Buza iNgcali: Yintoni ekufuneka uyazi malunga ne-HER2 + Diagnosis

Umxholo

• 1. Ithetha ntoni kanye kanye i-HER2-positive?
• 2. Ngaba ndiza kufuna utyando? Ukuba kunjalo, zeziphi iindlela zam?
• 3. Luluphi unyango olufumanekayo?
• 4. Zithini iinjongo zonyango?
• 5. Uthini umbono womhlaza webele we-HER2?
• 6. Ngaba zikhona iziphumo ebezingalindelekanga zonyango, kwaye ndinokuzilawula njani?
• 7. Ingaba lukhona utshintsho ebomini endimele ndilwenze emva koxilongo lwam?
• 8. Uyintoni umngcipheko wokuphindaphinda komhlaza webele we-HER2?

1. Ithetha ntoni kanye kanye i-HER2-positive?

I-HER2-positive imele ukukhula kwe-epidermal factor receptor 2. Iiseli emzimbeni zihlala zifumana imiyalezo yokukhula nokusasazeka kwii-receptors ezibekwe ngaphandle kweseli. Ezi receptors zinovelwano kwii-enzymes ezahlukeneyo, okanye abathunywa, eziveliswayo emzimbeni. Ii-receptors zilawula iiseli ezahlukeneyo kwaye zixelele ukuba zenze ntoni (okt, khula, usasaze, okanye ufe).

Ezi receptors zikwangaphandle kweeseli zomhlaza. Kodwa, iiseli zomhlaza zinokufumana ii-receptors ezininzi kuneseli eqhelekileyo. Eli nani lonyukayo, kunye nolunye utshintsho olujikeleze iseli yomhlaza, lubavumela ukuba bafumane imiyalezo emininzi ukuba ikhule kwaye isasazeke xa kuthelekiswa neeseli eziqhelekileyo, ezingezizo ezomhlaza. Ezi zinto sizibiza ngokuba zii-oncodrivers, oko kuthetha ukuba baqhuba umhlaza ukuba ukhule.

Kwezi meko, umhlaza unokuxhomekeka kakhulu kwii-receptors ukuqhubeka nokukhula nokusasazeka. Xa ezi receptors zivaliwe kwaye zingavunyelwa ukuba zifumane imiyalezo, iseli ayinakukhula okanye isasazeke.

Kumhlaza webele we-HER2-positive, inani le-HER2-receptors eziphumayo ngaphandle kweseli likhulu kunokuba linokuba kwiseli eqhelekileyo, engeyiyo eyomhlaza. Oku kunceda ukuqhuba umhlaza ukuba ukhule kwaye usasazeke.

2. Ngaba ndiza kufuna utyando? Ukuba kunjalo, zeziphi iindlela zam?

Iqela lakho le-oncology liya kugqiba ukuba ufuna utyando kwaye uxoxe ukuba loluphi uhlobo lotyando olulungele wena. Zininzi izinto ezahlukileyo zokuthatha isigqibo sokuba loluphi uhlobo lotyando oluza kwenziwa kunye nokuba uza kwenziwa nini utyando (nokuba kungaphambi okanye emva kwonyango lwenkqubo). Oogqirha bakho baya kuxoxa nawe malunga neenketho zakho, kwaye kunye, unokuza kwisigqibo.

3. Luluphi unyango olufumanekayo?

Izinketho zonyango zibandakanya unyango lwe-radiation, utyando, i-chemotherapy, kunye ne-endocrine therapy. Uya kuba nokufikelela kunyango olujolise ngokukodwa kwi-HER2 receptors.

Zininzi izinto ezimisela uhlobo kunye nexesha lonyango oza kulufumana. Oku kubandakanya ubudala bakho, nezinye iimeko zempilo, inqanaba lomhlaza, kunye nezinto ozikhethayo. Iqela lakho le-oncology kufuneka lixoxe ngazo zonke iindlela zonyango ezikhoyo kwimeko yakho ethile.

4. Zithini iinjongo zonyango?

Iinjongo zonyango zixhomekeke kwinqanaba lomhlaza webele onalo ekuchongeni. Kulabo abanesigaba se-0 ukuya kwi-3 somhlaza wamabele, injongo yonyango kukunyanga umhlaza kunye nokuthintela ukuphinda kwenzeke kwakhona.

