I-Aimovig (i-erenumab-aooe)

Umxholo

• Yintoni iAimovig?
• Uhlobo olutsha lweziyobisi
• I-Aimovig generic
• Iziphumo ebezingalindelekanga zeAimovig
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• Ukuphendula ngokuchaseneyo
• Ukuthoba umzimba / ukutyeba
• Iziphumo zexesha elide
• Ukuqunjelwa
• Ukulahleka kweenwele
• Isicaphucaphu
• Ukudinwa
• Urhudo
• Ukuphuthelwa
• Intlungu yezihlunu
• Ukurhawuzelela
• Iindleko zeAimovig
• Uncedo lwezezimali
• Ukusetyenziswa kweAimovig
• I-Aimovig yentloko ye-migraine
• Ukusetyenziswa okungavunyelwanga
• Idosi yeAimovig
• Iifom kunye namandla
• Isisombululo semigraine
• Kuthekani ukuba ndiphose idosi?
• Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?
• Ezinye iindlela zeAimovig
• Abachasi be-CGRP
• I-Aimovig vs. nezinye iziyobisi
• I-Aimovig vs. Ajovy
• I-Aimovig vs. iBotox
• I-Aimovig ngokuchasene nobuGcisa
• I-Aimovig vs.Topamax
• I-Aimovig kunye notywala
• Unxibelelwano lwe-Aimovig
• Indlela i-Aimovig eyenziwe ngayo
• Imiyalelo malunga nendlela yokuthatha iAimovig
• Ungayifaka njani inaliti
• Ixesha
• Ukuthatha i-Aimovig ngokutya
• Ukugcina
• Isebenza njani iAimovig
• Kuthatha ixesha elingakanani ukusebenza?
• I-Aimovig kunye nokukhulelwa
• I-Aimovig kunye nokuncancisa
• Imibuzo eqhelekileyo malunga neAimovig
• Ngaba ukumisa i-Aimovig kubangela ukurhoxa?
• Ngaba iAimovig yi-biologic?
• Ngaba unokusebenzisa iAimovig ukunyanga i-migraine?
• Ngaba iAimovig iyayinyanga imigraine?
• U-Aimovig wahluke njani kwezinye iziyobisi ze-migraine?
• Ukuba ndithatha i-Aimovig, ndingayeka ukuthatha amanye amayeza am okuthintela?
• Libanda elingaphezulu kwe-Aimovig
• Iimpawu libanda
• Kufuneka wenze ntoni xa uthe wagqithisa?
• Izilumkiso zeAimovig
• Ukupheliswa kweAimovig kunye nokugcinwa
• Ulwazi lobungcali lweAimovig
• Indlela yokusebenza
• I-Pharmacokinetics kunye ne-metabolism
• Ukungqinelana
• Ukugcina

Yintoni iAimovig?

I-Aimovig ligama lonyango elichazayo elisetyenziselwa ukukhusela iintlungu kubantu abadala. Iza ngepeni ye-autoinjector ekhethiweyo. Usebenzisa i-autoinjector ukuze uzinike inaliti ekhaya kanye ngenyanga. I-Aimovig inokumiselwa kwiidosi ezimbini: i-70 mg ngenyanga okanye i-140 mg ngenyanga.

I-Aimovig iqulethe ichiza erenumab. I-Erenumab yi-monoclonal antibody, eluhlobo lwesiyobisi esenziwe kwilebhu. Amachiza omzimba monoclonal ngamachiza enziwe ngeeseli zomzimba. Basebenza ngokuthintela umsebenzi weeproteni ezithile emzimbeni wakho.

