Fenfluramine

Umxholo

• Ngaphambi kokuba uthathe i-fenfluramine,
• I-Fenfluramine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo esiXwayiso ESIBALULEKILEYO okanye AMANYATHELO AKHETHEKILEYO, yeka ukuthatha i-fenfluramine kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

I-Fenfluramine inokubangela iingxaki ezinkulu zentliziyo kunye nemiphunga. Tshela ugqirha wakho ukuba ukhe unesifo sentliziyo okanye semiphunga. Ugqirha wakho uza kwenza i-echocardiogram (uvavanyo olusebenzisa amaza esandi ukulinganisa ukubanakho kwempompo yegazi) ngaphambi kokuba uqale ukuthatha i-fenfluramine, rhoqo kwiinyanga ezi-6 ngexesha lonyango, kunye nexesha elinye ukuya kwiinyanga ezi-3 ukuya kwezi-6 emva kwedosi yakho yokugqibela yefenfluramine.Biza ugqirha wakho ngoko nangoko ukuba unayo nayiphi na le miqondiso kunye neempawu ngexesha lonyango: ukuphefumla okufutshane, iintlungu zesifuba, ukudinwa okanye ubuthathaka, ukubetha kwentliziyo okukhawulezayo okanye okugungxayo ngokukodwa ngokwenza umsebenzi owandileyo, ukuba nentloko elula, ukuphelelwa ngamandla, ukubetha okungaqhelekanga, amaqatha okanye iinyawo ezidumbileyo, okanye Umbala oluhlaza okwesibhakabhaka kwimilebe nolusu.

Ngenxa yomngcipheko ngeli chiza, i-fenfluramine ifumaneka kuphela ngenkqubo ekhethekileyo yokuhanjiswa. Inkqubo ebizwa ngokuba yiFintepla Risk Evaluation and Mitigation Strategies (REMS). Wena, ugqirha wakho, kunye nekhemesti kufuneka ubhalise kwinkqubo yeFintepla REMS ngaphambi kokuba uyifumane.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-fenfluramine.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngefenfluramine kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Fenfluramine isetyenziselwa ukulawula ukuxhuzula ebantwaneni ukusukela kwiminyaka emi-2 nangaphezulu nge-Dravet syndrome (isifo esiqala ebuntwaneni kwaye sibangela ukuxhuzula kwaye kamva kungakhokelela kulibaziseko lophuhliso kunye notshintsho ekutyeni, ekulinganiseni nasekuhambeni). I-Fenfluramine ikwiklasi yamayeza abizwa ngokuba zii-anticonvulsants. Ayaziwa ngokuthe ngqo ukuba isebenza njani i-fenfluramine, kodwa inyusa inani lezinto zendalo kwingqondo ezinokuthi zinciphise ukubanjwa.

I-Fenfluramine iza njengesisombululo (ulwelo) ukuthatha ngomlomo. Ihlala ithathwa kabini ngemini kunye okanye ngaphandle kokutya. Thatha i-fenfluramine ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-fenfluramine ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho uya kukuqala ngedosi esezantsi ye-fenfluramine kwaye ngokuthe ngcembe uyonyuse idosi yakho, hayi ngaphezulu kwesinye kanye ngeveki.

Sebenzisa isirinji yomlomo eze namayeza ukulinganisa isisombululo. Sukusebenzisa icephe ukulinganisa idosi yakho. Iispuni zasekhaya azizizo izixhobo zokulinganisa ezichanekileyo, kwaye unokufumana amayeza amaninzi okanye awonelanga xa ulinganisa idosi yakho ngepuni yekhaya. Yipule ngesirinji yomlomo ngamanzi acocekileyo etephu kwaye uvumele umoya owomileyo emva kokusetyenziswa ngakunye. Sebenzisa isirinji yomlomo eyomileyo ngalo lonke ixesha uthatha iyeza.

Ukuba une-nasogastric (NG) okanye ityhubhu yesisu, ugqirha wakho okanye usokhemesti uyakuchaza ukuba uyilungiselela njani i-fenfluramine ukuyilawula.

