Ukuchaneka
Umxholo
- Ngaphambi kokuba uthathe i-entrectinib,
- I-Entrectinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
- Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
I-Entrectinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wesifo somhlaza wamaphaphu ongekho mncinci (i-NSCLC) kubantu abadala abasasazeke kwamanye amalungu omzimba. Isetyenziselwa ukunyanga iintlobo ezithile zamathumba aqinileyo kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu ezingenakunyangwa ngoqhaqho okanye ethe yasasazeka kwamanye amalungu omzimba kwaye yababuhlungu emva konyango ngamanye amayeza e-chemotherapy. I-Entrectinib ikudidi lwamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukumisa okanye ukucothisa ukusasazeka kweeseli zomhlaza.
I-Entrectinib iza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye yonke imihla. Thatha i-entrectinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-entrectinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.
Ginya zonke iifomsile; sukuwavula, uwahlafune, okanye uwaqhekeze.
Ukuba uhlanza ngokukhawuleza emva kokuba uthathe i-entrectinib, thabatha enye idosi ngokukhawuleza.
Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.
Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.
Ngaphambi kokuba uthathe i-entrectinib,
- xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-entrectinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile ze-entrectinib Buza usokhemesti wakho uluhlu lwezithako.
- xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya oku kulandelayo: i-aprepitant (Emend), amayeza athile okubulala anje nge-fluconazole (Diflucan), itraconazole (Omel, Sporanox), okanye ketoconazole; amayeza athile e-arrhythmias anje nge-amiodarone (Nexterone, Pacerone), procainamide, quinidine (eNuedexta), kunye ne-sotalol (Betapace, Sorine, Sotylize); i-azithromycin (iZithromax); i-clarithromycin (i-Biaxin, kwi-Prevpac); diltiazem (Cardizem, Tiazac, abanye); erythromycin (EES, Erythrocin, abanye); enzalutamide (Xtandi); amayeza athile e-HIV afana ne-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra, abanye), okanye saquinavir (Invirase); lithium (Lithobid); imodafinil (Provigil); nefazodone; oxcarbazepine (iTrileptal); phenobarbital; phenytoin (iDilantin, iPhenytek); ipioglitazone (Actos, eActoplus, eDuetact, eOseni); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, kwiRifater); i-steroids yomlomo efana ne-dexamethasone, i-methylprednisolone (iMedrol), kunye ne-prednisone (iRayos); kunye ne-verapamil (Calan). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-entrectinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
- xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort.
- xelela ugqirha wakho ukuba ubukhe wanayo imeko yenkqubo yemithambo-luvo, ithuba elide le-QT (ingxaki enqabileyo yentliziyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukubetha isiqaqa, okanye ukufa ngesiquphe), ukubetha kwentliziyo kancinci okanye okungaqhelekanga, isifo sentliziyo, ukusilela kwentliziyo, okanye isifo sentliziyo okanye sesibindi.
- xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Ukuba ungowasetyhini, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kwaye ubuncinci iiveki ezi-5 emva kwethamo lakho lokugqibela. Ukuba uyindoda, wena kunye neqabane lakho kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye ne-entrectinib kunye neenyanga ezi-3 emva kwedosi yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-entrectinib, biza ugqirha wakho ngokukhawuleza. I-Entrectinib inokwenzakalisa umntwana ongekazalwa.
- xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha i-entrectinib kunye neentsuku ezisi-7 emva kwedosi yokugqibela.
- Kuya kufuneka uyazi ukuba i-entrectinib inokubangela ukuba ube nesiyezi okanye ukudideka. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.
Ukuba uphosa idosi ngaphantsi kweeyure ezili-12, thatha idosi ephosiweyo kwakamsinya nje emva kokuba uyikhumbule kwaye emva koko uthathe idosi elandelayo ngexesha elimiselweyo. Nangona kunjalo, ukuba uphosa idosi ngaphezulu kweeyure ezili-12, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.
I-Entrectinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
- ukudinwa
- ukuqhina
- urhudo
- utshintsho lwencasa
- intloko ebuhlungu
- ukukhwehlela, umkhuhlane, okanye ezinye iimpawu zosulelo
- intlungu yesihlunu okanye edibeneyo
- umqolo obuhlungu
- utshintsho lobunzima
- irhashalala
- ubunzima bokuwa okanye ukulala
Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
- ubunzima ngokufunda, inkumbulo, ingqalelo, okanye ukusombulula iingxaki
- Utshintsho lweemvakalelo ezinje ngoxinzelelo, uxinzelelo, ukudideka, okanye ukuphazamiseka
- intlungu yethambo okanye ubunzima bokuhamba
- iingxaki zombono okanye utshintsho kumbono
- intlungu edibeneyo, ukuqina, ubomvu, okanye ukudumba
- iintlungu kwinxalenye ephezulu yesisu, ukuba tyheli kolusu okanye amehlo, ukulahleka kwesidlo, okanye ukopha okanye ukugruzuka ngokulula
- ukuqhawukelwa ngumphefumlo; ubunzima bokuphefumla xa ulele; okanye ukudumba kweengalo, imilenze, izandla okanye iinyawo
I-Entrectinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.
Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).
Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).
Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org
Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.
Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.
Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa nge-entrectinib. Ugqirha wakho angayalela iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-entrectinib.
Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.
Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.
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