Inaliti yeDupilumab

Umxholo

• Ngaphambi kokusebenzisa inaliti yedupilumab,
• Inaliti ye-Dupilumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Ukuba unazo naziphi na kwezi mpawu, yeka ukusebenzisa inaliti yedupilumab kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

Inaliti ye-Dupilumab isetyenziselwa ukunyanga iimpawu ze-eczema (atopic dermatitis; isifo solusu esenza ukuba ulusu lome kwaye lurhawuzelele kwaye ngamanye amaxesha lukhule lube bomvu, lube namaqhakuva) kubantu abadala nakubantwana abaneminyaka emi-6 nangaphezulu abangakwaziyo ukusebenzisa amanye amayeza imeko okanye onokhwekhwe ongaphendulanga kwamanye amayeza. Ikwasetyenziswa kunye namanye amayeza okuthintela ukuvutha, ukuphefumla kancinci, ukukhohlela kunye nokuqina kwesifuba ngenxa yeentlobo ezithile zesifuba kubantu abadala nakubantwana abaneminyaka eli-12 nangaphezulu abaneempawu ezingalawulwa ngamanye amayeza. Inaliti ye-Dupilumab ikwasetyenziswa kunye namanye amayeza ukunyanga i-rhinosinusitis engapheliyo kunye ne-nasal polyposis (impumlo eqhubekayo, ukudumba kwesinus kunye / okanye ukuxinana kwempumlo, kunye okanye ngaphandle kokunciphisa ivumba okanye iintlungu noxinzelelo ebusweni) kubantu abadala abaneempawu alulawulwa ngamanye amayeza. Inaliti ye-Dupilumab ikudidi lwamayeza abizwa ngokuba zii-antibodies ze-monoclonal. Isebenza ngokumisa isenzo sezinto ezithile emzimbeni ezibangela iimpawu zokhwekhwe.

Inaliti ye-Dupilumab iza njengesirinji ekhethiweyo kunye nepeni ekhethiweyo yokufaka inaliti (phantsi kolusu). Unyango lwe-eczema kubantu abadala, ihlala inikwa njenge-inaliti (s) ezimbini zedosi yokuqala, ilandelwe ngenaliti enye rhoqo kwiiveki ezi-2. Unyango lwe-eczema ebantwaneni abaneminyaka emi-6 ukuya kweli-17 ubudala, ihlala inikwa njengezitofu ezimbini zedosi yokuqala, ilandelwe ngenaliti enye kwiiveki ezi-2 ukuya kwezi-4 ngokuxhomekeke kubunzima bomntwana. Unyango lwe-asthma kubantu abadala nakubantwana abaneminyaka eli-12 nangaphezulu ubudala, ihlala inikezwa njengezitofu ezimbini zedosi yokuqala, ilandelwe ngenaliti enye qho kwiiveki ezi-2. Unyango lwe-rhinosinusitis engapheliyo kunye ne-nasal polyposis kubantu abadala, ihlala inikezwa ngenaliti enye kwiiveki ezimbini. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Sebenzisa inaliti ye-dupilumab kanye njengoko kuyalelwe. Musa ukuyitofa ngaphezulu okanye ngaphantsi okanye uyitofe rhoqo kunokuba umiselwe ngugqirha.

Ukuba usebenzisa i-dupilumab kwaye une-asthma, qhubeka uthabathe okanye usebenzise onke amanye amayeza amiselwe ngugqirha ukunyanga isifuba sakho. Sukuyeka ukuthatha nawaphi na amayeza akho okanye utshintshe iidosi zalo naliphi na iyeza lakho ngaphandle kokuba ugqirha wakho ukuxelele ukuba kufanelekile. Inaliti ye-Dupilumab inceda ukuthintela uhlaselo lwesifuba kodwa ayizukumisa uhlaselo lwesifuba esele luqale. Sukusebenzisa inaliti yedupilumab ngexesha lokuhlaselwa sisifuba. Ugqirha wakho uya kumisela i-inhaler ukuba ayisebenzise ngexesha lokuhlaselwa sisifo sombefu.

Unokufumana idosi yakho yokuqala yenaliti ye-dupilumab kwiofisi kagqirha wakho. Emva koko, ugqirha wakho unokukuvumela okanye umnakekeli ukuba enze inaliti ekhaya. Ngaphambi kokuba usebenzise inaliti yedupilumab ngokwakho, funda ulwazi lomenzi wesigulana esiza nonyango. Buza ugqirha wakho okanye usokhemesti akubonise okanye umntu oza kunika amayeza ukuba angatofa njani.

Sebenzisa isirinji nganye kunye nosiba kube kanye. Lahla iisirinji ezisetyenzisiweyo kunye neepeni kwisitya esinganyangekiyo. Thetha nogqirha wakho okanye usokhemesti malunga nokusilahla isikhongozeli esinganyangekiyo.

