Igama elithi Lenalidomide

Umxholo

• Ngaphambi kokuba uthathe i-lenalidomide,
• I-Lenalidomide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

Umngcipheko weziphene zokuzalwa ezisongela ubomi ezibangelwa yi-lenalidomide:

Zonke izigulana:

I-Lenalidomide akufuneki ithathwe zizigulana ezikhulelweyo okanye ezinokukhulelwa. Kukho umngcipheko omkhulu wokuba i-lenalidomide iya kubangela iziphene zokuzalwa ezinzima (iingxaki ezikhoyo ekuzalweni) okanye ukusweleka kosana olungekazalwa.

Inkqubo ebizwa ngokuba yi-REVLIMID REMS^TM imiselwe ukuqinisekisa ukuba abasetyhini abakhulelweyo abayithathi i-lenalidomide kwaye abasetyhini abakhulelwa ngelixa bathatha i-lenalidomide. Zonke izigulana, kubandakanya nabasetyhini abangakwaziyo ukukhulelwa kunye namadoda, banokufumana i-lenalidomide kuphela ukuba babhalisiwe kwi-REVLIMID REMS, banamayeza kagqirha obhaliswe kwi-REVLIMID REMS, kwaye bagcwalise amayeza kwikhemesti ebhaliswe kwi-REVLIMID REMS .

Uya kufumana ulwazi malunga nomngcipheko wokuthatha i-lenalidomide kwaye kufuneka utyikitye iphepha lemvume elinolwazi elichazayo ukuba uyayiqonda le ngcaciso ngaphambi kokuba ufumane amayeza. Ukuba ungaphantsi kweminyaka eli-18 ubudala, umzali okanye umgcini makasayine iphepha lemvume kwaye avume ukuqinisekisa ukuba uyazifezekisa ezi mfuno. Uya kudinga ukubona ugqirha wakho ngexesha lonyango lwakho ukuze uthethe malunga nemeko yakho kunye neziphumo ezibi ohlangabezana nazo okanye kuvavanyo lokukhulelwa njengoko kucetyisiwe yinkqubo. Kusenokufuneka ugcwalise uphando oluyimfihlo ekuqaleni konyango lwakho kwaye nangamaxesha athile ngexesha lonyango lwakho ukuze uqiniseke ukuba uyifumene kwaye uyayiqonda le ngcaciso kwaye unokulandela imiyalelo yokuthintela umngcipheko omkhulu kwiintsana ezingekazalwa.

Xelela ugqirha wakho ukuba awuyiqondi yonke into obuyixelelwe malunga neleneralomide kunye nenkqubo ye-REVLIMID REMS kunye nendlela yokusebenzisa iindlela zolawulo lokuzalwa ekuxoxwe ngazo nogqirha wakho, okanye ukuba awucingi ukuba uza kuba nakho ukugcina amadinga.

Musa ukunikela ngegazi ngelixa uthatha i-lenalidomide, ngalo naliphi na ikhefu kunyango lwakho, nakwiiveki ezi-4 emva kwedosi yokugqibela.

Musa ukwabelana ngeleneralomide naye nabani na ongomnye, nokuba umntu uneempawu ezifanayo nezakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngeleneralomide kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs), iwebhusayithi yomenzi, okanye iwebhusayithi yenkqubo yeReVLIMID REMS (http://www.revlimidrems.com) ukufumana Isikhokelo seyeza.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-lenalidomide.

Kwabaguli ababhinqileyo:

Ukuba unokukhulelwa, kuya kufuneka uhlangane neemfuno ezithile ngexesha lonyango lwakho ngeleneralomide.Kuya kufuneka usebenzise iindlela ezimbini ezamkelekileyo zolawulo lokuzalwa kwiiveki ezi-4 ngaphambi kokuba uqale ukuthatha i-lenalidomide, ngexesha lonyango, kubandakanya amaxesha xa ugqirha ekuxelela ukuba uyeke okwethutyana ukuthatha i-lenalidomide, kunye neeveki ezi-4 emva kwethamo lakho lokugqibela. Ugqirha wakho uza kukuxelela ukuba zeziphi iindlela zolawulo lokuzalwa ezamkelekileyo kwaye uya kukunika ulwazi olubhaliweyo malunga nolawulo lokuzalwa. Kuya kufuneka usebenzise ezi ndlela zimbini zolawulo lokuzalwa ngalo lonke ixesha ngaphandle kokuba unokuqinisekisa ukuba awuzukubanakho ukunxibelelana ngokwesondo nendoda kangangeeveki ezi-4 ngaphambi konyango lwakho, ngexesha lonyango lwakho, nangaluphi na uphazamiso kunyango lwakho, nakwiiveki ezi-4 emva idosi yakho yokugqibela.

