Inaliti yeBrexucabtagene Autoleucel

Umxholo

• Phambi kokufumana i-brexucabtagene autoleucel,
• I-Brexucabtagene autoleucel inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

Inaliti ye-Brexucabtagene autoleucel inokubangela ukusabela okunobungozi okanye okusongela ubomi okubizwa ngokuba yi-cytokine release syndrome (CRS). Ugqirha okanye umongikazi uya kukujonga ngononophelo ngexesha lokufakwa kwakho kunye ubuncinci iiveki ezi-4 emva koko. Tshela ugqirha wakho ukuba unesifo esivuthayo okanye ukuba unayo okanye ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Uya kunikwa amayeza imizuzu engama-30 ukuya kwengama-60 ngaphambi kokufakwa kwakho ukunceda ukuthintela iimpendulo kwi-brexucabtagene autoleucel. Ukuba ufumana naziphi na kwezi mpawu zilandelayo ngexesha nasemva kokufakwa, xelela ugqirha ngoko nangoko: umkhuhlane, ukugodola, ukukhawuleza kwentliziyo okanye ukubetha kwentliziyo, iintlungu zemisipha, ukungcangcazela, urhudo, ukudinwa, ukuba buthathaka, ukuphefumla nzima, ukuphefumla kancinci, ukukhohlela, ukudideka, isicaphucaphu, ukugabha, isiyezi, okanye iintloko.

Inaliti yeBrexucabtagene autoleucel inokubangela ukusabela okubukhali okanye okusongela ubomi. Ezi mpendulo zinokwenzeka emva konyango nge-brexucabtagene autoleucel. Tshela ugqirha wakho ukuba ukhe waxhuzula, wabethwa yistroke, okanye waphulukana nenkumbulo. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: intloko ebuhlungu, isiyezi, ubunzima bokulala okanye ukulala, ukungazinzi, ukudideka, ixhala, ukungcangcazela okungalawulekiyo komzimba, ukulahleka kwengqondo, ukuphazamiseka, ukuxhuzula, ukulahleka ukulinganisela, okanye ubunzima bokuthetha.

Inaliti ye-Brexucabtagene autoleucel ifumaneka kuphela kwinkqubo ekhethekileyo yokuhambisa ngenxa yomngcipheko weCRS kunye neetyhefu ze-neurological. Unokufumana amayeza kugqirha nakwiziko lokhathalelo lwempilo oluthatha inxaxheba kule nkqubo. Buza ugqirha wakho ukuba unemibuzo malunga nale nkqubo.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-brexucabtagene autoleucel.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-brexucabtagene autoleucel kwaye ngalo lonke ixesha uzalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Brexucabtagene autoleucel ikwasetyenziselwa ukunyanga i-mantle cell lymphoma (umhlaza okhula ngokukhawuleza oqala kwiiseli zamajoni omzimba) kubantu abadala ababuyileyo okanye abangaphenduliyo kolunye unyango. Inaliti yeBrexucabtagene autoleucel ikudidi lwamayeza abizwa ngokuba yi-autologous cellular immunotherapy, uhlobo lonyango olulungiselelwe kusetyenziswa iiseli ezivela kwigazi lesigulana. Isebenza ngokubangela amajoni omzimba (iqela leeseli, izicwili, kunye namalungu akhusela umzimba ekuhlaselweni ziintsholongwane, iintsholongwane, iiseli zomhlaza, kunye nezinye izinto ezibangela izifo) ukuba zilwe neeseli zomhlaza.

I-Brexucabtagene autoleucel iza njengokumiswa (ulwelo) ukuze kutofelwe ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi kwiofisi kagqirha okanye kwiziko lokumnika. Ihlala inikwa ngaphezulu kwesithuba semizuzu engama-30 njengedosi yexesha elinye. Phambi kokuba ufumane ithamo le-brexucabtagene autoleucel, ugqirha wakho okanye umongikazi uya kuhambisa amanye amayeza e-chemotherapy ukulungiselela umzimba wakho ukuba ufumane i-brexucabtagene autoleucel.

