Inaliti yeMethotrexate

Umxholo

• Ngaphambi kokufumana inaliti ye-methotrexate,
• I-Methotrexate inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Methotrexate inokubangela iziphumo ezibi kakhulu, ezisongela ubomi. Kuya kufuneka ufumane inaliti ye-methotrexate ukunyanga umhlaza osongela ubomi, okanye ezinye iimeko ezinzima kakhulu kwaye ezingenakunyangwa ngamanye amayeza. Thetha nogqirha wakho malunga nomngcipheko wokufumana inaliti ye-methotrexate kwimeko yakho.

Xelela ugqirha wakho ukuba ukhe wakha wanamanzi amaninzi kwisisu sakho okanye kwindawo ejikeleze imiphunga yakho kwaye ukuba ukhe unesifo sezintso. Xelela ugqirha wakho ukuba uthatha ii-nonsteroidal anti-inflammatory drug (NSAIDs) ezinje nge-aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), ibuprofen (Advil, Motrin), magnesium salicylate (Doan's), naproxen (Aleve, Naprosyn), okanye isalali. Ezi meko kunye namayeza anokunyusa umngcipheko wokuba uya kuba nemiphumo emibi ye-methotrexate. Ugqirha wakho uya kukujonga ngononophelo kwaye unokufuna ukukunika idosi esezantsi ye-methotrexate okanye uyeke unyango lwakho nge-methotrexate.

I-Methotrexate inokubangela ukwehla kwenani leeseli zegazi ezenziwe ngumongo wethambo lakho. Tshela ugqirha wakho ukuba unayo okanye wakhe wanenani eliphantsi lalo naluphi na uhlobo lweeseli zegazi okanye nayiphi na ingxaki ngeeseli zakho zegazi. Fowunela ugqirha ngoko nangoko ukuba unazo naziphi na kwezi mpawu zilandelayo: umqala obuhlungu, ukugodola, umkhuhlane, ukukhohlela nokuxinana okuqhubekayo, okanye ezinye iimpawu zosulelo; ukugruzuka okanye ukopha okungaqhelekanga; ukudinwa okungaqhelekanga okanye ubuthathaka; ulusu oluthuthu; okanye ukuphefumla okufutshane.

I-Methotrexate inokubangela ukonakala kwesibindi, ngakumbi xa ithathwa ixesha elide. Xelela ugqirha wakho ukuba uyasela okanye wakha wasela izixa ezikhulu zotywala okanye ukuba ukhe unesifo sesibindi. Ugqirha wakho usenokungafuni ukuba ufumane inaliti ye-methotrexate ngaphandle kokuba unesifo somhlaza esisongela ubomi kuba kukho umngcipheko ophezulu wokuba uya kuba nomonakalo wesibindi. Umngcipheko wokuba uhlakulele umonakalo wesibindi unokuphakama xa ukhulile, ukhuluphele, okanye unesifo sikashukela. Buza ugqirha wakho malunga nokusetyenziswa okukhuselekileyo kotywala ngelixa ufumana inaliti ye-methotrexate. Tshela ugqirha wakho ukuba ngaba uthatha nawaphi na amayeza alandelayo: iacitretin (Soriatane), azathioprine (Imuran), isotretinoin (Accutane), sulfasalazine (Azulfidine), okanye tretinoin (Vesanoid). Biza ugqirha wakho kwangoko ukuba unazo naziphi na kwezi mpawu zilandelayo: isicaphucaphu, ukudinwa kakhulu, ukungabikho kwamandla, ukungabi namdla, iintlungu kwindawo ephezulu yesisu, ukuba tyheli kolusu okanye amehlo, okanye iimpawu ezinje ngomkhuhlane. Ugqirha wakho unoku-odola i-biopsies yesibindi (ukususwa kwesiqwengana sesicwili sesibindi ukuze kuvavanywe elebhu) ngaphambi nangexesha lonyango lwakho nge-methotrexate.

I-Methotrexate inokubangela umonakalo wemiphunga. Tshela ugqirha wakho ukuba unayo okanye wakhe waba nesifo semiphunga. Biza ugqirha wakho ngokukhawuleza ukuba unazo naziphi na kwezi mpawu zilandelayo: ukukhohlela owomileyo, umkhuhlane, okanye ukuphefumla kancinci.

I-Methotrexate inokubangela umonakalo kumngxunya womlomo wakho, isisu okanye amathumbu. Xelela ugqirha wakho ukuba ukhe wanesilonda esiswini okanye ulcerative colitis (imeko ebangela ukudumba kunye nezilonda kumngxunya wekholoni [amathumbu amakhulu] kunye ne-rectum). Biza ugqirha wakho ngokukhawuleza ukuba unazo naziphi na kwezi mpawu zilandelayo: izilonda zomlomo, urhudo, umnyama, ukulinda, okanye izitulo ezinegazi, kunye nokugabha, ngakumbi ukuba ukugabha kunegazi okanye kujongeka ngathi yindawo yekofu.

