Inaliti ye-Ocrelizumab

Umxholo

• Inaliti ye-Ocrelizumab isetyenziselwa ukunyanga abantu abadala abaneendlela ezahlukeneyo ze-multiple sclerosis (MS; isifo apho imithambo-luvo ingasebenzi kakuhle kwaye abantu banokufumana ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwemisipha, kunye neengxaki zombono, intetho, kunye nolawulo lwesinyi) kubandakanya:
• Ngaphambi kokufumana inaliti ye-ocrelizumab,
• I-Ocrelizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo le-HOW, tsalela umnxeba kwangoko okanye ufumane unyango lonyango:

Inaliti ye-Ocrelizumab isetyenziselwa ukunyanga abantu abadala abaneendlela ezahlukeneyo ze-multiple sclerosis (MS; isifo apho imithambo-luvo ingasebenzi kakuhle kwaye abantu banokufumana ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwemisipha, kunye neengxaki zombono, intetho, kunye nolawulo lwesinyi) kubandakanya:

• Iifom zokuqhubela phambili (iimpawu zihamba ngokuthe ngcembe ngokuhamba kwexesha) ze-MS,
• I-CIS; Iimpawu zempawu zemithambo-luvo ezihlala ubuncinci iiyure ezingama-24),
• Iifom zokuphinda zibuyele kwakhona (ikhosi yesifo apho iimpawu ziyavela khona amaxesha ngamaxesha), okanye
• iifomati zesekondari eziqhubekayo (ikhosi yesifo apho ukubuyela umva kwenzeka rhoqo).

I-Ocrelizumab kwiklasi yamayeza abizwa ngokuba yi-monoclonal antibodies. Isebenza ngokumisa iiseli ezithile zamajoni omzimba ekwenzeni umonakalo.

Inaliti ye-Ocrelizumab iza njengesisombululo (ulwelo) ukuze ifakwe ngaphakathi ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi. Ihlala inikwa kube kanye kwiiveki ezimbini kwiidosi zokuqala ezimbini (kwiveki yesi-0 nakwiveki yesi-2), emva koko kuthiwe ukumnika kube kanye kwiinyanga ezi-6.

Inaliti ye-Ocrelizumab inokubangela iimpendulo ezimandla ngexesha lokufakwa kunye ukuya kuthi ga kusuku emva kokufumana ukumiliselwa. Unokunikwa amanye amayeza ukunyanga okanye ukunceda ukuthintela iimpendulo kwi-ocrelizumab. Ugqirha okanye umongikazi uya kukujonga ngokusondeleyo ngelixa ufumana ukumiliselwa kunye neyure enye emva koko ukubonelela ngonyango kwimeko yeziphumo ebezingalindelekanga ezithile kunyango. Ugqirha wakho unokumisa okwexeshana okanye ngokusisigxina unyango lwakho okanye anciphise idosi, ukuba uneziphumo ebezingalindelekanga ezithile. Tshela ugqirha wakho okanye umongikazi ukuba ufumana oku kulandelayo ngexesha okanye kwiiyure ezingama-24 emva kokufakwa kwakho: irhashalala; ukurhawuzelela; imihlathi ububomvu kwindawo yenaliti; ubunzima bokuphefumla okanye ukugwinya; ukukhohlela; ukuvutha; irhashalala; ukuziva ndityhafile; ukucaphuka komqala; umlomo okanye umqala obuhlungu; ukuqhawukelwa ngumphefumlo; ukudumba kobuso, amehlo, umlomo, umqala, ulwimi, okanye imilebe; ukugungxula; ifiva; ukudinwa; ukudinwa; intloko ebuhlungu; isiyezi; isicaphucaphu; okanye ukubetha kwentliziyo ebalekayo. Fowunela ugqirha wakho kwangoko okanye ufumane unyango olukhawulezileyo ukuba ufumana naziphi na kwezi mpawu emva kokuba ushiye iofisi kagqirha okanye indawo yezonyango.

