Rituximab kunye neHyaluronidase Inaliti yoLuntu

Umxholo

• Ngaphambi kokufumana inaliti ye-rituximab kunye ne-hyaluronidase,
• I-Rituximab kunye ne-hyaluronidase inaliti yabantu inokubangela iziphumo ebezingalindelekanga.Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Rituximab kunye ne-hyaluronidase inaliti yomntu ibangele ulusu, ulusu olusongela ubomi kunye nokuphendula komlomo. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: izilonda ezibuhlungu okanye izilonda kulusu, kwimilebe okanye emlonyeni; amadyungudyungu; irhashalala; okanye uxobuka ulusu.

Usenokuba bosulelwe yi-hepatitis B (intsholongwane esosulela isibindi kwaye inokubangela ukonakala kwesibindi) kodwa ungabinazo iimpawu zesifo. Kule meko, ukufumana i-rituximab kunye ne-hyaluronidase yenaliti inokunyusa umngcipheko wokuba usulelo lwakho lube lukhulu kakhulu okanye lusoyikise ubomi kwaye uya kuba neempawu. Tshela ugqirha wakho ukuba ukhe wosulelekile, kubandakanya usulelo lwentsholongwane ye-hepatitis B. Ugqirha wakho uya kuyalela uvavanyo lwegazi ukuze abone ukuba unesifo se-hepatitis B esingasebenziyo. Ukuba kukho imfuneko, ugqirha wakho unokukunika amayeza ukunyanga olu sulelo ngaphambi nangexesha lonyango lwakho nge-rituximab kunye ne-hyaluronidase inaliti yabantu. Ugqirha wakho uya kukujonga esweni usulelo lwe-hepatitis B ngexesha kunye neenyanga ezimbalwa emva konyango lwakho. Ukuba unazo naziphi na kwezi mpawu zilandelayo ngexesha okanye emva konyango lwakho, tsalela umnxeba kwangoko: ukudinwa okugqithisileyo, ukutyheli kwesikhumba okanye amehlo, ukuphelelwa ngumdla, isicaphucaphu okanye ukugabha, iintlungu zemisipha, iintlungu zesisu, okanye umchamo omnyama.

Abanye abantu abafumene i-rituximab kunye ne-hyaluronidase inaliti yomntu bakhula ngokuqhubekayo nge-leukoencephalopathy (PML; isifo esinqabileyo sobuchopho esinganyangekiyo, esinokuthintelwa, okanye esinganyangekiyo esihlala sibangela ukufa okanye ukukhubazeka kakhulu) ngexesha okanye emva konyango lwabo. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha wakho ngokukhawuleza: utshintsho olutsha okanye olukhawulezileyo ekucingeni nasekudidekeni; ubunzima bokuthetha okanye ukuhamba; ukulahleka kwemali eseleyo; ukuphelelwa ngamandla; utshintsho olutsha okanye olukhawulezileyo kumbono; okanye naziphi na ezinye iimpawu ezingaqhelekanga ezithi zivele ngesiquphe.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-rituximab kunye ne-hyaluronidase inaliti yomntu.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seMithi) xa uqala unyango ngenaliti ye-rituximab kwaye ngalo lonke ixesha ufumana iyeza. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nemingcipheko yokusebenzisa i-rituximab kunye ne-hyaluronidase inaliti yabantu.

I-Rituximab kunye ne-hyaluronidase inaliti yomntu isetyenziswa yodwa okanye namanye amayeza ukunyanga iintlobo ezahlukeneyo ze-non-Hodgkin's lymphoma (NHL; uhlobo lomhlaza oqala kuhlobo lweeseli ezimhlophe zegazi ezihlala zilwa nosulelo). I-Rituximab kunye ne-hyaluronidase inaliti yomntu ikwasetyenziswa kunye namanye amayeza ukunyanga i-lymphocytic leukemia (CLL; uhlobo lomhlaza weeseli ezimhlophe zegazi). I-Rituximab kunye ne-hyaluronidase inaliti yabantu ikwiklasi yamayeza abizwa ngokuba zii-antibodies ze-monoclonal. Iphatha iintlobo ezahlukeneyo ze-NHL kunye ne-CLL ngokubulala iiseli zomhlaza.

I-Rituximab kunye ne-hyaluronidase inaliti yomntu iza njengesisombululo (ulwelo) sokutofelwa ngaphantsi (phantsi kolusu, kwindawo yesisu) ngaphezulu kwemizuzu emi-5 ukuya kwezi-7. Ishedyuli yakho yokulinganisa iya kuxhomekeka kwimeko onayo, amanye amayeza owasebenzisayo, kunye nendlela ophendula ngayo emzimbeni wakho kunyango.

