Polatuzumab vedotin-piiq Inaliti

Umxholo

• Ngaphambi kokufumana inaliti ye-polatuzumab vedotin-piiq,
• IPolatuzumab vedotin-piiq inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo le-HOW, tsalela umnxeba kwangoko okanye ufumane unyango lonyango:

Inaliti ye-Polatuzumab vedotin-piiq isetyenziswa kunye ne-bendamustine (Belrapzo, Treanda) kunye ne-rituximab (Rituxan) kubantu abadala ukunyanga uhlobo oluthile lwe-non-Hodgkin's lymphoma (NHL; uhlobo lomhlaza oqala kuhlobo lweeseli ezimhlophe zegazi eziqhelekileyo Ukulwa nosulelo) olungakhange luphucule okanye luphuculwe kodwa lwabuya emva konyango ubuncinci ngamanye amayeza e-chemotherapy. I-Polatuzumab vedotin-piiq ikudidi lwamayeza abizwa ngokuba zii-anti-drug conjugates. Isebenza ngokubulala iiseli zomhlaza.

IPolatuzumab vedotin-piiq iza njengomgubo oxutywe nolwelo kwaye itofwe ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi kwiziko lonyango. Ihlala inikwa ngaphezulu kwemizuzu engama-30 ukuya kwengama-90 ngosuku loku-1 kumjikelo weentsuku ezingama-21. Umjikelo unokuphindwa amaxesha ama-6 okanye ixesha elide njengoko kucetyisiwe ngugqirha wakho. Ubude bonyango lwakho buxhomekeke kwindlela ophendula ngayo emzimbeni wakho kunyango nakwiziphumo ebezingalindelekanga ohlangabezana nazo.

Unokufumana impendulo enzulu okanye esongela ubomi ngelixa ufumana idosi ye-polatuzumab vedotin-piiq inaliti okanye kwiiyure ezingama-24 zokufumana idosi. Ugqirha wakho unokukuxelela ukuba uthathe amayeza athile ngaphambi kokufumana idosi yakho ukukhusela ezi mpendulo. Ugqirha okanye umongikazi uya kukujonga ngokusondeleyo ukuze ubone ukuba umzimba wakho uphendula njani kwi-polatuzumab vedotin-piiq. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho ngenaliti ye-polatuzumab vedotin-piiq. Ugqirha wakho unokuyalela amanye amayeza ukunceda ukuthintela okanye ukunciphisa ezi mpawu. Ukuba unazo naziphi na kwezi mpawu zilandelayo ngexesha okanye emva kokumfakelwa, xelela ugqirha wakho kwangoko: Ukugodola, ukurhawuzelela, imihlathi, umkhuhlane, ukuqhuma, irhashalala, ukuphefumla nzima, ukuphefumla kancinci, okanye ukuvutha.

Ugqirha wakho unokufuna ukulibazisa unyango lwakho, uhlengahlengise idosi yakho, okanye uyeke unyango lwakho ukuba uneziphumo ebezingalindelekanga. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-polatuzumab vedotin-piiq.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-polatuzumab vedotin-piiq,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-polatuzumab vedotin-piiq, nawaphi na amanye amayeza, okanye naziphi na izithako kwipalatuzumab vedotin-piiq. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: carbamazepine (Equetro, Tegretol, Teril); i-clarithromycin (i-Biaxin, kwi-PrevPac); amayeza okunyanga i-HIV kubandakanya i-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nevirapine (Viramune), ritonavir (Norvir, eKaletra), kunye ne-saquinavir (i-Invirase); itraconazole (Onmel, Sporanox), ketoconazole; nefazodone; phenobarbital, phenytoin (Dilantin, Phenytek); ipioglitazone (Actos); irifabutin (Mycobutin); kunye nerifampin (Rifadin, Rimactane, eRifamate). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-polatuzumab vedotin-piiq, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort.
• xelela ugqirha wakho ukuba unentsholongwane okanye unesifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele uqale ukufumana inaliti ye-polatuzumab vedotin-piiq de kube kuvavanyo lokukhulelwa lubonakalisile ukuba awukhulelwe. Ukuba ungumfazi okwaziyo ukukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neenyanga ezi-3 emva kwedosi yakho yokugqibela. Ukuba uyindoda kunye neqabane lomfazi onokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neenyanga ezi-5 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zolawulo lokuzalwa eziza kukusebenzela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa ufumana inaliti ye-polatuzumab vedotin-piiq, tsalela ugqirha wakho. Inaliti ye-Polatuzumab vedotin-piiq inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngexesha lonyango lwakho kunye neenyanga ezi-2 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba ufumana inaliti ye-polatuzumab vedotin-piiq.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphoswa idinga lokufumana idosi ye-polatuzumab vedotin-piiq, tsalela ugqirha kwangoko.

IPolatuzumab vedotin-piiq inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukugabha
• isiyezi
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• intlungu edibeneyo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo le-HOW, tsalela umnxeba kwangoko okanye ufumane unyango lonyango:

• ukudideka; isiyezi okanye ukulahleka kwemali; ubunzima bokuthetha okanye ukuhamba; okanye utshintsho kumbono
• ukuba ndindisholo okanye ukurhawuzelela kwezandla okanye kweenyawo; okanye ubuthathaka bemisipha, iintlungu, okanye ukutshisa
• ukugruzuka okulula okanye ukopha; ukopha kwiintsini okanye empumlweni; okanye igazi kumchamo okanye isitulo
• isicaphucaphu, ukugabha, urhudo nokudinwa
• ulusu olukhanyayo okanye ukudinwa okungaqhelekanga okanye ubuthathaka
• umkhuhlane, umqala obuhlungu, ingqele, iintlungu xa uchama, kunye neminye imiqondiso yosulelo
• ukudinwa okugqithisileyo; ubumthubi besikhumba okanye amehlo; ukuphelelwa ngumdla wokutya; umchamo omnyama; okanye iintlungu kwinxalenye ephezulu yesisu

Inaliti yePolatuzumab vedotin-piiq inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwipolatuzumab vedotin-piiq injection.

Buza usokhemesti wakho ukuba unayo nayiphi na imibuzo onayo malunga nenaliti ye-polatuzumab vedotin-piiq.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Polivy^®