Simeprevir

Umxholo

• Ngaphambi kokuba uthathe i-simeprevir,
• I-Simeprevir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo ESILUMKISO ESIBALULEKILEYO NOKULUMKELA, Biza ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

ISimeprevir ayisasebenzi eMelika. Ukuba ngoku uthatha i-simeprevir, kuya kufuneka ubize ugqirha wakho ukuba axoxe ngokutshintshela kolunye unyango.

Usenokuba bosulelwe yi-hepatitis B (intsholongwane esosulela isibindi kwaye inokubangela ukonakala kwesibindi) kodwa ungabinazo iimpawu zesifo. Kule meko, ukuthatha i-simeprevir kunokunyusa umngcipheko wokuba usulelo lwakho lube mandundu ngakumbi okanye lusoyikise ubomi kwaye uya kuba neempawu. Tshela ugqirha wakho ukuba ukhe wosulelwa yintsholongwane ye-hepatitis B. Ugqirha wakho uya ku-odola uvavanyo lwegazi ukuze abone ukuba unesifo bosulelo lwe-hepatitis B. Ugqirha wakho uya kukujonga esweni usulelo lwe-hepatitis B ngexesha kunye neenyanga ezimbalwa emva konyango lwakho. Ukuba kukho imfuneko, ugqirha unokukunika amayeza ukunyanga olu sulelo ngaphambi nangexesha lonyango lwakho nge-simeprevir. Ukuba unazo naziphi na kwezi mpawu zilandelayo ngexesha okanye emva konyango lwakho, tsalela umnxeba kwangoko: ukukhathala okugqithisileyo, ubumthubi besikhumba okanye amehlo, ukungabinamdla wokutya, isicaphucaphu okanye ukugabha, izitulo ezimhlophe, isisu esibuhlungu, okanye umchamo omnyama.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela iimvavanyo ezithile ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwi-simeprevir.

Thetha nogqirha wakho malunga nomngcipheko (s) wokuthatha i-simeprevir.

I-Simeprevir isetyenziswa kunye ne-ribavirin (Copegus, Rebetol) kunye ne-peginterferon alfa (Pegasys) ukunyanga i-hepatitis C engapheliyo (usulelo lwentsholongwane oluqhubekayo olonakalisa isibindi). I-Simeprevir ikudidi lwamayeza abizwa ngokuba zii-protease inhibitors. Isebenza ngokunciphisa inani le-virus ye-hepatitis C (HCV) emzimbeni. I-Simeprevir ayinakukuthintela ukusasazeka kwe-hepatitis C kwabanye abantu.

I-Simeprevir iza njengecapsule ukuba ithathe ngomlomo. Ihlala ithathwa kunye nokutya kanye ngemini. Thatha i-simeprevir malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-simeprevir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; ungahluleli, ungahlaleli, okanye uzityumze.