I-Aimovig inokusetyenziselwa ukuthintela zombini i-episodic migraine kunye ne-migraine engapheliyo. Umbutho weNtloko yeNtloko waseMelika ucebisa iAimovig kubantu:

• ayinakunciphisa inani labo lokuqaqanjelwa yintloko rhoqo ngenyanga namanye amachiza
• ngekhe uthathe amanye amayeza e-migraine ngenxa yeziphumo ebezingalindelekanga okanye ukuhlangana kweziyobisi

I-Aimovig ibonakalisiwe ukuba iyasebenza kwizifundo zeklinikhi. Kubantu abane-episodic migraine, phakathi kweepesenti ezingama-40 kunye neepesenti ezingama-50 zabo bathathe i-Aimovig iinyanga ezintandathu banciphisa inani labo leentsuku ze-migraine ngesiqingatha ubuncinci. Kwaye kubantu abane-migraine engapheliyo, malunga neepesenti ezingama-40 zabo bathathe i-Aimovig banciphisa inani labo leentsuku ze-migraine ngesiqingatha okanye ngaphezulu.

Uhlobo olutsha lweziyobisi

I-Aimovig yinxalenye yodidi olutsha lwamayeza abizwa ngokuba yi-calcitonin enxulumene ne-peptide (CGRP) echasene ne-gene. Olu hlobo lweziyobisi lwenzelwe ukukhusela iintlungu zentloko.

U-Aimovig ufumene ukuvunywa kwe-Food and Drug Administration (FDA) ngoMeyi ka-2018. Yayilunyango lokuqala ukuvunywa kwiklasi ye-CGRP echasene namachiza.

Amanye amachiza amabini kule klasi yamayeza avunywa emva kwe-Aimovig: Ubume (galcanezumab) kunye no-Ajovy (fremanezumab). Iyeza lesine, elibizwa ngokuba yi-eptinezumab, ngoku lifundwa kwizilingo zeklinikhi.

I-Aimovig generic

I-Aimovig ayifumaneki ngendlela eqhelekileyo. Kuza kuphela njengonyango lwegama lophawu.

I-Aimovig iqulethe ichiza i-erenumab, ekwabizwa ngokuba yi-erenumab-aooe. Ukuphela "-aooe" ngamanye amaxesha kongezwa ukubonisa ukuba iyeza lahlukile kumayeza afanayo anokwenziwa kwixesha elizayo. Ezinye iziyobisi ze-monoclonal antibody nazo zineefomathi zamagama ezinje.

Iziphumo ebezingalindelekanga zeAimovig

I-Aimovig inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha iAimovig. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga ezinokubakho zeAimovig, okanye iingcebiso ngendlela yokujongana neziphumo ebezingalunganga, thetha nogqirha okanye usokhemesti.

Phawula: Ukutya kunye noLawulo lweeDrug (FDA) kulandelela iziphumo ebezingalindelekanga ezivunyiweyo. Ukuba ungathanda ukunika ingxelo kwi-FDA isiphumo esibuhlungu onaso nge-Aimovig, ungakwenza oko ngeMedWatch.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo eziqhelekileyo ze-Aimovig zingabandakanya:

• Ukuphendula kwendawo yenaliti (ububomvu, ulusu olurhawuzayo, iintlungu)
• ukuqhina
• izihlunu zemithambo
• ukudumba kwezihlunu

Uninzi lweziphumo ebezingalindelekanga zinokuhamba emva kweentsuku ezimbalwa okanye iiveki ezimbalwa. Biza ugqirha wakho okanye usokhemesti ukuba uneziphumo ebezingalindelekanga ezibi kakhulu okanye iziphumo ezingahambiyo.

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezimandundu ezivela kuAimovig zinokwenzeka, kodwa aziqhelekanga. Isiphumo esibi kakhulu se-Aimovig sisisombululo esibi kakhulu. Jonga ngezantsi iinkcukacha.