Ukuba ukhetha ukuthatha i-lenalidomide, luxanduva lwakho ukuthintela ukukhulelwa iiveki ezi-4 ngaphambili, ngexesha, kunye nakwiiveki ezi-4 emva kwedosi yokugqibela. Kuya kufuneka uqonde ukuba naluphi na uhlobo lolawulo lokuzalwa alunakusilela. Ke ngoko, kubaluleke kakhulu ukunciphisa umngcipheko wokukhulelwa ngengozi ngokusebenzisa iindlela ezimbini zolawulo lokuzalwa. Xelela ugqirha wakho ukuba awuyiqondi yonke into obuyixelelwe malunga nolawulo lokuzalwa okanye awucingi ukuba uya kuba nakho ukusebenzisa iindlela ezimbini zolawulo lokuzalwa ngalo lonke ixesha.

Kuya kufuneka uneemvavanyo ezimbini ezimbi zokukhulelwa ngaphambi kokuba uqale ukuthatha i-lenalidomide. Kuya kufuneka ukuba uvavanywe ukukhulelwa elebhu ngamaxesha athile ngexesha lonyango lwakho. Ugqirha wakho uya kukuxelela ukuba nini kwaye phi.

Yeka ukuthatha i-lenalidomide kwaye ubize ugqirha wakho ngoko nangoko ukuba ucinga ukuba ukhulelwe, uyaphoswa lixesha lokuya exesheni, uphuma igazi ngokungaqhelekanga, okanye ulala ngesondo ngaphandle kokusebenzisa iindlela ezimbini zolawulo lokuzalwa. Ukuba ukhulelwe ngexesha lonyango lwakho okanye kwiintsuku ezingama-30 emva konyango lwakho, ugqirha wakho uya kuqhagamshelana nenkqubo ye-REVLIMID REMS, umvelisi weleneralomide, kunye noLawulo lwezoKutya kunye noLawulo lweziyobisi (FDA). Uyakuthetha nogqirha ogxile kwiingxaki ngexesha lokukhulelwa onokuthi akuncede wenze ukhetho olulungele wena nosana lwakho. Ulwazi malunga nempilo yakho kunye nempilo yosana lwakho luya kusetyenziswa ukunceda oogqirha bafunde ngakumbi malunga nefuthe lelenalidomide kwiintsana ezingekazalwa.

Kwizigulana ezingamadoda:

I-Lenalidomide ikhona kwisidoda sakho xa usela la mayeza. Kuya kufuneka usoloko usebenzisa ikhondom ye-latex, nokuba unayo i-vasectomy (utyando oluthintela indoda ekukhulelweni), ngalo lonke ixesha usabelana ngesondo nomntu obhinqileyo okhulelweyo okanye okwaziyo ukukhulelwa ngelixa uthatha i-lenalidomide, ngalo naliphi na ikhefu kunyango lwakho, nakwiiveki ezi-4 emva kwedosi yakho yokugqibela. Xelela ugqirha wakho ukuba unokwabelana ngesondo nomntu obhinqileyo ngaphandle kokusebenzisa ikhondom okanye ukuba iqabane lakho licinga ukuba angakhulelwa ngexesha lonyango lwakho nge-lenalidomide.

Musa ukunikela ngesidoda ngelixa uthatha i-lenalidomide, ngalo naliphi na ikhefu kunyango lwakho, nakwiiveki ezi-4 emva kwedosi yokugqibela.

Eminye imingcipheko yokuthatha i-lenalidomide:

I-Lenalidomide inokubangela ukwehla kwenani leentlobo ezithile zeeseli zegazi emzimbeni wakho. Ugqirha wakho uya kuyalela iimvavanyo zaselebhu rhoqo ngexesha lonyango lwakho ukuze abone ukuba inani leeseli zegazi lehlile kangakanani. Ugqirha wakho unokunciphisa idosi yakho, ukuphazamisa unyango lwakho, okanye ukunyanga ngamanye amayeza okanye unyango ukuba ukwehla kweeseli zakho zegazi kunzima. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: umqala obuhlungu, umkhuhlane, Ukugodola kunye nezinye iimpawu zosulelo; ukugruzuka okulula okanye ukopha; iintsini zokopha; okanye ukuphuma kweempumlo.

