanya i-gastroparesis (ukucothisa ukuhamba kokutya ukusuka esiswini ukuya emathunjini amancinci) okanye ezinye iingxaki zokwetyisa ukutya; i-pancreatitis (ukudumba kwepancreas), i-gallstones (iidipozithi eziqinileyo ezenza i-gallbladder), okanye inqanaba eliphezulu le-triglycerides (amafutha) egazini, okanye ipancreas, isibindi, okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwe ngelixa usebenzisa ixesha elingaphezulu, biza ugqirha wakho.
• buza ugqirha wakho malunga nokusetyenziswa okukhuselekileyo kweziselo ezinxilisayo ngelixa uthatha i-exenatide.
• buza ugqirha wakho ukuba wenzeni ukuba uyagula, uhlasele usulelo okanye umkhuhlane, amava oxinzelelo angaqhelekanga, okanye wenzakele. Ezi meko zinokuchaphazela iswekile yegazi lakho kunye nenani le-exenatide onokuyifuna.

Qiniseka ukuba ulandela yonke imithambo kunye nezincomo zokutya ezenziwe ngugqirha wakho okanye ugqirha otya ukutya. Kubalulekile ukutya ukutya okusempilweni.

Ukuba uphosa idosi yenaliti yokukhupha kwangoko (Byetta^®), tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukujoba idosi ephindwe kabini ukulungiselela eyilahlekileyo.

Ukuba uphosa idosi ye-exenatide eyandisiweyo-yokukhupha inaliti (Bydureon^®), Sebenzisa idosi ephosiweyo kwakamsinya nje emva kokuba uyikhumbule kwaye uqhubeke neshedyuli yakho yesiqhelo yeveki. Nangona kunjalo, ukuba kukho iintsuku ezingaphantsi kwe-3 (iiyure ezingama-72) kude kufike idosi yakho ehleliweyo elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukusebenzisa idosi ephindwe kabini ukwenza eyilahlekileyo.

Eli yeza linokubangela utshintsho kwiswekile yegazi lakho. Kuya kufuneka uyazi iimpawu zeswekile esezantsi kunye ephezulu yegazi kwaye wenzeni ukuba unayo le miqondiso.

Inaliti ye-Exenatide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• urhudo
• ukuqhina
• Imvakalelo yejittery
• isiyezi
• isilungulela
• intloko ebuhlungu
• ubuthathaka
• ukubila

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo okanye ezo zidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, yeka ukusebenzisa ixesha elingaphezulu kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• iintlungu eziqhubekayo eziqala ngasentla ngasekhohlo okanye embindini wesisu kodwa zisenokunabela ngasemva kunye okanye ngaphandle kokugabha
• urhwebo
• irhashalala
• ukurhawuzelela
• ubunzima bokuphefumla okanye ukugwinya
• iintlungu kwindawo yenaliti, ukudumba, iblisters, ukurhawuzelela, okanye amaqhuqhuva
• ukudumba kobuso, umqala, ulwimi, imilebe, amehlo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• iintlungu kwindawo yasekunene okanye ephezulu esiswini, isicaphucaphu, ukugabha, umkhuhlane, okanye ubumthubi besikhumba okanye amehlo
• utshintsho kumbala okanye kwinani lomchamo
• ukuchama kaninzi okanye ngaphantsi kunesiqhelo
• ukudumba kweengalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ukunciphisa ukutya

Ukugqithisa kunokubangela ezinye iziphumo. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa usebenzisa eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina iipeni ezingasetyenziswanga zangaphandle kwiibhokisi zaso zokuqala kwifriji ekhuselweyo ekukhanyeni. Nje ukuba isetyenziswe, gcina iipeni ezingaphandle kwiqondo lobushushu begumbi (ukuya kuthi ga kwi-77 ° F [25 ° C]) ekhuselweyo ekukhanyeni. Musa ukubanda. Sukusebenzisa exenatide ukuba ikhenkcezisiwe. Musa ukugcina iipeni ezingaphandle ngenaliti eqhotyoshelweyo. Gcina iipeni ezingaphandle apho abantwana bangenakufikelela khona.

Xa useluhambeni, qiniseka ukuba ugcina iipeni ezingaphezulu zomile. Iipeni ezingasetyenziswanga kufuneka zifriwe okanye zigcinwe kubushushu obubandayo phakathi kwe-36 ° F ukuya kwi-46 ° F (2 ° C ukuya kwi-8 ° C). Iipeni ezisetyenziswayo zingagcinwa kubushushu begumbi ukuya kuthi ga kwi-77 ° F (25 ° C) (hayi kwigumbi leglavu yemoto okanye kwenye indawo eshushu).

Yenza inqaku lomhla wokuqala ukusebenzisa ipeni engaphezulu, kwaye uyilahle ipeni emva kweentsuku ezingama-30, nokuba kukho isisombululo esishiyekileyo ebuhlanti.

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• isisu esibuhlungu kakhulu
• isicaphucaphu
• ukugabha kakhulu
• isiyezi
• Iimpawu zehypoglycemia

Iswekile yegazi lakho kunye nehemoglobin yeglycosylated (HbA1c) kufuneka ihlolwe rhoqo ukumisela impendulo yakho exenatide. Ugqirha wakho uya kukuxelela nendlela yokujonga impendulo yakho kolu nyango ngokulinganisa igazi lakho okanye umchamo wamanqanaba eswekile ekhaya. Landela le miyalelo ngononophelo.

Musa ukuvumela omnye umntu asebenzise amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Bydureon^®
• Byetta^®