Ukuphendula ngokuchaseneyo

Abanye abantu banokuphendula emva kokuthatha i-Aimovig. Olu hlobo lokuphendula lunokwenzeka ngamayeza amaninzi. Iimpawu zokuphendula kancinci kunokubandakanya:

• ukuba nerhashalala kulusu lwakho
• ukuziva urhawuzelele
• Ukuhlanjululwa (ukufudumala nokubomvu kwesikhumba sakho)

Rhoqo, kusenokwenzeka ukuba uxabane olunamandla ngakumbi lunokubakho. Iimpawu zokungabikho komzimba okunokubandakanya:

• ukudumba phantsi kolusu lwakho (ubukhulu becala kwizinkophe zakho, imilebe, izandla, okanye iinyawo)
• ukuziva uphefumla kancinci okanye unengxaki yokuphefumla
• ukudumba kulwimi lwakho, emlonyeni, nasemqaleni

Fowunela ugqirha ngoko nangoko ukuba ucinga ukuba unengxaki ye-Aimovig. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba unengxaki kaxakeka kwezonyango.

Ukuthoba umzimba / ukutyeba

Ukuphulukana nobunzima kunye nokufumana ubunzima akuzange kuxelwe kwizifundo zeklinikhi zeAimovig. Nangona kunjalo, abanye abantu banokubona utshintsho kubunzima babo ngexesha lonyango lwe-Aimovig. Oku kunokuba ngenxa ye-migraine uqobo kune-Aimovig.

Abanye abantu abanokuziva belambile ngaphambi, ngexesha, okanye emva kwentloko ebuhlungu. Ukuba oku kwenzeka rhoqo ngokwaneleyo, kunokukhokelela ekulahlekeni kobunzima obungafunekiyo. Ukuba ulahlekelwa ngumdla wakho xa unentloko ebuhlungu, sebenza nogqirha wakho ukwenza isicwangciso sokutya esiqinisekisa ukuba ufumana zonke izondlo ozifunayo.

Kwelinye icala lesiphelo, ukuzuza ubunzima okanye ukutyeba kuqhelekile kubantu abane-migraine. Kwaye izifundo zeklinikhi zibonise ukuba ukutyeba kakhulu kunokuba ngumngcipheko wokuqaqanjelwa yintloko ye-migraine okanye iintlungu ezixhaphakileyo zentloko.

Ukuba unomdla malunga nokuba ubunzima bakho buchaphazela njani intloko yakho ye-migraine, thetha nogqirha wakho malunga neendlela zokulawula ubunzima bakho.

Iziphumo zexesha elide

I-Aimovig liyeza elisandula ukwamkelwa kwiklasi entsha yamachiza. Ngenxa yoko, kukho uphando oluncinci kakhulu lwexesha elide olufumanekayo kukhuseleko luka-Aimovig, kwaye kuncinci okwaziwayo malunga neziphumo zexesha elide.

Kwisifundo esinye sokhuseleko lwexesha elide esiye saqhubeka kangangeminyaka emithathu, iziphumo ebezingalindelekanga ezixhaphakileyo ezichazwe kwiAimovig zezi:

• umqolo obuhlungu
• usulelo oluphezulu lokuphefumla (njengokubanda okuqhelekileyo okanye usulelo lwe-sinus)
• Iimpawu ezinjengomkhuhlane

Ukuba uneziphumo ebezingalindelekanga kwaye zinobuzaza okanye azihambi, thetha nogqirha wakho.

Ukuqunjelwa

Ukuqunjelwa kwenzeke kwiipesenti ezi-3 zabantu abathathe i-Aimovig kwizifundo zeklinikhi.

Iziphumo ebezingalindelekanga zinokubangelwa yindlela i-Aimovig echaphazela ngayo i-peptide enxulumene nemfuza ye-calcitonin (CGRP) emzimbeni wakho. I-CGRP yiprotein enokufunyanwa emathunjini kwaye idlale indima ekuhambeni okuqhelekileyo kwamathumbu. I-Aimovig ibhloka umsebenzi we-CGRP, kwaye eli nyathelo linokuthintela ukuhamba kwesiqhelo ngokuqhelekileyo.

