Everolimus

Umxholo

• Ngaphambi kokuba uthathe i-everolimus,
• I-Everolimus inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

Ukuthatha i-everolimus kunokunciphisa ukubanakho kwakho ukulwa nosulelo kwiibhaktiriya, intsholongwane kunye nefungi kwaye wandise umngcipheko wokuba ufumane usulelo olubi okanye olusongela ubomi. Ukuba unayo i-hepatitis B (uhlobo lwesifo sesibindi) ngaphambili, usulelo lwakho lunokusebenza kwaye unokuhlakulela iimpawu ngexesha lonyango lwakho kunye neeverolimus. Tshela ugqirha wakho ukuba unayo okanye wakha waba ne-hepatitis B okanye ukuba unayo okanye ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Xelela ugqirha wakho kunye nosokhemesti ukuba uthatha amanye amayeza acinezela amajoni omzimba njenge-azathioprine (Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), dexamethasone (Decadron, Dexpak), methotrexate (Rheumatrex, Trexall), prednisolone (Orapred, Pediapred, Prelone), prednisone (Sterapred), sirolimus (Rapamune), kunye netacrolimus (Prograf). Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngokukhawuleza: ukudinwa okugqithisileyo; ubumthubi besikhumba okanye amehlo; ukuphelelwa ngumdla wokutya; isicaphucaphu; intlungu edibeneyo; umchamo omnyama; ilindle eluthuthu; iintlungu kwindawo ephezulu yesisu; irhashalala; kunzima, kubuhlungu, okanye ukuchama rhoqo; intlungu yendlebe okanye umjelo; intlungu yesinus kunye noxinzelelo; okanye umqala obuhlungu, ukukhohlela, umkhuhlane, ukugodola, ukuziva ungaphilanga okanye ezinye iimpawu zosulelo.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-everolimus.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lomguli lomenzi (Isikhokelo seMithi [iZortress] okanye iphetshana lolwazi ngesigulana [Afinitor, Afinitor Disperz]) xa uqala unyango nge-everolimus kwaye ngalo lonke ixesha uzalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga neengozi zokuthatha i-everolimus.

Kwizigulana ezithatha i-everolimus ukunqanda ukwala ukufakelwa:

Kuya kufuneka uthathe i-everolimus phantsi kweliso likagqirha onamava ekunyamekeleni ukufakelwa kwezigulana kwaye unike amayeza acinezela amajoni omzimba.

Umngcipheko wokuba ube nomhlaza, ngakumbi i-lymphoma (umhlaza wenxalenye yenkqubo yomzimba yokuzikhusela) okanye umhlaza wolusu uyanda ngexesha lonyango lwakho ne-everolimus. Tshela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho ukhe waba nomhlaza wolusu okanye ukuba unesikhumba esihle. Ukunciphisa umngcipheko womhlaza wolusu, cwangcisa ukunqanda ukukhanya kwelanga okungafunekiyo okanye ixesha elide (ukukhanya kweebhedi kunye nezibane zelanga) kunye nokunxiba iimpahla ezikhuselayo, izibuko zelanga, kunye nelanga elangeni ngexesha lonyango lwakho. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: indawo ebomvu, ephakanyisiweyo, okanye enesikhumba; izilonda ezintsha, amaqhuma, okanye ukudumba kolusu; izilonda ezingapholiyo; amaqhuma okanye ubunzima naphina emzimbeni wakho; utshintsho lolusu; ukubila ebusuku; amadlala adumbileyo entanyeni, emakhwapheni, okanye emhlubulweni; ingxaki yokuphefumla; iintlungu zesifuba; okanye ubuthathaka okanye ukudinwa okungapheliyo.

Ukuthatha i-everolimus kunokunyusa umngcipheko wokuba ube nezifo ezithile ezinqabileyo nezinobuzaza, kubandakanya ukusuleleka kwintsholongwane ye-BK, intsholongwane enokuthi yonakalise izintso kwaye ibangele ukuba izintso ezifakelweyo zisilele), kunye ne-leukoencephalopathy eqhubekayo. Usulelo lwengqondo olungenakunyangeka, ukuthintelwa, okanye ukunyangwa kwaye oko kuhlala kubangela ukufa okanye ukukhubazeka kakhulu). Biza ugqirha wakho ngokukhawuleza ukuba unazo naziphi na kwezi mpawu zilandelayo ze-PML: ubuthathaka kwelinye icala lomzimba eliba mandundu ngokuhamba kwexesha; ukungxama kweengalo okanye imilenze; utshintsho kwindlela ocinga ngayo, ukuhamba, ukulinganisela, ukuthetha, ukubona, okanye amandla ahlala iintsuku ezininzi; intloko; ukuxhuzula; ukudideka; okanye utshintsho kubuntu.

