Lomntu

Umxholo

• Ngaphambi kokuthatha i-lomitapide,
• I-Lomitapide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, yeka ukuthatha lomitapide kwaye ufowunele ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Lomitapide inokubangela umonakalo omkhulu esibindini. Tshela ugqirha wakho ukuba ukhe unesifo sesibindi okanye ukuba wakhe waba neengxaki zesibindi ngelixa usela amanye amayeza.Ugqirha wakho angakuxelela ukuba ungathathi lomitapide. Xelela ugqirha wakho ukuba usela utywala. Ukusela utywala kunokunyusa umngcipheko wokuba ube neengxaki zesibindi. Sukusela ngaphezulu kwesiselo esinxilisayo ngosuku ngelixa uthatha i-lomitapide. Tshela ugqirha wakho kunye nosokhemesti ukuba uthatha iacetaminophen (Tylenol, abanye), amiodarone (Cordarone), doxycycline (Doryx, Vibramycin, others), isotretinoin (Accutane), methotrexate (Rheumatrex), minocycline (Dynacin, Minocin), tamoxifif) ), okanye tetracycline (Sumycin). Ukuba unazo naziphi na kwezi mpawu zilandelayo nangaliphi na ixesha kunyango lwakho, yeka ukuthatha lomitapide kwaye ubize ugqirha kwangoko: ukudinwa kakhulu, ukunqongophala kwamandla, ubuthathaka, isicaphucaphu okanye ukugabha kuya kusiba mandundu okanye kungapheli, iintlungu ezingaphezulu yinxalenye yesisu, ukungabinamdla wokutya, ukuba tyheli kolusu okanye amehlo, umkhuhlane, okanye iimpawu ezifana nomkhuhlane. Ugqirha wakho unokufuna ukutshintsha idosi okanye ayeke okanye alibazise unyango lwakho ukuba uneengxaki zesibindi.

Inkqubo ebizwa ngokuba yiJuxtapid REMS^® yamkelwe yi-Food and Drug Administration (i-FDA) ngenxa yokuba kunokwenzeka ukuba umonakalo wesibindi onxulunyaniswa nokusetyenziswa kwe-lomitapide. Bonke abantu abamiselwe i-lomitapide kufuneka babe ne-lomitapide prescription evela kugqirha obhaliswe kwiJuxtapid REMS^®, kwaye ugcwaliselwe amayeza kwikhemesti ebhaliswe kwiJuxtapid REMS^® ukuze ufumane la mayeza.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi naphambi konyango lwakho ukujonga impendulo yomzimba wakho kwi-lomitapide.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-lomitapide kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Lomitapide isetyenziswa kunye notshintsho kwindlela yokutya (isithintelo se-cholesterol kunye nokutya okunamafutha) kunye nezinye iindlela zonyango ukunciphisa isixa se-cholesterol esine-lipoprotein (LDL) ('cholesterol embi'), iyonke cholesterol, kunye nezinye izinto ezinamafutha egazini ebantwini ene-homozygous family hypercholesterolemia (HoFH; imeko ezuzwe njengelifa apho i-cholesterol ayinakususwa emzimbeni ngesiqhelo). I-Lomitapide akufuneki isetyenziselwe ukunciphisa amanqanaba e-cholesterol kubantu abangenayo i-HoFH. I-Lomitapide ikudidi lwamayeza abizwa ngokuba ngamayeza athoba i-cholesterol. Isebenza ngokunciphisa imveliso ye-cholesterol emzimbeni ukunciphisa inani le-cholesterol elinokwakha kwiindonga zeemithambo kunye nokuvimba ukuhamba kwegazi ukuya entliziyweni, kwingqondo nakwezinye iindawo zomzimba.

Ukuqokelelwa kwecholesterol kunye namafutha ecaleni kweendonga zemithambo yakho (inkqubo eyaziwa njenge-atherosclerosis) inciphisa ukuhamba kwegazi kwaye, ke, unikezelo lweoksijini entliziyweni yakho, kwingqondo nakwamanye amalungu omzimba wakho. Ukunciphisa izinga lakho legazi le-cholesterol kunye namafutha kunokunceda ukukhusela isifo senhliziyo, i-angina (intlungu yesifuba), ukubetha kunye nokuhlaselwa kwentliziyo.

ILomitapide iza njengephilisi emayithathwe ngomlomo. Ihlala ithathwa kanye ngemini. I-Lomitapide kufuneka ithathwe ngaphandle kokutya kwisisu esingenanto, ubuncinci iiyure ezi-2 emva kwesidlo sangokuhlwa. Sela iglasi yamanzi kunye nedosi nganye ye-lomitapide.

Thatha lomitapide malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha lomitapide ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; musa ukwahlulahlula, ukuhlafuna, ukunyibilikisa, okanye ukuzoba.

