Indawo yokuhlala

Umxholo

• Ngaphambi kokuba uthathe i-cobicistat,
• ICobicistat inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba olu phawu lubi okanye aluhambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

I-Cobicistat isetyenziselwa ukwandisa inani le-atazanavir (Reyataz, e-Evotaz) kubantu abadala kunye nabantwana abanobunzima obungama-77 eekhilogram okanye i-darunavir (Prezista, e-Prezcobix) kubantu abadala kunye nabantwana abanobunzima obungama-88 kg (40 kg) kwi igazi xa la mayeza esetyenziselwa ukunyanga intsholongwane kaGawulayo. ICobicistat ikwiklasi yamayeza abizwa ngokuba yi-cytochrome P450 3A (CYP3A) inhibitors. Isebenza ngokwandisa isixa se-atazanavir okanye i-darunavir emzimbeni ukuze babe nefuthe elikhulu.

ICobicistat iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa ngokutya kanye ngemini kunye neatazanavir okanye idarunavir. Thatha i-cobicistat kunye ne-atazanavir okanye i-darunavir ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-cobicistat ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Kubalulekile ukuba uhlale uthabatha i-cobicistat ngaxeshanye ne-atazanavir okanye i-darunavir.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-cobicistat,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-cobicistat, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-cobicistat. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha nawaphi na amayeza alandelayo: alfuzosin (Uroxatral); icarbamazepine (Carbatrol, Epitol, Equetro, Tegretol); i-cisapride (Propulsid) (ayifumaneki e-U.S.); icolchicine (Colcrys, Mitigare, kwiCol-Probenecid); idronarone (iMultaq); amayeza e-ergot anje nge-dihydroergotamine (iDHE 45, Migranal), ergotamine (Ergomar, eCafergot, eMigergot), kunye ne-methylergonovine (Methergine); lomitapide (Juxtapid); I-lovastatin (Altoprev); ilurasidone (iLatuda); midazolam (Iindinyana) ngomlomo; phenobarbital; phenytoin (iDilantin, iPhenytek); ipimozide (Orap); I-ranolazine (iRanexa); irifampin (Rimactane, Rifadin, eRifamate, eRifater); sildenafil (kuphela uphawu lweRevatio olusetyenziselwa isifo semiphunga); isimvastatin (Flolipid, Zocor); I-wort yaseSt. okanye i-triazolam (Halcion). Ukuba uthatha i-atazanavir kunye ne-cobicistat, xelela ugqirha wakho ukuba uthatha i-drospirenone kunye ne-ethinyl estradiol (ezinye izinto zokucwangcisa zomlomo ezinje nge-Beyaz, Safyral, Yasmin, Yaz, nabanye); indinavir (Crixivan), irinotecan (Camptosar), okanye nevirapine (Viramune). Ugqirha wakho uya kukuxelela ukuba ungathathi i-cobicistat ukuba uthatha naliphi na kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ; amayeza antiplatelet anje nge-clopidogrel (Plavix) kunye ne-ticagrelor (Brilinta); atorvastatin (Lipitor, kwiCaduet); i-benzodiazepines efana ne-diazepam (Valium), i-estazolam, i-midazolam inikwe ngaphakathi (kwi-vein), kunye ne-zolpidem (Ambien, Edluar, Intermezzo); iibhloko ze-beta ezinje nge-carvedilol (Coreg), metoprolol (Lopressor), kunye ne-timolol; i-boceprevir (iVictrelis) (ayifumaneki kwi-US); i-bosentan (iTracleer); ibuprenorphine (Belbuca, Butrans, Probuphine); buprenorphine kunye naloxone (Suboxone, Zubsolv); buspirone; iicalcium block blockers ezinje ngeamlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, nifedipine (Adalat, Afeditab, Procardia), kunye neverapamil (Calan, Verelan, others); i-clarithromycin (i-Biaxin, kwi-PrevPac); ii-corticosteroids ezifana ne-beclomethasone (Beconase AQ), i-budesonide (i-Rhinocort Aqua), i-ciclesonide (i-Omnaris), i-dexamethasone (i-Decadron), i-fluticasone (i-Flonase, i-Flovent), i-methylprednisolone (i-Medrol), i-momentasone (i-Flonase) kunye ne-triamcinolone (i-Nasacort) dasatinib (Sprycel); efavirenz (Sustiva, eAtripla); erythromycin (E.E.S, Erytab, abanye); i-etravirine (ukungakhathali); fentanyl (Abstral, Actiq, Fentora, nabanye); itraconazole (Onmel, Sporanox); ketoconazole; amayeza oxinzelelo afana ne-amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), kunye ne-trazodone; amayeza okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Cordarone, Nexterone, Pacerone), digoxin (Lanoxin), disopyramide (Norpace), flecainide, mexiletine, propafenone (Rythmol), kunye nequinidine (eNuedexta); amayeza okubanjwa njenge-clonazepam (iKlonopin), i-eslicarbazepine (i-Aptiom), kunye ne-oxcarbazepine (i-Trileptal); amayeza acinezela amajoni omzimba anje ngecyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), kunye netacrolimus (Astagraf, Envarsus XR, Prograf); lopinavir (eKaletra); i-maraviroc (i-Selzentry); imethadone (iDolophine, iMethadose); I-nilotinib (iTasigna); izinto zokucwangcisa ngomlomo (iipilisi zolawulo lokuzalwa); iperphenazine; ezithile ze-phosphodiesterase (PDE5) inhibitors ezinje nge-avanafil (Stendra), sildenafil (Viagra), tadalafil (Adcirca, Cialis), kunye vardenafil (Levitra); iquetiapine (iSeroquel); irifabutin (Mycobutin); irisperidone (iRisperdal); i-ritonavir (iNorvir, eKaletra); irivaroxaban powder (Xarelto); irosuvastatin; isalmeterol (iSerevent, eAdvair); isimeprevir (iOlysio); telaprevir (Incivek) (ayifumaneki eMelika); telithromycin (Ketek); i-tenofovir (iViread, eAtripla, iComplera, iTruvada, ezinye), thioridazine; tramadol (Conzip, Ultram, kwi-Ultracet); vinblastine; vincristine (Marqibo Kit); kunye ne-voriconazole (Vfend). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-cobicistat ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha i-cobicistat kunye ne-atazanavir kwaye uthatha ii-antacids (Maalox, Mylanta, Tums, nabanye), thatha iiyure ezi-2 ngaphambi okanye kwiiyure ezi-2 emva kobuhlanti kunye neatazanavir.
• ukuba uthatha i-cobicistat kunye ne-atazanavir kwaye uthatha amayeza okugaya isisu, ukutsha kwentliziyo, okanye izilonda (H₂ blockers) njenge-cimetidine, i-famotidine (i-Pepcid, kwi-Duexis), i-nizatidine (i-Axid), okanye i-ranitidine (i-Zantac), zithathe ngexesha elinye okanye ubuncinci iiyure ezili-10 emva kokuthatha i-H₂ blocker.
• ukuba uthatha i-cobicistat kunye ne-atazanavir kwaye uthatha amayeza okugaya, ukuqaqamba kwentliziyo, okanye izilonda (proton pump inhibitors) ezinje nge esomeprazole (Nexium, eVimovo), lansoprazole (Prevacid), omeprazole (Prilosec, e Zegerid), pantoprazole (Protonix), okanye i-rabeprazole (AcipHex) ibathathe ubuncinci iiyure ezili-12 emva kokuthatha iproton pump inhibitor.
• xelela ugqirha wakho ukuba ukhe unesifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-cobicistat, tsalela ugqirha wakho. Akufuneki uncancise xa wosulelwe yi-HIV okanye ukuba uthatha i-cobicistat.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba idosi yakho elandelayo ifanelekile kwiiyure ezili-12 okanye nangaphezulu, thabatha idosi ephosiweyo kwakamsinya nje ukuba uyikhumbule. Nangona kunjalo, ukuba idosi elandelayo iya kuthathwa ngaphantsi kweeyure ezili-12, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

ICobicistat inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba olu phawu lubi okanye aluhambi:

• isicaphucaphu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• mthubi ulusu okanye amehlo
• irhashalala
• ukuncipha kokuchama

ICobicistat inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ngaphambi kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-cobicistat.

Gcina unikezelo lwamayeza ngesandla. Sukulinda de uphelelwe ngamayeza ukuze uphinde uzalise amayeza akho.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Tybost^®

• Evotaz^® (Equlathe iAtazanavir, iCobicistat)
• Prezcobix^® (Equlathe iCobicistat, iDarunavir)