Ukuba uthatha i-lenalidomide kunye ne-dexamethasone ukunyanga i-myeloma eninzi, kukho umngcipheko owandileyo wokuba uphuhlise iqhekeza legazi emlenzeni wakho onokuthi uhambe ngokuhamba kwegazi uye kwimiphunga yakho, okanye uhlaselwe sisifo sentliziyo okanye ukubetha. Ugqirha wakho unokuyalela amanye amayeza ukuba athathwe kunye ne-lenalidomide ukunciphisa umngcipheko. Xelela ugqirha wakho ukuba uyatshaya, ukuba ukhe waba negazi elixineneyo, nokuba ukhe wanalo uxinzelelo lwegazi oluphezulu okanye amanqanaba aphezulu enqatha egazini lakho. Xelela ugqirha wakho malunga nawo onke amayeza owathathayo kuba amayeza athile anokunyusa umngcipheko wokuba uphuhlise igazi xa uthatha i-lenalidomide ene-dexamethasone kubandakanya i-darbepoetin (Aranesp), i-epoetin alfa (i-Epogen, i-Procrit), kunye namayeza ane-estrogen enje Unyango lwehomoni okanye unyango lwezinto zokucwangcisa zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa, okanye inaliti) Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: ukuphefumla kancinci; Intlungu yesifuba enokusasazeka kwiingalo, entanyeni, emqolo, emhlathini, okanye esiswini; ukukhohlela; ububomvu okanye ukudumba engalweni okanye emlenzeni; ukubila; isicaphucaphu; ukugabha; ubuthathaka ngequbuliso okanye ukuba ndindisholo, ngakumbi kwicala elinye lomzimba; intloko ebuhlungu; ukudideka; okanye ubunzima ngombono, intetho, okanye ukulinganisela.

I-Lenalidomide isetyenziselwa ukunyanga uhlobo oluthile lwe-myelodysplastic syndrome (iqela leemeko apho umongo wethambo uvelisa iiseli zegazi ezingalunganga kwaye zingavelisi iiseli zegazi ezoneleyo). I-Lenalidomide ikwasetyenziswa kunye ne-dexamethasone ukunyanga abantu abane-myeloma (uhlobo lomhlaza womongo wethambo). Isetyenziselwa ukunyanga abantu abane-myeloma emininzi emva kokufakwa kwe-hematopoietic stem-cell (HSCT; inkqubo apho iiseli ezithile zegazi zisuswe emzimbeni zaze zabuyela emzimbeni). I-Lenalidomide ikwasetyenziselwa ukunyanga abantu abane-mantle cell lymphoma (umhlaza okhula ngokukhawuleza oqala kwiiseli zomzimba) abaye baphathwa nge-bortezomib (Velcade) kunye nelinye elinye iyeza. I-Lenalidomide akufuneki isetyenziselwe ukunyanga abantu abane-lymphocytic leukemia (uhlobo lomhlaza weeseli ezimhlophe zegazi eziya zisiba mandundu ngokuhamba kwexesha) ngaphandle kokuba bathathe inxaxheba kuvavanyo lweklinikhi (uphando lophando ukubona ukuba amayeza angasetyenziswa ngokukhuselekileyo kwaye ukunyanga imeko ethile). I-Lenalidomide ikwiklasi yamayeza abizwa ngokuba ziiarhente ze-immunomodulatory agents. Isebenza ngokunceda umongo wethambo ukuvelisa iiseli eziqhelekileyo zegazi kunye nokubulala iiseli ezingaqhelekanga kumongo wethambo.

