IBedaquiline

Umxholo

• Ngaphambi kokuba uthathe i-bedaquiline,
• I-Bedaquiline inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Bedaquiline kufuneka isetyenziselwe kuphela ukunyanga abantu abanesifo sephepha esinganyangekiyo ngamachiza amaninzi (MDR-TB; isifo esosulelayo esihlasela imiphunga kunye namanye amalungu omzimba kwaye esinganyangekiyo ubuncinci kumayeza amabini aqhele ukusetyenziselwa Phatha imeko) xa ezinye iindlela zonyango zingenakusetyenziswa. Kwisifundo seklinikhi, babebaninzi abantu abaswelekileyo phakathi kwabantu abathathe i-bedaquiline kunabantu ababengalisebenzisi iyeza. Nangona kunjalo, i-MDR-TB sisifo esisongela ubomi, ke wena nogqirha wakho nithathe isigqibo sokuba kufuneka ninyangwe nge-bedaquiline ukuba ngaba olunye unyango alunakusetyenziswa.

I-Bedaquiline inokubangela utshintsho olunzulu okanye olusongela ubomi kwisingqi sentliziyo yakho. Kuya kufuneka ubene-electrocardiogram (ECG; uvavanyo olulinganisa umsebenzi wombane wentliziyo) ngaphambi konyango lwakho kunye namaxesha aliqela ngexesha lonyango lwakho ukuze ubone ukuba eli yeza liyichaphazela njani isingqisho sentliziyo yakho. Tshela ugqirha wakho ukuba wena okanye omnye umntu kusapho lwakho unexesha elide le-QT syndrome (ingxaki enqabileyo yentliziyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe) kwaye ukuba ukhe wanesifo sentliziyo esicothayo okanye esingaqhelekanga, isifo sedlala esingasebenzi kakuhle, amanqanaba asezantsi e-calcium, i-magnesium, okanye i-potassium egazini lakho, ukusilela kwentliziyo, okanye isifo sentliziyo esandula ukwenzeka. Xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uthatha nawaphi na amayeza alandelayo: , levofloxacin (Levaquin), moxifloxacin (Avelox), kunye ne-telithromycin (Ketek). Ukuba uhlakulela ukubetha kwentliziyo okukhawulezayo okanye okungaqhelekanga okanye ukuba uyaphela, tsalela umnxeba kwangoko.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-bedaquiline kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-bedaquiline.

I-Bedaquiline isetyenziswa kunye namanye amayeza ubuncinci ukunyanga isifo sephepha esinganyangekiyo ngamayeza (MDR-TB; usulelo olubi oluchaphazela imiphunga kunye namanye amalungu omzimba kwaye alunakunyangwa ngamanye amayeza aqhele ukusetyenziselwa ukunyanga imeko) kubantu abadala nakubantwana abaneminyaka emi-5 nangaphezulu abanobunzima ubuncinci i-33 lbs (15 kg) echaphazele imiphunga. IBedaquiline akufuneki isetyenziselwe ukunyanga i-TB echaphazela ikakhulu amanye amalungu omzimba. I-Bedaquiline ikudidi lwamayeza abizwa ngokuba yi-anti-mycobacterials. Isebenza ngokubulala iintsholongwane ezibangela i-MDR-TB.

IBedaquiline iza njengecwecwe lokuthatha ngomlomo ngamanzi. Ihlala ithathwa kunye nokutya kanye ngemini iiveki ezi-2 kwaye kathathu ngeveki iiveki ezingama-22. Xa uthatha i-bedaquiline kathathu ngeveki, vumela ubuncinci iiyure ezingama-48 phakathi kwamayeza. Thatha i-bedaquiline ngexesha elifanayo losuku nangeentsuku ezifanayo zeveki veki nganye. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-bedaquiline ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba wena okanye umntwana wakho aninakho ukuginya i-20 mg yecwecwe iphelele, ungabaphula ngesiqingatha kumanqaku amanqaku.

Ukuba wena okanye umntwana wakho aninakho ukuginya iipilisi ezingama-20 mg ziphelele okanye zinesiqingatha, iipilisi zinganyibilika ngecephe le-1 (5 ml) yamanzi kwikomityi yokusela (hayi ngaphezulu kweepilisi ezintlanu). Ungasela lo mxube ngoko nangoko okanye ukwenze kube lula, kongeza itispuni enye (5 ml) yamanzi ongezelelweyo, imveliso yobisi, ijusi yeapile, ijusi yeorenji, ijusi yecranberry, okanye isiselo sekhabhon, okanye kungenjalo, ukutya okuthambileyo yongezwa. Emva koko, ginya yonke loo mxube kwangoko. Emva kokuthatha idosi, yeka indebe ngesixa esincinci solwelo olongezelelekileyo okanye ukutya okuthambileyo kwaye uthathe ngokukhawuleza ukuze uqiniseke ukuba ufumana idosi yonke. Ukuba ufuna ngaphezulu kweepilisi ezingama-20 mg ze-bedaquiline, phinda la manyathelo angentla ude ufike kumthamo wakho omiselweyo.