I-Rituximab kunye ne-hyaluronidase inaliti yomntu inokubangela iimpendulo ezibi ngelixa ufumana amayeza okanye ngaphakathi kweeyure ezingama-24 emva kokufumana idosi. Uya kufumana idosi nganye ye-rituximab kunye ne-hyaluronidase yenaliti yabantu kwiziko lonyango, kwaye ugqirha okanye umongikazi uya kukujonga ngononophelo ngelixa ufumana amayeza kunye nemizuzu eli-15 ubuncinci emva kokufumana iyeza. Uya kufumana amayeza athile ukunceda ukuthintela ukusabela okungafunekiyo ngaphambi kokuba ufumane idosi nganye ye-rituximab kunye ne-hyaluronidase inaliti yabantu.

Kuya kufuneka ufumane idosi yakho yokuqala njengemveliso yenaliti ye-rituximab ejojowe kancinci ngaphakathi (emthanjeni). Emva kwethamo lokuqala unokufumana i-rituximab kunye ne-hyaluronidase inaliti yomntu phantsi kolusu, kuxhomekeke kwindlela ophendula ngayo kunyango lwe-intravenous ngemveliso yenaliti ye-rituximab.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-rituximab kunye ne-hyaluronidase,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-rituximab, i-hyaluronidase, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-rituximab kunye ne-hyaluronidase inaliti yabantu. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha.
• xelela ugqirha wakho ukuba unayo nayiphi na imiqathango ekhankanywe kwicandelo LESILUMKISO ELIBALULEKILEYO kwaye ukuba ubukhe wanesifo sokudumba kwesibindi kohlobo C okanye ezinye iintsholongwane ezinjengerhashalala, iherpes (intsholongwane enokubangela izilonda ezibandayo okanye ukudumba kwamadyunguza kwilungu lobufazi. indawo), i-shingles, intsholongwane ye-West Nile (intsholongwane esasazeka ngokulunywa yingcongconi kwaye inokubangela iimpawu ezibi), parvovirus B19 (isifo sesihlanu; intsholongwane eqhelekileyo ebantwaneni edla ngokubangela iingxaki ezinkulu kwabanye abantu abadala), okanye icytomegalovirus (a intsholongwane eqhelekileyo edla ngokubangela iimpawu ezibukhali kubantu abenza buthathaka amajoni omzimba okanye abosulelekileyo ngexesha lokuzalwa), ukubetha kwentliziyo okungaqhelekanga, iintlungu esifubeni, ezinye iingxaki zentliziyo, okanye ingxaki yemiphunga okanye yezintso. Xelela ugqirha wakho ukuba unalo naluphi na uhlobo losulelo ngoku okanye ukuba unayo okanye wakhe wanesifo esingazukuhamba okanye usulelo oluza ludlule.
• xelela ugqirha wakho ukuba ukhulelwe okanye ukuba ucwangcisa ukukhulelwa. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho nge-rituximab kunye ne-hyaluronidase inaliti yomntu kunye neenyanga ezili-12 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neentlobo zolawulo lokuzalwa oluza kukusebenzela. Ukuba ukhulelwa ngelixa usebenzisa i-rituximab kunye ne-hyaluronidase inaliti yabantu, tsalela ugqirha wakho. I-Rituximab inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise ngexesha lonyango lwakho nge-rituximab kunye ne-hyaluronidase inaliti yomntu kunye neenyanga ezi-6 emva kwedosi yakho yokugqibela.
• Buza ugqirha wakho ukuba ufanele ukufumana naluphi na ugonyo ngaphambi kokuba uqale unyango lwakho nge-rituximab kunye ne-hyaluronidase inaliti yabantu. Awunalo ugonyo ngexesha lonyango ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphoswa idinga lokufumana i-rituximab kunye ne-hyaluronidase inaliti yabantu, tsalela ugqirha ngoko nangoko.

I-Rituximab kunye ne-hyaluronidase inaliti yabantu inokubangela iziphumo ebezingalindelekanga.Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• ukugungxula
• ukulahleka kweenwele
• iintlungu, ukucaphuka, ukudumba, ukuba bomvu okanye ukurhawuzelela kwindawo apho bekutofelwe khona inaliti
• umsipha, ukudibana, okanye iintlungu zomqolo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• imihlathi, irhashalala, ukurhawuzelela, ukudumba kwemilebe, ulwimi, okanye umqala, ukuphefumla kancinci, ukuphefumla nzima okanye ukugwinya
• ukuvutha
• isiyezi okanye isiqaqa
• ubuthathaka
• urhudo
• ukunqongophala kwamandla
• iintlungu zesifuba
• ukubetha okanye ukubetha kwentliziyo okungaqhelekanga
• umqala obuhlungu, umkhuhlane, ukugodola, ukukhohlela, indlebe ebuhlungu, intloko ebuhlungu, okanye ezinye iimpawu zosulelo
• amabala amhlophe emqaleni okanye emlonyeni
• kunzima, kubuhlungu, okanye ukuchama rhoqo
• ubomvu, ukuthamba, ukudumba okanye ukufudumala kwendawo yesikhumba

I-Rituximab kunye ne-hyaluronidase inaliti yabantu inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa usebenzisa eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• URituxan Hycela^®