Uyintoni ulindelo lobomi lwe-ATTR Amyloidosis?

Umxholo

• Ixesha lokuphila kunye namaxabiso okusinda
• Izinto ezichaphazela amathuba okusinda
• Iindidi ze-ATTR amyloidosis
• I-amyloidosis eqhelekileyo ye-ATTR
• Uhlobo lwe-ATTR amyloidosis
• Ezinye iintlobo ze-amyloidosis
• Izinketho zonyango
• Ukuthatha

Kwi-amyloidosis, iiproteni ezingaqhelekanga kumzimba zitshintsha imilo kwaye zidibane ukwenza i-amyloid fibrils. Ezo fibrils zakha izicwili kunye namalungu, ezinokubathintela ekusebenzeni ngokufanelekileyo.

I-ATTR amyloidosis yenye yeentlobo eziqhelekileyo ze-amyloidosis. Kwakhona kwaziwa ngokuba yi-transthyretin amyloidosis. Ibandakanya iprotein eyaziwa ngokuba yi-transthyretin (TTR), eveliswa esibindini.

Kubantu abane-ATTR amyloidosis, i-TTR yenza iiflumps ezinokwakha kwimithambo-luvo, entliziyweni, okanye kwamanye amalungu omzimba. Oku kunokubangela ukusilela kobomi kumzimba.

Funda ukuze ufunde indlela le meko inokuchaphazela ngayo ixesha lokuphila komntu kunye nezinto ezichaphazela amazinga okusinda, kunye nolwazi lwangemvelaphi malunga neentlobo ezahlukeneyo ze-ATTR amyloidosis kunye nendlela abaphathwa ngayo.

Ixesha lokuphila kunye namaxabiso okusinda

Ixesha lokuphila kunye namaxabiso okusinda ayahluka ngokuxhomekeka kuhlobo lwe-ATTR amyloidosis umntu anayo. Ezi ntlobo zimbini ziphambili zihlobo losapho kunye nohlobo lwasendle.

Ngokomndilili, abantu abane-ATTR amyloidosis yosapho bahlala kangangeminyaka esi-7 ukuya kweli-12 emva kokuba befumene isifo, ngokweZiko loLwazi ngezifo kunye noRare.

Uphononongo olupapashwe kwiphephancwadi Ukujikeleza kufumanise ukuba abantu abane-ATTR amyloidosis baphila uhlobo oluphakathi kweminyaka emi-4 emva kokuxilongwa. Inqanaba lokusinda kweminyaka emi-5 phakathi kwabathathi-nxaxheba yayingama-36 epesenti.

I-ATTR amyloidosis ihlala ibangela ukuba i-amyloid fibrils yakhe entliziyweni. Oku kunokubangela izingqisho zentliziyo engaqhelekanga kunye nokusongela kwentliziyo okusilela kwentliziyo.

Akukho lunyango lonyango lwe-ATTR amyloidosis. Nangona kunjalo, ukuxilongwa kwangoko kunye nonyango kunokunceda ukucothisa ukukhula kwesi sifo.

Izinto ezichaphazela amathuba okusinda

Izinto ezininzi zinokuchaphazela amaxabiso okusinda kunye nobomi bokuphila kwabantu abane-ATTR amyloidosis, kubandakanya:

• uhlobo lwe-ATTR amyloidosis abanayo
• ngawaphi amalungu achaphazelekayo
• xa iimpawu zabo zaqala
• baqala kwangoko njani unyango
• Oluphi unyango abalufumanayo
• impilo yabo iyonke

Uphando oluthe kratya luyafuneka ukuze kufundwe indlela iindlela ezahlukeneyo zonyango ezinokuchaphazela ngayo amaxabiso okusinda kunye nolindelo lobomi kubantu abakule meko.

Iindidi ze-ATTR amyloidosis

Uhlobo lwe-ATTR amyloidosis anayo umntu luya kuchaphazela umbono wabo wexesha elide.

Ukuba uhlala ne-ATTR amyloidosis, kodwa awuqinisekanga ukuba loluphi uhlobo, buza ugqirha wakho. Ezi ntlobo zimbini ziphambili zihlobo losapho kunye nohlobo lwasendle.

Ezinye iintlobo ze-amyloidosis zinokuphinda zikhule xa iiproteni ngaphandle kwe-TTR zidibana neefibrili ze-amyloid.

I-amyloidosis eqhelekileyo ye-ATTR

I-ATTR amyloidosis eyaziwayo ikwabizwa ngokuba lilifa le-ATTR amyloidosis. Kubangelwa kukutshintsha kwemfuzo okunokudluliselwa kumzali kuye emntwaneni.

