Inaliti ye-Irinotecan

Umxholo

• Ngaphambi kokufumana irinotecan,
• I-Irinotecan inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

Inaliti ye-Irinotecan kufuneka inikezwe phantsi kweliso likagqirha onamava ekunikeni amayeza e-chemotherapy kumhlaza.

Unokufumana ezi mpawu zilandelayo ngelixa ufumana idosi ye-irinotecan okanye ukuya kuthi ga kwiiyure ezingama-24 emva koko: impumlo egxumayo, ukonyuka kwamathe, ukuncipha kwabafundi (imijikelezo emnyama phakathi kwamehlo), amehlo anamanzi, ukubila, ukugungxula, urhudo maxa wambi abizwa ngokuba 'sisisu esihambisayo'), kunye neempawu zesisu. Tshela ugqirha wakho ukuba unazo naziphi na kwezi mpawu. Ugqirha wakho unokukunika amayeza okuthintela okanye ukunyanga ezi mpawu.

Usenokufumana urhudo oluqatha (ngamanye amaxesha lubizwa ngokuba '' sisifo sorhudo emva kwexesha '') ngaphezulu kweeyure ezingama-24 emva kokuba ufumene irinotecan. Olu hlobo lohudo lunokusongela ubomi kuba lunokuhlala ixesha elide kwaye lukhokelele ekuphelelweni ngamanzi emzimbeni, usulelo, ukusilela kwezintso, kunye nezinye iingxaki. Xelela ugqirha wakho ukuba ukhe wanaso okanye wakha wanaso isithintelo samathumbu (ukuvaleka emathunjini akho). Tshela ugqirha wakho kunye nosokhemesti ukuba ngaba uthatha nawaphi na amayeza alandelayo: amanye amayeza e-chemotherapy kumhlaza; umchamo ('iipilisi zamanzi'); okanye i-laxatives ezinje nge-bisacodyl (Dulcolax) okanye i-senna (e-Correctol, Ex-Lax, Peri-Colace, Senokot).

Ngaphambi kokuba uqale unyango lwakho nge-irinotecan, thetha nogqirha wakho malunga nokuba wenzeni xa unorhudo emva kwexesha. Ugqirha wakho uyakukuxelela ukuba ugcine i-loperamide (Imodium AD) isesandleni ukuze uqale ukuyithatha kwangoko ukuba uvela kurhudo emva kwexesha. Ugqirha wakho uya kukuxelela ukuba uthathe i-loperamide rhoqo ngamaxesha emini nasebusuku. Qiniseka ukuba ulandela umkhombandlela kagqirha wakho ngokuthatha i-loperamide; ezi ziya kwahluka kunemikhombandlela eprintwe kwileyibhile yephakheji ye-loperamide. Ugqirha wakho uya kukuxelela nokuba kukuphi ukutya ekufuneka ukutyile kunye nokutya ekufuneka ukuphephe ukulawula isifo sohudo ngexesha lonyango lwakho. Sela amanzi amaninzi kwaye ulandele oku kutya ngononophelo.

Biza ugqirha wakho kwangoko okokuqala xa urhudo lunyango. Fowunela ugqirha ngoko nangoko ukuba unazo naziphi na kwezi mpawu: ifiva (ubushushu bungaphezulu kwe-100.4 ° F); ukugungqa ukugodola; ilindle emnyama okanye egazini; urhudo olungapheli kwiiyure ezingama-24; ukukhanya kwentloko, isiyezi, okanye ukuphelelwa ngamandla; isicaphucaphu okanye ukugabha okukuyekisa ukusela nantoni na. Ugqirha wakho uyakukujonga ngononophelo kwaye angakuphatha ngamanzi okanye i-antibiotics xa kufuneka njalo.

I-Irinotecan inokubangela ukwehla kwenani leeseli zegazi ezenziwe ngumongo wethambo lakho. Tshela ugqirha wakho ukuba unesifo segazi okanye isifo sikaGilbert (ukunciphisa amandla okuphula i-bilirubin, into yendalo emzimbeni) kwaye ukuba uphathwa ngemitha esiswini sakho okanye kwi-pelvis (indawo phakathi kwamathambo esinqe. ) okanye ukuba ukhe wanyangwa ngolu hlobo lwemitha. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: umkhuhlane, ukugodola, ukukhohlela, okanye ezinye iimpawu zosulelo; ukuqhawukelwa ngumphefumlo; ukubetha kwentliziyo ngokukhawuleza; intloko ebuhlungu; isiyezi; ulusu oluthuthu; ukudideka; ukudinwa kakhulu, okanye ukopha okungaqhelekanga okanye ukugruzuka.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-irinotecan.

Thetha nogqirha wakho malunga nemingcipheko yokusebenzisa irinotecan.

I-Irinotecan isetyenziswa yodwa okanye idityaniswe namanye amayeza ukunyanga ikholoni okanye umhlaza we-rectal (umhlaza oqala emathunjini amakhulu). I-Irinotecan ikwiklasi yamayeza e-antineoplastic ebizwa ngokuba yi-topoisomerase I inhibitors. Isebenza ngokumisa ukukhula kweeseli zomhlaza.

