Inaliti ye-Ibritumomab

Umxholo

• Ngaphambi kokufumana inaliti ye-ibritumomab,
• Inaliti ye-Ibritumomab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na iimpawu ezidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO okanye naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko:
• Iimpawu libanda kungaquka oku kulandelayo:

Iiyure ezininzi ngaphambi kwedosi nganye yenaliti ye-ibritumomab, iyeza elibizwa ngokuba yi-rituximab (Rituxan) linikwa. Ezinye izigulana ziye zaba neengozi ezinobungozi okanye ezisongela ubomi ngelixa zifumana i-rituximab okanye kungekudala emva kokuba zifumene i-rituximab. Ezi mpendulo zenzeke rhoqo ngethamo lokuqala le-rituximab. Abanye abaguli basweleke kwisithuba seeyure ezingama-24 emva kokufumana i-rituximab. Tshela ugqirha wakho ukuba ngaba uxabisa i-rituximab okanye amayeza enziwe kwiiprotheyini ze-murine (imouse), okanye ukuba awuqinisekanga ukuba amayeza owaphikisayo ayenziwe kwiiproteni ze-murine. Xelela ugqirha wakho ukuba wakhe waphathwa ngonyango olwenziwe kwiiprotein zomchamo. Ukuba kunjalo, unokuba nokwenzeka ukuba ube nempendulo ephikisayo kwi-rituximab. Ugqirha wakho uya ku-oda iimvavanyo ukuze abone ukuba kunokwenzeka ukuba ube neempendulo ezichaseneyo ne-rituximab.

Ugqirha wakho uya kukunika amayeza ngaphambi kokuba ufumane i-rituximab ukukunceda ukuthintela ukuphendula kwi-rituximab. Ukuba ufumana impendulo kwi-rituximab, ugqirha unokuyeka ukukunika amayeza okwexeshana okanye akunike kancinci. Ukuba impendulo iyingozi, ugqirha uya kuyeka ukumiliselwa kwe-rituximab kwaye akazukuqhubeka nonyango lwakho ngenaliti ye-ibritumomab. Tshela ugqirha wakho ngoko nangoko ukuba unazo naziphi na kwezi mpawu zilandelayo ngexesha okanye emva nje konyango lwakho nge-rituximab: ukukhohlela; ubunzima bokuphefumla okanye ukugwinya; ukuqinisa umqala; imihlathi ukurhawuzelela; ukudumba kwamehlo, ubuso, imilebe, ulwimi, umlomo, okanye umqala; iintlungu esifubeni, emhlathini, engalweni, ngasemva, okanye entanyeni; ukudideka; ukulahleka kwengqondo; ukubetha kwentliziyo ngokukhawuleza; ukubila; ulusu oluthuthu; ukuphefumla ngokukhawuleza; ukuncipha kokuchama; okanye izandla neenyawo ezibandayo.

Unyango nge-rituximab kunye ne-ibritumomab inaliti inokubangela ukwehla okukhulu kwinani leeseli zegazi emzimbeni wakho. Oku kuncipha kunokwenzeka kwiiveki ezisi-7 ukuya kwezi-9 emva konyango kwaye kunokuhlala iiveki ezili-12 okanye ngaphezulu. Oku kuncipha kunokubangela ukosuleleka okunzulu okanye okusongela ubomi okanye ukopha. Ugqirha wakho ngekhe akunike inaliti ye-ibritumomab ukuba iiseli zakho zegazi zichaphazeleke kanobom ngumhlaza, ukuba unothambo lomongo wethambo, ukuba awukwazanga ukuvelisa iiseli ezaneleyo (iiseli ezifumaneka kumongo wethambo onokukhula Naluphi na uhlobo lweseli yegazi) ukuba unotshintsho lomongo wethambo, okanye ukuba sele unenani eliphantsi leeseli zegazi. Xelela ugqirha wakho ukuba ngaba uthatha nawaphi na amayeza alandelayo: ii-anticoagulants ('blood thinner') ezifana ne-warfarin (Coumadin, Jantoven); i-aspirin kunye nezinye iziyobisi ezichasayo (i-NSAIDs) ezifana ne-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve); kunye neclopidogrel (Plavix). Ukuba unayo nayiphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: isikhumba esiluthuthu; ubuthathaka; ukugruzuka okanye ukopha okungaqhelekanga; amabala amfusa okanye amabala esikhumbeni; ilindle emnyama okanye egazini; ukugabha okunegazi okanye okujongeka njengendawo yekofu; urhudo; okanye umqala obuhlungu, umkhuhlane, Ukugodola, ukukhohlela, okanye ezinye iimpawu zosulelo.

