Selinexor

Umxholo

• Ngaphambi kokuba uthathe i-selinexor,
• I-Selinexor inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Selinexor isetyenziswa kunye ne-dexamethasone ukunyanga i-myeloma (uhlobo lomhlaza womongo wethambo) obuyileyo okanye ongaphendulanga kwezinye iindlela zonyango ezi-4. I-Selinexor iphinda isetyenziswe kunye ne-bortezomib kunye ne-dexamethasone ukunyanga i-myeloma ezininzi kwizigulana esele ziphathwe ngamanye amayeza. Isetyenziselwa ukunyanga iintlobo ezithile ze-B-cell lymphoma enkulu (i-DLBCL; uhlobo lomhlaza oqala kwiiseli ezimhlophe zegazi) kubantu abadala abanomhlaza obuyileyo okanye ongaphenduliyo kwezinye iindlela zonyango ezimbini. USelinexor ukwiklasi yamayeza ebizwa ngokuba zii-selective inhibitors zokuthumela ngaphandle kwenyukliya (SINE). Isebenza ngokubulala iiseli zomhlaza.

I-Selinexor iza njengecwecwe lokuthatha ngomlomo kunye nangaphandle kokutya. Ukusetyenziswa ngokudibanisa ne-dexamethasone kunyango lwe-myeloma okanye unyango lwe-DLBCL, i-selinexor ihlala ithathwa ngeentsuku zoku-1 kunye ne-3 zeveki nganye. Ukusetyenziswa ngokudibeneyo ne-bortezomib kunye ne-dexamethasone kunyango lwe-myeloma emininzi, i-selinexor ihlala ithathwa kube kanye ngeveki. Thatha i-selinexor malunga nexesha elifanayo lemini yonke imihla oyithathayo. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-selinexor ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo ngamanzi; ungahluleli, ungahlaleli, okanye uzityumze.

Ukuba uyagabha emva kokuthatha i-selinexor, musa ukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho angakuxelela ukuba uthathe amayeza ukuthintela isicaphucaphu nokugabha ngaphambi nangexesha lonyango lwakho nge-selinexor.

Ugqirha wakho unokufuna ukuyeka okanye ukuphazamisa unyango lwakho okanye ukunciphisa umthamo wakho xa uneziphumo ezithile. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-selinexor.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-selinexor,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-selinexor, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-selinexor. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba unentsholongwane okanye usandul 'ukusuleleka, ukuba uneengxaki zokopha, okanye ukuba uneengxaki zamehlo (iliso lelensi).
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Kuya kufuneka ukuba ube novavanyo lokukhulelwa olubi ngaphambi kokuba uqale ukuthatha i-selinexor. Ukuba ungumfazi, akufuneki ukhulelwe ngelixa uthatha i-selinexor kunye ukuya kuthi ga kwiveki e-1 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba uyindoda, wena kunye neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kwaye niqhubeke nokusebenzisa ulawulo lokuzalwa kangangeveki e-1 emva kwedosi yakho yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-selinexor, biza ugqirha ngokukhawuleza. I-Selinexor inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha i-selinexor kunye neveki e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini.
• Kuya kufuneka uyazi ukuba i-selinexor inokukwenza wozele okanye ikwenze ube nesiyezi okanye ufe isiqaqa. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ugqirha wakho uya kuphakamisa ukuba uphuze utywala obaneleyo kwaye udle iikhalori ezaneleyo ngexesha lonyango lwakho.

Ukuba uyaphoswa yidosi, yeqa idosi kwaye uthathe amayeza akho kusuku kunye nexesha lakho elilandelayo elihleliweyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Selinexor inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• urhudo
• ukuqhina
• ukuhla ukusinda
• Ukuphelelwa ngumdla wokutya
• ukudinwa kakhulu
• ubunzima bokulala okanye ukulala
• intloko ebuhlungu
• utshintsho lwencasa

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukopha ngokulula okanye ukugruzuka
• ukudinwa, ulusu olukhanyayo, okanye ukuphefumla okufutshane
• umkhuhlane, ukukhohlela, ukugodola, okanye ezinye iimpawu zosulelo
• ukubona izinto okanye ukuva amazwi angekhoyo
• ukudideka
• ukungaboni kakuhle okanye umbono ophindwe kabini
• ukwanda kobuntununtunu ekukhanyeni nakwilitha

I-Selinexor inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kujonga ubunzima bomzimba wakho kwaye ayalele iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-selinexor.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Xpovio^®