I-Irinotecan iza njengamanzi ukuba inikwe ngaphezulu kwemizuzu engama-90 efakwa ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi. Ihlala inganikwa ngaphezulu kokuphindaphindwe ngeveki, ngokweshedyuli etshintsha iveki enye okanye ezingaphezulu xa ufumana i-irinotecan kwiveki enye okanye nangaphezulu xa ungalifumani iyeza. Ugqirha wakho uya kukhetha ishedyuli eya kusebenza ngcono kuwe.

Ugqirha wakho unokufuna ukulibazisa unyango lwakho kwaye ahlengahlengise idosi yakho ukuba uneziphumo ebezingalindelekanga ezithile. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-irinotecan.

Ugqirha wakho unokukunika amayeza okuthintela isicaphucaphu, ukugabha ngaphambi kokuba ufumane idosi nganye ye-irinotecan. Ugqirha wakho unokukunika amanye amayeza ukukhusela okanye ukunyanga ezinye iziphumo ebezingalindelekanga.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

I-Irinotecan ngamanye amaxesha isetyenziswa kunye namanye amayeza ukunyanga umhlaza wamaphaphu weseli encinci. Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana irinotecan,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-irinotecan, i-sorbitol, okanye nawaphi na amanye amayeza.
• xelela ugqirha wakho ukuba uthatha i-ketoconazole (Nizoral). Ugqirha wakho uya kukuxelela ukuba ungathathi i-ketoconazole kwiveki enye ngaphambi kokuba uqale unyango lwakho nge-irinotecan okanye ngexesha lonyango lwakho.
• xelela ugqirha wakho ukuba uthatha i-wort yaseSt. Akufanele uthathe i-wort yaseSt.John iiveki ezi-2 ngaphambi kokuba uqale unyango lwakho nge-irinotecan okanye ngexesha lonyango lwakho.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nalawo angabhaliswanga, iivithamini, izongezo zesondlo kunye neemveliso zamayeza owathathayo okanye oceba ukuwathatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: atazanavir (Reyataz); gemfibrozil (iLopid); amayeza okubanjwa afana ne-carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal), phenytoin (Dilantin, Phenytek); irifabutin (Mycobutin); kunye nerifampin (Rifadin, Rimactane, eRifamate kunye neRifater). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe unesifo seswekile; ukunganyamezelani kwe-fructose (ukungakwazi ukwetyisa iswekile yendalo efumaneka kwiziqhamo); okanye isibindi, imiphunga, okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ucwangcise ukuba ngutata womntwana. Wena okanye iqabane lakho akufuneki ukuba ukhulelwe ngelixa ufumana i-irinotecan. Uya kudinga uvavanyo lokukhulelwa olubi ngaphambi kokuba uqale ukufumana eli yeza. Ukuba ungumfazi, sebenzisa ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neenyanga ezi-6 emva kwedosi yakho yokugqibela. Ukuba uyindoda kwaye iqabane lakho linakho ukukhulelwa, kuya kufuneka nisebenzise ulawulo lokuzala (iikhondom) ngexesha lonyango kunye neenyanga ezi-3 emva kwedosi yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa ufumana i-irinotecan, tsalela ugqirha wakho. Irinotecan inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufanelanga ukuncancisa ngelixa ufumana inaliti ye-irinotecan, kunye neentsuku ezisi-7 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga nemingcipheko yokufumana inaliti ye-irinotecan.
• ukuba uyenziwa utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba ufumana irinotecan.
• Kuya kufuneka uyazi ukuba i-irinotecan inokukwenza ube nesiyezi okanye ichaphazele umbono wakho, ngakumbi kwiiyure zokuqala ezingama-24 emva kokuba ufumene idosi. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
• thetha nogqirha wakho ngaphambi kokuba ufumane naluphi na ugonyo ngexesha lonyango lwakho nge-irinotecan.

Ugqirha wakho uza kukuxelela malunga nokutya okukhethekileyo ekufuneka kulandelwe ukunceda ukulawula urhudo ngexesha lonyango lwakho. Landela le miyalelo ngononophelo.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yegrapefruit ngelixa ufumana eli yeza.

I-Irinotecan inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• ukuqhina
• ukudumba nezilonda emlonyeni
• isilungulela
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• ukulahleka kweenwele
• ubuthathaka
• ukozela
• intlungu, ngakumbi iintlungu zomqolo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• iintlungu zesifuba
• mthubi ulusu okanye amehlo
• isisu esidumbileyo
• ukutyeba okungalindelekanga okanye okungaqhelekanga
• ukudumba kweengalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• irhashalala
• urhwebo
• ukurhawuzelela
• ubunzima bokuphefumla okanye ukugwinya

Abanye abantu abafumene irinotecan bakhula amahlwili egazini emilenzeni, emiphungeni, kwingqondo, nakwiintliziyo. Akukho lwazi lwaneleyo ukuxelela ukuba ngaba i-irinotecan ibangele ukugoba kwegazi. Thetha nogqirha wakho malunga neengozi zokufumana i-irinotecan.

I-Irinotecan inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• umqala obuhlungu, umkhuhlane, ukugodola, ukukhohlela kunye nezinye iimpawu zosulelo
• urhudo oluqatha

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• ICamptosar^®

• I-CPT-11