Inaliti yeBurosumab-twza

Umxholo

• Ngaphambi kokusebenzisa inaliti ye-burosumab-twza,
• Inaliti yeBurosumab-twza inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana enye yezi mpawu, tsalela ugqirha wakho:

Inaliti yeBurosumab-twza isetyenziselwa ukunyanga i-X-enxulumene ne-hypophosphatemia (XLH; isifo esizuzwe njengelifa apho umzimba ungagcini i-phosphorus kwaye oko kukhokelela kumathambo abuthathaka) kubantu abadala nakubantwana kwiinyanga ezi-6 ubudala nangaphezulu. Isetyenziselwa ukunyanga i-osteomalacia (ithumba ebangela ukulahleka kwe-phosphorus emzimbeni ekhokelela kumathambo abuthathaka) engenakususwa ngonyango kubantu abadala nakubantwana abaneminyaka emi-2 ubudala nangaphezulu, inaliti yeBurosumab-twza iklasi yamayeza ebizwa ngokuba yi-fibroblast factor factor 23 (FGF23) ethintela ii-antibodies. Isebenza ngokuthintela isenzo sento ethile yendalo emzimbeni ebangela iimpawu zeXLH.

Inaliti yeBurosumab-twza iza njengesisombululo (ulwelo) ukuze ifakwe ngaphakathi (phantsi kolusu) ngugqirha okanye ngumongikazi. Unyango lwe-X edityaniswe ne-hypophosphatemia, ihlala itofwa kanye kwiiveki ezi-2 zabantwana iinyanga ezi-6 ukuya kwi-17 ubudala, kunye kube kanye kwiiveki ezi-4 zabantu abadala. Unyango lwe-osteomalacia eyenziwe ngamathumba, kubantwana abaneminyaka emi-2 ukuya kweli-17 ubudala, ihlala itofelwa kanye kwiiveki ezi-2. Unyango lwe-osteomalacia ebangelwa yithumba kubantu abadala, ihlala itofwa rhoqo emva kweeveki ezi-4 kwaye njengoko idosi inyukile inokuthi ifakwe ngaphakathi kwiiveki ezimbini. Ugqirha wakho okanye umongikazi uya kulifaka iyeza engalweni yakho ephezulu, ethangeni eliphezulu, ezinqeni, okanye kwindawo yesisu, kwaye usebenzise indawo yenaliti eyahlukileyo ngalo lonke ixesha.

Tshela ugqirha wakho ukuba uthatha naziphi na izongezo ze-phosphate okanye izongezo ezithile ze-vitamin D ezinje ngecalcitriol (Rocaltrol) okanye paricalcitol (Zemplar). Kuya kufuneka uyeke ukuthatha ezi veki ziyi-1 phambi kokuba uqale unyango.

Ugqirha wakho unokuyonyusa idosi yakho (hayi ngaphezulu kwesibini kwiiveki ezi-4), okanye usenokutsiba idosi, kuxhomekeke kwiziphumo zovavanyo lwakho lwelebhu.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokusebenzisa inaliti ye-burosumab-twza,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-burosumab-twza, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-burosumab-twza injection. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba unesifo sezintso. Ugqirha wakho unokukuxelela ukuba ungasebenzisi inaliti ye-burosumab-twza.
• xelela ugqirha wakho ukuba ukhe okanye awukhe ube ne-restless leg syndrome (RLS; imeko ebangela ukungonwabi emilenzeni kunye nomnqweno onamandla wokuhambisa imilenze, ngakumbi ebusuku naxa uhleli okanye ulele).
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa ufumana inaliti ye-burosumab-twza, tsalela ugqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa ixesha lokufumana idosi, yenza enye idinga ngokukhawuleza.

Inaliti yeBurosumab-twza inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• ukugabha
• ifiva
• iintlungu ezingalweni, emilenzeni, okanye emqolo
• iintlungu zemisipha
• ukuqhina
• isiyezi

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana enye yezi mpawu, tsalela ugqirha wakho:

• ubomvu, ukukhawuleza, imihlathi, ukurhawuzelela, ukuvuvukala, iintlungu, okanye ukutyumka kufutshane okanye kwindawo apho iyeza lafakwa khona
• irhashalala okanye urticaria
• ubuhlungu emilenzeni; Umnqweno onamandla wokuhambisa imilenze, ngakumbi ebusuku naxa uhleli okanye ulele

Inaliti yeBurosumab-twza inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola iimvavanyo ezithile zelebhu ngaphambi kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwisitofu se-burosumab-twza.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• ICrysvita^®