I-Dolutegravir

Umxholo

• Ngaphambi kokuba uthathe i-dolutegravir,
• I-Dolutegravir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LOKUKHUSELWA OKUQHELEKILEYO, yeka ukuthatha i-dolutegravir kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

I-Dolutegravir isetyenziswa namanye amayeza ukunyanga usulelo lwe-immunodeficiency virus (HIV) kubantu abadala nakubantwana kwiiveki ezi-4 ubudala nangaphezulu abanobunzima obungama-6.6 lbs (3 kg). Isetyenziswa ngokudibanisa ne-rilpivirine (i-Edurant) ukunyanga i-HIV kubantu abadala abathile ukubuyisela amayeza abo e-HIV ngoku athathiweyo kangangeenyanga ezi-6. I-Dolutegravir ikudidi lwamayeza abizwa ngokuba yi-HIV integrase inhibitors. Isebenza ngokunciphisa inani le-HIV egazini lakho kwaye yonyusa inani leeseli zomzimba ezinceda ukulwa usulelo emzimbeni wakho. Nangona i-dolutegravir ingayinyangi i-HIV, ukuyisebenzisa kunye namanye amayeza kunganciphisa ithuba lakho lokufumana isifo se-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezinje ngezifo ezomeleleyo okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokuhambisa (ukusasaza) intsholongwane kagawulayo kwabanye abantu.

I-Dolutegravir iza njengecwecwe kwaye njengethebhulethi yokumiswa (ithebhulethi inyibilike kulwelo) ukuyithatha ngomlomo. Ihlala ithathwa kanye okanye kabini ngemini kunye okanye ngaphandle kokutya. Thatha i-dolutegravir malunga namaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-dolutegravir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Musa ukuhlafuna, ukusika, okanye ukuchoboza iipilisi zokumiswa ngomlomo. Ungayiginya ipilisi yonke, enye ngexesha, okanye uwaxube namanzi okusela ngaphambi kokusetyenziswa.

Ukuba uxuba iipilisi zokumiswa ngomlomo emanzini okusela, yongeza inani elichaziweyo leetafile kwindebe yedosi. Ukuba uthatha iipilisi (1) ezi-1 okanye ezi-3 zokumiswa ngomlomo, yongeza itispuni e-1 (5 ml) yamanzi okusela kwikomityi. Ukuba uthatha iipilisi ezi-4, 5, okanye ezi-6 zokumiswa ngomlomo, yongeza iitispuni ezi-2 (10 ml) zamanzi okusela kwikomityi. Sukusebenzisa naluphi na ulwelo ukunyibilikisa ithebhulethi. Swayipha ikomityi kangange-1 okanye 2 yemizuzu okanye de umxube upheliswe ngokupheleleyo; umxube uzakuvela unamafu. Xa iicwecwe zokumiswa zichithwa ngokupheleleyo, sela umxube kanye emva kokuxubeka. Ukuba sele ingaphezulu kwemizuzu engama-30 emva kokuxuba umxube, lahla umxube.

Ukuba unika umntwana iipilisi zomxube wokunqunyanyiswa, qiniseka ukuba uthe tye xa usitya. Ukuba kusekho umxube kwikomityi, yongeza enye itispuni (5 ml) yamanzi okusela kwikomityi, ujikeleze, kwaye unike wonke umntwana ukuze aqiniseke ukuba umntwana ufumana idosi epheleleyo.

Ukuba unika iipilisi umxube wokunqunyanyiswa kusana, sebenzisa isirinji yomlomo ebonelelweyo ukulinganisa kunye nokunika idosi. Beka incam yesirinji kwindebe ye-dosing ngomxube olungiselelwe ukuyizobela kwisirinji. Beka incam yesirinji yomlomo emlonyeni womntwana ngokuchasene nangaphakathi esidleleni. Cofa kancinci kwi-plunger ukunika idosi kancinci. Vumela ixesha lokuba usana luginye lo mxube. Yongeza enye itispuni (5 ml) yamanzi okusela kwikomityi uze ujikeleze.Zoba umxube oseleyo kwisirinji uze uwunike lonke usana. Phinda ukuba kukho nawuphi na umxube ohleli kwisirinji ukuqinisekisa ukuba usana lufumana idosi epheleleyo. Umxube kufuneka unikwe umntwana kwimizuzu engama-30 yokuxuba. Emva kwethamo, hlamba ikomityi kunye nenxalenye yesirinji ngokwahlukeneyo ngamanzi. Vumela iinxalenye ukuba zome ngokupheleleyo ngaphambi kokuba ziphinde zidityaniswe kwaye zigcinwe.

