IGlyburide kunye neMetformin

Umxholo

• Ngaphambi kokuba uthathe i-glyburide kunye ne-metformin,
• Eli yeza linokubangela utshintsho kwiswekile yegazi lakho. Kuya kufuneka uyazi iimpawu zeswekile esezantsi kunye ephezulu yegazi kwaye wenzeni ukuba unayo le miqondiso.
• I-Glyburide kunye ne-metformin zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ukuba ufumana naziphi na kwezi mpawu zilandelayo okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:
• Iimpawu zokudlula ngaphezulu zinokubandakanya iimpawu zehypoglycemia kunye noku kulandelayo:

I-Metformin isenokungafane ibangele imeko enobungozi, esongela ubomi ebizwa ngokuba yi-lactic acidosis. Xelela ugqirha wakho ukuba unesifo sezintso. Ugqirha wakho uya kukuxelela ukuba ungathathi i-glyburide kunye ne-metformin. Kwakhona, xelela ugqirha wakho ukuba ungaphezulu kweminyaka engama-65 ubudala kwaye ukuba ukhe wahlaselwa sisifo sentliziyo; ukubetha; I-ketoacidosis yeswekile (iswekile esegazini ephezulu ngokwaneleyo ukuba ibangele iimpawu ezinzima kwaye ifuna unyango olungxamisekileyo); isiqaqa; okanye isifo sentliziyo okanye sesibindi. Xelela ugqirha wakho ukuba uthatha i-acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, eQsymia), okanye zonisamide (Zonegran).

Xelela ugqirha wakho ukuba ngaba ubusandula ukufumana ezi meko zilandelayo, okanye ukuba uziphuhlisa ngexesha lonyango: usulelo olubi; urhudo oluqatha, ukugabha, okanye umkhuhlane; okanye ukuba usela amanzi angaphantsi kunesiqhelo ngaso nasiphi na isizathu. Kuya kufuneka uyeke ukuthatha i-glyburide kunye ne-metformin de uchache.

Ukuba wenza utyando, kubandakanya utyando lwamazinyo, okanye nayiphi na inkqubo ephambili yonyango, xelela ugqirha ukuba uthatha i-glyburide kunye ne-metformin. Kwakhona, xelela ugqirha wakho ukuba uceba ukwenza nayiphi na inkqubo ye-x-ray apho idayi ifakwa khona, ngakumbi ukuba uyasela okanye wakha wasela utywala kakhulu okanye unesifo sesibindi okanye ukusilela kwentliziyo. Kuya kufuneka uyeke ukuthatha i-glyburide kunye ne-metformin ngaphambi kwenkqubo kwaye ulinde iiyure ezingama-48 ukuqala unyango kwakhona. Ugqirha wakho uza kukuxelela ngokuthe ngqo xa kufuneka uyeke ukuthatha i-glyburide kunye ne-metformin kwaye kufuneka uqale nini ukuyithatha kwakhona.

Ukuba ufumana naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-glyburide kunye ne-metformin kwaye ubize ugqirha ngoko nangoko: ukudinwa kakhulu, ubuthathaka, okanye ukungonwabi; isicaphucaphu; ukugabha; isisu esibuhlungu; ukunciphisa ukutya; ukuphefumla ngokunzulu nangokukhawuleza okanye ukuphefumla kancinci; isiyezi; intloko emhlophe; ngokukhawuleza okanye ukubetha kwentliziyo; ukutyibilika kolusu; iintlungu zemisipha; okanye uzive ubanda ezandleni okanye ezinyaweni.

Tshela ugqirha wakho ukuba uhlala usela utywala okanye ngamanye amaxesha usela izixa ezikhulu zotywala ngexesha elifutshane (ukuzinkcinkca ngotywala). Ukusela utywala kukonyusa umngcipheko wokuba ne-lactic acidosis okanye kunokubangela ukwehla kweswekile egazini. Ukusela utywala ngelixa uthatha i-glyburide kunye ne-metformin kunqabile kunokubangela iimpawu ezinjengokugungxula (ukububomvu kobuso), intloko ebuhlungu, isicaphucaphu, ukugabha, iintlungu zesifuba, ubuthathaka, umbono ophuthileyo, ukudideka kwengqondo, ukubila, ukukrwitsha, ubunzima bokuphefumla kunye noxinzelelo. Buza ugqirha wakho ukuba bungakanani utywala obukhuselekileyo xa ungasela i-glyburide kunye ne-metformin.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi nangexesha lonyango ukujonga ukuba zisebenza kakuhle kangakanani izintso zakho kunye nempendulo yomzimba wakho kwi-glyburide kunye ne-metformin. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-glyburide kunye ne-metformin.