Unyango nge-rituximab kunye ne-ibritumomab inaliti inokubangela ulusu olunobuzaza okanye olubulalayo. Ezi mpendulo zinokwenzeka kwakamsinya emva kweentsuku ezimbalwa kunyango okanye kangangeenyanga ezi-4 emva konyango. Tshela ugqirha wakho ngoko nangoko ukuba uphuhlisa iblisters kulusu lwakho okanye ngaphakathi emlonyeni okanye empumlweni, irhashalala, okanye isikhumba. Ugqirha wakho akasayi kuphinda akunike ngenaliti ye-ibritumomab ukuba uvelisa ezi mpawu.

Emva kokuba ufumene idosi yakho yokuqala yenaliti ye-ibritumomab, ugqirha wakho uya kuyalela ii-imaging scans (iimvavanyo ezibonisa umfanekiso wazo zonke okanye inxalenye yomzimba ngaphakathi) ukubona ukuba iyeza lisasazeka njani emzimbeni wakho. Ukuba amayeza awasasazekanga emzimbeni wakho njengoko kulindelwe, awuyi kufumana idosi yakho yesibini yenaliti ye-ibritumomab.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngexesha lonyango lwakho kwaye ukuya kuthi ga kwiinyanga ezi-3 emva konyango lwakho ukujonga impendulo yomzimba wakho kwisitofu se-ibritumomab.

Thetha nogqirha wakho malunga nemingcipheko yokufumana inaliti ye-ibritumomab.

Inaliti ye-Ibritumomab isetyenziswa kunye ne-rituximab (Rituxan) ukunyanga iintlobo ezithile ze-non-Hodgkin's lymphoma (NHL; umhlaza oqala kwiiseli zomzimba) ezingakhange ziphuculwe okanye eziye zambi emva konyango namanye amayeza. Isetyenziselwa ukunyanga iintlobo ezithile ze-NHL kubantu abaphuculweyo emva konyango ngamanye amayeza e-chemotherapy. Inaliti ye-Ibritumomab ikwiklasi yamayeza abizwa ngokuba zii-antibodies ze-monoclonal ezine-radioisotopes. Isebenza ngokudibanisa iiseli zomhlaza kunye nokukhupha imitha ukonakalisa iiseli zomhlaza.