I-Fenfluramine iyanceda ukulawula ukuxhuzula, kodwa ayinyangi. Qhubeka nokuthatha i-fenfluramine nokuba uziva uphilile. Sukuyeka ukuthatha i-fenfluramine ngaphandle kokuthetha nogqirha wakho. Ukuba uyeka ngequbuliso ukuthatha i-fenfluramine, unokufumana iimpawu zokurhoxa njengokutsha okanye ukuwohloka okuwohlokayo. Ugqirha wakho uya kunciphisa umthamo wakho ngokuthe ngcembe.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-fenfluramine,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-fenfluramine, nawaphi na amanye amayeza, okanye nasiphi na isithako esisisombululo se-fenfluramine Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha okanye ufumana la mayeza alandelayo okanye uyekile ukuwasebenzisa kwiintsuku ezili-14 ezidlulileyo: i-monoamine oxidase (MAO) inhibitors kubandakanya isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline ( I-Eldepryl, i-Emsam, iZelapar), kunye ne-tranylcypromine (iParnate). Ukuba uyeka ukuthatha i-fenfluramine, kuya kufuneka ulinde ubuncinci iintsuku ezili-14 ngaphambi kokuba uqale ukuthatha i-MAO inhibitor.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: iziyobisi ezifana ne-bupropion (Aplenzin, Wellbutrin); amayeza oxinzelelo; icyproheptadine; i-dextromethorphan (efumaneka kumayeza amaninzi okukhohlela; kwiNuedexta); I-efavirenz (iSustiva); lithium (Lithobid); amayeza okugula ngengqondo; amayeza e-migraine iintloko ezinje nge-almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), kunye zolmitriptan (Zomig); omeprazole (Prilosec); irifampin (Rifadin, Rimactane, eRifamate, eRifater); ukuthomalalisa; amayeza okubanjwa njenge carbamazepine (Carbatrol, Equetro, Tegretol, Teril), clobazam (Onfi, Sympazan), phenobarbital, phenytoin (Dilantin, Phenytek), kunye ne-stiripentol (Diamcomit); i-serotonin-reuptake inhibitors ekhethiweyo efana ne-fluoxetine (Prozac, Sarafem, Selfemra), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), kunye ne-sertraline (Zoloft); i-serotonin-norepinephrine reuptake inhibitors (SNRI) enjenge-desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), milnacipran (Savella), kunye ne-venlafaxine (i-Effexor); iipilisi zokulala; izinto zokuthomalalisa; ithenda kunye ne-tricyclic antidepressants (’mood elevators’) ezinjenge desipramine (Norpramin) okanye protriptyline (Vivactil). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-fenfluramine, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza kunye nezongezelelo zesondlo ozithathayo, ngakumbi iSt John's wort kunye ne-tryptophan.
• xelela ugqirha wakho ukuba unayo okanye wakha wanayo i-glaucoma (ukwanda koxinzelelo kwiso elinokubangela ukulahleka kombono) okanye uxinzelelo lwegazi. Kwakhona xelela ugqirha wakho ukuba ukhe wanalo uxinzelelo, iingxaki zemoods, iingcinga zokuzibulala okanye indlela oziphethe ngayo okanye isifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-fenfluramine, tsalela umnxeba ugqirha wakho.
• Kuya kufuneka uyazi ukuba i-fenfluramine inokukwenza wozele kwaye yenze kube nzima kuwe ukwenza imisebenzi efuna ukuphapha okanye ukulungelelanisa umzimba. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
• buza ugqirha wakho malunga nokusetyenziswa okukhuselekileyo kweziselo ezinxilisayo kunye namayeza aqukethe utywala (ukukhohlela kunye neemveliso ezibandayo, ezinje ngeNyquil, kunye nezinye iimveliso ezingamanzi) ngelixa uthatha i-fenfluramine. Utywala bunokongeza ukozela okubangelwa leli yeza.
• Kuya kufuneka uyazi ukuba impilo yakho yengqondo inokutshintsha ngeendlela ezingalindelekanga kwaye ungazibulala (ucinga ngokuzenzakalisa okanye ukuzibulala okanye ukucwangcisa okanye ukuzama ukwenza njalo) ngelixa uthatha i-fenfluramine. Inani elincinci labantu abadala kunye nabantwana abaneminyaka emi-5 ubudala nangaphezulu (malunga ne-1 kubantu abangama-500) abathathe ii-anticonvulsants, ezinjenge-fenfluramine, ukunyanga iimeko ezahlukeneyo ngexesha lezifundo zeklinikhi bazibulala ngexesha lonyango lwabo. Abanye baba bantu bakhulise iingcinga zokuzibulala kunye nokuziphatha kwiveki nje enye emva kokuba beqalisile ukuthatha amayeza. Wena kunye nogqirha wakho niya kuthatha isigqibo sokuba ngaba ingozi yokuthatha iyeza le-anticonvulsant inkulu kuneengozi zokungawasebenzisi amayeza. Wena, usapho lwakho, okanye umntu omkhathalelayo kufuneka ubize ugqirha wakho ngoko nangoko ukuba unazo naziphi na kwezi mpawu zilandelayo: uloyiko; ukuphazamiseka okanye ukungazinzi; okutsha okanye ukuhla kokucaphuka, uxinzelelo, okanye uxinzelelo; ukwenza izinto eziyingozi; ubunzima bokuwa okanye ukulala; ndlongondlongo, umsindo okanye ubundlobongela; i-mania (i-frenzied, i-mood engaqhelekanga) ukucinga ngokuzenzakalisa okanye ukuzibulala, okanye ukucwangcisa okanye ukuzama ukwenza njalo; okanye naluphi na olunye utshintsho olungaqhelekanga kwindlela oziphethe ngayo okanye kwimood. Qiniseka ukuba usapho lwakho okanye umntu okhathalelayo uyazi ukuba zeziphi iimpawu ezinokuba nobuzaza ukuze babize ugqirha ukuba awukwazi ukuzifunela unyango ngokwakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Fenfluramine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• ukugabha
• ukungazinzi okanye iingxaki zokuhamba
• ukuhlahlela amathe okanye ukugqithisa
• ubunzima bokulala okanye ukulala
• ukuwa
• umkhuhlane, ukukhohlela, okanye ezinye iimpawu zosulelo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo esiXwayiso ESIBALULEKILEYO okanye AMANYATHELO AKHETHEKILEYO, yeka ukuthatha i-fenfluramine kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• Ukuphazamiseka, ukubona izinto ezingekhoyo, umkhuhlane, ukubila, ukudideka, ukubetha kwentliziyo okukhawulezayo, ukugodola, ukuqina kwemisipha okanye ukujija, ukulahleka kokulungelelaniswa, isicaphucaphu, ukugabha, okanye urhudo
• ukungaboni kakuhle okanye utshintsho lombono, kubandakanya ukubona iihalos (ulwandlalo olungqongqo ujikeleze izinto) okanye amachaphaza anemibala