Indibaniselwano ye-glyburide kunye ne-metformin isetyenziselwa ukunyanga uhlobo lweswekile (imeko apho umzimba ungasebenzisi i-insulin ngokwesiqhelo kwaye ngenxa yoko ayinakho ukulawula isixa seswekile esegazini) kubantu abanesifo seswekile esingenakulawulwa kukutya nokuzilolonga kuphela. IGlyburide ikudidi lwamachiza abizwa ngokuba yi-sulfonylureas, kwaye i-metformin ikudidi lweziyobisi ekuthiwa zii-biguanides. I-Glyburide yehlisa iswekile yegazi ngokubangela ukuba iipancreas zivelise i-insulin (into yendalo efunekayo ukophula iswekile emzimbeni) kunye nokunceda umzimba ukuba usebenzise i-insulin ngokufanelekileyo. Eli yeza liza kunceda ukunciphisa iswekile yegazi kubantu abanemizimba evelisa i-insulin ngokwendalo. I-Metformin inceda umzimba wakho ukulawula inani leswekile (iswekile) egazini lakho. Iyanciphisa inani leswekile oyifunxayo ekutyeni kwakho kunye nenani leswekile eyenziwe sisibindi sakho. Inceda umzimba wakho ukuba usebenzise i-insulin yayo ngokufanelekileyo. I-Glyburide kunye ne-metformin azisetyenziselwa ukunyanga uhlobo lweswekile 1 (imeko apho umzimba ungayivelisi i-insulin kwaye ngenxa yoko ayinakho ukulawula ubungakanani beswekile egazini) okanye isifo seswekile ketoacidosis (imeko enokubakho xa iswekile ephezulu yegazi inganyangwa ).

Ukudibana kweGlyburide kunye ne-metformin kuza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa amaxesha amabini ukuya kwemihla ngemihla ngokutya. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-glyburide kunye ne-metformin ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho uya kukuqala ngedosi esezantsi ye-glyburide kunye ne-metformin kwaye unokunyusa ngokuthe ngcembe idosi yakho, hayi ngaphezulu kwesinye kwiiveki ezi-2. kuxhomekeke kwimpendulo yakho. Jonga eswekile yegazi lakho ngokusondeleyo.

I-Glyburide kunye ne-metformin indibaniselwano ilawula isifo seswekile kodwa ayisinyangi. Qhubeka uthathe i-glyburide kunye ne-metformin nokuba uziva uphilile. Sukuyeka ukuthatha i-glyburide kunye ne-metformin ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

La mayeza ngamanye amaxesha amiselweyo kwezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-glyburide kunye ne-metformin,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-glyburide, i-metformin, nasiphi na isithako esikwi-glyburide kunye neepilisi ze-metformin, okanye nawaphi na amanye amayeza. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-bosentan (Tracleer). Ugqirha wakho unokukuxelela ukuba ungathathi i-glyburide ukuba uthatha eli yeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amiloride (Midamor); i-angiotensin-converting enzyme (ACE) inhibitors enjenge benazepril (Lotensin, eLotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon) , ramipril (Altace), kunye netrandolapril (Mavik); ii-anticoagulants (’izinciphisi zegazi’) ezifana ne-warfarin (Coumadin, Jantoven); i-aspirin okanye ezinye iziyobisi ezichasayo (i-NSAIDs) ezinje nge-ibuprofen (Advil, Motrin) okanye naproxen (Aleve, Naprosyn); ii-beta-blockers ezinje nge-atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, eCorzide), kunye nepropranolol (Hemangeol, Inderal, InnoPran); iicalcium block blockers ezinje ngeamlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), okanye verapamil (Calan, Covera, Verelan, in Tarka); ichloramphenicol; cimetidine (iTagamet); i-clarithromycin (i-Biaxin, kwi-Prevpac); icyclosporine (Gengraf, Neoral, Sandimmune); idigoxin (Lanoxin); iDisopyramide (iNorpace); umchamo ('iipilisi zamanzi'); i-fluconazole (iDiflucan); fluoxetine (Prozac, Sarafem, Selfemra); i-furosemide (iLasix); Unyango lwehormone; i-insulin okanye amanye amayeza eswekile; isoniazid (Laniazid, eRifamate, eRifater); I-MAO inhibitors ezifana ne-isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), kunye ne-tranylcypromine (iParnate); amayeza e-allergies, i-asthma kunye nokubanda; amayeza okugula ngengqondo kunye nesicaphucaphu; miconazole (Lotrimin, Monistat, nabanye); morphine (MS Contin, ezinye); niacin; izinto zokucwangcisa ngomlomo (iipilisi zolawulo lokuzalwa); i-steroids yomlomo efana ne-dexamethasone, i-methylprednisolone (iMedrol), kunye ne-prednisone (iRayos); phenytoin (iDilantin, iPhenytek); probenecid (iBenemid, eColbenemid); ukuvelisa; quinidine (kwiNuedexta); ikwinine; I-quinolone kunye ne-fluoroquinolone antibiotics efana ne-cinoxacin (engasafumaneki e-US, Cinobac), ciprofloxacin (Cipro), enoxacin (engasekhoyo e-US, Penetrex), gatifloxacin, levofloxacin (Levaquin), lomefloxacin (ayisafumaneki e-US , Maxaquin), moxifloxacin (Avelox), nalidixic acid (ayisafumaneki e-US, NegGram), norfloxacin (ayisafumaneki e-US, Noroxin), ofloxacin (ayisafumaneki e-US, Floxin), sparfloxacin iyafumaneka e-US, Zagam), trovafloxacin kunye ne-alatrofloxacin indibaniselwano (ayisafumaneki e-US, Trovan); i-ranitidine (iZantac); rifampin; Intlungu ye-salicylate iyanciphisa njenge-choline magnesium trisalicylate, i-choline salicylate (Arthropan), i-diflunisal, i-magnesium salicylate (i-Doan's, abanye), okanye i-salsalate (i-Argesic, i-Disalcid, i-Salgesic); i-sulfa antibiotics njenge-cotrimoxazole (Bactrim, Septra); isulfasalazine (Azulfidine); amayeza e-thyroid; triamterene (Dyrenium, eMaxzide, abanye); itrimethoprim (Primsol, eBactrim, ngoSeptra); okanye i-vancomycin (iVancocin, abanye).
• Ukongeza kwiimeko ezidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, xelela ugqirha wakho ukuba wena okanye naliphi na ilungu losapho lwakho unaso okanye wakha wanesiphene se-G6PD (imeko efunyanwa njengelifa ebangela ukutshatyalaliswa kwangaphambili kweeseli ezibomvu zegazi okanye i-hemolytic anemia); xelela ugqirha wakho ukuba ukhe okanye wakha wanengxaki yehomoni ebandakanya iadrenal, pituitary, okanye idlala lengqula; okanye i-acidosis engapheliyo okanye engapheliyo.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-glyburide kunye ne-metformin, tsalela ugqirha wakho.
• cwangcisa ukuthintela ukukhanya elangeni ngokungeyomfuneko okanye ixesha elide kunye nokunxiba impahla ekhuselayo, iiglasi zelanga kunye nescreen selanga. I-Glyburide kunye ne-metformin zingenza ulusu lwakho luthathise ilanga.
• xelela ugqirha wakho ukuba utya kancinci okanye usebenze kakhulu kunesiqhelo. Oku kunokuchaphazela iswekile yegazi lakho. Ugqirha wakho uya kukunika imiyalelo ukuba oku kuyenzeka.

