IPomalidomide

Umxholo

• Ngaphambi kokuthatha i-pomalidomide,
• IPomalidomide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo esiXwayiso ESIBALULEKILEYO okanye AMANYATHELO AKHETHEKILEYO, yeka ukuthatha ipomalidomide kwaye ubize ugqirha ngoko nangoko:

Umngcipheko weziphene ezinzima, ezisongela ubomi zokuzalwa ezibangelwa yi-pomalidomide.

Zonke izigulana ezithatha i-pomalidomide:

I-Pomalidomide akufuneki ithathwe zizigulana ezikhulelweyo okanye ezinokukhulelwa. Kukho umngcipheko ophezulu wokuba i-pomalidomide iya kubangela ukulahleka kokukhulelwa okanye iya kubangela ukuba umntwana azalwe enesiphene sokuzalwa (iingxaki ezikhoyo ngexesha lokuzalwa).

Inkqubo ebizwa ngokuba yiPomalyst REMS^® isetiwe yokuqinisekisa ukuba abasetyhini abakhulelweyo abayithathi i-pomalidomide kwaye abasetyhini abakhulelwa ngelixa bethatha i-pomalidomide. Zonke izigulana, kubandakanya nabasetyhini abangakwaziyo ukukhulelwa kunye namadoda, banokufumana i-pomalidomide kuphela ukuba babhalisiwe kwi-Pomalyst REMS^®, Unayo amayeza kagqirha obhaliswe kwiPomalyst REMS^®, kwaye ugcwalise amayeza amayeza kwikhemesti ebhaliswe kwiPomalyst REMS^®.

Uya kufumana ulwazi malunga nemingcipheko yokuthatha i-pomalidomide kwaye kufuneka utyikitye iphepha lemvume elinolwazi elichazayo ukuba uyayiqonda le ngcaciso ngaphambi kokuba ufumane amayeza. Uya kudinga ukubona ugqirha wakho ngexesha lonyango lwakho ukuze uthethe malunga nemeko yakho kunye neziphumo ezibi ohlangabezana nazo okanye kuvavanyo lokukhulelwa njengoko kucetyisiwe yinkqubo.

Xelela ugqirha wakho ukuba awuyiqondi yonke into obuyixelelwe malunga ne-pomalidomide kunye ne-Pomalyst REMS^® Inkqubo kunye nendlela yokusebenzisa iindlela zolawulo lokuzalwa ekuxoxwe ngazo nogqirha wakho, okanye ukuba awucingi ukuba uza kuba nakho ukugcina amadinga.

Musa ukunikela ngegazi ngelixa uthatha i-pomalidomide kunye neeveki ezi-4 emva konyango lwakho.

Ungabelani pom pomomomomide naye nabani na ongomnye, nokuba umntu uneempawu ezifanayo nezakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-pomalidomide kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye http://www.celgeneriskmanagement.com ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-pomalidomide.

Kwabaguli ababhinqileyo abathatha ipomalidomide:

Ukuba unokukhulelwa, kuya kufuneka uhlangabeze iimfuno ezithile ngexesha lonyango lwakho nge-pomalidomide. Kufuneka uhlangabeze ezi mfuno nokuba ubune-tubal ligation ('iityhubhu ezibotshiweyo,' utyando ukunqanda ukukhulelwa). Unokuxolelwa ekufezekiseni ezi mfuno kuphela ukuba awuyi exesheni iinyanga ezingama-24 zilandelelana kwaye ugqirha wakho uthi udlulile ukuya exesheni ('utshintsho lobomi') okanye utyandiwe ukuze kususwe isibeleko sakho kunye / okanye omabini amaqanda. Ukuba akukho nanye kwezi iyinyani kuwe, kuya kufuneka uhlangabezane neemfuno ezingezantsi.

Kuya kufuneka usebenzise iindlela ezimbini ezamkelekileyo zolawulo lokuzalwa iiveki ezi-4 ngaphambi kokuba uqale ukuthatha i-pomalidomide, ngexesha lonyango lwakho, kubandakanya amaxesha xa ugqirha ekuxelela ukuba uyeke okwethutyana ukuthatha i-pomalidomide, kunye neeveki ezi-4 emva konyango lwakho. Ugqirha wakho uza kukuxelela ukuba zeziphi iindlela zolawulo lokuzalwa ezamkelekileyo kwaye uya kukunika ulwazi olubhaliweyo malunga nolawulo lokuzalwa. Kuya kufuneka usebenzise ezi ndlela zimbini zokulawula ukuzalwa maxa onke ngaphandle kokuba ungathembisa ukuba awuyi kuba nakunxibelelana ngokwesondo nendoda kangangeeveki ezi-4 ngaphambi konyango lwakho, ngexesha lonyango lwakho, nangaluphi na uphazamiso kunyango lwakho, nakwiiveki ezi-4 emva unyango lwakho.