Inqanaba 4 lomhlaza webele kuthetha ukuba umhlaza usasazeke ngaphaya kwebele kunye ne-lymph node zalapha. Kule nqanaba, injongo yonyango kukulawula ukukhula komhlaza kunye nokuthintela nawuphi na umonakalo kwilungu okanye iintlungu.

Ngelishwa, inqanaba lesine umhlaza wamabele awunyangeki. Kodwa ngokufika kwamachiza amatsha kunye namayeza amatsha, kunokwenzeka ukuba uhlale kwisithuba sesifo esomeleleyo ixesha elide.

5. Uthini umbono womhlaza webele we-HER2?

Umbono womhlaza webele we-HER2-oxhomekeke kwizinto ezimbalwa ezahlukeneyo. Oku kubandakanya inqanaba lomhlaza, amandla akho okunyamezela unyango, ubudala bakho, kunye nemeko yakho yangoku yezempilo.

Ukufika kwamachiza amatsha amatsha asebenzayo asebenza ngokudibeneyo nezinye iindlela zonyango ziyaqhubeka nokuphucula imeko yabasetyhini abanesifo somhlaza webele i-HER2.

6. Ngaba zikhona iziphumo ebezingalindelekanga zonyango, kwaye ndinokuzilawula njani?

Iziphumo zonyango ziya kuxhomekeka kuhlobo lonyango olufumanayo. Ngokubanzi, abaguli banokunyamezelana ne-monoclonal antibodies ezisetyenziselwa ukujolisa kwi-HER2-positive receptors kakuhle.

Ezinye zeempembelelo ezinokubakho zibandakanya ukudinwa, iintlungu ezidibeneyo, intloko ebuhlungu kunye nokuqaqanjelwa sisisu. Uninzi lweziphumo ebezingalindelekanga zincinci kubukrakra.

Rhoqo, ii-antibodies ze-monoclonal ezisetyenziselwa ukunyanga umhlaza webele we-HER2-onokubangela ukuba buthathaka kwezihlunu zentliziyo. Iqela lakho le-oncology liza kuxoxa nawe ngomngcipheko kwaye likubeke esweni ngokusondeleyo kuyo nayiphi na imiqondiso yale ngxaki inqabileyo.

7. Ingaba lukhona utshintsho ebomini endimele ndilwenze emva koxilongo lwam?

Ngokubanzi, kuya kufuneka ulandele indlela yokuphila esempilweni emva kokuxilongwa ngumhlaza wamabele. Yeka ukutshaya xa utshaya, ukunciphisa ukusela utywala kwisiselo esinye okanye ngaphantsi ngemini, kwaye wenze umthambo olinganiselweyo yonke imihla.

Kuya kufuneka uphinde ulandele ukutya okusempilweni okuphezulu kwiziqhamo, imifuno, kunye neeproteni ezinamafutha asezantsi. Nciphisa ukungenisa iswekile ecoliweyo kunye nokutya okunamafutha amaninzi.

8. Uyintoni umngcipheko wokuphindaphinda komhlaza webele we-HER2?

Kwizigulana ezinesigaba sokuqala somhlaza webele we-HER2 (amanqanaba ama-0 ukuya kwele-3), iminyaka eli-10 yokubuyela umva kwendawo isukela kuma-79 ukuya kuma-95 epesenti. Uluhlu luxhomekeke kwinqanaba lomhlaza xa kufunyaniswa isifo kunye nohlobo lotyando.

Nangona kunjalo, zininzi izinto ezinokuba negalelo kumngcipheko wakho wokuphindeka. Xoxa ngomngcipheko wakho kunye neqela lakho le-oncology.

Iingcebiso ezinikezelwa nguThemba Qamoos, umongikazi kwezempilo yabasetyhini. Ithemba lineminyaka engaphezu kwe-15 yamava esebenza kwimpilo yabasetyhini kunye ne-oncology. Uchithe umsebenzi wakhe wobungcali esebenza neenkokheli eziphambili zoluvo kwicandelo kwizibhedlele zaseyunivesithi ezinje ngeStanford, Northwestern, kunye neLoyola. Ukongeza, iThemba lisebenza neqela elinamacandelo ahlukeneyo kwizifundo ngenjongo yokuphucula ukhathalelo lwabasetyhini abanomhlaza eNigeria.