Ukuba ufumana ukuqunjelwa ngexesha lonyango kunye neAimovig, thetha nogqirha wakho okanye usokhemesti malunga namayeza anokukunceda.

Ukulahleka kweenwele

Ukulahleka kweenwele ayisiyompembelelo esecaleni enxulunyaniswe neAimovig. Ukuba ufumanisa ukuba uphulukana neenwele, thetha nogqirha wakho malunga nonobangela kunye nonyango.

Isicaphucaphu

Isicaphucaphu asiyompembelelo esecaleni echazwe ngokusetyenziswa kweAimovig. Nangona kunjalo, abantu abaninzi abane-migraine banokuziva benesicaphucaphu xa beqaqanjelwa yintloko.

Ukuba uziva unesiyezi xa uqaqanjelwa yintloko, inokukunceda uhlale kwigumbi elimnyama nelithuleyo, okanye uphume phandle uye kufumana umoya omtsha. Unokucela ugqirha wakho okanye usokhemesti malunga namayeza anokunceda ukuthintela okanye ukunyanga isicaphucaphu.

Ukudinwa

Ukukhathala (ukunqongophala kwamandla) asiyompembelelo esecaleni edityaniswe neAimovig. Kodwa ukuziva udiniwe luphawu oluqhelekileyo lwe-migraine abantu abaninzi abaziva ngayo ngaphambi, ngexesha, okanye emva kwentloko ye-migraine eyenzekayo.

Olunye uphononongo lweklinikhi lubonise ukuba abantu abane-migraine abanentloko ebuhlungu ngakumbi banokuziva bekhathele.

Ukuba ukhathazwa kukudinwa, thetha nogqirha wakho malunga neendlela zokuphucula amanqanaba akho amandla.

Urhudo

Urhudo asiyompembelelo esecaleni echazwe ngokusetyenziswa kweAimovig. Nangona kunjalo, luphawu olunqabileyo lwe-migraine. Kunokubakho unxibelelwano phakathi kwe-migraine kunye nesifo sokukrala kwamathumbu kunye nezinye iingxaki zesisu.

Ukuba unesifo sohudo esihlala ixesha elide kuneentsuku ezimbalwa, thetha nogqirha wakho.

Ukuphuthelwa

Ukuphuthelwa (ingxaki yokulala) asiyompembelelo esecaleni eye yafunyanwa kwizifundo zeklinikhi zeAimovig. Nangona kunjalo, uphando oluthile lweklinikhi lufumene ukuba abantu abane-migraine abanesifo sokulala bavame ukuba neentloko ze-migraine eziqhelekileyo. Ngapha koko, ukunqongophala kokulala kunokuba sisizathu sokuqaqanjelwa yintloko kunye nokunyusa umngcipheko wokuba ne-migraine engapheliyo.

Ukuba ulala kwaye ucinga ukuba inokuchaphazela intloko yakho ye-migraine, thetha nogqirha wakho malunga neendlela zokulala ngcono.

Intlungu yezihlunu

Kwizifundo zeklinikhi, abantu abafumene i-Aimovig khange bafumane zintlungu jikelele. Abanye babenemikhwa yemisipha kunye ne-spasms, kwaye kufundo lwexesha elide lokhuseleko, abantu abathatha i-Aimovig bafumana iintlungu zangasemva.

Ukuba uneentlungu zomzimba ngelixa uthatha i-Aimovig, kunokuba ngenxa yezinye izizathu. Umzekelo, iintlungu zemisipha entanyeni inokuba luphawu lwe-migraine kwabanye abantu. Kwakhona, ukusabela kwendawo yenaliti, kubandakanya iintlungu kwindawo ejikeleze inaliti, kunokuziva ngathi zintlungu zemisipha. Olu hlobo lwentlungu kufuneka luhambe zingaphelanga iintsuku ezimbalwa zenaliti.