Ukusebenzisa i-methotrexate kunokunyusa umngcipheko wokuba uphuhlise i-lymphoma (umhlaza oqala kwiiseli zomzimba). Ukuba uhlakulela i-lymphoma, inokuhamba ngaphandle kwonyango xa uyeka ukuthatha i-methotrexate, okanye kunokufuna unyango nge-chemotherapy.

Ukuba uthatha i-methotrexate ukunyanga umhlaza, unokuhlakulela iingxaki ezithile ezinokuba sengozini okanye ezisongela ubomi njengoko i-methotrexate isebenza ukutshabalalisa iiseli zomhlaza. Ugqirha wakho uya kukujonga ngononophelo kwaye azinyange ezi ngxaki ukuba zinokwenzeka.

I-Methotrexate inokubangela ulusu olunobuzaza okanye olusongela ubomi. Ukuba uhlangabezana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: umkhuhlane, irhashalala, iblister, okanye isikhumba esikhulayo.

I-Methotrexate inokuwunciphisa umsebenzi wamajoni akho omzimba, kwaye unokuba nosulelo olubi. Tshela ugqirha wakho ukuba unayo nayiphi na intsholongwane kwaye unayo okanye unayo nayiphi na imeko echaphazela amajoni akho omzimba. Ugqirha wakho unokukuxelela ukuba akufuneki ufumane i-methotrexate ngaphandle kokuba unomdlavuza osongela ubomi. Ukuba ufumana iimpawu zosulelo ezinje ngomqala obuhlungu, ukukhohlela, umkhuhlane, okanye ukugodola, tsalela umnxeba kwangoko.

Ukuba ufumana i-methotrexate ngelixa uphathwa ngonyango lwe-radiation kumhlaza, i-methotrexate inokunyusa umngcipheko wokuba unyango lwe-radiation luza kubangela ukonakala kulusu lwakho, emathanjeni okanye kwamanye amalungu omzimba.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwimethotrexate kunye nokunyanga iziphumo ebezingalindelekanga ngaphambi kokuba zibe nzima.

Tshela ugqirha wakho ukuba wena okanye iqabane lakho ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba ufumane i-methotrexate. Sebenzisa indlela ethembekileyo yolawulo lokuzalwa ukuze wena okanye iqabane lakho lingakhulelwa ngexesha okanye kungekudala emva konyango. Ukuba uyindoda, wena neqabane lakho labasetyhini kufuneka niqhubeke nokusebenzisa ulawulo lokuzalwa kangangeenyanga ezi-3 emva kokuyeka ukusebenzisa i-methotrexate. Ukuba ungumfazi, kuya kufuneka uqhubeke nokusebenzisa uzalo de ube nokuya exesheni emva kokuba uyekile ukusebenzisa i-methotrexate. Ukuba wena okanye iqabane lakho ukhulelwe, biza ugqirha wakho ngokukhawuleza. I-Methotrexate inokubangela ingozi okanye ukufa kwimveku.

Inaliti ye-Methotrexate isetyenziswa yodwa okanye idityaniswe namanye amayeza ukunyanga amathumba akwi-gestational trophoblastic tumors (uhlobo lwethumba elenza ngaphakathi kwisibeleko sowasetyhini ngelixa ekhulelwe), umhlaza webele, umhlaza wemiphunga, eminye imihlaza yomhlaza entloko nasentanyeni; iintlobo ezithile zegazi (umhlaza weeseli ezimhlophe zegazi), kubandakanya i-lymphocytic leukemia (YONKE) kunye ne-leukemia ye-meningeal (umhlaza kugqatso lwentambo yomqolo kunye nengqondo) iintlobo ezithile ze-non-Hodgkin's lymphoma (iintlobo zomhlaza eziqala kuhlobo lweeseli ezimhlophe zegazi ezihlala zilwa nosulelo); i-T-cell lymphoma (CTCL), iqela lomhlaza lomzimba okomzimba oqala ukubonakala njengokukrala kolusu); kunye ne-osteosarcoma (umhlaza owenzeka emathanjeni) emva kotyando ukususa ithumba. Inaliti ye-Methotrexate ikwasetyenziselwa ukunyanga i-psoriasis (isifo solusu apho umbala obomvu, onamaxolo wenza iindawo ezithile zomzimba) ezingenakulawulwa lolunye unyango. Inaliti ye-Methotrexate ikwasetyenziswa kunye nokuphumla, unyango lomzimba kwaye ngamanye amaxesha amanye amayeza ukunyanga isifo samathambo (RA; imeko apho umzimba uhlasela amalungu ayo, ubangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi) ongenakulawulwa amanye amayeza. I-Methotrexate ikudidi lwamayeza abizwa ngokuba zii-antimetabolites. IMethotrexate inyanga umhlaza ngokunciphisa ukukhula kweeseli zomhlaza. IMethotrexate inyanga i-psoriasis ngokunciphisa ukukhula kweeseli zolusu ukuyeka isikali ekubeni senziwe. I-Methotrexate inokunyanga isifo samathambo ngokunciphisa umsebenzi wamajoni omzimba.