Ngenye indlela, ukwenza kube lula ukuginya, ungazityumza iipilisi ezingama-20 mg kwaye wongeze kukutya okuthambileyo okufana neyogathi, iapile, ibhanana ecoliweyo, okanye ioatmeal kwaye uginye wonke umxube kwangoko. Emva kokuthatha idosi, yongeza inani elincinci lokutya okuthambileyo kwaye uthabathe kwangoko ukuze uqiniseke ukuba ufumana idosi yonke.

Ukuba unayo ityhubhu ye-nasogastric (NG), ugqirha wakho okanye usokhemesti uyakukucacisela ukuba uyilungiselela njani i-bedaquiline ukunika ngetyhubhu ye-NG.

Qhubeka nokuthatha i-bedaquiline de ugqibe amayeza kwaye ungaphoswa ngamayeza, nokuba uziva ungcono. Ukuba uyeka ukuthatha i-bedaquiline kwakamsinya okanye weqe amathamo, usulelo lwakho alunakunyangwa ngokupheleleyo kwaye intsholongwane isenokunganyangeki kwiintsholongwane. Oku kuyakwenza ukuba usulelo lwakho lube nzima ukunyanga kwixa elizayo. Ukwenza kube lula kuwe ukuba uthathe onke amayeza akho njengoko kuyalelwe, unokuthatha inxaxheba kwinkqubo yonyango eqwalaselwe ngokuthe ngqo. Kule nkqubo, umsebenzi wokhathalelo lwempilo uya kukunika idosi nganye yamayeza kwaye uya kujonga njengoko uginya amayeza.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-bedaquiline,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-bedaquiline, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-bedaquiline. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zilandelayo: carbamazepine (Equetro, Tegretol, Teril, nabanye); amayeza athile osulelo lwe-immunodeficiency virus (HIV) aquka i-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), lopinavir (e-Kaletra), nelfinavir (Viracept), ritonavir (Norvir, e-Kaletra, e-Viekira Pak); itraconazole (Onmel, Sporanox); ketoconazole (Nizoral); nefazodone; phenobarbital; phenytoin (Dilantin); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate, eRifater); kunye ne-rifapentine (Priftin). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-bedaquiline, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wakha une-HIV, okanye isibindi okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwe ngelixa uthatha i-bedaquiline, tsalela umnxeba ugqirha wakho. Ukuba uncelisa, xelela ugqirha wakho ukuba umntwana wakho unamehlo aphuzi okanye ulusu okanye utshintsho kumbala womchamo wabo okanye isitulo.
• thintela ukusela iziselo ezinxilisayo ngelixa uthatha i-bedaquiline. Ukusela utywala kwandisa umngcipheko wokuba uya kuba neziphumo ebezingalindelekanga ezimbi ezivela kwi-bedaquiline.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Ukuba uphoswa ithamo ngexesha leeveki ezimbini zokuqala zonyango lwakho, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ukuba uphosa idosi ukusuka kwiveki yesi-3 kuzo zonke iiveki ezisele zonyango lwakho, thatha idosi ephosiweyo ngokutya nje ukuba uyikhumbule kwaye uqhubeke namaxesha ama-3 ngeveki yokuhlela idosi. Qinisekisa ukuba kukho iiyure ezingama-24 ubuncinci phakathi kokuthatha idosi ephosiweyo kunye nedosi elandelayo ehleliweyo. Sukuthatha idosi ephindwe kabini ukuyenzela elahlekileyo okanye uthathe ngaphezulu kwedosi yakho yeveki kwisithuba seentsuku ezisi-7.

I-Bedaquiline inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intlungu edibeneyo
• intloko ebuhlungu
• irhashalala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukudinwa kakhulu
• Ukuphelelwa ngumdla wokutya
• isicaphucaphu
• mthubi ulusu okanye amehlo
• umchamo omnyama ngombala
• intshukumo ekhanyayo yamathumbu
• iintlungu kwindawo ephezulu yesisu
• ifiva
• ukhohlela igazi
• iintlungu zesifuba

I-Bedaquiline inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya, ubushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Gcina ipakethe ye-desiccant (eyomisa) kwibhotile yeyeza ukugcina iipilisi zomile.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-bedaquiline.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Sirturo^®