Ukuba unentlungu yomzimba engapheli okanye echaphazela umgangatho wobomi bakho, thetha nogqirha wakho malunga nokukhetha intlungu.

Ukurhawuzelela

Ukurhawuzelela ngokubanzi ayisosiphumo esibi esibonwe kwizifundo zeklinikhi zeAimovig. Nangona kunjalo, ulusu olurhawuzayo kwindawo apho i-Aimovig itofwe khona kuxelwa rhoqo.

Ulusu olurhawuzayo kufutshane nendawo yenaliti kufuneka luhambe zingaphelanga iintsuku ezimbalwa. Ukuba unobuncwane obungapheliyo, okanye ukuba ukurhawuzelela kunzima, thetha nogqirha wakho.

Iindleko zeAimovig

Njengawo onke amayeza, amaxabiso e-Aimovig ayahluka.

Ixabiso lakho liya kuxhomekeka kwi-inshurensi yakho, indawo okuyo, kunye nekhemesti oyisebenzisayo.

Uncedo lwezezimali

Ukuba ufuna inkxaso yemali ukuhlawula i-Aimovig, uncedo luyafumaneka.

U-Amgen no-Novartis, abavelisi be-Aimovig, banikezela ngenkqubo yeKhadi lokuFikelela le-Aimovig Ally elinokukunceda ubhatale kancinci kugqitywe ngandlela nganye. Ngolwazi oluthe kratya kunye nokufumanisa ukuba uyafaneleka na, tsalela umnxeba ku-833-246-6844 okanye undwendwele iwebhusayithi yenkqubo.

Ukusetyenziswa kweAimovig

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anje ngeAimovig ukunyanga okanye ukuthintela iimeko ezithile.

I-Aimovig yentloko ye-migraine

I-Aimovig ivunyiwe yi-FDA kuthintelo lwentloko ye-migraine kubantu abadala. Ezi ntloko zibukhali zezona mpawu zixhaphakileyo zemigraine, imeko ye-neurological.

Ezinye iimpawu zinokuthi zenzeke ngentloko yentloko, njenge:

• isicaphucaphu
• ukugabha
• uvakalelo ekukhanyeni nakwisandi
• unengxaki yokuthetha

I-Migraine inokuhlelwa njenge-episodic okanye engapheliyo, ngokwe-International Headache Society. I-Aimovig ivunyiwe ukukhusela zombini i-episodic migraine kunye neentloko ezingapheliyo zentloko. Ukwahluka phakathi kwezi ntlobo ze-migraine zi:

• I-episodic migraine ibangela iintlungu ezingaphantsi kwe-15 zentloko okanye iintsuku ze-migraine ngenyanga
• I-migraine engapheliyo ibangela i-15 okanye ngaphezulu kweentsuku zentloko ngenyanga ngaphezulu kweenyanga ezintathu, ubuncinci iintsuku ezisibhozo zibe ziintsuku zemigraine.

Ukusetyenziswa okungavunyelwanga

I-Aimovig inokusetyenziselwa ngaphandle kwelebheli kwezinye iimeko. Ukusetyenziswa kwelebula engekho xa kusebenze iyeza elamkelweyo lokunyanga imeko enye emiselweyo ukunyanga imeko eyahlukileyo.

I-Aimovig yeentloko zentloko ezisebenzisanayo

I-Aimovig ayivunyelwanga yi-FDA ukuthintela iintloko zentloko, kodwa inokusetyenziselwa ngaphandle kwelebheli ukulungiselela le njongo. Okwangoku ayaziwa ukuba iAimovig iyasebenza ekuthinteleni iintloko zentloko ezisebenzisanayo.

Iintloko zentloko ezisebenzisanayo zintlungu ezibuhlungu ezenzeka ngokwamaqela (iintloko ezininzi zithuba nje elifutshane). Banokuba zi-episodic okanye ezingapheliyo. Iintloko zeentloko ze-Episodic zinamaxesha amade phakathi kwamaqoqo entloko. Iintloko zentloko engapheliyo inexesha elifutshane phakathi kwamaqoqo entloko.