Kuya kufuneka uthathe isongezelelo sevithamini ngexesha lonyango lwakho nge-lomitapide Qiniseka ukuba ulandela iingcebiso ezenziwe ngugqirha wakho ngononophelo.

Qhubeka nokuthatha i-lomitapide nokuba uziva uphilile. Sukuyeka ukuthatha lomitapide ungakhange uthethe nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha i-lomitapide,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-lomitapide, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiifomsule ze-lomitapide Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha amayeza okubola afana ne-fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne-voriconazole (Vfend); I-boceprevir (iVictrelis); Aprepitant (Hlomela); ciprofloxacin (Cipro); i-clarithromycin (i-Biaxin); crizotinib (Xalkori); I-diltiazem (iCardizem, iDilacor, iTiazac); i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin); I-HIV protease inhibitors njenge amprenavir (Agenerase), atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (eKaletra), nelfinavir (Viracept), saquinavir (Invirase), ritirase) eKaletra), ritonavir kunye netipranavir (Aptivus), kunye ne-teleprevir (Incivek); imatinib (Gleevec); nefazodone; telithromycin (Ketek); Kunye neverapamil (Calan, Covera, Isoptin, Verelan). Ugqirha wakho uya kukuxelela ukuba ungathathi i-lomitapide ukuba uthatha elinye okanye nangaphezulu la mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zilandelayo: aliskiren (Tekturna); alprazolam (Xanax); I-ambrisentan (iLetairis); amiodarone (Cordarone, Pacerone); i-amlodipine (iNorvasc, kwiCaduet); bicalutamide (Casodex); Iililostazol (Pletal); amayeza athile omlomo weswekile afana ne-saxagliptin (i-Onglyza eKombiglyze) kunye ne-sitagliptin (Januvia, eJanumet); i-cimetidine (iTagament); icolchicine (iiColcrys); dabigatran (Pradaxa); idigoxin (Lanoxin); i-everolimus (i-Afinitor, iZortress); i-fexofenadine (Allegra); i-fluoxetine (Prozac); i-fluvoxamine (iLuvox); isoniazid (INH, Nydrazid); lapatinib (iTykerb); i-maraviroc (i-Selzentry); amayeza athintela amajoni omzimba anjenge cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) kunye ne tacrolimus (Prograf); I-nilotinib (iTasigna); izinto zokucwangcisa ngomlomo (iipilisi zolawulo lokuzalwa); amanye amayeza athoba i-cholesterol njenge-atorvastatin (Lipitor, eCaduet, eLiptruzet), lovastatin (Mevacor), kunye ne-simvastatin (iZocor, eSimcor, eVytorin); pazopanib (Votrient); i-ranitidine (iZantac); I-ranolazine (iRanexa); ticagrelor (Brilinta); iTolvaptan (iSamsca); topotecan (IHycamtin); iwarfarin (Coumadin); kunye zileuton (Zyflo). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-lomitapide, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iginkgo okanye igolide.
• ukuba uthatha icholestyramine (Questran), colesevelam (WellChol), okanye colestipol (Colestid), yithathe iiyure ezi-4 ngaphambi okanye iiyure ezi-4 emva kwe-lomitapide.
• xelela ugqirha wakho ukuba ngaba wakha wanyamezela i-galactose okanye i-glucose-galactose malabsorption (imeko ezuzwe njengelifa apho umzimba ungakwaziyo ukunyamezela i-lactose), iingxaki eziqhubekayo zesisu okanye isisu, okanye ipancreas okanye isifo sezintso.
• Tshela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ungowasetyhini onokukhulelwa, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uthathe i-lomitapide. Ukuba unokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngelixa uthatha i-lomitapide. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwe ngelixa uthatha i-lomitapide, yeka ukuthatha amayeza kwaye ubize ugqirha ngokukhawuleza. I-Lomitapide ingalonakalisa usana olungekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufanelanga ukuncancisa ngelixa uthatha i-lomitapide.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Ugqirha wakho uza kukuxelela ukuba utye ukutya okunamafutha asezantsi. Ukutya ukutya okunamafutha asezantsi kunokunciphisa amathuba okuba ube neengxaki zesisu kubandakanya isicaphucaphu, ukugabha, isisu esibuhlungu, kunye norhudo ngelixa uthatha lomitapide. Landela zonke iingcebiso zokutya ezenziwe ngugqirha wakho okanye ugqirha otya ukutya ngononophelo.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethosi rhoqo ngosuku olulandelayo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Lomitapide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• isicaphucaphu
• ukugabha
• isisu esibuhlungu
• ukuqhina
• ukudumba
• irhasi
• isisu esimoshakele
• ukuhla ukusinda
• intloko ebuhlungu
• isiyezi
• umqala obuhkungu
• impumlo enemifinya
• umqolo obuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, yeka ukuthatha lomitapide kwaye ufowunele ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• urhudo oluqatha
• intloko elula
• kunciphise ukuphuma komchamo

I-Lomitapide inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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