Inaliti ye-Ibritumomab iza njengombane oza kungeniswa emthanjeni ngaphezulu kwemizuzu eli-10 ngugqirha oqeqeshelwe ukunyanga abaguli ngamayeza e-radioactive. Inikwa njengenxalenye yerejimeni ethile yonyango lomhlaza. Ngosuku lokuqala lonyango, idosi ye-rituximab inikwa kwaye idosi yokuqala yenaliti ye-ibritumomab ayinikiwanga ngaphezulu kweeyure ezi-4 emva koko. Ukulinganisa ukujonga ukubona ukuba inaliti ye-ibritumomab isasazeke kangakanani emzimbeni kwenziwa iiyure ezingama-48 ukuya kwezingama-72 emva kokuba kunikwe idosi yenaliti ye-ibritumomab. Iskeni esongeziweyo sinokwenziwa ukuba siyafuneka kwiintsuku ezimbalwa ezizayo. Ukuba iziphumo zeskena (s) zibonisa ukuba inaliti ye-ibritumomab isasazekile emzimbeni njengoko kulindelwe, idosi yesibini ye-rituximab kunye nedosi yesibini yenaliti ye-ibritumomab iya kunikwa iintsuku ezi-7 ukuya kwezi-9 emva kokuba kunikwe idosi zokuqala.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-ibritumomab,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-ibritumomab, nawaphi na amayeza akhankanywe kwicandelo LESILUMKISO ESIBALULEKILEYO, nawaphi na amanye amayeza, okanye naziphi na izithako kwiinaliti ye-ibritumomab. Buza ugqirha wakho okanye usokhemesti uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wakha wanayo na imeko yonyango.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa ufumana ibritumomab. Ukuba ungowasetyhini, kuyakufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuqala unyango kwaye usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye neenyanga ezili-12 emva kwedosi yakho yokugqibela. Ukuba uyindoda eneqabane lomfazi, sebenzisa ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango kunye nakwiinyanga ezili-12 emva kwedosi yakho yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa ufumana inaliti ye-ibritumomab, biza ugqirha ngoko nangoko. Inaliti ye-Ibritumomab inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncancise ngelixa ufumana ibritumomab kunye neenyanga ezi-6 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga nemingcipheko yokufumana ibritumomab.
• ukuba uyenziwa utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba ufumene inaliti ye-ibritumomab.
• awunalo ugonyo ngexesha lonyango kunye neenyanga ezili-12 emva kwedosi yakho yokugqibela ungakhange uqale uthethe nogqirha wakho.
• Kuya kufuneka uyazi ukuba i-radioactivity kwidosi yesibini yenaliti ye-ibritumomab inokubakho kulwelo lomzimba wakho ukuya kuthi ga kwiveki emva kokufumana idosi. Ukuthintela i-radioactivity ekubeni isasazeke kubantu abakufutshane nawe, kufuneka uqiniseke ukuba uhlamba izandla zakho kakuhle emva kokusebenzisa igumbi lokuhlambela, sebenzisa ikhondom ngalo lonke ixesha usabelana ngesondo, kwaye uphephe ukwanga okunzulu. Landela lemiqathango yonyango ngexesha lonyango lwakho kunye neentsuku ezisi-7 emva kokuba ufumene idosi yesibini yenaliti ye-ibritumomab.
• Kuya kufuneka uyazi ukuba inaliti ye-ibritumomab iqulethe i-albhamuin (imveliso eyenziwe ngegazi lomnikeli ophilayo). Nangona kukho ithuba elincinci kakhulu lokuba intsholongwane ingasasazeka ngegazi, akukho zifo zezifo zentsholongwane ezivela kule mveliso ezichazwe.
• Kuya kufuneka uyazi ukuba xa ufumana inaliti ye-ibritumomab, umzimba wakho unokukhulisa ii-antibodies (izinto ezisegazini ezinceda amajoni omzimba ukuba aqonde kwaye ahlasele izinto zangaphandle) kwiiprotein zomchamo. Emva kokuba unyango lwakho ngenaliti ye-ibritumomab, qiniseka ukuba uxelele bonke oogqirha bakho ukuba iphathwe ngenaliti ye-ibritumomab.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Shayela ugqirha wakho ngokukhawuleza ukuba awukwazi ukugcina ixesha lokufumana i-ibritumomab injection.

Inaliti ye-Ibritumomab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• isisu esibuhlungu okanye ukudumba
• ukuqhina
• isilungulela
• Ukuphelelwa ngumdla wokutya
• intloko ebuhlungu
• ixhala
• isiyezi
• ubunzima bokulala okanye ukulala
• umqolo, ukudibana, okanye iintlungu zemisipha
• ukugungxula

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na iimpawu ezidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO okanye naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko:

• ubomvu, ukuthamba, okanye inxeba elivulekileyo kwindawo apho lalifakwe khona iyeza

Abanye abantu abafumene inaliti ye-ibritumomab bakhulisa ezinye iintlobo zomhlaza ezinje ngeleukemia (umhlaza oqala kwiiseli ezimhlophe zegazi) kunye ne-myelodysplastic syndrome (imeko apho iiseli zegazi zingakhuli ngesiqhelo) kwiminyaka yokuqala yokuqala emva kokuba befumene amayeza. Thetha nogqirha wakho malunga neengozi zokufumana eli yeza.

Inaliti ye-Ibritumomab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ulusu oluthuthu
• ubuthathaka
• ukuqhawukelwa ngumphefumlo
• ukudinwa kakhulu
• ukugruzuka okanye ukopha okungaqhelekanga
• amabala amfusa okanye amabala kulusu
• umqala obuhlungu, umkhuhlane, Ukugodola, ukukhohlela, kunye neminye imiqondiso yosulelo

Buza ugqirha wakho okanye usokhemesti nayiphi na imibuzo onayo malunga nenaliti ye-ibritumomab.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• UZevalin^®