Larotrectinib

Umxholo

• Ngaphambi kokuba uthathe i-larotrectinib,
• I-Larotrectinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwiCandelo LOKUQINISEKISA OKHETHEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Larotrectinib isetyenziselwa ukunyanga uhlobo oluthile lwamathumba aqinileyo kubantu abadala nakubantwana inyanga e-1 ubudala nangaphezulu ethe yasasazeka kwamanye amalungu omzimba okanye ayinakuphathwa ngempumelelo ngotyando. Eli yeza lisetyenziswa kuphela ukuba akukho lunye unyango olukhoyo kwaye amathumba aye aba mandundu emva kokufumana olunye unyango. I-Larotrectinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga exelela iiseli zomhlaza ukuba zande. Oku kunokunceda ukunciphisa ukukhula kwamathumba.

I-Larotrectinib iza njengephilisi kunye nesisombululo (ulwelo) ukuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kabini imihla ngemihla. Thatha i-larotrectinib malunga namaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-larotrectinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iicapsule ngamanzi; sukuzihlafuna okanye uzityumze.

Sebenzisa isirinji yomlomo (isixhobo sokulinganisa) ukulinganisa ngokuchanekileyo kwaye uthathe umthamo wakho wesisombululo se-larotrectinib. Buza usokhemesti wakho ngesirinji yomlomo ukuba ayifakwanga nonyango lwakho. Sukusebenzisa itispuni yasekhaya ukulinganisa isisombululo. Guqula isirinji yomlomo nganye emva kokuyisebenzisa kangangeentsuku ezisi-7 okanye ukuba yonakele. Landela imiyalelo yomenzi malunga nendlela yokusebenzisa nokucoca isirinji yomlomo. Buza ugqirha wakho okanye usokhemesti ukuba unayo nayiphi na imibuzo.

Ukuba unika isisombululo emntwaneni, beka incam yesirinji yomlomo emlonyeni womntwana ngokuchasene nangaphakathi esidleleni. Gcina umntwana kwindawo emileyo okwemizuzu embalwa kanye emva kokunika idosi ye-larotrectinib. Ukuba umntwana uchitha idosi okanye awuqinisekanga ukuba idosi yonke inikiwe, musa ukunika elinye idosi.

Ukuba uhlanza ngokukhawuleza emva kokuthatha i-larotrectinib, ungaphindi umthamo. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokufuna ukumisa okwexeshana okanye ngokusisigxina unyango lwakho okanye unciphise idosi yakho ye-larotrectinib ngexesha lonyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho kunye ne-larotrectinib.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-larotrectinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-larotrectinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile ze-larotrectinib okanye isisombululo. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-antifungals ezithile ezinje nge-itraconazole (Onmel, Sporanox) kunye ne ketoconazole; iAvanafil (iStendra); buspirone; i-clarithromycin (i-Biaxin, kwi-PrevPac); amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye ifunyenwe isifo se-immunodeficiency syndrome (i-AIDS) efana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kunye i-saquinavir (i-Invirase); amayeza athile acinezela amajoni omzimba anjenge-everolimus (Afinitor, Zortress), sirolimus (Rapamune), kunye ne-tacrolimus (Astagraf, Envarsus XR, Prograf); lovastatin; midazolam; nefazodone; ipioglitazone (Actos); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate, eRifater); amayeza athile okubanjwa njenge-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, kunye phenytoin (Dilantin, Phenytek); sildenafil (Revatio, Viagra), simvastatin (Flolipid, Zocor); kunye ne-vardenafil (Levitra, Staxyn). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-larotrectinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort. Musa ukuthatha i-wort yaseSt.John ngelixa uthatha i-larotrectinib.
• xelela ugqirha wakho ukuba ukhe okanye wakha wanazo iimeko ezichaphazela inkqubo yeemvakalelo okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye usebenzise ulawulo lokuzalwa ukukhusela ukukhulelwa ngexesha lonyango lwakho kunye neveki e-1 emva kwedosi yakho yokugqibela. Ukuba uyindoda, wena kunye neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye nakwiveki e-1 emva kwethamo lakho lokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa. I-Larotrectinib inokunciphisa ukuzala kwabasetyhini. Nangona kunjalo, akufuneki ucinge ukuba awungekhe ukhulelwe. Ukuba wena okanye iqabane lakho ukhulelwe, biza ugqirha wakho ngokukhawuleza. I-Larotrectinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise ngexesha lonyango lwakho kunye neveki e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba i-larotrectinib inokubangela ukozela, isiyezi, okanye ukudideka. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphantsi kweeyure ezingama-6 ngaphambi kwedosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Larotrectinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukukhohlela
• ukuqhina
• urhudo
• isicaphucaphu
• ukugabha
• isisu esibuhlungu
• intloko ebuhlungu
• ukuxinana kwempumlo
• ukutyeba kwakho
• umsipha, ukudibana, okanye iintlungu zomqolo
• ubuthathaka bemisipha
• ukwanda kokoma; utshintsho kwixabiso okanye umbala womchamo; isikhumba esomileyo; okanye isiqaqa

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwiCandelo LOKUQINISEKISA OKHETHEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• intetho ecothayo okanye enzima; ukuwa ngengozi; okanye ukurhawuzelela, ukuba ndindisholo, okanye ukutshisa ezandleni nasezinyaweni
• ifiva
• ukudumba ezandleni, iinyawo, amaqatha okanye imilenze esezantsi
• ukuqhawukelwa ngumphefumlo
• ukudinwa okungaqhelekanga okanye ubuthathaka; okanye ulusu olukhanyayo
• ukuphelelwa ngumdla wokutya; isicaphucaphu; ukugabha; ubumthubi besikhumba okanye amehlo; okanye iintlungu kwinxalenye ephezulu yesisu

I-Larotrectinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina iifomsile kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Gcina isisombululo somlomo kwifriji kwaye uvale ngokuqinileyo; sukuma ngumkhenkce. Lahla nasiphi na isisombululo somlomo esingasetyenziswanga kwiintsuku ezingama-90 emva kokuvula ibhotile okokuqala.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango ukujonga impendulo yomzimba wakho kwi-larotrectinib. Kwezinye iimeko, ugqirha wakho uya ku-odola uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa nge-larotrectinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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