I-Fenfluramine inokubangela ukulahleka kwesidlo kunye nokulahleka kwesisindo. Ukuba uphawula ukuba umntwana wakho uphulukana nobunzima, biza ugqirha wakho. Ugqirha wakho uya kujonga ukukhula kunye nobunzima bomntwana wakho ngononophelo. Thetha nogqirha wakho ukuba unenkxalabo malunga nokukhula komntwana wakho okanye ubunzima xa ethatha la mayeza.

I-Fenfluramine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina isisombululo somlomo kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Musa ukufriji okanye ubambe isisombululo. Lahla nasiphi na isisombululo somlomo esingasetyenziswanga esisele kwiinyanga ezi-3 emva kokuqala ukuvula ibhotile okanye emva komhla "wokulahla emva" kwileyibhile, nokuba ngowuphi umhla okhawulezayo.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• abafundi abaxubileyo
• ukubuyela umva
• ukukhawuleza kwentliziyo okanye okungaqhelekanga
• ukugungxula
• ukungazinzi
• ixhala
• ukungcangcazela
• ukuxhuzula
• isiqaqa (ukulahleka kwengqondo ixesha elithile)
• Ukuphazamiseka, ukubona izinto ezingekhoyo, umkhuhlane, ukubila, ukudideka, ukubetha kwentliziyo okukhawulezayo, ukungcangcazela, ukuqina kwemisipha okanye ukujija, ukulahleka kokulungelelaniswa, isicaphucaphu, ukugabha, okanye urhudo

Musa ukuvumela nabani na ukuba athathe amayeza akho. I-Fenfluramine yinto elawulwayo. Imigqaliselo inokugcwaliswa kuphela linani eliqingqiweyo lamaxesha; buza usokhemesti wakho ukuba unayo nayiphi na imibuzo.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Fintepla^®