Fingolimod

Umxholo

• Ngaphambi kokuba uthathe i-fingolimod,
• I-Fingolimod inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Fingolimod isetyenziselwa ukuthintela iziqendu zeempawu kunye nokucotha ukwanda kokukhubazeka kubantu abadala nakubantwana abaneminyaka eli-10 ubudala nangaphezulu ngeendlela zokubuyela umva (ikhosi yesifo apho iimpawu ziyaqhambuka amaxesha ngamaxesha) ze-multiple sclerosis (MS; isifo apho imithambo-luvo ingasebenzi kakuhle kwaye abantu banokufumana ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwezihlunu, kunye neengxaki zombono, intetho, kunye nolawulo lwesinyi). I-Fingolimod ikudidi lwamayeza abizwa ngokuba yi-sphingosine l-phosphate receptor modulators. Isebenza ngokunciphisa isenzo samaseli omzimba anokubangela ukonakala kwentliziyo.

I-Fingolimod iza njengephilisi ukuyithatha ngomlomo. Ihlala ithathwa kanye ngemini kunye okanye ngaphandle kokutya. Thatha i-fingolimod malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-fingolimod ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

I-Fingolimod inokubangela ukuba ukubetha kwentliziyo kucothise kubantu abadala nasebantwaneni, ngakumbi kwiiyure zokuqala ezi-6 emva kokuba uthathe idosi yakho yokuqala, nasemva kwedosi yokuqala xa idosi inyuswe ebantwaneni. Uya kufumana i-electrocardiogram (i-ECG; uvavanyo olurekhoda umsebenzi wombane wentliziyo) ngaphambi kokuba uthathe idosi yakho yokuqala kwaye kwakhona emva kweeyure ezingama-6 emva kokuba uthathe idosi. Uya kuthatha idosi yakho yokuqala ye-fingolimod kwiofisi kagqirha wakho okanye kwelinye iziko lonyango. Kuya kufuneka uhlale kwindawo yonyango ubuncinci iiyure ezingama-6 emva kokuba uthathe amayeza ukuze ube nokubekwa esweni. Ungadinga ukuhlala kwiziko lonyango ixesha elingaphezulu kweeyure ezingama-6 okanye ubusuku bonke ukuba unemiqathango ethile okanye uthatha amayeza athile anyusa umngcipheko wokuba ukubetha kwentliziyo yakho kucothe okanye ukuba ukubetha kwentliziyo yakho kuhamba kancinci kunokuba bekulindelwe okanye kuyaqhubeka ukucotha emva kwe-6 yokuqala iiyure. Kuya kufuneka ukuba uhlale kwiziko lonyango ubuncinci iiyure ze-6 emva kokuba uthathe idosi yakho yesibini ukuba ukubetha kwentliziyo yakho kunciphisa kakhulu xa uthatha idosi yakho yokuqala. Tshela ugqirha wakho ukuba unesiyezi, ukhathala, iintlungu zesifuba, okanye ukubetha kwentliziyo okungahambi kakuhle nangaliphi na ixesha ngexesha lonyango lwakho, ngakumbi kwiiyure zokuqala ezingama-24 emva kokuba uthathe idosi yakho yokuqala.