Uya kuthatha i-simeprevir kunye ne-peginterferon alfa kunye ne-ribavirin kangangeeveki ezili-12. Emva koko uza kuyeka ukuthatha i-simeprevir kwaye uthathe ipeginterferon kunye ne-ribavirin iiveki ezili-12 okanye ezingama-36 ezongezelelweyo. Ubude bonyango lwakho buxhomekeke ekubeni ulufumene na unyango lwangaphambili kwi-hepatitis C, ukuba uphendule njani kunyango lwangaphambili, ukuba uphendula njani kunyango, nokuba ngaba uneziphumo ebezingalindelekanga ezibi. Qhubeka nokuthatha i-simeprevir, i-peginterferon alfa, kunye ne-ribavirin logama nje zimiselwe ngugqirha. Ungayeki ukuthatha nawaphi na amayeza ngaphandle kokuthetha nogqirha wakho nokuba uziva uphilile.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-simeprevir,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-simeprevir, i-sulfa drug, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiifomsule ze-simeprevir. Buza usokhemesti wakho okanye ujonge ulwazi lomenzi wesigulana uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amayeza athile okubulala anje nge-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), okanye voriconazole (Vfend); iicalcium block blockers ezinje ngeamlodipine (Norvasc), diltiazem (Cardizem, Dilacor XR, Tiazac), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), okanye verapamil (Calan, Verelan, abanye); amayeza athile e-cholesterol ephezulu njenge-atorvastatin (Lipitor, eCaduet), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), okanye simvastatin (Flolipid, Zocor, eVytorin); i-cisapride (Propulsid) (ayifumaneki e-U.S.); i-clarithromycin (i-Biaxin, kwi-Prevpac); amayeza ane-cobicistat (Stribild); erythromycin (EES, Eryc, Ery-tab, others), amayeza athile e-HIV afana ne-atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), saquinavir (Invirase), okanye tipranavir (Aptivus); amayeza athile okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), flecainide (Tambocor), mexiletine, propafenone (Rythmol SR), okanye iquinidine (eNuedexta); icyclosporine (Gengraf, Neoral, Sandimmune); dexamethasone; idigoxin (Lanoxin); I-ledipasvir (iHarvoni); i-midazolam ethathwe ngomlomo; irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate, eRifater); irifapentine (Priftin); amayeza athile okubanjwa njenge-carbamazepine (Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, okanye phenytoin (Dilantin, Phenytek); sildenafil (kuphela uphawu lweRevatio olusetyenziselwa isifo semiphunga); i-sirolimus (iRapamune); itacrolimus (Prograf); i-tadalafil (kuphela i-Adcirca brand esetyenziselwa isifo semiphunga); telithromycin (Ketek); i-triazolam (Halcion) ethathwe ngomlomo; vardenafil (Levitra, Staxyn), okanye warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-simeprevir, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi inkunkuma yobisi okanye iSt. Akufanele uthathe ubisi lobisi okanye iSt John's wort ngexesha lonyango lwakho nge-simeprevir.
• xelela ugqirha wakho ukuba ukhe wafakelwa isibindi, ukuba ufumana ifototherapy, ukuba ungowasempuma Asia, kwaye ukuba ukhe wanalo naluphi na uhlobo lwesifo sesibindi ngaphandle kwesifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye unokukhulelwa. Ukuba uyindoda, xelela ugqirha wakho ukuba iqabane lakho likhulelwe, liceba ukukhulelwa, okanye kunokwenzeka ukuba ukhulelwe. I-Simeprevir kufuneka ithathwe nge-ribavirin enokwenzakalisa kakhulu umntwana ongekazalwa. Kuya kufuneka usebenzise iindlela ezimbini zolawulo lokuzalwa ukukhusela ukukhulelwa kuwe okanye kwiqabane lakho ngexesha lonyango ngala mayeza kunye neenyanga ezi-6 emva konyango lwakho. Thetha nogqirha wakho malunga neendlela onokuzisebenzisa; izinto zokucwangcisa zehomoni (iipilisi zolawulo lokuzalwa, iziqwengana, izinto zokufakelwa, imisesane, okanye inaliti) zisenokungasebenzi kakuhle kwabasetyhini abathatha la mayeza. Wena okanye iqabane lakho kufuneka nivavanyelwe ukukhulelwa ngaphambi konyango, inyanga nenyanga ngexesha lonyango, kunye neenyanga ezi-6 emva konyango lwakho. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha la mayeza, biza ugqirha ngokukhawuleza.
• xelela ugqirha wakho ukuba uncelisa.
• Cwangcisa ukuthintela ukukhanya kwelanga ngokungeyomfuneko okanye ixesha elide kwaye unxibe iimpahla zokuzikhusela, iiglasi zelanga, umnqwazi kunye nescreen elangeni ngexesha lonyango lwakho nge-simeprevir. Kulumkele ukusetyenziswa kweebhedi zokulungisa, izibane zelanga, okanye ezinye iintlobo zonyango olukhanyayo ngexesha lonyango lwakho. I-Simeprevir inokwenza ulusu lwakho lubuthathaka kwilanga. Biza ugqirha wakho ngoko nangoko ukuba ufumana ukutshiswa lilanga okanye ukutshiswa, ukuba bomvu, ukudumba, iblisters kulusu lwakho, okanye amehlo abomvu okanye atshisayo.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokutya nje ukuba ukhumbule. Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 ngaphambi kwexesha elimiselweyo ledosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Simeprevir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukurhawuzelela
• isicaphucaphu
• iintlungu zemisipha

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo ESILUMKISO ESIBALULEKILEYO NOKULUMKELA, Biza ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• ubunzima bokuphefumla
• irhashalala
• izilonda zomlomo okanye izilonda
• amehlo abomvu okanye adumbileyo ("iliso elipinki")

I-Simeprevir inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya, ubushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Olysio^®