Ceritinib

Umxholo

• Ngaphambi kokuba uthathe i-ceritinib,
• I-Ceritinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiCandelo LOKUKHUSELEKILEYO, Biza ugqirha ngoko nangoko:

I-Ceritinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wesifo somhlaza ongasencinci (i-NSCLC) ethe yasasazeka kwamanye amalungu omzimba. I-Ceritinib ikudidi lwamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

I-Ceritinib iza njengecapsule kunye necwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye nokutya kanye ngemini. Thatha i-ceritinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ceritinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uhlanza emva kokuthatha i-ceritinib, ungathathi elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokunciphisa umthamo wakho we-ceritinib, ukunyanga ngamanye amayeza, okanye akuxelele ukuba uyeke ukuthatha i-ceritinib ixesha elithile ngexesha lonyango lwakho. Oku kuya kuxhomekeka ekubeni lisebenza njani na iyeza kunye naziphi na iziphumo ebezingalindelekanga onokuzifumana. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-ceritinib.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-ceritinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba u-allergen kwi-ceritinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifilisi zeepilisi okanye iipilisi. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qinisekisa ukukhankanya nayiphi na kwezi zilandelayo: amiodarone (Nexterone, Pacerone); anagrelide (Agrylin); ii-anticoagulants (’izinciphisi zegazi’) ezifana ne-warfarin (Coumadin, Jantoven); ii-beta blockers ezinje nge-atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), propranolol (Inderal) kunye ne-sotalol (iBetapace, iSorine, iSotylize); icarbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye ifunyenwe isifo se-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kunye i-saquinavir (i-Invirase); chloroquine; chlorpromazine; ililostazol; ciprofloxacin (Cipro); ikitalopram (uCelexa); I-clarithromycin; iklonidine (Catapres, Kapvay); ii-corticosteroids; icyclosporine (Gengraf, Neoral, Sandimmune); idigoxin (Lanoxin); I-diltiazem (iCardizem, iDilacor, iTiazac); iDisopyramide (iNorpace); dofetilide (iTikosyn); I-donepezil (iAricept); idronarone (iMultaq); I-escitalopram (iLexapro); fentanyl (Abstral, Actiq, Duragesic, Fentora, Subsys); i-flecainide (iTambocor); i-fluconazole (iDiflucan); haloperidol (iHaldol); ibutilide (iCorvert); itraconazole (Onmel, Sporanox, Tolsura); ketoconazole; levofloxacin; imethadone (iDolophine, iMethadose); moxifloxacin (Avelox); nefazodone; I-ondansetron (iZuplenz, iZofran); ipentamidine (iPentam); phenobarbital; phenytoin (iDilantin, iPhenytek); ipimozide (Orap); ipioglitazone (Actos, eDuetact, eOseni); ukuvelisa; quinidine (kwiNuedexta); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, kwiRifater); sildenafil (Revatio); i-sirolimus (iRapamune); itacrolimus (Astagraf, Prograf); thioridazine; vardenafil (Levitra, Staxyn); Kunye neverapamil (Calan, Covera, Isoptin, Verelan). Uninzi lwamanye amayeza anokusebenzisana ne-ceritinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort.
• xelela ugqirha wakho ukuba ukhe unesifo seswekile okanye uneswekile ephezulu yegazi, ukusilela kwentliziyo, ukubetha kwentliziyo okungaqhelekanga, isongezo se-QT (isingqisho sentliziyo esingaqhelekanga esinokukhokelela ekuphelelweni lithemba, ukuphulukana nokuqonda, ukuxhuzula, okanye ukufa ngesiquphe) potassium okanye i-magnesium egazini lakho, i-pancreatitis (ukuvuvukala kwepancreas), okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa uthatha i-ceritinib. Kuya kufuneka ukuba ube novavanyo lokukhulelwa ngaphambi kokuba uqale unyango, kwaye kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye neenyanga ezi-6 ubuncinci emva kwethamo lakho lokugqibela. Ukuba uyindoda eneqabane lomfazi elinokuthi likhulelwe, kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango kwaye ubuncinci iinyanga ezi-3 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. I-Ceritinib inokulimaza umntwana wakho ongakazalwa. Ukuba wena okanye iqabane lakho ukhulelwe ngexesha lonyango kunye ne-ceritinib, biza ugqirha wakho ngokukhawuleza.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise umntwana ngelixa uthatha i-ceritinib kwaye ubuncinci iiveki ezi-2 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-ceritinib.
• Kuya kufuneka uyazi ukuba unokufumana i-hyperglycemia (inyuse iswekile yegazi lakho) ngelixa usela eliyeza. Tshela ugqirha wakho ngokukhawuleza ukuba unayo nayiphi na impawu zilandelayo ngelixa uthatha i-ceritinib: ukunxanwa okugqithisileyo, ukuchama rhoqo, ukulamba kakhulu, ukungaboni kakuhle, intloko, ukukhathazeka ukucinga okanye ukugxila, ukuphefumla kunjengeziqhamo, okanye ukhathala.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba ngaphakathi kweeyure ezili-12 zedosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Ceritinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• urhudo
• ukugabha
• ukuqhina
• isisu esibuhlungu
• isilungulela
• kunzima ukugwinya
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• ukudinwa
• irhashalala
• ukurhawuzelela
• utshintsho kumbono
• umsipha, ithambo, ingalo yangasemva, okanye iintlungu zomlenze
• intloko ebuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu okanye ezo zidweliswe kwiCandelo LOKUKHUSELEKILEYO, Biza ugqirha ngoko nangoko:

• iintlungu kwindawo ephezulu yesisu
• ukugruzuka okanye ukopha okungaqhelekanga
• umchamo omnyama
• ubumthubi besikhumba namehlo
• ukunciphisa ukutya
• Iimpawu ezinjengomkhuhlane
• ukurhawuzelela
• ukuqhawukelwa ngumphefumlo
• umkhuhlane, ingqele, umqala obuhlungu, ukukhohlela okungapheliyo kunye nokudibana, okanye ezinye iimpawu zosulelo
• Intlungu yesifuba okanye ukungonwabi
• utshintsho kwintliziyo
• ukubetha kwentliziyo
• isiyezi
• intloko elula
• isiqaqa
• iintlungu eziqhubekayo eziqala phezulu ngasekhohlo okanye embindini wesisu kodwa zisenokunabela ngasemva
• ukuxhuzula

I-Ceritinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya, ubushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-ceritinib. Ugqirha wakho uya ku-odola uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukufumanisa ukuba umhlaza wakho unganyangwa nge-ceritinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Zykadia^®