Inaliti ye-Denosumab

Umxholo

• Inaliti ye-Denosumab (Prolia) iyasetyenziswa
• Inaliti yeDenosumab (Xgeva) isetyenziselwa inaliti yeDenosumab ikwiklasi yamayeza abizwa ngokuba yiRANK ligand inhibitors. Isebenza ukukhusela ukulahleka kwethambo ngokuthintela i-receptor ethile emzimbeni ukunciphisa ukonakala kwethambo. Isebenza ukunyanga i-GCTB ngokuthintela i-receptor ethile kwiiseli zethumba ezicothisa ukukhula kwethumba. Isebenza ukunyanga amanqanaba aphezulu e-calcium ngokunciphisa ukonakala kwethambo njengoko ukonakala kwamathambo kukhupha ikhalsiyam.
• Phambi kokufumana inaliti yedenosumab,
• Inaliti ye-Denosumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

Inaliti ye-Denosumab (Prolia) iyasetyenziswa

• ukunyanga i-osteoporosis (imeko apho amathambo esiba buthathaka kwaye aphele kwaye aphuke ngokulula) kwabasetyhini abaye bayeka ukuya exesheni ('' utshintsho lobomi; '' ukuphela kwexesha lokuya exesheni) abanomngcipheko okhulayo wokophuka (amathambo aphukileyo) okanye ongakwaziyo ukuthatha okanye ongaphendulanga kwamanye amayeza onyango lwe-osteoporosis.
• ukunyanga amadoda anobungozi obandayo bokuqhekeka (amathambo aphukileyo) okanye abangakwaziyo ukuthatha okanye abangaphendulanga kwamanye amayeza onyango lwe-osteoporosis.
• Unyango lwe-osteoporosis olubangelwa ngamayeza e-corticosteroid emadodeni nakwabasetyhini abaya kuthi bathathe amayeza e-corticosteroid ubuncinci iinyanga ezi-6 kwaye babe nomngcipheko owandileyo wokuqhekeka okanye abangakwaziyo ukuthatha okanye abangaphendulanga kolunye unyango lwamayeza e-osteoporosis.
• ukunyanga ukulahleka kwethambo emadodeni anyangelwa umhlaza wedlala lobudoda ngamayeza athile abangela ukonakala kwamathambo,
• ukunyanga ukulahleka kwethambo kwabasetyhini abanomhlaza wamabele abafumana amayeza athile anyusa umngcipheko wokuqhekeka.

Inaliti yeDenosumab (Xgeva) isetyenziselwa inaliti yeDenosumab ikwiklasi yamayeza abizwa ngokuba yiRANK ligand inhibitors. Isebenza ukukhusela ukulahleka kwethambo ngokuthintela i-receptor ethile emzimbeni ukunciphisa ukonakala kwethambo. Isebenza ukunyanga i-GCTB ngokuthintela i-receptor ethile kwiiseli zethumba ezicothisa ukukhula kwethumba. Isebenza ukunyanga amanqanaba aphezulu e-calcium ngokunciphisa ukonakala kwethambo njengoko ukonakala kwamathambo kukhupha ikhalsiyam.

• ukunciphisa umngcipheko wokophuka kwabantu abane-myeloma (umhlaza oqala kwiiseli ze-plasma kwaye ubangele ukonakala kwethambo), nakubantu abaneentlobo ezithile zomhlaza eziqale kwelinye ilungu lomzimba kodwa zanwenwela emathanjeni.
• kubantu abadala nakwabanye abakwishumi elivisayo ukunyanga ithumba elikhulu leethambo (GCTB; uhlobo lwethumba) elingenakunyangwa ngoqhaqho.
• ukunyanga amanqanaba aphezulu e-calcium abangelwa ngumhlaza kubantu abangaphendulanga kwamanye amayeza.

Inaliti yeDenosumab iza njengesisombululo (ulwelo) sokutofwa (ngaphantsi kolusu) engalweni yakho ephezulu, ethangeni eliphezulu, okanye kwindawo yesisu. Ihlala itofwe ngugqirha okanye ngumongikazi kwiofisi yezonyango okanye eklinikhi. Inaliti ye-Denosumab (Prolia) ihlala inikwa kube kanye kwiinyanga ezi-6. Xa inaliti yedenosumab (Xgeva) isetyenziselwa ukunciphisa umngcipheko wokuqhekeka kwi-myeloma emininzi, okanye umhlaza osasazeke waya emathanjeni, ihlala inikwa kube kanye kwiiveki ezi-4. Xa inaliti yedenosumab (Xgeva) isetyenziselwa ukunyanga ithumba elikhulu leseli, okanye amanqanaba aphezulu e-calcium abangelwa ngumhlaza, ihlala inikwa rhoqo ngeentsuku ezisi-7 kwiidosi ezintathu zokuqala (ngosuku 1, usuku lwe-8, kunye nosuku lwe-15) emva koko kanye kwiiveki ezi-4 ukuqala kwiiveki ezi-2 emva kweedosi zokuqala ezintathu.

