Iselpercatinib

Umxholo

• Ngaphambi kokuba uthathe i-selpercatinib,
• I-Selpercatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Selpercatinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wesifo somhlaza wamaphaphu ongekho mncinci (i-NSCLC) kubantu abadala abasasazeke kwamanye amalungu omzimba kubantu abadala. Isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wedlala lengqula kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu ethe yasasazeka kwamanye amalungu omzimba. I-Selpercatinib ikwasetyenziselwa ukunyanga olunye uhlobo lomhlaza we-thyroid oye wasasazeka kwamanye amalungu omzimba kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu abaye baphathwa ngokungaphumeleli nge-iodine ye-radioactive. I-Selpercatinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

I-Selpercatinib iza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa kabini yonke imihla (rhoqo emva kweeyure ezili-12) kunye okanye ngaphandle kokutya. Thatha i-selpercatinib ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-selpercatinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; sukuwavula, uwahlafune, okanye uwaqhekeze.

Ukuba uhlanza emva kokuthatha i-selpercatinib, musa ukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokunciphisa idosi yakho, okanye uphazamise okanye uyeke unyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka uthathe i-selpercatinib nokuba uziva uphilile. Sukuyeka ukuthatha i-selpercatinib ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-selpercatinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-selpercatinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile ze-selpercatinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: Aprepitant (Hlomela); carbamazepine (Carbatrol, Tegretol, Equetro, nabanye); i-clarithromycin (i-Biaxin, kwi-Prevpac); diltiazem (Cardizem, Cartia, Tiazac, nabanye); i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin); amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye ifunyenwe isifo se-immunodeficiency syndrome (i-AIDS) kubandakanya i-efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), kunye ne-saquinavir (Invirase) ; nefazodone; phenobarbital; phenytoin (iDilantin, iPhenytek); ipioglitazone (Actos); quinidine (kwiNuedexta); repaglinide (Prandin); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate, eRifater); kunye ne-verapamil (Calan, Verelan, abanye). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-selpercatinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha i-H₂ iyeza le-blocker lokugaya ukutya, ukubola kwentliziyo, okanye izilonda ezinje nge-cimetidine (Tagamet), i-famotidine (i-Pepcid), i-nizatidine (i-Axid), okanye i-ranitidine (i-Zantac), thatha i-selpercatinib ubuncinci iiyure ezi-2 ngaphambi okanye kwiiyure ezili-10 emva kokuthatha elinye lala mayeza.
• ukuba uthatha i-antacid equlethe i-aluminium, i-magnesium, i-calcium, okanye i-simethicone; okanye amayeza amdaka afana ne-aspirin ene-buffered, thatha i-selpercatinib ubuncinci iiyure ezi-2 ngaphambi okanye ubuncinci iiyure ezi-2 emva kokuba uthathe elinye lala mayeza.
• ukuba uthatha iproton-pump inhibitor efana ne-esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), kunye ne-rabeprazole (AcipHex), thatha idosi nganye ye-selpercatinib kunye nokutya.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wakha wacotha, wakhawuleza, okanye akabetha entliziyweni; ixesha elide leQT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe); igazi elonyukayo; iingxaki zokopha; okanye isifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Akufanele ukhulelwe ngelixa uthatha i-selpercatinib. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye usebenzise ulawulo lokuzalwa ukukhusela ukukhulelwa ngexesha lonyango lwakho kunye ne-selpercatinib kunye neveki e-1 emva kwedosi yakho yokugqibela. Ukuba uyindoda, wena kunye neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango lwenu nge-selpercatinib kunye ne-1 iveki emva kwethamo lokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-selpercatinib, biza ugqirha wakho ngokukhawuleza. I-Selpercatinib inokubangela ingozi yomntwana.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha i-selpercatinib kunye neveki e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-selpercatinib.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-selpercatinib. Ugqirha wakho unokukuxelela ukuba ungathathi i-selpercatinib kwiintsuku ezisi-7 ngaphambi kotyando okanye inkqubo yakho kwaye uya kukuxelela xa kufuneka uqale ukuthatha amayeza kwakhona.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphakathi kweeyure ezingama-6 zedosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Selpercatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• umlomo owomileyo
• urhudo
• ukuqhina
• isicaphucaphu
• ukugabha
• isisu esibuhlungu
• intloko ebuhlungu
• ukudinwa
• ukukhohlela
• ukuqhawukelwa ngumphefumlo
• ukudumba kweengalo, imilenze, izandla neenyawo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• iintlungu kwindawo ephezulu yesisu; ukugruzuka okanye ukopha okungaqhelekanga; umchamo omnyama; okanye utyheli kolusu kunye neliso
• ukubetha kwentliziyo
• utywala okanye intloko
• isiqaqa
• ukukhohlela okanye ukugabha igazi okanye into ebonakala ngathi yindawo yekhofi; ukopha okungaqhelekanga okanye ukugruzuka, ipinki; umchamo obomvu, okanye mnyama; okanye obomvu okanye ukulinda ukuhamba kwamathumbu amnyama
• isicaphucaphu; ukugabha; ukuqhawukelwa ngumphefumlo; izihlunu; ubuthathaka; ukuxhuzula; okanye ukudumba kweengalo nemilenze
• umkhuhlane, irhashalala, okanye ukudibana okanye iintlungu zomzimba

I-Selpercatinib inokubangela ukuba amathambo ayeke ukukhula msinyane kulutsha olusakhulayo. Thetha nogqirha womntwana wakho malunga neengozi zokunika umntwana wakho eli yeza.

I-Selpercatinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kujonga uxinzelelo lwegazi rhoqo kwaye ayalele iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-selpercatinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Retevmo^®