I-Fingolimod inokunceda ukulawula i-multiple sclerosis kodwa ayizukuyinyanga. Ungayeki ukuthatha i-fingolimod ngaphandle kokuthetha nogqirha wakho. Ukuba awuyithathi i-fingolimod usuku olu-1 okanye ngaphezulu kwiiveki ezimbini zokuqala zonyango, kangangeveki enye okanye ngaphezulu kwiveki yesithathu neyesine yonyango okanye kwiiveki ezi-2 okanye ngaphezulu emva kwenyanga yokuqala yonyango, thetha nogqirha wakho ngaphambi uqala ukuyithatha kwakhona. Unokufumana ukubetha kwentliziyo okucothayo xa uqala ukuthatha i-fingolimod kwakhona, ke kuya kufuneka uphinde uqalise amayeza kwiofisi kagqirha wakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-fingolimod kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-fingolimod,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-fingolimod, Ukuba ngaba une-aleji engalunganga kwi-fingolimod okanye nasiphi na isithako esenziwe kwiifomsolimod capsules (irhashalala, imihlathi, ukudumba kobuso, amehlo, umlomo, umqala, ulwimi, imilebe, izandla, iinyawo, amaqatha, okanye imilenze esezantsi), ugqirha wakho uya kuthi ungaxeleli fingolimod. Kwakhona xelela ugqirha wakho ukuba uxabana nalo naliphi na iyeza, okanye naziphi na izithako ezikwiifomsolimod capsules. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha amayeza ngokubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), ibutilide (Corvert), procainamide, quinidine (eNuedexta), kunye ne-sotalol (I-Betapace, iSorine, iSotylize). Ugqirha wakho uya kukuxelela ukuba ungathathi i-fingolimod ukuba uthatha elinye okanye ngaphezulu kwala mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye ocwangcisa ukuwathatha ngexesha lonyango lwakho ngefingolimod Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-beta-blockers enjenge-atenolol (Tenormin, kwi-Tenoretic), i-carteolol, i-labetalol (iTrandate), i-metoprolol (i-Lopressor, i-Toprol-XL, i-Dutoprol, i-Lopressor HCT), i-nadolol (i-Corgard, kwi Corzide), nebivolol (Bystolic, kwi-Byvalson), propranolol (Inderal LA, Innopran XL), kunye ne-timolol; diltiazem (Cardizem, Cartia, Tiazac, nabanye); chlorpromazine; ikitalopram (uCelexa); idigoxin (Lanoxin); erythromycin (EES, Ery-Tab, PCE, nabanye); haloperidol (iHaldol); ketoconazole; amayeza iingxaki zentliziyo; imethadone (iDolophine, iMethadose); kunye neverapamil (Calan, Verelan, eTarka).Ndixelele ugqirha ukuba uthatha nawaphi na amayeza alandelayo, okanye ukuba uwathathe ngaphambili: ii-corticosteroids ezinjenge-dexamethasone, i-methylprednisolone, kunye ne-prednisone; amayeza omhlaza; kunye namayeza okwenza buthathaka okanye ukulawula amajoni omzimba anje nge-mitoxantrone, natalizumab (Tysabri), kunye ne-teriflunomide (Aubagio), Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akuqwalasele ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-fingolimod, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe wanayo okanye unayo nayiphi na kwezi meko kwiinyanga ezintandathu ezidlulileyo: isifo sentliziyo, i-angina (iintlungu zesifuba), ukubetha okanye ukubetha kwentliziyo, okanye ukusilela kwentliziyo. Xelela ugqirha wakho ukuba une-QT syndrome ende (imeko eyonyusa umngcipheko wokuba nokubetha kwentliziyo okungaqhelekanga okunokubangela ukuba utyhafile okanye usweleke ngesiquphe) okanye isingqisho sentliziyo esingaqhelekanga. Ugqirha wakho unokukuxelela ukuba ungathathi i-fingolimod.
• xelela ugqirha wakho ukuba wakhe wawa isiqaqa, wahlaselwa sisifo sentliziyo, wabethwa sistroke, okanye wabethwa kancinci, okanye ukuba unefiva okanye ezinye iimpawu zosulelo, ukuba unosulelo oluza ludlule okanye olungapheliyo, kwaye ukuba ukhe unesifo seswekile; ubuthongo bokulala (imeko apho uyeke kancinci ukuphefumla amaxesha amaninzi ebusuku) okanye ezinye iingxaki zokuphefumla; igazi elonyukayo; uveitis (ukudumba kwamehlo) okanye ezinye iingxaki zamehlo; ukubetha kwentliziyo kancinci; amanqanaba asezantsi e-potassium okanye i-magnesium egazini lakho; umhlaza wolusu, okanye isifo sentliziyo okanye sesibindi. Xelela ugqirha wakho ukuba usandula ukufumana iyeza lokugonya.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa, okanye uncelisa. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye neenyanga ezi-2 emva kwedosi yakho yokugqibela. Ukuba ukhulelwa ngelixa uthatha i-fingolimod okanye kwiinyanga ezi-2 emva kwedosi yakho yokugqibela, tsalela ugqirha wakho.
• awunalo ugonyo ngexesha lonyango lwakho nge-fingolimod okanye iinyanga ezi-2 emva kwedosi yakho yokugqibela ungakhange uthethe nogqirha wakho. Thetha nogqirha wakho womntwana malunga nokugonywa umntwana wakho anokufuna ukukufumana ngaphambi kokuba aqale unyango lwakhe nge-fingolimod.
• xelela ugqirha wakho ukuba awuzange ube nayo irhashalala kwaye awulifumani iyeza lokugonya irhashalala. Ugqirha wakho angayalela uvavanyo lwegazi ukuze abone ukuba ubonakalisiwe na kumbungu wenkukhu. Unokufuna ukufumana isitofu sokugonya irhashalala uze ulinde inyanga enye ngaphambi kokuba uqale unyango lwakho nge-fingolimod.
• cwangcisa ukuthintela ukukhanya kwelanga ngokungeyomfuneko okanye ixesha elide kunye nokukhanya kwe-UV (njengamathebhu okususa) kunye nokunxiba iimpahla ezikhuselayo, izibuko zelanga kunye nelanga. I-Fingolimod inokwenza ulusu lwakho lubonakale ngakumbi kwiziphumo eziyingozi zokukhanya kwelanga, kwaye inokunyusa umngcipheko wokuba nomhlaza wolusu.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye ubize ugqirha ngaphambi kokuba uthathe idosi elandelayo. Kuya kufuneka ubekwe esweni njengoko uqala kwakhona amayeza akho. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Fingolimod inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ubuthathaka
• umqolo obuhlungu
• iintlungu ezandleni okanye ezinyaweni
• urhudo
• intlungu zesisu
• isicaphucaphu
• intloko ebuhlungu okanye migraine
• ukulahleka kweenwele