I-Everolimus inokubangela ukujiya kwegazi kwimithambo yegazi yezintso zakho ezifakiweyo. Oku kunokwenzeka kakhulu kwiintsuku ezingama-30 zokuqala emva kokufakelwa kwakho kwezintso kwaye kunokubangela ukuba ukufakelwa kungaphumeleli. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: iintlungu kwi-groin yakho, ezantsi umva, icala, okanye isisu; ukuncipha kokuchama okanye ukungabikho kokuchama; igazi kumchamo wakho; umchamo omnyama-mnyama; ifiva; isicaphucaphu; okanye ukugabha.

Ukuthatha i-everolimus ngokudibanisa ne-cyclosporine kunokubangela umonakalo kwizintso zakho. Ukunciphisa lo mngcipheko, ugqirha wakho uya kulungelelanisa idosi ye-cyclosporine kwaye abeke iliso kumanqanaba amayeza kunye nendlela ezisebenza ngayo izintso zakho. Ukuba ufumana enye yezi mpawu zilandelayo, biza ugqirha ngokukhawuleza: ukunciphisa ukuchama okanye ukudumba kweengalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi.

Kwizifundo zeklinikhi, abantu abaninzi abathathe i-everolimus basweleka kwiinyanga ezimbalwa zokuqala emva kokufumana ukufakelwa kwentliziyo kunabantu abangakhange bathathe i-everolimus. Ukuba ufumene ukufakelwa kwentliziyo, thetha nogqirha wakho malunga nemingcipheko yokuthatha i-everolimus.

I-Everolimus (Afinitor) isetyenziselwa ukunyanga i-renal cell carcinoma (RCC; umhlaza oqala kwizintso) esele inyangwe ngokungaphumeleli ngamanye amayeza. I-Everolimus (i-Afinitor) ikwasetyenziselwa ukunyanga uhlobo oluthile lomhlaza webele osele uqhubekile osele wanyangwa kunye namanye amayeza. I-Everolimus (i-Afinitor) ikwasetyenziselwa ukunyanga uhlobo oluthile lomhlaza wepancreas, isisu, amathumbu, okanye imiphunga ethe yasasazeka okanye yaqhubela phambili kwaye ayinakunyangwa ngoqhaqho. I-Everolimus (Afinitor) ikwasetyenziselwa ukunyanga izicubu zezintso kubantu abane-tuberous sclerosis complex (TSC; imeko yemfuza ebangela ukuba amathumba akhule kwizitho ezininzi). I-Everolimus (i-Afinitor kunye ne-Afinitor Disperz) ikwasetyenziselwa ukunyanga i-subependymal giant cell astrocytoma (SEGA; uhlobo lwesisu sobuchopho) kubantu abadala nakubantwana abaneminyaka eli-1 ubudala nangaphezulu abane-TSC. I-Everolimus (Afinitor Disperz) ikwasetyenziswa kunye namanye amayeza ukunyanga iintlobo ezithile zokubanjwa kwabantu abadala kunye nabantwana abaneminyaka emi-2 ubudala nangaphezulu abane-TSC. I-Everolimus (iZortress) isetyenziswa namanye amayeza ukunqanda ukwala ukufakelwa (ukuhlaselwa kwento efakelweyo ngamajoni omzimba womntu ofumene ilungu) kubantu abadala abathile abafumene ukufakelwa kwezintso. U-Everolimus ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. U-Everolimus uphatha umhlaza ngokumisa iiseli zomhlaza ekuveliseni nasekunciphiseni ukunikezelwa kwegazi kwiiseli zomhlaza. I-Everolimus ithintela ukukhatywa kokuncitshiswa ngokunciphisa umsebenzi wamajoni omzimba.