Qiniseka ukuba ulandela yonke imithambo kunye nezincomo zokutya ezenziwe ngugqirha wakho okanye ugqirha otya ukutya. Kubalulekile ukutya ukutya okusempilweni.

Ngaphambi kokuba uqale ukuthatha i-glyburide kunye ne-metformin, buza ugqirha wakho ukuba wenzeni ukuba ulibale ukuthatha idosi okanye ngempazamo uthathe idosi eyongezelelweyo. Bhala le miyalelo phantsi ukuze ubhekise kubo kamva.

Njengomgaqo ngokubanzi, thabatha idosi ephosiweyo kwakamsinya nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Eli yeza linokubangela utshintsho kwiswekile yegazi lakho. Kuya kufuneka uyazi iimpawu zeswekile esezantsi kunye ephezulu yegazi kwaye wenzeni ukuba unayo le miqondiso.

I-Glyburide kunye ne-metformin zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isisu esibuhlungu
• isicaphucaphu okanye ukugabha
• urhudo
• isiyezi

Ukuba ufumana naziphi na kwezi mpawu zilandelayo okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• iintlungu zesifuba
• irhashalala
• mthubi ulusu okanye amehlo
• izitulo ezikhanyayo
• umchamo omnyama
• iintlungu kwindawo ephezulu yesisu
• ukopha okungaqhelekanga okanye ukugruzuka
• ifiva
• umqala obuhkungu
• ukudumba kwamehlo, ubuso, imilebe, ulwimi, okanye umqala

Kwesinye isifundo, abantu abathathe iyeza elifana ne-glyburide ukunyanga isifo seswekile kunokwenzeka ukuba babulawe ziingxaki zentliziyo kunabantu ababephathwe nge-insulin kunye notshintsho ekutyeni.

I-Glyburide kunye ne-metformin zinokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya, ubushushu obungaphaya, kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya iimpawu zehypoglycemia kunye noku kulandelayo:

• ukuxhuzula
• ukulahleka kwengqondo
• ukudinwa kakhulu
• ubuthathaka
• ukungonwabi
• ukugabha
• isicaphucaphu
• isisu esibuhlungu
• ukunciphisa ukutya
• ukuphefumla okunzulu, okukhawulezayo
• ukuqhawukelwa ngumphefumlo
• isiyezi
• intloko elula
• ukukhawuleza kwentliziyo okanye ukubetha kwentliziyo
• Ukuhluza ulusu
• iintlungu zemisipha
• ndiziva ndibanda

Ugqirha wakho uza kukuxelela indlela yokujonga impendulo yakho kwi-glyburide kunye ne-metformin ngokulinganisa amanqanaba eswekile yegazi ekhaya. Landela le miyalelo ngononophelo.

Kufuneka usoloko unxibe isacholo esichaza isifo seswekile ukuze uqiniseke ukuba ufumana unyango olufanelekileyo ngexesha likaxakeka.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Iglucovance^® (Iqulethe iGlyburide, Metformin)