Ukuba usebenzisa isirinji ekhethiweyo okanye ipeni ebiyelweyo efrijiweyo, beka isirinji kwindawo ethe tyaba ngaphandle kokuyisusa inaliti kwaye uyivumele ifudumale kubushushu begumbi (imizuzu engama-30 yesirinji ekhethiweyo eyi-200 mg kunye nemizuzu engama-45 kwi-300 mg isirinji okanye ipeni ekhethiweyo ngaphambi kokuba ulungele ukutofa amayeza. Sukuzama ukufudumeza amayeza ngokuwutshisa kwimicrowave, ngokuwabeka emanzini ashushu, okanye ngayo nayiphi na enye indlela.

Sukushukumisa isirinji okanye usiba oluqukethe idupilumab.

Soloko ujonga isisombululo se-dupilumab ngaphambi kokuyifaka. Jonga ukuba umhla wokuphelelwa awukadluli, kwaye ulwelo lucacile kwaye alunambala okanye alutyheli. Umbane awunakuba namasuntswana abonakalayo. Sukusebenzisa isirinji okanye usiba ukuba luqhekekile okanye lophukile, ukuba luphelelwe lixesha okanye lukhenkcekile, okanye ukuba ulwelo lunamafu okanye luqulathe amasuntswana amancinci.

Ungayifaka inaliti yedupilumab naphi na ngaphambili kwethanga lakho (umlenze ongasentla) okanye isisu (isisu) ngaphandle kwenkaba yakho kunye nendawo eyi-intshi ezimbini (iisentimitha ezi-5) kuyo. Ukuba umnonopheli utofa iyeza, umva wengalo ephezulu unokusetyenziswa. Ukunciphisa amathuba okuqaqamba okanye ububomvu, sebenzisa indawo eyahlukileyo yenaliti nganye. Musa ukujova kwindawo apho ulusu luthambile, lutyumkileyo, lubomvu, okanye lukhuni okanye apho uneziva okanye ukolula amanqaku.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokusebenzisa inaliti yedupilumab,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-dupilumab, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-dupilumab injection. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amayeza omlomo okanye omoya we-corticosteroid anje nge-dexamethasone, methylprednisolone (Medrol), kunye ne-prednisone (iRayos). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wanengxaki yamehlo, okanye ukuba une-hookworm, iroundworm, whipworm, okanye usulelo lwe-threadworm (usulelo lweentshulube ezihlala ngaphakathi emzimbeni).Ukuba ufumana i-dupilumab kunyango lwe-atropic dermatitis, xelela ugqirha wakho ukuba ngaba une-asthma.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa usebenzisa inaliti yedupilumab, tsalela ugqirha wakho.
• jongana nogqirha wakho ukubona ukuba ufuna ukufumana naluphi na ugonyo. Awunalo ugonyo ngexesha lonyango ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa idosi yenaliti yedupilumab, jola idosi yakho ephosiweyo kwakamsinya nje ukuba uyikhumbule kwaye uphinde uqalise ishedyuli yakho yoqobo. Nangona kunjalo, ukuba ngaphezulu kweentsuku ezingama-7 emva kwethamo lakho elilahlekileyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukusebenzisa idosi ephindwe kabini ukwenza eyilahlekileyo. Biza ugqirha wakho ukuba uphose idosi kwaye unemibuzo malunga nokwenza.

Inaliti ye-Dupilumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ububomvu okanye iintlungu kwindawo yenaliti
• intlungu yomqala
• izilonda zomlomo okanye zomlomo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• iingxaki zamehlo ezintsha okanye ezibaxekileyo, kubandakanya iintlungu zamehlo, umbono ophuthileyo, amehlo (abomvu) okanye abomvu, iinkophe ezibomvu okanye ezidumbileyo, okanye utshintsho kumbono
• ukukhawuleza, ukuphefumula, umkhuhlane, intlungu yesifuba, ukuva izikhonkwane kunye neenaliti, okanye ukuphazamiseka kwiingalo okanye emilenzeni

Ukuba unazo naziphi na kwezi mpawu, yeka ukusebenzisa inaliti yedupilumab kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• ukudumba kobuso, iinkophe, ulwimi, okanye umqala
• ukudumba kwamalungu enkovu
• ubunzima bokuginya okanye ukuphefumla
• ukuqina esifubeni okanye emqaleni
• ukurhawuzelela
• irhashalala
• urhwebo
• Ukuphelelwa ngamandla, ukuba nesiyezi, okanye ukuziva ungenentloko
• intlungu edibeneyo
• tyaba, eqinile, eshushu, ebomvu kwaye buhlungu amaqhuma esikhumba
• ifiva

Inaliti ye-Dupilumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa usebenzisa eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozelo sokuqala lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina inaliti yedupilumab efrijini okanye kubushushu begumbi ukuya kwiintsuku ezili-14. Musa ukubanda. Gcina iisirinji kunye neepeni kwiibhokisi zazo zokuqala ukuzikhusela ekukhanyeni.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho.

Musa ukuvumela omnye umntu asebenzise amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Ukuphinda kabini^®