Ukuba ukhetha ukuthatha i-pomalidomide, luxanduva lwakho ukuthintela ukukhulelwa iiveki ezi-4 ngaphambili, ngexesha, kunye nakwiiveki ezi-4 emva konyango lwakho. Kuya kufuneka uqonde ukuba naluphi na uhlobo lolawulo lokuzalwa alunakusilela. Ke ngoko, kubaluleke kakhulu ukunciphisa umngcipheko wokukhulelwa ngengozi ngokusebenzisa iindlela ezimbini zolawulo lokuzalwa. Xelela ugqirha wakho ukuba awuyiqondi yonke into obuyixelelwe malunga nolawulo lokuzalwa okanye awucingi ukuba uya kuba nakho ukusebenzisa iindlela ezimbini zolawulo lokuzalwa ngalo lonke ixesha.

Kuya kufuneka uneemvavanyo ezimbini ezimbi zokukhulelwa ngaphambi kokuba uqale ukuthatha i-pomalidomide. Kuya kufuneka ukuba uvavanywe ukukhulelwa elebhu ngamaxesha athile ngexesha lonyango lwakho. Ugqirha wakho uya kukuxelela ukuba nini kwaye phi.

Yeka ukuthatha i-pomalidomide kwaye ubize ugqirha wakho ngoko nangoko ukuba ucinga ukuba ukhulelwe, uyaphoswa lixesha lokuya exesheni, okanye ulala ngesondo ngaphandle kokusebenzisa iindlela ezimbini zolawulo lokuzalwa. Ukuba ukhulelwe ngexesha lonyango lwakho okanye kwiintsuku ezingama-30 emva konyango lwakho, ugqirha wakho uya kuqhagamshelana ne-Pomalyst REMS^® Inkqubo, umenzi we-pomalidomide, kunye noLawulo lokutya kunye neDrug (FDA).

Kwizigulana ezingamadoda ezithatha i-pomalidomide:

IPomalidomide ikhona kwisidoda (ulwelo olunesidoda esikhutshwa kwilungu lobudoda ngexesha le-orgasm). Kuya kufuneka usebenzise i-latex okanye ikhondom eyenziweyo, nokuba unayo ivasectomy (utyando oluthintela indoda ekubangeleni ukukhulelwa), ngalo lonke ixesha usabelana ngesondo nomntu obhinqileyo okhulelweyo okanye okwaziyo ukukhulelwa ngelixa uthatha i-pomalidomide kunye neentsuku ezingama-28 emva konyango lwakho. Xelela ugqirha wakho ukuba unokwabelana ngesondo nomntu wasetyhini ngaphandle kokusebenzisa ikhondom okanye ukuba iqabane lakho licinga ukuba unokukhulelwa ngexesha lonyango lwakho nge-pomalidomide.

Musa ukunikela ngesidoda ngelixa uthatha i-pomalidomide kunye neeveki ezi-4 emva konyango lwakho.

Umngcipheko wamahlwili egazi:

Ukuba uthatha i-pomalidomide ukunyanga i-myeloma emininzi (uhlobo lomhlaza womongo wethambo), kukho umngcipheko wokuba uya kuhlaselwa sisifo sentliziyo, ukubetha, okanye igazi eliguqe umlenze wakho (deep vein thrombosis; DVT) that inokuhamba ngokuhamba kwegazi liye emiphungeni yakho (embolism ye-pulmonary embolism, PE). Tshela ugqirha wakho ukuba uye wahlaselwa sisifo sentliziyo okanye wabetha icala. Ugqirha wakho unokukuxelela ukuba ungathathi i-pomalidomide. Xelela ugqirha wakho ukuba uyatshaya okanye usebenzisa icuba, ukuba ukhe wahlaselwa sisifo sentliziyo okanye wabethwa yistroke, kwaye ukuba ukhe wanalo uxinzelelo lwegazi oluphezulu, okanye amanqanaba aphezulu egazi echolesterol okanye amafutha, ugqirha wakho unokukunika amanye amayeza. kuthathwe kunye ne-pomalidomide ukunciphisa lo mngcipheko. Ukuba ufumana naziphi na kwezi mpawu zilandelayo ngelixa uthatha i-pomalidomide, xelela ugqirha ngokukhawuleza: intloko ebuhlungu; ukugabha; iingxaki zokuthetha; isiyezi okanye ukudinwa; ukulahleka ngokukhawuleza okupheleleyo okanye okukodwa kombono; ubuthathaka okanye ukuphazamiseka kwengalo okanye umlenze; Intlungu yesifuba enokusasazeka kwiingalo, entanyeni, emhlathini, ngasemva, okanye esiswini; ukuqhawukelwa ngumphefumlo; ukudideka; okanye iintlungu, ukudumba, okanye bomvu emlenzeni omnye.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-pomalidomide.

