Osimertinib

Umxholo

• Ngaphambi kokuthatha i-osimertinib,
• I-Osimertinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Osimertinib isetyenziselwa ukunceda ukuthintela uhlobo oluthile lwesifo somhlaza wamaphaphu esincinci (NSCLC) ekubuyeni emva kokuba isisu sisuswe ngotyando kubantu abadala. Isetyenziswa njengonyango lokuqala lohlobo oluthile lwe-NSCLC olunwenwe kwamanye amalungu omzimba kubantu abadala. I-Osimertinib ikwasetyenziselwa ukunyanga iintlobo ezithile ze-NSCLC ethe yasasazeka kwamanye amalungu omzimba kubantu abadala abangenakuphathwa ngempumelelo ngamanye amayeza e-chemotherapy. U-Osimertinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukumisa okanye ukucothisa ukusasazeka kweeseli zomhlaza kwaye kunokunceda ukuncipha amathumba.

I-Osimertinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye ngemini. Ubude bonyango lwakho buxhomekeke kwindlela elisebenza ngayo eli yeza, kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Thatha i-osimertinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-osimertinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba awukwazi ukuwaginya amacwecwe, beka icwecwe kwiipuni ezine (2 oz [60 ml] zamanzi kwaye uzivuthulule de ibe licwecwe elincinci. Sela lo mxube ngoko nangoko. Thela esinye isiqingatha sekomityi (4 oz [120 mL]) kwikomityi yamanzi (8 oz [240 mL]) kwisitya osisebenzisileyo, uhlambe, uze usele ukuqinisekisa ukuba ufumana idosi epheleleyo ye-osimertinib. Sukusebenzisa amanzi e-carbonated okanye naluphi na olunye ulwelo ukunyibilikisa ithebhulethi ye-osimertinib. Musa ukuyityumza ithebhulethi okanye ubushushu bomxube. Ukuba unayo ityhubhu ye-nasogastric (NG), ugqirha wakho okanye usokhemesti uyakuchaza ukuba ungawunika njani lo mxube ngombhobho we-NG.

Ugqirha wakho unokumisa okwethutyana okanye ngokusisigxina unyango lwakho okanye unciphise idosi yakho ye-osimertinib kuxhomekeke kwiziphumo ozifumeneyo. Qiniseka ukuba uthetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Ungayeki ukuthatha i-osimertinib ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha i-osimertinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa u-osimertinib, nawaphi na amanye amayeza, okanye nasiphi na isithako esikwipilisi ye-osimertinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: anagrelide (Agrylin); iarseniki trioxide (Trisenox); icarbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); chloroquine (Aralen); chlorpromazine; Iililostazol (Pletal); ikitalopram (uCelexa); I-donepezil (iAricept); I-escitalopram (iLexapro); haloperidol (iHaldol); intliziyo okanye uxinzelelo lwegazi amayeza; imethadone (iDolophine, iMethadose); oxaliplatin (Eloxatin); phenytoin (iDilantin, iPhenytek); ipimozide (Orap); quinidine (kwiNuedexta); irifampin (Rifadin, Rimactane, eRifamate, Rifater); irosuvastatin (Crestor); isulfasalazine (Azulfidine); thioridazine; topotecan (IHycamtin); kunye ne-vandetanib (Caprelsa). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-osimertinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.Ugqirha wakho mhlawumbi uza kukuxelela ukuba ungathathi i-wort yaseSt.John ngelixa uthatha i-osimertinib.
• xelela ugqirha wakho ukuba ukhe okanye wakha wanayo i-QT syndrome (imeko eyonyusa umngcipheko wokuba nesifo sentliziyo esingaqhelekanga esinokubangela isiqaqa okanye ukufa ngesiquphe); ukubetha kwentliziyo ngokungaqhelekanga; ukusilela kwentliziyo (imeko apho intliziyo ingakwazi ukumpompa igazi elaneleyo kwamanye amalungu omzimba); ephezulu okanye esezantsi kunamanqanaba aqhelekileyo esodiyam, potasium, calcium, okanye imagniziyam egazini lakho; iingxaki zamehlo; okanye ezinye iimeko zemiphunga.
• Kuya kufuneka uyazi ukuba i-osimertinib inokunciphisa ukuzala emadodeni nakwabasetyhini. Nangona kunjalo, awufanelanga ukucinga ukuba wena okanye iqabane lakho aninakukhulelwa. Tshela ugqirha wakho ukuba ukhulelwe, okanye ucwangcise ukukhulelwa. Uya kudinga ukuthatha uvavanyo lokukhulelwa ngaphambi kokuqala unyango kwaye akufuneki ukhulelwe ngelixa uthatha i-osimertinib. Sebenzisa ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye ne-osimertinib, kunye neeveki ezi-6 emva kwedosi yakho yokugqibela. Ukuba uyindoda kwaye iqabane lakho linokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-osimertinib, biza ugqirha wakho ngokukhawuleza. U-Osimertinib unokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Ugqirha wakho unokukuxelela ukuba ungancancisi ngexesha lonyango lwakho kunye nakwiiveki ezi-2 emva kwedosi yakho yokugqibela.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi emva kwexesha okanye uthathe idosi ephindwe kabini ukwenza into ephosiweyo.

I-Osimertinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• irhashalala
• ukurhawuzelela
• isikhumba esomileyo okanye esiqhekekileyo
• onokhwekhwe
• isicaphucaphu
• ukugabha
• Ukuphelelwa ngumdla wokutya
• ukudumba okanye izilonda emlonyeni
• umqolo obuhlungu
• utshintsho lwezipikili kubandakanya ukudumba, ukuba bomvu, iintlungu, ukwahlukana, ukwaphuka, nokwahlukana okanye ukulahleka kwi-nailbed

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ngokukhawuleza, okanye ukubetha kwentliziyo; ukuqhawukelwa ngumphefumlo; ukudumba kwamaqatha okanye iinyawo, okanye uziva unentloko elula
• ifiva; okutsha okanye okuba mandundu kokuphefumla; ubunzima bokuphefumla, okanye ukukhohlela
• ukudumba kolusu okanye ukuxobuka
• amabala amfusa, ukuba bomvu, okanye imihlathi kwiingalo, kwimilenze esezantsi, okanye ezinqeni
• iintlungu zesifuba
• ukudinwa kakhulu
• ukudumba, ubomvu, iinyembezi okanye iintlungu zamehlo; uvakalelo ekukhanyeni; okanye utshintsho lombono

I-Osimertinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zomsebenzi wentliziyo ngaphambi nangexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile kuwe ukuba uthathe i-osimertinib, kwaye ujonge impendulo yomzimba wakho kunyango. Ugqirha wakho unokuyalela uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukufumanisa ukuba umhlaza wakho unokunyangwa nge-osimertinib.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• UTagrisso^®