I-Doxorubicin

Umxholo

• Phambi kokufumana inaliti yedoksorubicin,
• I-Doxorubicin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Doxorubicin kufuneka ilawulwe kuphela emthanjeni. Nangona kunjalo, inokuvuza kwizicubu ezijikelezileyo kubangele ukucaphuka okukhulu okanye ukonakala. Ugqirha wakho okanye umongikazi uya kubeka esweni indawo yakho yolawulo ngale mpendulo. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: iintlungu, ukurhawuzelela, ukuba bomvu, ukudumba, iblisters, okanye izilonda kwindawo apho lalifakwe khona iyeza.

I-Doxorubicin inokubangela iingxaki zentliziyo okanye ezisongela ubomi nangaliphi na ixesha ngexesha lonyango okanye iinyanga ukuya kwiminyaka emva kokuba unyango lwakho luphelile. Ugqirha wakho uya ku-odola uvavanyo ngaphambi nangexesha lonyango lwakho ukuze abone ukuba intliziyo yakho isebenza kakuhle ngokwaneleyo na ukuze ufumane i-doxorubicin ngokukhuselekileyo. Olu vavanyo lunokubandakanya i-electrocardiogram (ECG; uvavanyo olurekhoda umsebenzi wombane wentliziyo) kunye ne-echocardiogram (uvavanyo olusebenzisa amaza esandi ukulinganisa ukubanakho kwentliziyo yokupompa igazi). Ugqirha wakho unokukuxelela ukuba awufanele ukufumana la mayeza ukuba unentliziyo engaqhelekanga okanye ukuba iimvavanyo zibonisa ukuba amandla empompo egazi anciphile. Tshela ugqirha wakho ukuba ukhe wanalo naluphi na uhlobo lwesifo sentliziyo, isifo sentliziyo, okanye unyango lwe-radiation (x-ray) kunyango lwesifuba. Xelela ugqirha wakho kunye nosokhemesti ukuba uthatha okanye wakhe wafumana amayeza athile e-cyclophosphamide (Cytoxan), daunorubicin (Cerubidine, DaunoXome), epirubicin (Ellence), idarubicin (Idamycin), mitoxantrone (Novantrone), paclitaxel (Abraxane Onxol), trastuzumab (Herceptin), okanye verapamil (Calan, Isoptin). Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngokukhawuleza: ukuphefumla kancinci; ubunzima bokuphefumla; ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi; okanye ukukhawuleza, ukungahambi kakuhle, okanye ukubetha kwentliziyo.

I-Doxorubicin inokubangela ukwehla okukhulu kwinani leeseli zegazi kumongo wethambo lakho. Ugqirha wakho uya kuyalela iimvavanyo zaselebhu rhoqo ngaphambi nangexesha lonyango lwakho. Ukwehla kwenani leeseli zegazi emzimbeni wakho kunokubangela iimpawu ezithile kwaye kungonyusa umngcipheko wokuba ube nosulelo olubi okanye ukopha. Tshela ugqirha wakho kunye nosokhemesti ukuba uthatha i-azathioprine (Imuran), cyclosporine (Neoral, Sandimmune), methotrexate (Rheumatrex), okanye progesterone (Provera, Depo-Provera). Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngoko nangoko: umkhuhlane, umqala obuhlungu, ukukhohlela okuqhubekayo nokuxinana, okanye ezinye iimpawu zosulelo; ukopha okungaqhelekanga okanye ukugruzuka; enegazi okanye emnyama, ilindle; ukugabha kwegazi; okanye ukugabha igazi okanye izinto ezimdaka ezifana namabala ekofu.

I-Doxorubicin inokuwunyusa umngcipheko wokuba ne-leukemia (umhlaza weeseli ezimhlophe zegazi), ngakumbi xa inikwa ngeedosi eziphezulu okanye kunye namanye amayeza e-chemotherapy kunye nonyango lwe-radiation (x-ray).

Xelela ugqirha wakho ukuba ukhe unesifo sesibindi. Ugqirha wakho unokukuxelela ukuba akufuneki ufumane la mayeza okanye unokutshintsha idosi yakho ukuba unesifo sesibindi.

I-Doxorubicin kufuneka inikwe kuphela phantsi kweliso likagqirha onamava ekusebenziseni amayeza e-chemotherapy.

I-Doxorubicin isetyenziswa ngokudibanisa namanye amayeza ukunyanga iintlobo ezithile zesinyi, ibele, imiphunga, isisu kunye nomhlaza we-ovari; IHodgkin's lymphoma (isifo sikaHodgkin) kunye ne-non-Hodgkin's lymphoma (umhlaza oqala kwiiseli zomzimba); kunye neentlobo ezithile ze-leukemia (umhlaza weeseli ezimhlophe zegazi), kubandakanya i-lymphoblastic leukemia (YONKE) kunye ne-leukemia ye-myeloid (AML, ANLL). I-Doxorubicin ikwasetyenziswa yodwa kwaye idityaniswe namanye amayeza ukunyanga iintlobo ezithile zomhlaza wedlala lengqula kunye neentlobo ezithile zethishu ethambileyo okanye ithambo lesarcomas (umhlaza owenza izihlunu namathambo). Isetyenziselwa ukunyanga i-neuroblastoma (umhlaza oqala kwiiseli zemithambo-luvo kwaye kwenzeka ikakhulu ebantwaneni) kunye nethumba likaWilms (uhlobo lomhlaza wezintso olwenzeka ebantwaneni). I-Doxorubicin ikudidi lwamayeza abizwa ngokuba zii-anthracyclines. Isebenza ngokunciphisa okanye ukumisa ukukhula kweeseli zomhlaza emzimbeni wakho.