I-Ocrelizumab inokunceda ukulawula iimpawu ze-sclerosis kodwa ayizinyangi.Ugqirha wakho uyakukujonga ngononophelo ukuze ubone ukuba isebenza njani i-ocrelizumab. Kubalulekile ukuxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngenaliti ye-ocrelizumab kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-ocrelizumab,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-ocrelizumab, nawaphi na amanye amayeza, okanye naziphi na izithako kwiinaliti ze-ocrelizumab. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ngokukhankanya amayeza acinezela amajoni akho omzimba afana nala alandelayo: ii-corticosteroids kubandakanya i-dexamethasone, i-methylprednisolone (iMedrol), kunye ne-prednisone (iRayos); icyclosporine (Gengraf, Neoral, Sandimmune); daclizumab (iZinbryta); fingolimod (iGilenya); mitoxantrone; natalizumab (iTysabri); itacrolimus (Astagraf, Prograf); okanye teriflunomide (Aubagio). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wakha wanesifo sokudumba kwesibindi kohlobo B (HBV; intsholongwane eyosulela isibindi kwaye inokubangela ukonakala kwesibindi okanye umhlaza wesibindi). Ugqirha wakho uya kukuxelela ukuba ungafumani i-ocrelizumab.
• xelela ugqirha wakho ukuba unayo nayiphi na intsholongwane ngaphambi kokuba uqale unyango lwakho ngenaliti ye-ocrelizumab.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Sebenzisa ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye ne-ocrelizumab kunye neenyanga ezi-6 emva kwedosi yokugqibela. Ukuba ukhulelwa ngelixa ufumana i-ocrelizumab, tsalela ugqirha wakho. Ukuba ufumana inaliti ye-ocrelizumab ngexesha lokukhulelwa kwakho, qiniseka ukuba uthethe nogqirha womntwana wakho malunga noku emva kokuba umntwana wakho ezelwe. Usana lwakho lusenokufuna ukulibazisa ukufumana amachiza athile.
• xelela ugqirha wakho ukuba ukhe wagonywa kutshanje okanye ucwangciselwe ukufumana naluphi na ugonyo. Kuya kufuneka ufumane iintlobo ezithile zokugonya okungenani iiveki ezi-4 ngaphambili kunye nezinye ubuncinci iiveki ezi-2 ngaphambi kokuba uqale unyango ngenaliti ye-ocrelizumab. Awunalo ugonyo ngaphandle kokuthetha nogqirha wakho ngexesha lonyango lwakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa ixesha lokufumana i-ocrelizumab, tsalela umnxeba ugqirha ngokukhawuleza ukuba umisele kwakhona idinga.

I-Ocrelizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukudumba okanye iintlungu ezandleni, iingalo, imilenze, okanye iinyawo
• urhudo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo le-HOW, tsalela umnxeba kwangoko okanye ufumane unyango lonyango:

• umkhuhlane, ukugodola, ukukhohlela okungapheliyo, okanye ezinye iimpawu zosulelo
• izilonda zomlomo
• izibonda (ukukhawuleza okungenzeka kubantu abaye bafumana inkukhu yenkukhu ngaphambili)
• izilonda ezijikeleze amalungu esini okanye i-rectum
• usulelo lolusu
• ubuthathaka kwelinye icala lomzimba; ubugxwayiba beengalo nemilenze; utshintsho lombono; utshintsho ekucingeni, kwimemori nasekuziqhelaniseni; ukudideka; okanye utshintsho kubuntu

I-Ocrelizumab inokunyusa umngcipheko wee-cancer ezithile, kubandakanya nomhlaza webele. Thetha nogqirha wakho malunga neengozi zokufumana eli yeza.

I-Ocrelizumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwisitofu se-ocrelizumab.

Buza usokhemesti wakho ukuba unayo nayiphi na imibuzo onayo malunga nenaliti ye-ocrelizumab.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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