I-Pomalidomide isetyenziselwa ukudibanisa ne-dexamethasone ukunyanga i-myeloma (uhlobo lomhlaza womongo wethambo) olungakhange luphuculwe ngexesha okanye kwiintsuku ezingama-60 zonyango kunye namanye amayeza amabini, kubandakanya i-lenalidomide (i-Revlimid) kunye ne-proteasome inhibitor enje bortezomib (Velcade) okanye icarfilzomib (Kyprolis). Isetyenziselwa ukunyanga i-Kaposi's sarcoma (uhlobo lomhlaza olwenza ukuba izicubu ezingaqhelekanga zikhule kwiindawo ezahlukeneyo zomzimba) ezinxulumene nokufumana isifo se-immunodeficiency syndrome (i-AIDS) emva konyango olungaphumelelanga namanye amayeza okanye kubantu abane-Kaposi's sarcoma Usulelo lwe-HIV. I-Pomalidomide ikudidi lwamayeza abizwa ngokuba ziiarhente ze-immunomodulatory agents. Isebenza ngokunceda umongo wethambo ukuvelisa iiseli eziqhelekileyo zegazi kunye nokubulala iiseli ezingaqhelekanga kumongo wethambo.

I-Pomalidomide iza njengephilisi ukuyithatha ngomlomo. Ihlala ithathwa kanye yonke imihla kunye okanye ngaphandle kokutya ngeentsuku zoku-1 ukuya kwezingama-21 zomjikelo weentsuku ezingama-28. Le patheni yeentsuku ezingama-28 inokuphindwa njengoko kucetyiswa ngugqirha wakho. Thatha i-pomalidomide ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha pomalidomide ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iicapsule ngamanzi; ungawaphuli okanye uwahlafune. Musa ukuvula iifomsile okanye uziphathe ngaphezulu kwemfuneko. Ukuba ulusu lwakho ludibana neephilisi okanye i-powder ezaphukileyo, hlamba indawo esecaleni ngesepha namanzi. Ukuba nayiphi na imixholo yecapsule ifike emehlweni akho, hlamba amehlo akho kwangoko ngamanzi.

Ugqirha wakho unokufuna ukumisa isigxina okanye okwexeshana unyango lwakho okanye unciphise idosi yakho xa uneziphumo ebezingalindelekanga. Qiniseka ukuba uxelela ugqirha wakho indlela oziva ngayo ngexesha lonyango lwakho nge pomalidomide.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha i-pomalidomide,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-pomalidomide, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile ze-pomalidomide. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: carbamazepine (Carbatrol, Tegretol, Teril, others); ciprofloxacin (Cipro); i-fluvoxamine (iLuvox); kunye ne ketoconazole (Nizoral). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-pomalidomide, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ufumana idialysis (unyango lokucoca igazi xa izintso zingasebenzi kakuhle) okanye unesifo sesibindi.
• sukuncancisa xa uthatha ipomalidomide.
• xelela ugqirha wakho ukuba usebenzisa iimveliso zecuba. Ukutshaya icuba kunokunciphisa ukusebenza kweli yeza.
• Kuya kufuneka uyazi ukuba i-pomalidomide inokukwenza uzive unesiyezi okanye udidekile. Sukuqhuba imoto, sebenzisa oomatshini, okanye wenze eminye imisebenzi efuna ukuba uqaphele ngokupheleleyo de ube uyazi ukuba lonyango lukuchaphazela njani.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 kude kube yidosi elandelayo ehleliweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IPomalidomide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• urhudo
• isicaphucaphu
• ukugabha
• Ukuphelelwa ngumdla wokutya
• utshintsho lobunzima
• ukushukuma okungalawulekiyo kwilungu lomzimba
• ukubila okungaqhelekanga okanye ukubila ebusuku
• ixhala
• isikhumba esomileyo
• ukudumba kweengalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ngokudibeneyo, umsipha, okanye iintlungu zomqolo
• ingxaki yokulala okanye ukulala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo esiXwayiso ESIBALULEKILEYO okanye AMANYATHELO AKHETHEKILEYO, yeka ukuthatha ipomalidomide kwaye ubize ugqirha ngoko nangoko:

• irhashalala
• ukurhawuzelela
• urhwebo
• ukudumba nokuxobuka kolusu
• ukudumba kwamehlo, ubuso, ulwimi, umqala, izandla, iingalo, iinyawo, amaqatha okanye imilenze esezantsi
• ubunzima bokuphefumla okanye ukugwinya
• ukudinwa
• umkhuhlane, umqala obuhlungu, Ukugodola, ukukhohlela, okanye ezinye iimpawu zosulelo
• Amehlo atyheli okanye ulusu
• umchamo omnyama
• iintlungu okanye ukungaphatheki kakuhle kwindawo ephezulu yesisu
• ukuchama okunzima, rhoqo, okanye okubuhlungu
• ulusu oluthuthu
• ukudinwa okungaqhelekanga okanye ubuthathaka
• ukopha okungaqhelekanga okanye ukugruzuka
• impumlo
• ukuba ndindisholo, ukutshisa, okanye ukubetha ezandleni okanye ezinyaweni
• ukuxhuzula

I-Pomalidomide inokunyusa umngcipheko wokuba uphuhlise eminye imihlaza. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-pomalidomide.

I-Pomalidomide inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni.Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Buyisela nawaphi na amayeza angasafunekiyo kwikhemesti okanye kumenzi wakho. Buza usokhemesti wakho ukuba unemibuzo malunga nokubuyisa amayeza akho.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-pomalidomide.

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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