Selumetinib

Umxholo

• Ngaphambi kokuba uthathe i-selumetinib,
• I-Selumetinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Selumetinib isetyenziselwa ukunyanga uhlobo lwe-neurofibromatosis 1 (NF1; inkqubo yovalo ebangela ukuba amathumba akhule kwimithambo-luvo) kubantwana abaneminyaka emi-2 ubudala nangaphezulu abane-plexiform neurofibromas (PN; amathumba athambileyo) angenakususwa ngokupheleleyo ngotyando. U-Selumetinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotheni engaqhelekanga ebonisa ukuba amathumba kufuneka akhule. Oku kunceda ukumisa okanye ukucothisa ukukhula kwethumba.

I-Selumetinib iza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa kabini ngemini kwisisu esingenanto. Musa ukutya nakuphi na ukutya iiyure ezingama-2 ngaphambi okanye iyure e-1 emva kwedosi nganye. Thatha i-selumetinib malunga nexesha elifanayo (ii) yonke imihla, malunga neeyure ezili-12 ngaphandle. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-selumetinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iicapsule ngamanzi; sukuwavula, uwahlafune, okanye uwaqhekeze.

Ukuba uhlanza emva kokuthatha i-selumetinib, ungathathi elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho anganciphisa umthamo wakho okanye ayeke unyango lwakho okwethutyana okanye ngokusisigxina ukuba uneziphumo ebezingalindelekanga ezithile. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-selumetinib.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-selumetinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-selumetinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile ze-selumetinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-anticoagulants ('i-blood thinner') efana ne-warfarin (Coumadin, Jantoven); ii-antifungals ezinjenge fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), kunye ne voriconazole (Vfend); Aprepitant (Hlomela); i-clarithromycin (i-Biaxin, kwi-Prevpac); iklopidogrel (iPlavix); i-corticosteroids efana ne-betamethasone (i-Celestone), i-budesonide (i-Entocort), i-cortisone (i-Cortone), i-dexamethasone (i-Decadron, i-Dexpak, i-Dexasone, abanye), i-hydrocortisone (i-Cortef, i-Hydrocortone), i-methylprednisolone (i-Medrol, i-Meprolone, abanye), i-prednisolone (i-Prelisolone (i-Prelisolone) ), kunye ne-prednisone (iRayos); diltiazem (Cardizem, Dilacor, Tiazac, nabanye); i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin); amayeza athile e-HIV kubandakanya indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, eKaletra), kunye ne-saquinavir (Fortovase, Invirase); idelalisib (iZydelig); nefazodone; phenobarbital; irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate, eRifater); i-verapamil (Calan, Covera); kunye ne-vitamin E eyongezelelweyo. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wanengxaki yokubona, kunzima ukugwinya, okanye isifo sentliziyo okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Ukuba ungowasetyhini, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kwaye ubuncinci iveki enye emva kwethamo lakho lokugqibela. Ukuba uyindoda, wena kunye neqabane lakho kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango lwenu nge-selumetinib kunye neveki e-1 emva kwedosi yenu yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-selumetinib, biza ugqirha wakho ngokukhawuleza. I-Selumetinib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha i-selumetinib kunye neveki e-1 emva kwedosi yokugqibela.

Kuphephe ukutya igrapefruit okanye ukusela ijusi yegrapefruit ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphakathi kweeyure ezingama-6 zedosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Selumetinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukugabha
• ukuqhina
• isisu esibuhlungu
• isicaphucaphu
• isikhumba esomileyo
• intloko ebuhlungu
• izilonda zomlomo
• ukurhawuzelela
• ubomvu bujikeleze iinzipho
• impumlo iyopha
• ukudinwa
• Ukuphelelwa ngumdla wokutya
• ukulahleka kweenwele okanye utshintsho lombala weenwele

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ifiva
• ukopha okungaqhelekanga
• ulusu olukhanyayo okanye ukudinwa
• ukungaboni kakuhle; ukulahleka kombono; amabala amnyama kumbono wakho; okanye olunye utshintsho lombono
• urhudo
• irhashalala, iblisters okanye isikhumba
• iintlungu zemisipha, iintlungu, okanye ubuthathaka; okanye umchamo omnyama
• ukukhohlela okanye ukuvutha; ukuqhawukelwa ngumphefumlo; ukudumba kwamaqatha neenyawo; okanye ukudinwa kakhulu

I-Selumetinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Musa ukuyisusa i-desiccant (ipakethi encinci ebandakanyiweyo njengezingxobo zokufunxa ukufuma) kwibhotile yakho.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina konke ukuqeshwa nogqirha wakho, ugqirha wamehlo, kunye nelabhoratri. Ugqirha wakho uya ku-odola iimvavanyo ezithile zebhu, kubandakanya iimviwo zamehlo, ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwi-selumetinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Koselugo^®