Olu tshintsho lwemfuza lubangela ukuba i-TTR ingazinzi kangako kunesiqhelo. Oku kuphakamisa amathuba okuba i-TTR yenze i-amyloid fibrils.

Iinguqu ezininzi ezahlukeneyo zemfuza zinokubangela i-ATTR amyloidosis yosapho. Kuxhomekeka kutshintsho oluthile lomntu, imeko inokuthi ichaphazele imithambo-luvo yabo, iintliziyo zabo, okanye zombini.

Iimpawu ze-ATTR ye-amyloidosis yosapho iqala ebudaleni kwaye iba mandundu ngokuhamba kwexesha.

Uhlobo lwe-ATTR amyloidosis

Uhlobo lwe-ATTR i-amyloidosis ayibangelwa lulo naluphi na utshintsho kwimfuza. Endaweni yokuba ikhule ngenxa yeenkqubo zokuguga.

Kolu hlobo lwe-ATTR amyloidosis, i-TTR iyazinza kancinci ngobudala kwaye iqala ukwenza i-amyloid fibrils. Ezo fibrils zihlala zibekwa entliziyweni.

Olu hlobo lwe-ATTR amyloidosis luchaphazela amadoda angaphezu kweminyaka engama-70 ubudala.

Ezinye iintlobo ze-amyloidosis

Ezinye iintlobo ze-amyloidosis zikhona, kubandakanya i-AL kunye ne-AA amyloidosis. Ezi ntlobo zibandakanya iiproteni ezahlukeneyo kune-ATTR amyloidosis.

I-AL amyloidosis ikwabizwa ngokuba yi-amyloidosis ephambili. Ibandakanya izinto ezingaqhelekanga zomzimba, ezaziwa ngokuba yimixokelelwane yokukhanya.

I-AA amyloidosis ikwabizwa ngokuba yi-amyloidosis yesibini. Ibandakanya iproteni eyaziwa ngokuba yi-serum amyloid A. Ihlala ibangelwa lusulelo okanye isifo sokudumba, esifana nesifo samathambo.

Izinketho zonyango

Ukuba une-ATTR amyloidosis, icebo lonyango elicetyiswayo liza kuxhomekeka kuhlobo oluthile onalo, kunye namalungu achaphazelekayo kunye neempawu ezikhulayo.

Kuxhomekeke kwisifo sakho, banokumisela enye okanye ezingaphezulu kwezi zilandelayo:

• ukufakelwa kwesibindi, esetyenziselwa ukunyanga iimeko ezithile ze-ATTR amyloidosis
• Izithulisa ze-ATTR, iklasi yamayeza anceda ukunciphisa ukuveliswa kwe-TTR kubantu abane-ATTR amyloidosis yosapho
• Izinto zokuqinisa i-ATTR, iklasi yamayeza anokunceda ukuyeka i-TTR ekubeni yenze i-amyloid fibrils kubantu abanosapho okanye uhlobo lwasendle i-ATTR amyloidosis

Oogqirha bakho banokucebisa ngezinye iindlela zonyango ukunceda ukulawula iimpawu ezinokubakho kunye neengxaki ze-ATTR amyloidosis.

Umzekelo, olu nyango luxhasayo lunokubandakanya utshintsho kwindlela yokutya, i-diuretics, okanye utyando ukunceda ukunyanga ukusilela kwentliziyo.

Olunye unyango lwe-ATTR amyloidosis lukwafundwa kuvavanyo lweklinikhi, kubandakanya iziyobisi ezinokunceda ukucacisa i-amyloid fibrils emzimbeni.

Ukuthatha

Ukuba une-ATTR amyloidosis, thetha nogqirha wakho ukuze ufunde okungakumbi ngonyango lwakho kunye nembono yexesha elide.

Ukuchongwa kwangoko kunye nonyango kunokunceda ukucothisa ukukhula kwesi sifo, ukunciphisa iimpawu kunye nokuphucula ixesha lokuphila.

Isicwangciso sakho sonyango esinconywayo siya kuxhomekeka kuhlobo oluthile lwesifo onaso, kunye namalungu achaphazelekayo.

Unyango olutsha lunokufumaneka nakwixesha elizayo ukunceda ukuphucula amaxabiso okusinda kunye nomgangatho wobomi kubantu abakule meko.

Ugqirha wakho unokukunceda ufunde malunga nonyango lwamva nje.