Inaliti ye-Mipomersen

Umxholo

• Ngaphambi kokufaka inaliti ye-mipomersen,
• Inaliti ye-Mipomersen inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

Inaliti ye-Mipomersen inokubangela ukonakala kwesibindi. Xelela ugqirha wakho ukuba uyasela okanye wakha wasela izixa ezikhulu zotywala kwaye ukuba ukhe unesifo sesibindi, kubandakanya nomonakalo wesibindi owakhula ngelixa wawusebenzisa elinye iyeza. Ugqirha wakho uya kukuxelela ukuba ungasebenzisi inaliti ye-mipomersen ukuba unesifo sesibindi. Tshela ugqirha wakho kunye nosokhemesti ukuba uhlala uthatha i-acetaminophen (iTylenol, kwamanye amayeza entlungu) kwaye ukuba uthatha i-amiodarone (Cordarone, Pacerone); amanye amayeza e-cholesterol ephezulu; imethotrexate (Rheumatrex, Trexall); tamoxifen (Soltamox); okanye i-tetracycline antibiotics efana ne-doxycycline (Doryx, Vibra-Tabs, Vibramycin), minocycline (Dynacin, Minocin), kunye ne-tetracycline (Sumycin). Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: isicaphucaphu, ukugabha, ukungabinamdla wokutya, iintlungu zesisu, ukudinwa kakhulu, ukuba tyheli kolusu okanye amehlo, umchamo omnyama, okanye ukurhawuzelela.

Ukusela utywala kwandisa umngcipheko wokuba uya kukhula ukonakala kwesibindi ngexesha lonyango lwakho ngenaliti yemipomersen. Musa ukusela ngaphezu kwesinye isiselo esinxilisayo ngosuku ngelixa usebenzisa le mayeza.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola iimvavanyo ezithile ngaphambi kunye nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwisitofu se-mipomersen.

Ngenxa yomngcipheko wokonakala kwesibindi, inkqubo sele isetelwe ukubeka iliso kwizigulana ezisebenzisa inaliti yemipomersen. Ugqirha wakho kuya kufuneka agqibe uqeqesho kunye nerejista ngaphambi kokuyalela eli yeza. Uyakwazi kuphela ukufumana amayeza akho kwikhemesti eqinisekisiweyo yokuhambisa inaliti yemipomersen. Buza ugqirha wakho ngolwazi olungakumbi malunga nendlela yokufumana amayeza akho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngenaliti yemipomersen kwaye ngalo lonke ixesha uzalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nomngcipheko wokusebenzisa inaliti ye-mipomersen.

Inaliti ye-Mipomersen isetyenziselwa ukunciphisa amanqanaba e-cholesterol kunye nezinye izinto ezinamafutha egazini kubantu abane-homozygous Family hypercholesterolemia (HoFH; imeko enqabileyo njengelifa ebangela amanqanaba aphezulu e-cholesterol egazini, enyusa umngcipheko wesifo esibi sentliziyo). Abanye abantu abane-HoFH banokunyangwa nge-LDL apheresis (inkqubo esusa i-LDL egazini), kodwa inaliti ye-mipomersen akufuneki isetyenziswe kunye nonyango. Inaliti ye-Mipomersen akufuneki isetyenziselwe ukunciphisa amanqanaba e-cholesterol kubantu abangenayo i-HoFH. Inaliti ye-Mipomersen ikudidi lwamayeza abizwa ngokuba yi-antisense oligonucleotide (ASO) inhibitors. Isebenza ngokuthintela izinto ezithile ezinamafutha ekubeni zenziwe emzimbeni.

Inaliti ye-Mipomersen iza njengesisombululo sokutofa phantsi kolusu. Ihlala itofwe kanye ngeveki. Tofa isitofu semipomersen kwangolo suku lweveki kwaye ujikeleze ixesha elifanayo lemini ngalo lonke ixesha usitofa. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Sebenzisa inaliti ye-mipomersen kanye njengoko kuyalelwe. Musa ukuyitofa ngaphezulu okanye ngaphantsi okanye uyitofe rhoqo kunokuba umiselwe ngugqirha.

Inaliti ye-Mipomersen inokunceda ukulawula i-cholesterol yakho kodwa ayizukuyinyanga imeko yakho. Kungathatha iinyanga ezi-6 okanye ngaphezulu ukuba inqanaba lakho le-cholesterol lehle kakhulu. Qhubeka nokusebenzisa inaliti ye-mipomersen nokuba uziva uphilile. Sukuyeka ukusebenzisa inaliti ye-mipomersen ngaphandle kokuthetha nogqirha wakho.

Ungayitofa ngokwakho imipomersen okanye ube nomhlobo okanye isalamane esikufakele amayeza. Ugqirha wakho uyakukubonisa okanye umntu oza kuthi afake iyeza ukuba ungalitofa njani. Wena kunye nomntu oza kutofa amayeza kufuneka ufunde imiyalelo yomenzi yokusetyenziswa eza nonyango. Buza ugqirha wakho ukuba unawo nawuphi na umbuzo okanye awuqondi ukuba ungayifaka njani imipomersen.

