Dasabuvir, Ombitasvir, Paritaprevir, kunye neRitonavir

Umxholo

• Ngaphambi kokuba uthathe i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir,
• I-Dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko

IDasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir ayisafumaneki eMelika.

Usenokuba bosulelwe yi-hepatitis B (intsholongwane esosulela isibindi kwaye inokubangela ukonakala kwesibindi) kodwa ungabinazo iimpawu zesifo. Kule meko, ukuthatha indibaniselwano ye-dasabuvir, i-ombitasvir, i-paritaprevir, kunye ne-ritonavir kunokunyusa umngcipheko wokuba usulelo lwakho lube lubi kakhulu okanye lusongele ubomi kwaye uya kuba neempawu. Tshela ugqirha wakho ukuba ukhe wosulelwa yintsholongwane ye-hepatitis B. Ugqirha wakho uya ku-odola uvavanyo lwegazi ukuze abone ukuba ukhe wosuleleka sisifo se-hepatitis B. Ugqirha wakho uya kukujonga esweni usulelo lwe-hepatitis B ngexesha kunye neenyanga ezimbalwa emva konyango lwakho. Ukuba kukho imfuneko, ugqirha unokukunika amayeza ukunyanga olu sulelo ngaphambi nangexesha lonyango lwakho ngokudityaniswa kwe-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir. Ukuba unazo naziphi na kwezi mpawu zilandelayo ngexesha okanye emva konyango lwakho, tsalela umnxeba kwangoko: ukukhathala okugqithisileyo, ubumthubi besikhumba okanye amehlo, ukungabinamdla wokutya, isicaphucaphu okanye ukugabha, izitulo ezimhlophe, isisu esibuhlungu, okanye umchamo omnyama.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwindibaniselwano ye-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir.

Thetha nogqirha wakho malunga nomngcipheko (s) wokuthatha indibaniselwano ye-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir.

I-Dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir isetyenziswa yodwa okanye idityaniswe ne-ribavirin (Copegus, Rebetol, Ribasphere) ukunyanga usulelo lwe-hepatitis C olungapheliyo (ukudumba kwesibindi okubangelwa yintsholongwane). I-Dasabuvir yi-non-nucleoside NS5B polymerase inhibitor. Isebenza ngokunciphisa inani le-HCV emzimbeni. I-Ombitasvir yintsholongwane ye-hepatitis C (HCV) ye-NS5A inhibitor. Isebenza ngokumisa intsholongwane ebangela i-hepatitis C ukuba isasazeke emzimbeni. IParitaprevir sisiqhushumbisi seprotease. Isebenza ngokunciphisa inani le-HCV emzimbeni. I-Ritonavir sisithinteli seprotease. Kuyanceda ukonyusa inani leparitaprevir emzimbeni ukuze amayeza abe nefuthe elikhulu.

Indibaniselwano ye-dasabuvir, i-ombitasvir, i-paritaprevir, kunye ne-ritonavir iza njengepilisi ezandisiweyo (ezisebenza ixesha elide) ezizakuthathwa ngomlomo. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha idasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir ngexesha elifanayo yonke imihla. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Amacwecwe akhululayo angena kwiphakheji eneentsuku ezingama-28 zonyango. Iphekhi nganye yedosi yemihla ngemihla iqulethe iipilisi ezintathu eziqulethe indibaniselwano yedasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir. Thatha i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir (iipilisi ezintathu) rhoqo kusasa ngokutya. Landela imiyalelo kwiphakheji yedosi nganye yemihla ngemihla malunga nokuba ungazisusa njani iipilisi.

Ginya iipilisi zokukhululwa ezandisiweyo; ungahluleli, ungahlaleli, okanye uzityumze.