Phambi kokuba unikwe inaliti ye-brexucabtagene autoleucel inaliti, iisampulu zeeseli zakho ezimhlophe ziya kuthathwa kwiziko lokuqokelela iiseli kusetyenziswa inkqubo ebizwa ngokuba yileukapheresis (inkqubo esusa iiseli ezimhlophe zegazi emzimbeni). Ngenxa yokuba eli yeza lenziwa kwiiseli zakho, kufuneka unikwe wena kuphela. Kubalulekile ukuba ufike ngexesha kwaye ungaphoswa kukuqokelelwa (okanye) kokuqokelelwa kweeselfowuni okanye ukufumana idosi yonyango. Kuya kufuneka ucwangcise ukuhlala kufutshane nalapho ufumene unyango lwe-brexucabtagene autoleucel okungenani iiveki ezi-4 emva kwedosi yakho. Umboneleli wakho wezononophelo lwempilo uya kujonga ukuba unyango lwakho luyasebenza na kwaye akubeke esweni naziphi na iziphumo ebezingalindelekanga ezinokubakho. Thetha nogqirha wakho malunga nendlela yokulungiselela i-leukapheresis kunye nento onokuyilindela ngexesha nasemva kwenkqubo.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Phambi kokufumana i-brexucabtagene autoleucel,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-brexucabtagene autoleucel, nawaphi na amanye amayeza, okanye nasiphi na isithako se-brexucabtagene autoleucel. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe waba nemiphunga, izintso, intliziyo, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Uya kudinga kuvavanyo lokukhulelwa ngaphambi kokuba uqale i-brexucabtagene autoleucel. Ukuba ukhulelwa ngelixa ufumana i-brexucabtagene autoleucel, tsalela umnxeba kwangoko.
• Kuya kufuneka uyazi ukuba inaliti ye-brexucabtagene autoleucel inokukwenza wozele kwaye ubangele ukudideka, ubuthathaka, isiyezi, ukuxhuzula, kunye neengxaki zokulungelelanisa. Sukuqhuba imoto okanye usebenzise oomatshini ubuncinci iiveki ezisibhozo emva kwethamo le-brexucabtagene autoleucel.
• musa ukunikela ngegazi, amalungu, izicwili, okanye iiseli zokufakelwa emva kokuba ufumene inaliti ye-brexucabtagene autoleucel.
• jongana nogqirha wakho ukubona ukuba ufuna ukufumana naluphi na ugonyo. Awunalo naluphi na ugonyo ngaphandle kokuthetha nogqirha wakho ubuncinci iiveki ezi-6 ngaphambi kokuqala ichemotherapy, ngexesha lonyango lwe-brexucabtagene autoleucel, de ugqirha akuxelele ukuba amajoni akho omzimba abuyile.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa ixesha lokuqokelela iiseli zakho, kuya kufuneka ubize ugqirha wakho kunye neziko lokuqokelela kwangoko. Ukuba uphosa ixesha lokuqeshwa ukuze ufumane idosi ye-brexucabtagene autoleucel, kufuneka ubize ugqirha ngoko nangoko.

I-Brexucabtagene autoleucel inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• isisu esibuhlungu
• Ukuphelelwa ngumdla wokutya
• iintlungu zomlomo
• kunzima ukugwinya
• irhashalala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• ulusu olukhanyayo okanye umphefumlo omfutshane
• umkhuhlane, umqala obuhlungu, ingqele, okanye ezinye iimpawu zosulelo
• Ukuncipha kokuchama rhoqo okanye isixa
• ukuba ndindisholo, iintlungu, ukurhawuzelela, okanye ukutshiswa ziinyawo okanye izandla

Inaliti yeBrexucabtagene autoleucel inokunyusa umngcipheko wokuvela komhlaza othile. Thetha nogqirha wakho malunga neengozi zokufumana eli yeza.

Inaliti yeBrexucabtagene autoleucel inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina lonke ixesha lokudibana nogqirha wakho, indawo yokuqokelela iiseli, kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile zelebhu ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwisitofu se-brexucabtagene autoleucel.

Buza usokhemesti wakho ukuba unayo nayiphi na imibuzo onayo malunga ne-brexucabtagene autoleucel.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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