I-Everolimus iza njengecwecwe lokuthatha ngomlomo kunye nethebhulethi yokumisa emanzini kwaye ithathe ngomlomo. Xa i-everolimus ithathwa ukunyanga izicubu zezintso, i-SEGA, okanye ukuxhuzula kubantu abane-TSC; RCC; okanye ibele, ipancreatic, isisu, ithumbu, okanye umhlaza wemiphunga, ihlala ithathwa kanye ngemini. Xa i-everolimus ithathwa ukuthintela ukungamkelwa kokufakwa, ihlala ithathwa kabini ngemini (rhoqo emva kweeyure ezili-12) ngexesha elinye njengecyclosporine. I-Everolimus kufuneka ihlale ithathwa kunye nokutya okanye ihlale ingenakho ukutya. Thatha i-everolimus malunga nexesha elifanayo (ii) yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-everolimus ngqo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Iipilisi ze-Everolimus ziza kwiipakethe ze-blister ezizodwa ezinokuvulwa ngesikere. Sukuvula ipakethi ye blister de ube ukulungele ukuginya ithebhulethi yayo.

Kufuneka uthathe iipilisi ze-everolimus okanye iipilisi ze-everolimus zokumiswa ngomlomo. Musa ukuthatha indibaniselwano yazo zombini ezi mveliso.

Ginya iipilisi ngokupheleleyo ngeglasi epheleleyo yamanzi; ungahluleli, ungahlaleli, okanye uzityumze. Musa ukuthatha iipilisi ezityunyuziweyo okanye ezaphukileyo. Tshela ugqirha wakho okanye usokhemesti ukuba awukwazi ukuginya iipilisi.

Ukuba uthabatha iipilisi zokumiswa ngomlomo (Afinitor Disperz), kufuneka uzixube ngamanzi ngaphambi kokusetyenziswa. Sukuwaginya onke la macwecwe, kwaye ungawaxubisi ngejusi okanye nayiphi na into engamanzi ngaphandle kwamanzi. Musa ukuwulungisa umxube ngaphezu kwemizuzu engama-60 phambi kokuba ucebe ukuwusebenzisa, uze ulahle lo mxube ukuba awusetyenziswanga emva kwemizuzu engama-60. Musa ukulungiselela amayeza kumphezulu owasebenzisayo ukulungiselela okanye ukutya ukutya. Ukuba uza kulungiselela omnye umntu amayeza, kuya kufuneka unxibe iigloves ukunqanda ukunxibelelana namayeza. Ukuba ukhulelwe okanye ucwangcisa ukukhulelwa, kuya kufuneka uphephe ukulungiselela amayeza omnye umntu, kuba ukunxibelelana ne-everolimus kunokulimaza usana lwakho olungekazalwa.

Unokudibanisa iipilisi zokumiswa ngomlomo kwisirinji yomlomo okanye kwiglasi encinci. Ukulungiselela umxube kwisirinji yomlomo, susa ipligger kwisirinji yomlomo eyi-10-mL kwaye ubeke inani elimiselweyo lamacwecwe emgqonyeni wesirinji ngaphandle kokophula okanye ukutyumza iipilisi. Unokulungiselela ukuya kwi-10 mg ye-everolimus kwisirinji ngaxeshanye, ke ukuba idosi yakho ingaphezulu kwe-10 mg, kuya kufuneka uyilungiselele kwisirinji yesibini. Faka endaweni yesipringi kwisirinji uze uzobe malunga ne-5 ml yamanzi kunye ne-4 mL yomoya kwisirinji kwaye ubeke isirinji kwisikhongozeli incam ebhekise phezulu. Linda imizuzu emi-3 ukuvumela amacwecwe ukuba anqunyanyiswe. emva koko thatha isirinji kwaye uyiphendule inyuse kwaye uyihlise kasihlanu. Beka isirinji emlonyeni wesigulana kwaye utyhale isixhobo sokufaka iyeza. Emva kokuba isiguli siginyile iyeza, gcwalisa isirinji efanayo nge-5 ml yamanzi kunye ne-4 mL yomoya kwaye ujikeleze isirinji ukucoca naziphi na amasuntswana asesirinji. Nika lo mxube kwisigulana ukuze siqiniseke ukuba sifumana onke amayeza.