Musa ukutshintsha kwiipilisi uye kwiithebhulethi zokumiswa ngaphandle kokuqala uthethe nogqirha wakho.

Qhubeka nokuthatha i-dolutegravir nokuba uziva uphilile. Sukuyeka ukuthatha i-dolutegravir ngaphandle kokuthetha nogqirha wakho. Xa unikezelo lwakho lwe-dolutegravir luyehla, fumana ngakumbi kugqirha wakho okanye kwikhemesti. Ukuba uyeka ukuthatha i-dolutegravir okanye uphose iidosi, imeko yakho inokuba mandundu kwaye kube nzima ukunyanga ngamayeza.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-dolutegravir,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabana nedolutegravir, nawaphi na amanye amayeza, okanye nasiphi na isithako esikwiipilisi zedolutegravir. Buza usokhemesti wakho okanye ujonge ulwazi lomenzi wesigulana uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-dofetilide (Tikosyn). Ugqirha wakho uya kukuxelela ukuba ungathathi i-dolutegravir ukuba uthatha eli yeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo, ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: dalfampridine (Ampyra); amanye amayeza e-HIV kubandakanya i-efavirenz (Sustiva, e-Atripla), etravirine (Intelence), fosamprenavir (Lexiva) ethathwe nge-ritonavir (Norvir), nevirapine (Viramune), kunye ne-tipranavir (Aptivus) ethathwe nge-ritonavir (Norvir); amayeza athile okubanjwa kubandakanya i-carbamazepine (Carbatrol, Equetro, Tegretol), oxcarbazepine (Oxtellar XR, Trileptal), phenobarbital, kunye ne phenytoin (Dilantin, Phenytek); metformin (iGlumetza, iGlucophage, iRiomet); kunye nerifampin (Rifadin, Rimactane, eRifamate, eRifater). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• ukuba uthatha ii-antacids, laxatives, okanye ii-multivitamini ezine-aluminium, i-magnesium, okanye i-calcium; izongezo zekhalsiyam; izongezo zentsimbi; I-sucralfate (iKarafate); okanye amayeza angqiniweyo anjenge-aspirin ebanjiweyo, thatha emva kweeyure ezi-2 okanye kwiiyure ezi-6 ngaphambi kokuba uthathe i-dolutegravir. Nangona kunjalo, ukuba uthatha i-dolutegravir kunye nokutya, ungazithatha ezi zongezo ngaxeshanye uthathe i-dolutegravir.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe unesifo sezintso okanye ufumana unyango lwe-dialysis okanye isifo sesibindi kubandakanya i-hepatitis B okanye i-hepatitis C.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Uya kudinga ukuthatha uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango. Thetha nogqirha wakho malunga neendlela ezifanelekileyo zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwa ngelixa uthatha i-dolutegravir, tsalela umnxeba kwangoko. I-Dolutegravir inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufuneki uncancise xa wosulelwe yi-HIV okanye ukuba uthatha i-dolutegravir.
• Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho. Oku kunokubangela ukuba ube neempawu zolu sulelo. Ukuba uneempawu ezintsha okanye eziba mandundu emva kokuqala unyango nge-dolutegravir, qiniseka ukuxelela ugqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Dolutegravir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ubunzima bokulala okanye ukulala
• intloko ebuhlungu
• isisu esibuhlungu
• irhasi
• urhudo
• ukutyeba kwakho

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LOKUKHUSELWA OKUQHELEKILEYO, yeka ukuthatha i-dolutegravir kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• irhashalala
• ifiva
• ziva gula
• ukudinwa kakhulu
• intlungu yesihlunu okanye edibeneyo
• ukudumba okanye ukuxobuka kolusu
• Amadyungudyungu okanye izilonda emlonyeni
• amehlo abomvu okanye adumbileyo
• ukudumba kwamehlo, ubuso, imilebe, umlomo, ulwimi, okanye umqala
• ubunzima bokuphefumla okanye ukugwinya
• mthubi wamehlo okanye ulusu
• umchamo omnyama
• iintshukumo ezinamatheleyo
• isicaphucaphu
• ukugabha
• Ukuphelelwa ngumdla wokutya
• iintlungu kwinxalenye ephezulu yesisu

I-Dolutegravir inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Musa ukuyisusa i-desiccant (ipakethi encinci enezinto ezifunxa ukufuma ukugcina iyeza lome) kwibhotile.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile zelebhu ukujonga impendulo yomzimba wakho kwi-dolutegravir.

Gcina unikezelo lwe dolutegravir ezandleni. Sukulinda de uphelelwe ngamayeza ukuze uphinde uzalise amayeza akho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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• UJuluca^® (njengemveliso yokudibanisa equlathe i-dolutegravir, rilpivirine)