Inaliti ye-Methotrexate iza njengomgubo oxutywe nolwelo ukuze ifakwe inaliti intramuscularly (in a muscle), intravenously (into a vein), intra-arterially (into a artery), or intrathecally (in the fluid-filled space of the canal spinal ). Ubude bonyango buxhomekeke kwiintlobo zamachiza owathathayo, ukuba umzimba wakho uphendula njani kuwo, kunye nohlobo lomhlaza okanye imeko onayo.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

I-Methotrexate ngamanye amaxesha isetyenziswa ngokudibeneyo namanye amayeza ukunyanga umhlaza wesinyi. Ngamanye amaxesha kusetyenziselwa ukunyanga isifo sikaCrohn (imeko apho amajoni omzimba ahlasela khona umgca wokugaya ukutya, obangela iintlungu, urhudo, ukwehla kobunzima kunye nomkhuhlane) kunye nezinye izifo ezikhuselayo (iimeko ezithi zikhule xa amajoni omzimba ehlasela iiseli ezisempilweni umzimba ngempazamo). Buza ugqirha wakho malunga nomngcipheko wokusebenzisa eli yeza kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-methotrexate,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-methotrexate, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-methotrexate injection. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zilandelayo: folic acid (ifumaneka yodwa okanye isithako kwezinye iivithamini); amanye amayeza e-rheumatoid arthritis; phenytoin (Dilantin); probenecid (iBenemid); iproton pump inhibitors (ii-PPIs) ezinje nge-esomeprazole (Nexium), omeprazole (Prilosec, Prilosec OTC, Zegerid), pantoprazole (Protonix); i-sulfonamides efana ne-co-trimoxazole (Bactrim, Septra), sulfadiazine, sulfamethizole (Urobiotic), kunye ne-sulfisoxazole (Gantrisin); kunye ne-theophylline (Theochron, Theolair). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wakha wanayo nayiphi na imiqathango ekhankanywe kwicandelo LESILUMKISO ESIBALULEKILEYO okanye kwinqanaba elisezantsi legazi.
• Musa ukuncancisa ngelixa ufumana inaliti ye-methotrexate.
• Kuya kufuneka uyazi ukuba i-methotrexate inokubangela ukuba ube nesiyezi okanye ikwenze wozele. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
• cwangcisa ukuthintela ukukhanya kwelanga ngokungeyomfuneko okanye ixesha elide okanye ukukhanya kwe-ultraviolet (iibhedi zokutsala kunye nezibane zelanga) kwaye unxibe iimpahla zokuzikhusela, iiglasi zelanga kunye nescreen selanga. IMethotrexate inokwenza ulusu lwakho lubuthathaka kwilanga okanye ekukhanyeni kwelanga. Ukuba une-psoriasis, izilonda zakho zinokuba mbi ngakumbi xa uveza ulusu lwakho elangeni ngelixa ufumana i-methotrexate.
• awunalo ugonyo ngexesha lonyango lwakho nge-methotrexate ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

I-Methotrexate inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intlungu edibeneyo okanye yemisipha
• amehlo abomvu
• Iintsini ezidumbileyo
• ukulahleka kweenwele

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukugabha
• ukungaboni kakuhle okanye ukulahleka kombono ngesiquphe
• umkhuhlane wequbuliso, intloko ebuhlungu kunye nentamo elukhuni
• ukuxhuzula
• ukudideka okanye ukulahleka kwememori
• ubuthathaka okanye ubunzima bokuhambisa elinye okanye omabini amacala omzimba
• ukuhamba nzima okanye ukuhamba ungazinzanga
• ukulahleka kwengqondo
• ukuthetha kakuhle
• ukuncipha kokuchama
• ukudumba kobuso, iingalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• urhwebo
• ukurhawuzelela
• irhashalala
• ubunzima bokuphefumla okanye ukugwinya

I-Methotrexate inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• izilonda emlonyeni nasemqaleni
• umqala obuhlungu, ingqele, umkhuhlane, ukukhohlela okuqhubekayo nokuxinana, okanye ezinye iimpawu zosulelo
• ukugruzuka okanye ukopha okungaqhelekanga
• mnyama kunye nokulinda okanye izitulo ezinegazi
• ukugabha okunegazi
• Izinto ezigabileyo ezibonakala ngathi ziindawo zekofu

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• UAbhitrexate^®¶
• UFolex^®¶
• Mexate^®¶

• Amethopterin
• MTX

^¶ Le mveliso inophawu akusekho kwimarike. Ezinye iindlela ezinokubakho zinokubakho.