Ukulungiselela lo mxube kwiglasi, beka inani elimiselweyo lamacwecwe kwiglasi encinci yokusela engagcini ngaphezulu kwe-100 ml (malunga nee-ounces ezi-3) ngaphandle kokutyumza okanye ukophula iipilisi. Unokulungiselela ukuya kwi-10 mg ye-everolimus kwiglasi ngaxeshanye, ke ukuba idosi yakho ingaphezulu kwe-10 mg, kuya kufuneka uyilungiselele kwiglasi yesibini. Yongeza i-25 mL (malunga ne-1 enye) yamanzi kwiglasi. Lindela imizuzu emi-3 uze unyanzele umxube ngobunono ngecephe. Isigulana sisele wonke umxube kwangoko. Yongeza enye i-25 mL yamanzi kwiglasi kwaye ugxobhoze ngecephe elifanayo ukucoca naziphi na izinto ezikhoyo kwiglasi. Isigulana masisele lo mxube ukuze siqiniseke ukuba sifumana onke amayeza.

Ugqirha wakho unokuhlengahlengisa idosi yakho ye-everolimus ngexesha lonyango lwakho kuxhomekeke kwiziphumo zovavanyo lwegazi, impendulo yakho kunyango, iziphumo ebezingalindelekanga ohlangabezana nazo, kunye notshintsho kwamanye amayeza owathathayo nge-everolimus.Ukuba uthatha i-everolimus ukunyanga i-SEGA okanye ukuxhuzula, ugqirha wakho uya kuyilungisa idosi yakho hayi rhoqo rhoqo kube kanye kwiiveki ezi-1 ukuya kwezi-2, kwaye ukuba uthatha i-everolimus ukunqanda ukwala ukufakelwa, ugqirha wakho uya kuyilungisa idosi yakho hayi rhoqo zonke iintsuku ezi-4 ukuya kwezi-5. Ugqirha wakho angayeka unyango lwakho kangangexesha elithile ukuba uneziphumo ebezingalindelekanga ezibi. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho kunye neeverolimus.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-everolimus,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-everolimus, sirolimus (Rapamune), temsirolimus (Torisel), nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi zeeverolimus. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qinisekisa ukukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zinto zilandelayo: Prinivil, Zestril), moexipril (Univasc) perindopril (Aceon), quinapril (Accupril), ramipril (Altace), okanye trandolapril (Mavik); amprenavir (Agenerase), atazanavir (Reyataz), aprepitant (Emend), carbamazepine (Carbatrol, Epitol, Tegretol), clarithromycin (Biaxin, e-Prevpac), digoxin (Digitek, Lanoxicaps, Lanoxin), diltiazem (Cardizem, Dizizi, Dizizi efavirenz (e Atripla, Sustiva), erythromycin (EES, E-Mycin, Erythrocin), fluconazole (Diflucan), fosamprenavir (Lexiva), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole (Nizvodaz), , nevirapine (Viramune), nicardipine (Cardene), phenobarbital (Luminal), phenytoin (Dilantin, Phenytek), rifabutin (Mycobutin), rifampin (Rifadin, eRifamate, eRifater), rifapentine (Priftint), ritonavir ), saquinavir (Invirase), telithromycin (Ketek), verapamil (Calan, Covera, Isoptin, Verelan) kunye nevoriconazole (Vfend). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-everolimus, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe unesifo seswekile okanye uneswekile ephezulu yegazi; amanqanaba aphezulu e-cholesterol okanye i-triglycerides egazini lakho; isifo sezintso okanye sesibindi; okanye nayiphi na imeko ekuthintela ekutyeni ukutya okuqukethe iswekile, isitashi, okanye iimveliso zobisi ngesiqhelo.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa Ukuba ungumfazi okwaziyo ukukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho nakwiiveki ezisi-8 emva kwedosi yakho yokugqibela. Ukuba uyindoda kunye neqabane lomfazi onokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho nakwiiveki ezi-4 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zolawulo lokuzalwa eziza kukusebenzela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-everolimus, biza ugqirha wakho. U-Everolimus unokulimaza umbungu. Xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngexesha lonyango lwakho kunye nakwiiveki ezi-2 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-everolimus.