Qhubeka nokuthatha i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir nokuba uziva uphilile. Ubude bonyango lwakho (iiveki ezili-12 ukuya kwezi-24) luxhomekeke kwimeko yakho, ukuba uphendula njani kunyango, nokuba uneziphumo ebezingalindelekanga ezibi. Sukuyeka ukuthatha i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-dasabuvir, i-ombitasvir, i-paritaprevir, kunye ne-ritonavir, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir yeepilisi ezandisiweyo. Ukuba uye wasabela ngendlela enzulu okanye esongela ubomi kwi-ritonavir (irhashalala, ukuqhwitha okanye ukuxobuka kolusu), ugqirha wakho uya kuthi makangathathi i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-alfuzosin (Uroxatral); iapalutamide (Erleada); atorvastatin (Lipitor, kwiCaduet); icarbamazepine (Carbatrol, Epitol, Equetro, Tegretol); i-cisapride (iPropulsid; ayisafumaneki e-U.S.); idronarone (iMultaq); efavirenz (Sustiva, eAtripla); amayeza aqukethe i-ergot anjenge-dihydroergotamine mesylate (DHE 45, Migranal), ergotamine (Ergomar, eCafergot, eMigergot), kunye ne-methylergonovine (Methergine); i-ethinyl estradiol yezokucwangcisa yomlomo efana ('neepilisi zoqingqo-nzala'), iipatches, iiringi zelungu lobufazi kunye nezinye iimveliso ze-ethinyl estradiol; i-everolimus (i-Afinitor, iZortress); gemfibrozil (iLopid); lomitapide (Juxtapid); I-lovastatin (Altoprev); ilurasidone (iLatuda); midazolam (ngomlomo); phenytoin (iDilantin, iPhenytek); phenobarbital; ipimozide (Orap); I-ranolazine (iRanexa); irifampin (Rifadin, Rimactane, eRifamate, eRifater); sildenafil (Revatio) kunyango lwexinzelelo lwe-pulmonary arterial hypertension; isimvastatin (Flolipid, Zocor, eVytorin); i-sirolimus (iRapamune); I-wort yaseSt. itacrolimus (Astagraf XL, Envarsus XR, Prograf); okanye i-triazolam (Halcion). Kwakhona xelela ugqirha wakho ukuba uthatha i-colchicine (Colcrys, Mitigare) kwaye unesifo sesibindi okanye sezintso. Ugqirha wakho uyakukuxelela ukuba ungathathi i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-acetaminophen kunye ne-hydrocodone (Anexsia, Zyfrel); alprazolam (Xanax); ii-angiotensin receptor blockers (ARBs) ezinje nge-candesartan (Atacand, e-Atacand HCT), losartan (Cozaar, e-Hyzaar), okanye valsartan (Diovan, eDiovan HCT, e-Exforge); ii-anticoagulants (’izinciphisi zegazi’) ezifana ne-warfarin (Coumadin, Jantoven); buprenorphine kunye naloxone (Suboxone, Zubsolv); iicalcium block blockers ezinje ngeamlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), nifedipine (Adalat, Procardia), okanye verapamil (Calan, Verelan, others); icarisoprodol (iSoma); cyclobenzaprine (Amrix); icyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); elagolix (Orilissa); i-encorafenib (iBraftovi); fostamatinib (iTavalisse); i-fluticasone (iFlonase, iFlovent, eAdvair); i-furosemide (iLasix); ibrutinib (Imbruvica); ivosidenib (Tibsovo); ketoconazole; amayeza okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Nexterone, Pacerone), bepridil (engasafumaneki e-US), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), okanye i-quinidine (eNuedexta); metformin (Glucophage, Riomet, nabanye); omeprazole (Prilosec); ipravastatin (Pravachol); iquetiapine (iSeroquel); i-rilpivirine (i-Edurant; eComplera, e-Odefsey); i-ritonavir (i-Norvir, e-Kaletra) isetyenziswa ngokudibeneyo nezinye i-HIV protease inhibitors ezinje nge atazanavir (Reyataz), darunavir (Prezista), kunye ne lopinavir (e Kaletra); irosuvastatin (Crestor); isalmeterol (iSerevent, eAdvair); kunye ne-voriconazole (Vfend). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ngaba unaso nasiphi na isifo sesibindi ngaphandle kwe-hepatitis C. Ugqirha wakho angakuxelela ukuba ungathathi i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir.
• xelela ugqirha wakho ukuba ukhe wafakelwa isibindi, isifo seswekile, okanye intsholongwane (i-HIV).
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir, tsalela ugqirha wakho.
• Kuya kufuneka uyazi ukuba i-dasabuvir, i-ombitasvir, i-paritaprevir, kunye ne-ritonavir inokunciphisa ukusebenza kwezicwangcisi zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa, inaliti, kunye nezixhobo zangaphakathi). Sebenzisa olunye uhlobo lolawulo lokuzalwa ngelixa uthatha i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir kunye neeveki ezi-2 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga nohlobo lolawulo lokuzalwa oluza kukusebenzela ngexesha nasemva konyango lwakho nge-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir.
• khumbula ukuba ungaseli utywala kwiiyure ezi-4 zokuthatha i-dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir yeepilisi ezandisiweyo.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Kubalulekile ukuba ungaphoswa okanye ungatsiba naziphi na iidosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ubunzima bokulala okanye ukulala
• ukukhohlela
• ukucaphuka
• intloko ebuhlungu
• urhudo
• ukudumba kwezihlunu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko

• irhashalala
• ubomvu obomvu kwesikhumba
• ukurhawuzelela
• urhwebo
• ukudinwa okanye ukungabikho kwamandla
• ubuthathaka
• ukudideka

I-Dasabuvir, ombitasvir, paritaprevir, kunye ne-ritonavir inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina la mayeza ebhokisini engenile, evaliwe ngokuqinileyo, kwaye kude nokufikelela kwabantwana. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Sukuzisusa iipilisi kwipakethe yedosi yemihla ngemihla ebonelelwe ngumenzi de ube ukulungele ukuzithatha.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• IViekira XR^® (njengemveliso yokudibanisa equlathe iDasabuvir, iOmbitasvir, iParitaprevir, kunye neRitonavir)