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• ukubetha kwentliziyo kancinci
• irhashalala, urticaria, ukurhawuzelela; ukudumba kobuso, iliso, umlomo, umqala, ulwimi okanye imilebe; okanye kunzima ukugwinya okanye ukuphefumla
• umqala obuhlungu, iintlungu zomzimba, umkhuhlane, Ukugodola, ukukhohlela, kunye nezinye iimpawu zosulelo kunye nonyango kunye neenyanga ezi-2 emva konyango
• intloko ebuhlungu, ukuqina kwentamo, umkhuhlane, ubuntununtunu ekukhanyeni, isicaphucaphu, okanye ukudideka ngexesha lonyango kunye neenyanga ezi-2 emva konyango lwakho
• Ubuhlungu, ukutshisa, ukuba ndindisholo, okanye ukuqaqanjelwa sisikhumba, ubuntununtunu bokubamba, irhashalala, okanye ukurhawuzelela ngexesha lonyango kunye neenyanga ezi-2 emva konyango
• intloko ebukhali ngesiquphe, ukudideka, utshintsho kumbono, okanye ukuxhuzula
• ukufiphala, izithunzi, okanye indawo engaboniyo kumbono wombono wakho; uvakalelo ekukhanyeni; umbala ongaqhelekanga kumbono wakho okanye ezinye iingxaki zombono
• utshintsho kwimole esele ikhona; indawo entsha emnyama esikhumbeni; izilonda ezingapholiyo; ukukhula kwisikhumba sakho njenge-bump enokuthi ikhanye, imhlophe emhlophe, ibala lolusu, okanye ipinki, okanye naluphi na utshintsho kolusu lwakho
• ubuthathaka kwelinye icala lomzimba okanye ubucukubhede beengalo okanye imilenze eya isiba mandundu ngokuhamba kwexesha; utshintsho kwindlela ocinga ngayo, kwimemori, okanye kulungelelwano; ukudideka okanye utshintsho kubuntu; okanye ukuphelelwa ngamandla
• okutsha okanye okuya kusiba mandundu nokuphefumla okufutshane
• isicaphucaphu, ukugabha, ukungabinamdla wokutya, iintlungu esiswini, ubumthubi besikhumba okanye amehlo, okanye umchamo omnyama

I-Fingolimod inokunyusa umngcipheko wokuba nomhlaza wolusu kunye ne-lymphoma (umhlaza oqala kwiiseli ezilwa nosulelo). Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

Ukonyuka ngesiquphe kweziqendu zeempawu ze-MS kunye nokwanda kokukhubazeka kungenzeka ngaphakathi kweenyanga ezi-3 ukuya kwezi-6 emva kokuba uyeke ukuthatha i-fingolimod. Tshela ugqirha wakho ukuba ngaba iimpawu zakho ze-MS ziya zisiba mbi emva kokuyeka i-fingolimod.

I-Fingolimod inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ukubetha kwentliziyo okucothayo okanye okungaqhelekanga

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu, kunye novavanyo lolusu kunye neliso, kwaye uya kubeka esweni uxinzelelo lwegazi ngaphambi kwaye ngexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile kuwe ukuba uqale ukuthatha okanye uqhubeke nokuthatha i-fingolimod.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-fingolimod.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Gilenya^®