I-Lenalidomide iza njengepilisi yokuthatha ngomlomo. Xa i-lenalidomide isetyenziselwa ukunyanga i-myelodysplastic syndrome, ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye yonke imihla. Xa i-lenalidomide isetyenziselwa ukunyanga i-myeloma okanye i-mantle cell lymphoma, ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye ngeentsuku zokuqala ezingama-21 zomjikelo weentsuku ezingama-28. Xa i-lenalidomide isetyenziselwa ukunyanga i-myeloma emininzi emva kwe-HSCT, ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye ngeentsuku ezingama-28 zomjikelo weentsuku ezingama-28. Inkqubo yomjikelo weentsuku ezingama-28 inokuphindwa njengoko kucetyiswa ngugqirha ngokusekwe ekuphenduleni komzimba wakho kweli yeza. Thatha i-lenalidomide malunga nexesha elifanayo lemihla ngemihla oyithathayo. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-lenalidomide ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Gwinya zonke njengezingxobo ngamanzi amaninzi; musa ukuwaphula, ungawuhlafune, okanye uwavule. Phatha iifomsile kancinci kangangoko kunokwenzeka. Ukuba uchukumisa i-capsule ye-lenalidomide eyaphukileyo okanye iyeza elikwi-capsule, hlamba loo ndawo yomzimba wakho ngesepha namanzi. Ukuba iyeza elikwipilisi lingena emlonyeni, empumlweni, okanye emehlweni, lihlanze ngamanzi amaninzi.

Ugqirha wakho unokufuna ukuphazamisa unyango lwakho okanye ukunciphisa idosi yakho ukuba uneziphumo ebezingalindelekanga ezithile. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-lenalidomide.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-lenalidomide,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-lenalidomide, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwii-capsule ze-lenalidomide. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nedigoxin (Lanoxin). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ngaba awunyamezeli i-lactose kwaye ukuba unayo okanye wakhe waba nezintso, idlala lengqula okanye isifo sesibindi. Xelela ugqirha wakho ukuba ukhe wathatha i-thalidomide (Thalomid) kwaye wenza irhashalala ngexesha lonyango lwakho.
• xelela ugqirha wakho ukuba uncelisa okanye uceba ukuncancisa.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba bekungaphantsi kweeyure ezili-12 okoko ubucwangciselwe ukuthatha idosi, thatha idosi ephosiweyo kwakamsinya nje ukuba uyikhumbule. Ukuba bekungaphezulu kweeyure ezili-12, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Lenalidomide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• isisu esibuhlungu
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• ubuthathaka
• isiyezi
• utshintsho kwisakhono sokungcamla
• intlungu okanye ukutshiswa kolwimi, umlomo, okanye umqala
• ukuncipha kwengqondo yokuthinta
• ukutshisa okanye ukubetha ezandleni okanye ezinyaweni
• ubunzima bokulala okanye ukulala
• ukudakumba
• ngokudibeneyo, umsipha, ithambo, okanye iintlungu zomqolo
• ukuchama okubuhlungu, rhoqo, okanye okungxamisekileyo
• ukubila
• isikhumba esomileyo
• ukukhula kweenwele okungaqhelekanga kwabasetyhini
• ukushukuma okungalawulekiyo kwilungu lomzimba
• ukunciphisa umnqweno wesini okanye amandla

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukudumba kobuso, umqala, ulwimi, imilebe, amehlo, iingalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ubunzima bokuphefumla okanye ukugwinya
• ukudinwa
• ukukhawuleza, ukucotha, ukubetha, okanye ukubetha kwentliziyo okungaqhelekanga
• ukuxhuzula
• irhashalala
• iintlungu zolusu
• ukudubula, ukuxobuka, okanye ukuchitha ulusu
• amadlala adumbileyo entanyeni
• izihlunu zemithambo
• iintlungu kwinxalenye ephezulu yesisu
• mthubi ulusu okanye amehlo
• umchamo omnyama ngombala
• ukudinwa
• igazi, amafu, okanye umchamo obuhlungu
• ukonyuka okanye ukuncipha kokuchama

Ukuba uthatha i-lenalidomide ukunyanga i-myeloma ezininzi kwaye ufumana i-melphalan (Alkeran) okanye ukufakelwa kweseli yegazi, unokuba semngciphekweni omkhulu wokukhulisa umhlaza omtsha. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-lenalidomide. Ugqirha wakho uya kukujonga njengomhlaza ngexesha lonyango lwakho nge-lenalidomide.

I-Lenalidomide inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Buyisela naliphi na iyeza eliphelelwe lixesha okanye elingasafunekiyo kugqirha wakho, ikhemesti ekunike iyeza, okanye umenzi.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ukurhawuzelela
• urhwebo
• irhashalala

Gcina lonke ixesha lokudibana nogqirha wakho. Ugqirha wakho unoku-odola iimvavanyo ezithile ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-lenalidomide.

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Uhlaziyo^®