• awunalo ugonyo ngaphandle kokuthetha nogqirha wakho. Ngexesha lokunyanga kwakho i-everolimus, kuya kufuneka uphephe ukunxibelelana nabanye abantu abasandula kugonywa.
• thetha nogqirha womntwana wakho malunga nokugonywa umntwana wakho anokufuna ukukufumana ngaphambi kokuba aqale unyango lwakhe nge-everolimus.
• Kuya kufuneka uyazi ukuba unokuba nezilonda okanye ukudumba emlonyeni ngexesha lonyango lwakho nge-everolimus, ngakumbi kwiiveki zokuqala ezi-8 zonyango. Xa uqala unyango nge-everolimus, ugqirha wakho unokumisela umlomo othile ukuze anciphise ithuba lokuba ufumane izilonda zomlomo okanye izilonda kunye nokunciphisa ubunzima bazo. Landela imiyalelo kagqirha wakho ngendlela yokusebenzisa le nto yokuhlamba umlomo. Tshela ugqirha wakho ukuba uvela izilonda okanye uva iintlungu emlonyeni wakho. Akufanele usebenzise nayiphi na into yokuhlamba umlomo ngaphandle kokuthetha nogqirha wakho okanye usokhemisi kuba iintlobo ezithile zomlomo oqukethe utywala, i-peroxide, iodine, okanye i-thyme zinokuzenza mandundu izilonda kunye nokudumba.
• Kuya kufuneka uyazi ukuba amanxeba okanye ukusika, kubandakanya ukusikwa kwesikhumba okwenziwe ngexesha lokufakelwa kwezintso kunokuphilisa kancinci kunesiqhelo okanye kungaphilisi ngokufanelekileyo ngexesha lonyango lwakho nge-everolimus. Fowunela ugqirha wakho ngoko nangoko ukuba ukusikwa kwesikhumba kufakelo lwakho lwezintso okanye naliphi na inxeba lishushu, libomvu, libe buhlungu okanye lidumbe; igcwalisa igazi, ulwelo, okanye ubofu; okanye iqala ukuvula.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Ukuba ukhumbula idosi ephosiweyo kwisithuba seeyure ezingama-6 zexesha owawucwangciselwe ukulithatha, thatha idosi ephosiweyo ngoko nangoko. Nangona kunjalo, ukuba ngaphezulu kweeyure ezingama-6 zidlulile ukusukela kwixesha elimiselweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Everolimus inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• utshintsho kwisakhono sokungcamla ukutya
• ukuhla ukusinda
• umlomo owomileyo
• ubuthathaka
• intloko ebuhlungu
• ubunzima bokulala okanye ukulala
• impumlo
• isikhumba esomileyo
• induna
• iingxaki ngezikhonkwane
• ukulahleka kweenwele
• iintlungu ezingalweni, emilenzeni, emqolo okanye kumalungu
• izihlunu zemithambo
• ukuphoswa okanye ukungahambi kakuhle kokuya exesheni
• ukuphuma kwegazi okunzima
• kunzima ukufumana okanye ukugcina ulwakhiwo
• ixhala
• Ubundlongondlongo okanye olunye utshintsho kwindlela yokuziphatha

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• urhwebo
• ukurhawuzelela
• ukudumba kwezandla, iinyawo, iingalo, imilenze, amehlo, ubuso, umlomo, imilebe, ulwimi, okanye umqala
• ukudinwa
• ubunzima bokuphefumla okanye ukugwinya
• ukuvutha
• ukugungxula
• iintlungu zesifuba
• ukunxanwa kakhulu okanye indlala
• ukopha okungaqhelekanga okanye ukugruzuka
• ulusu oluthuthu
• ukukhawuleza kwentliziyo okanye okungaqhelekanga
• isiyezi
• ukuxhuzula

I-Everolimus inokunciphisa ukuzala kwamadoda nabasetyhini. Thetha nogqirha wakho malunga neengozi zokuthatha i-everolimus.

I-Everolimus inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina la mayeza kwipakethe ye-blister engenile, ivaliwe ngokuqinileyo, kwaye ingafumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya nobushushu obungaphezulu kunye nobumanzi (hayi kwigumbi lokuhlambela). Gcina iipakethi zeblister kunye neepilisi zomile.

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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• Ummeli Disperz^®
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