I-Doxorubicin iza njengesisombululo (ulwelo) okanye njengomgubo oxutywe kunye nolwelo oza kufakwa ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi kwiziko lonyango. Ihlala inikwa kube kanye kwiintsuku ezingama-21 ukuya kwezi-28. Ubude bonyango buxhomekeke kwiintlobo zamachiza owathathayo, ukuba umzimba wakho uphendula njani kuwo, kunye nohlobo lomhlaza onawo.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

I-Doxorubicin ngamanye amaxesha isetyenziselwa ukunyanga umhlaza wesibeleko, i-endometrium (ulwelwesi lwesibeleko), kunye nomlomo wesibeleko (ukuvulwa kwesibeleko); umhlaza wedlala lobudoda (umhlaza welungu lokuzala); umhlaza wepancreatic; umhlaza adrenocortical (umhlaza namadlala adrenal); umhlaza wesibindi; I-Kaposi's sarcoma enxulumene nesifo se-immunodeficiency syndrome (i-AIDS); I-Ewing’s sarcoma (uhlobo lomhlaza wamathambo) ebantwaneni; mesothelioma (umhlaza ngaphakathi kwesifuba okanye isisu); myeloma ezininzi (uhlobo lomhlaza womongo wethambo); kunye ne-lymphoblastic leukemia (CLL; uhlobo lomhlaza weeseli ezimhlophe zegazi). Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Phambi kokufumana inaliti yedoksorubicin,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-doxorubicin, i-daunorubicin (i-Cerubidine, i-DaunoXome), i-epirubicin (i-Ellence), i-idarubicin (i-Idamycin), nawaphi na amanye amayeza, okanye naziphi na izithako kwi-doxorubicin injection. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nokunye oku kulandelayo: amayeza athile e-chemotherapy anje nge cytarabine (DepoCyt), dexrazoxane (Zinecard), mercaptopurine (Purinethol), streptozocin (Zanosar); phenobarbital (iLuminal Sodium); okanye phenytoin (Dilantin). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza anokusebenzisana ne-doxorubicin, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ubukhe wanazo naziphi na iimeko zonyango.
• Kuya kufuneka uyazi ukuba i-doxorubicin inokuphazamisa umjikelo oqhelekileyo wokuya exesheni (ixesha) kubafazi kwaye inokumisa ukuveliswa kwesidoda emadodeni. Nangona kunjalo, awufanele ucinge ukuba awungekhe ukhulelwe okanye awungekhe umithise omnye umntu. Abasetyhini abakhulelweyo okanye abancancisayo kufuneka baxelele oogqirha babo ngaphambi kokuba baqale ukufumana eli chiza. Akufanele ukhulelwe okanye uncancise ngelixa ufumana inaliti ye-doxorubicin. Ukuba ukhulelwa ngelixa ufumana i-doxorubicin, tsalela ugqirha wakho. Sebenzisa indlela ethembekileyo yolawulo lokuzalwa ukukhusela ukukhulelwa. I-Doxorubicin inokwenzakalisa umntwana ongekazalwa.
• awunalo ugonyo ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

I-Doxorubicin inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• izilonda emlonyeni nasemqaleni
• ukulahleka kwesidlo (kunye nokulahleka kwesisindo)
• ukutyeba kwakho
• isisu esibuhlungu
• urhudo
• ukwanda kokoma
• ukudinwa okungaqhelekanga okanye ubuthathaka
• isiyezi
• ukulahleka kweenwele
• Ukwahlulwa kozipho okanye uzwane kwibhokisi yezipikili
• ukurhawuzelela, ukubomvu, amanzi, okanye ukucaphuka kwamehlo
• iintlungu zamehlo
• intlungu, ukutshisa, okanye ukubetha ezandleni nasezinyaweni
• umbala omnyama womchamo (kangangeentsuku ezi-1 ukuya kwezi-2 emva kwedosi)

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• urhwebo
• irhashalala
• ukurhawuzelela
• ubunzima bokuphefumla okanye ukugwinya
• ukuxhuzula

I-Doxorubicin inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• izilonda emlonyeni nasemqaleni
• umkhuhlane, umqala obuhlungu, ingqele, okanye ezinye iimpawu zosulelo
• ukopha okungaqhelekanga okanye ukugruzuka
• izitulo ezimnyama kunye nokulinda
• Igazi elibomvu ilindle
• ukugabha okunegazi
• Izinto ezigabileyo ezibonakala ngathi ziindawo zekofu

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-doxorubicin.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Adriamycin^®¶
• IRubex^®¶

• IHydroxydaunomycin Hydrochloride
• IHydroxydoxorubicin Hydrochloride

^¶ Le mveliso inophawu akusekho kwimarike. Ezinye iindlela ezinokubakho zinokubakho.