Ugqirha wakho uya kukuxelela ukuba uthathe izongezo ze-calcium kunye novithamini D ngelixa unyangwa ngenaliti yedenosumab. Thatha la machiza ngokuchanekileyo njengoko kuyalelwe.

Xa inaliti yedenosumab (Prolia) isetyenziselwa ukunyanga i-osteoporosis okanye ukulahleka kwethambo, ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngenaliti yedenosumab kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Phambi kokufumana inaliti yedenosumab,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-denosumab (Prolia, Xgeva), nawaphi na amanye amayeza, i-latex, okanye nasiphi na isithako senaliti yedenosumab. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• Kuya kufuneka uyazi ukuba inaliti yedenosumab iyafumaneka phantsi kwegama lophawu uProlia noXgeva. Akufanele ufumane imveliso engaphezulu kwesinye equkethe i-denosumab ngaxeshanye. Qiniseka ukuba uxelela ugqirha wakho ukuba uphathwa nangale mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha.Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: angiogenesis inhibitors ezifana ne-axitinib (Inlyta), bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), okanye sunitinib (Sutent); ii-bisphosphonates ezinje nge-alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), zoledronic acid (Reclast); umhlaza chemotherapy amayeza; amayeza athintela amajoni omzimba anje nge-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), sirolimus (Rapamune), kunye netacrolimus (Astagraf XL, Envarsus, Prograf) ; ii-steroids ezinje nge-dexamethasone, methylprednisolone (A-Methapred, Depo-Medrol, Medrol, Solu-Medrol), kunye ne-prednisone (iRayos); okanye amayeza asetyenziselwa ukunciphisa amanqanaba e-calcium, njenge-cinacalcet (iSensipar). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe waba nenqanaba eliphantsi le-calcium egazini lakho. Ugqirha wakho uya kujonga inqanaba lecalcium egazini lakho ngaphambi kokuba uqale unyango kwaye uya kuthi mhlawumbi ungafumani ngenaliti yedenosumab ukuba inqanaba liphantsi kakhulu.
• xelela ugqirha wakho ukuba ufumana unyango lwe-dialysis okanye ukuba unayo okanye wakhe wanayo i-anemia (imeko apho iiseli ezibomvu zegazi zingazisi ioksijini eyaneleyo kuwo onke amalungu omzimba); umhlaza; naluphi na uhlobo losulelo, ngakumbi emlonyeni wakho; iingxaki ngomlomo, ngamazinyo, ngeentsini, okanye ngamazinyo emboleko; ukuhlinzwa kwamazinyo okanye komlomo (kususwe amazinyo, ukufakelwa amazinyo); nayiphi na imeko emisa igazi lakho ekunqandeni ngesiqhelo; nayiphi na imeko enciphisa ukusebenza kwamajoni akho omzimba; utyando kwi-thyroid gland okanye i-parathyroid gland (i-gland encinci entanyeni); utyando ukususa inxenye yamathumbu akho amancinci; iingxaki ngesisu okanye amathumbu akho enza ukuba kubenzima emzimbeni wakho ukufunxa izakhamzimba; i-polymyalgia rheumatica (ukuphazamiseka okubangela iintlungu zemisipha kunye nobuthathaka); isifo seswekile, okanye parathyroid okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Uya kudinga uvavanyo lokukhulelwa olubi ngaphambi kokuba uqale unyango ngenaliti yedenosumab. Akufanele ukhulelwe ngelixa ufumana inaliti yedenosumab. Kuya kufuneka usebenzise indlela ethembekileyo yolawulo lokuzalwa ukuthintela ukukhulelwa ngelixa ufumana inaliti yedenosumab kwaye ubuncinci iinyanga ezintlanu emva konyango lwakho lokugqibela. Ukuba ukhulelwa ngelixa ufumana inaliti yedenosumab, okanye kwiinyanga ezintlanu zonyango lwakho, tsalela umnxeba kwangoko. UDenosumab unokulimaza umbungu.
• Kuya kufuneka uyazi ukuba inaliti yedenosumab inokubangela i-osteonecrosis yomhlathi (i-ONJ, imeko enzima yethambo lomhlathi), ngakumbi ukuba uqhaqho lwamazinyo okanye unyango ngelixa ufumana eliyeza. Ugqirha wamazinyo kufuneka ahlolisise amazinyo akho kwaye enze naluphi na unyango olufunekayo, kubandakanya ukucoca okanye ukulungisa amazinyo okufakela angalunganga, ngaphambi kokuba uqale ukufumana inaliti yedenosumab. Qiniseka ukuba uhlamba amazinyo kwaye ucoce umlomo wakho ngokufanelekileyo ngelixa ufumana inaliti yedenosumab. Thetha nogqirha wakho ngaphambi kokuba ufumane unyango lwamazinyo ngelixa ufumana eli yeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphoswa idinga lokufumana inaliti yedenosumab, kuya kufuneka ubize umnikezeli wakho wezempilo ngokukhawuleza. Idosi ephosiweyo kufuneka inikwe kwakamsinya nje ukuba iphinde icwangciswe kwakhona. Xa inaliti yedenosumab (Prolia) isetyenziselwa i-osteoporosis okanye ukulahleka kwethambo, emva kokufumana idosi ephosiweyo, inaliti yakho elandelayo kufuneka icwangciselwe iinyanga ezi-6 ukusukela kumhla wenaliti yakho yokugqibela.

