IMifepristone (Korlym)

Umxholo

• Ngaphambi kokuba uthathe i-mifepristone,
• I-Mifepristone inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

Kwabaguli ababhinqileyo:

Musa ukuthatha i-mifepristone ukuba ukhulelwe okanye ucwangcise ukukhulelwa. I-Mifepristone inokubangela ukulahleka kokukhulelwa. Kuya kufuneka uvavanyo lokukhulelwa olungelulo ngaphambi kokuqala unyango kunye ne-mifepristone nangaphambi kokuba uqale unyango kwakhona ukuba uyeka ukuluthatha ngaphezulu kweentsuku ezili-14. Ukuba unokukhulelwa, kuya kufuneka uphephe ukukhulelwa ngexesha lonyango lwakho kunye ne-mifepristone. Kuya kufuneka usebenzise iindlela ezamkelekileyo zolawulo lokuzalwa ngexesha lonyango lwakho kwaye ubuncinci kwinyanga e-1 emva kokuba ligqityiwe unyango lwakho. Ugqirha wakho uya kukuxelela ukuba zeziphi iindlela zolawulo lokuzalwa ezamkelekileyo. Ukuba ucinga ukuba ukhulelwe, uphoswa lixesha lokuya exesheni, okanye ulala ngesondo ngaphandle kokusebenzisa inzala ngelixa uthatha i-mifepristone okanye kwinyanga e-1 emva konyango lwakho, tsalela umnxeba kwangoko.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-mifepristone.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango kunye ne-mifepristone kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nomngcipheko (s) wokuthatha i-mifepristone.

I-Mifepristone (i-Korlym) isetyenziselwa ukunyanga i-hyperglycemia (iswekile ephezulu yegazi) kubantu abanoluhlobo oluthile lwe-Cushing's syndrome apho umzimba wenza i-cortisol eninzi kakhulu (ihomoni) kwaye abangaphumelelanga ngotyando okanye abanakho ukwenza utyando ukunyanga le meko. I-Mifepristone ikudidi lwamayeza abizwa ngokuba yi-cortisol receptor blockers. Isebenza ngokuthintela umsebenzi we-cortisol.

I-Mifepristone ikwafumaneka njengomnye umkhiqizo (Mifeprex) osetyenziswa wedwa okanye udityaniswe nelinye iyeza lokuphelisa ukukhulelwa kwangoko. Le monograph inika kuphela ulwazi malunga ne-mifepristone (Korlym) esetyenziselwa ukulawula i-hyperglycemia kubantu abanoluhlobo oluthile lwe-Cushing's syndrome. Ukuba usebenzisa i-mifepristone ukuphelisa ukukhulelwa, funda i-monograph enesihloko esithi mifepristone (Mifeprex), ebhaliweyo malunga nale mveliso.

I-Mifepristone iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini ngokutya. Thatha i-mifepristone malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-mifepristone ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze. Tshela ugqirha wakho okanye usokhemesti ukuba awukwazi ukuginya iipilisi.

Ugqirha wakho uza kukuqala ngedosi esezantsi ye-mifepristone kwaye ngokuthe ngcembe uyonyuse umthamo wakho, hayi rhoqo kunakuqala rhoqo kwiiveki ezi-2 ukuya kwezi-4. Ukuba uyeka ukuthatha i-mifepristone, tsalela umnxeba ugqirha wakho. Ugqirha wakho kusenokufuneka ukuba aqale kwakhona kwiqondo eliphantsi le-mifepristone kwaye ngokuthe ngcembe wandise idosi yakho.

I-Mifepristone inokuyilawula imeko yakho kodwa ayiyinyangi. Ingathatha iiveki ezi-6 okanye ngaphezulu ngaphambi kokuba uve isibonelelo se-mifepristone. Qhubeka nokuthatha i-mifepristone nokuba uziva uphilile.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-mifepristone,