Inaliti ye-Mipomersen iza kwiisirinji ezizaliswe kwangaphambili nakwiibhotile. Ukuba usebenzisa iingqayi zenaliti ye-mipomersen, ugqirha wakho uza kukuxelela ukuba loluphi uhlobo lwesirinji ekufuneka ulusebenzisile kwaye ungalitsalela njani na iyeza kwisirinji. Sukuxuba amanye amayeza kwisirinji ngenaliti yemipomersen.

Thatha inaliti ye-mipomersen kwifriji okungenani imizuzu engama-30 ngaphambi kokuba ucwangcise ukuyitofa ukuvumela amayeza ukuba eze kubushushu begumbi. Gcina isirinji kwisingxobo sayo ukuyikhusela ekukhanyeni ngeli xesha. Ungazami ukufudumeza isirinji ngokusitshisa nangayiphi na indlela.

Ngalo lonke ixesha jonga inaliti ye-mipomersen ngaphambi kokuyitofa. Qiniseka ukuba ukupakisha kuyatywinwa, akunakonakaliswa kwaye kubhalwe igama elichanekileyo lonyango kunye nomhla wokuphelelwa kwawo ongadlulanga. Jonga ukuba isisombululo esikwibhotile okanye kwisirinji sicacile kwaye ayinambala okanye sityheli kancinane. Sukusebenzisa ibhotile okanye isirinji ukuba yonakele, iphelelwe lixesha, ibala lombala, okanye kunamafu okanye ukuba inamasuntswana.

Ungayifaka i-mipomersen naphi na kwicala elingaphandle leengalo zakho ezingaphezulu, amathanga akho, okanye isisu sakho, ngaphandle kwenkaba yakho (iqhosha lesisu) kunye nendawo eyi-intshi ezi-2 ejikeleze yona. Khetha indawo eyahlukileyo ngalo lonke ixesha utofa iyeza. Musa ukutofa ulusu olubomvu, oludumbileyo, olosulelekileyo, olunezikrelemnqa, olubhalwe umvambo, olutshiswe lilanga okanye oluchaphazeleka lulusu okanye isifo solusu esifana ne-psoriasis.

Isirinji okanye ibhotile ezaliswe kwangaphambili iqulethe kuphela inaliti eyaneleyo yeedipomersen yedosi enye. Ungazami ukusebenzisa iibhotile okanye iisirinji ngaphezulu kwesinye. Lahla iisirinji ezisetyenzisiweyo kwisitya esinganyangekiyo. Buza ugqirha wakho okanye usokhemesti ngendlela yokusilahla isikhongozeli esinganyangekiyo.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufaka inaliti ye-mipomersen,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-mipomersen, nawaphi na amanye amayeza, okanye nasiphi na isithako senaliti yemipomersen Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• sukufaka naliphi na iyeza ngaxeshanye xa utofa i-mipomersen. Buza ugqirha wakho okanye usokhemesti ukuba uza kuwafaka nini na amayeza akho.
• xelela ugqirha wakho ukuba ukhe unesifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Kuya kufuneka usebenzise ulawulo lokuzalwa ukukhusela ukukhulelwa ngexesha lonyango lwakho. Thetha nogqirha wakho malunga neendlela zolawulo lokuzalwa eziza kukusebenzela. Ukuba ukhulelwe ngexesha lonyango lwakho, yeka ukusebenzisa inaliti ye-mipomersen kwaye ubize ugqirha ngoko nangoko.

Yitya ukutya okune-fat-fat, low-cholesterol. Qiniseka ukuba ulandela yonke imithambo kunye nezincomo zokutya ezenziwe ngugqirha wakho okanye ugqirha otya ukutya. Ungandwendwela iNational Cholesterol Education Programme (NCEP) kwiwebhusayithi http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf ngolwazi olongezelelekileyo malunga nokutya.

Ukuba ukhumbula ubuncinci iintsuku ze-3 ngaphambi kwethamo lakho elilandelayo, thabatha idosi ephosiweyo kwangoko. Nangona kunjalo, ukuba ukhumbula ngaphantsi kweentsuku ezi-3 ngaphambi kwedosi yakho ehleliweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukujoba idosi ephindwe kabini ukulungiselela eyilahlekileyo.

Inaliti ye-Mipomersen inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ububomvu, iintlungu, ukuthamba, ukudumba, ukudumba, ukurhawuzelela, okanye ukutyumka ulusu apho utofa khona imipomersen
• Iimpawu ezinje ngomkhuhlane ezinje ngomkhuhlane, ukugodola, iintlungu zemisipha, iintlungu ezidibeneyo, ubuthathaka kunye nokudinwa okunokwenzeka ukuba kwenzeke kwiintsuku ezimbini zokuqala emva kokuba utofe imipomersen
• intloko ebuhlungu
• ubunzima bokulala okanye ukulala
• iintlungu ezingalweni okanye emilenzeni

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• iintlungu zesifuba
• ukubetha kwentliziyo
• ukudumba kweengalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• irhashalala
• urhwebo
• ukudumba kobuso, umqala, ulwimi, imilebe, okanye amehlo
• ukudinwa
• ubunzima bokuginya okanye ukuphefumla

Inaliti ye-Mipomersen inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa usebenzisa eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kwifriji kwaye uyikhusele ekukhanyeni. Ukuba akukho friji ikhoyo, unokugcina amayeza kwiqondo lobushushu egumbini ukuya kwiintsuku ezili-14.

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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