Inaliti ye-Denosumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ibomvu, yomile, okanye irhawuzelela ulusu
• ukuphuma kwamadyungudyungu kulusu
• ulusu oluxobukayo
• umqolo obuhlungu
• iintlungu ezingalweni zakho
• ukudumba kweengalo okanye imilenze
• intlungu yesihlunu okanye edibeneyo
• isicaphucaphu
• urhudo
• ukuqhina
• intlungu zesisu
• intloko ebuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukuqina kwemisipha, ukujija, iicramps, okanye i-spasms
• ukuba ndindisholo okanye ukurhawuzelela iminwe, iinzwane, okanye umlomo
• urhashalala, irhashalala, ukurhawuzelela, ukuphefumla nzima okanye ukugwinya, ukudumba kobuso, amehlo, umqala, ulwimi okanye imilebe,
• umkhuhlane okanye ukubanda
• ubomvu, ukuthamba, ukudumba okanye ukufudumala kwendawo yesikhumba
• umkhuhlane, ukukhohlela, ukuphefumla kancinci
• ukuhambisa indlebe okanye iintlungu ezinzima zendlebe
• Rhoqo okanye ngokungxamisekileyo isidingo sokuchama, ukuziva uvutha xa uchama
• iintlungu ezinzima zesisu
• iintsini ezibuhlungu okanye ezidumbileyo, ukukhululeka kwamazinyo, ukuba ndindisholo okanye ukuziva unzima emhlathini, ukuphilisa umhlathi kakubi
• ukopha okungaqhelekanga okanye ukugruzuka
• isicaphucaphu, ukugabha, intloko ebuhlungu, kunye nokunciphisa ukuphaphama emva kokumisa i-denosumab kunye nokuya kuthi ga kunyaka omnye emva koko

Inaliti ye-Denosumab inokuwunyusa umngcipheko wokuba uqhekeze ithambo (okanye) lamathambo wakho Ungaziva iintlungu esinqeni, emgodini, okanye emathangeni kangangeeveki ezininzi okanye iinyanga ngaphambi kokuba amathambo aqhekeze, kwaye unokufumanisa ukuba enye okanye zombini amathambo akho aphukile nangona ungakhange uwe okanye ufumane olunye umothuko. Akuqhelekanga ukuba ithambo lethanga liphule kubantu abasempilweni, kodwa abantu abane-osteoporosis banokulophula eli thambo nokuba abafumani ngenaliti yedenosumab. Inaliti ye-Denosumab inokubangela nokuba amathambo aphukileyo aphile kancinci kwaye inokuphazamisa ukukhula kwethambo kunye nokuthintela amazinyo ekungeneni ngokufanelekileyo ebantwaneni. Thetha nogqirha wakho malunga nemingcipheko yokufumana inaliti yedenosumab.

Inaliti ye-Denosumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Musa ukushukumisa inaliti yedenosumab. Gcina kwifriji kwaye uyikhusele ekukhanyeni. Musa ukubanda. Inaliti yeDenosumab inokugcinwa kubushushu begumbi ukuya kwiintsuku ezili-14.

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukuze aqiniseke ukuba kukhuselekile ukuba ufumane inaliti yedenosumab kwaye ujonge impendulo yomzimba wakho kwisitofu sedenosumab.

Musa ukuvumela omnye umntu asebenzise amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Inkqubela^®
• Xgeva^®