• xelela ugqirha wakho ukuba uxabisa i-mifepristone, nawaphi na amanye amayeza, okanye nasiphi na isithako esikhona kwiipilisi ze-mifepristone. Buza usokhemesti wakho okanye ujonge ulwazi lomenzi wesigulana uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha na la mayeza alandelayo okanye uwathathe kwezi veki zimbini zidlulileyo: ii-corticosteroids ezinjenge betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, nabanye) , fludrocortisone (Floriner), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, abanye), prednisolone (Prelone, abanye), prednisone (Deltasone, Meticorten, Sterapred, abanye), kunye netramamcinolone (Aristocort, Azmacort); amayeza athintela amajoni omzimba anje ngecyclosporine (Neoral, Sandimmune), sirolimus (Rapamune), kunye netacrolimus (Prograf); dihydroergotamine (DHE 45, Migranal); ergotamine (Ergomar, eCafergot, eMigergot); fentanyl (iDuragesic); I-lovastatin (Mevacor); ipimozide (Orap); quinidine (Quinidex); kunye ne-simvastatin (iZocor). Ugqirha wakho uya kukuxelela ukuba ungathathi i-mifepristone ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye neemveliso zamayeza owathathayo okanye owathathe kwezi veki zimbini zidlulileyo. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-anticoagulants ('i-blood thinner') efana ne-warfarin (Coumadin); izinto zokubulala ezinje nge-itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), okanye voriconazole (Vfend); i-aspirin kunye nezinye iziyobisi ezichasayo (i-NSAIDs) ezifana ne-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve, Naprosyn); ibupropion (Wellbutrin); ciprofloxacin (Cipro); i-clarithromycin (i-Biaxin); ikhonkco (Vaprisol); i-diltiazem (iCardizem); i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin); ifluvastatin (Lescol); izinto zokucwangcisa zehomoni ezinje ngeepilisi zolawulo lokuzalwa, izinto zokufakelwa, iipatches, iiringi, okanye inaliti; amayeza e-hepatitis C afana ne-boceprevir (i-Victrelis) kunye ne-telaprevir (Incivek); amayeza e-HIV okanye i-AIDS afana ne-amprenavir (Agenerase), atazanavir (Reyataz), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir kunye ne-ritonavir indibaniselwano (Kaletra), nelfinavir (Viracept), ritonavir (Norvir) kunye ne-saquinavir (Fortovase, Invirase); amayeza okubanjwa njenge-carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), phenytoin (Dilantin); amayeza esifo sephepha afana nerifabutin (Mycobutin), rifampin (Rifadin, Rimactane, eRifamate, eRifater) kunye ne-rifapentine (Priftin); nefazodone (Serzone); repaglinide (Prandin); telithromycin (Ketek); kunye ne-verapamil (Calan, Isoptin, abanye). Uninzi lwamanye amayeza anokusebenzisana ne-mifepristone, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort.
• xelela ugqirha wakho ukuba ukhe wafakelwa ilungu elithile okanye ukuba unesifo sedlala. Ukuba ungumfazi kwaye awuzange wenze utyando ukuze ususe isibeleko sakho, xelela ugqirha wakho ukuba ukhe wopha engachazwanga kwilungu lobufazi, i-endometrial hyperplasia (ukugqobhoza komtya wesibeleko), okanye umhlaza endometrium (umhlaza webala isibeleko sakho). Ugqirha wakho uya kukuxelela ukuba ungathathi i-mifepristone.
• xelela ugqirha wakho ukuba ukhe wasilela kwentliziyo, ixesha elide le-QT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe), i-potassium esezantsi egazini, ukungoneliseki kwe-adrenal (imeko apho amadlala adrenal musa ukuvelisa ngokwaneleyo iihomoni ezithile ezifunekayo kwimisebenzi ebalulekileyo yomzimba), ukuphazamiseka kokopha, okanye isibindi, izintso, okanye isifo sentliziyo.
• xelela ugqirha wakho ukuba uncelisa.

Sukutya igrapefruit okanye usele ijusi yeziqhamo xa usela la mayeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Mifepristone inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• ukugabha
• umlomo owomileyo
• urhudo
• ukuqhina
• intlungu edibeneyo okanye yemisipha
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• irhashalala
• ukurhawuzelela

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• isicaphucaphu
• Ukuphelelwa ngumdla wokutya
• utywala okanye intloko
• ukudinwa okungaqhelekanga okanye ubuthathaka
• uvalo okanye ukucaphuka
• ukungcangcazela
• ukubila
• ubuthathaka bemisipha, iintlungu, okanye iicampu
• ukukhawuleza, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• ukopha okungalindelekanga kwilungu lobufazi okanye ukubonwa
• ukuqhawukelwa ngumphefumlo

I-Mifepristone inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-mifepristone.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Korlym^®