I-Aimovig khange ivavanyelwe ukuthintela iintloko zeklasta kwizifundo zeklinikhi. Nangona kunjalo, ezinye iziyobisi ezikwiklasi enye yamayeza njenge-Aimovig, kubandakanya ne-Emgality kunye ne-Ajovy, ziye zavavanywa.

Kwisifundo esinye seklinikhi, u-Emgality wafunyanwa ekuncedeni ukuthintela iintloko zeentloko ze-episodic. Kodwa kuvavanyo lweklinikhi luka-Ajovy, umenzi weziyobisi wayeka ukufunda kwangoko kuba u-Ajovy wayengasebenzi ukunciphisa inani leentloko ezingapheliyo zabantu abasesifundweni.

I-Aimovig yeentloko ze vestibular

I-Aimovig ayivunyelwanga yi-FDA ukuthintela okanye ukunyanga iintloko zentloko. Intloko ye-Vestibular yahlukile kwi-classic migraine yentloko kuba ihlala ingebuhlungu. Abantu abaneentloko ze-vestibular banokuziva benesiyezi okanye amava e-vertigo. Ezi mpawu zinokuhlala imizuzwana ukuya kwiiyure.

Izifundo zeklinikhi khange zenziwe ukubonisa ukuba i-Aimovig iyasebenza ekuthinteleni okanye ekunyangeni i-vestibular headaches. Kodwa abanye oogqirha basenokukhetha ukumisela iyeza ngaphandle kwelebheli kule meko.

Idosi yeAimovig

Umthamo we-Aimovig ogqirha ugqirha wakho aya kuxhomekeka kwizinto ezininzi. Oku kubandakanya ubuzaza bemeko oyisebenzisayo ukunyanga i-Aimovig.

Ngokuqhelekileyo, ugqirha wakho uya kukuqala kwiqondo eliphantsi kwaye ulungelelanise ixesha elide ukufikelela kumthamo olungele wena. Ekugqibeleni baya kumisela idosi encinci enika isiphumo esifunekayo.

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, qiniseka ukuthatha idosi ekumisela ugqirha wakho. Ugqirha wakho uya kumisela eyona idosi ilungele iimfuno zakho.

Iifom kunye namandla

I-Aimovig iza ngethamo elinye, i-autoinjector ekhethiweyo esetyenziselwa ukunika inaliti engaphantsi (inaliti ehamba phantsi kolusu). I-autoinjector iza ngamandla omnye: 70 mg ngenaliti nganye. I-autoinjector nganye yenzelwe ukuba isetyenziswe kube kanye kuphela emva koko ilahlwe.

Isisombululo semigraine

I-Aimovig inokumiselwa ngeedosi ezimbini: 70 mg okanye i-140 mg. Nokuba ithathwa ithathwa kanye ngenyanga.

Ukuba ugqirha wakho ukumisela i-70 mg, uya kunika inaliti enye ngenyanga (usebenzisa i-autoinjector enye). Ukuba ugqirha wakho ukumisela i-140 mg, uya kunika inaliti ezimbini ngenyanga, enye ilandele enye (usebenzisa ii-autoinjectors ezimbini).

Ugqirha wakho uza kuqala unyango kwi-70 mg ngenyanga. Ukuba le dosi ayinciphisi inani lakho leentsuku ze-migraine ngokwaneleyo, ugqirha wakho unokunyusa idosi yakho ukuya kwi-140 mg ngenyanga.

Kuthekani ukuba ndiphose idosi?

Thatha idosi kwangoko nje ukuba uqaphele ukuba uphose enye. Idosi yakho elandelayo kufuneka ibe yinyanga enye emva kwayo. Khumbula umhla omtsha ukuze ukwazi ukucwangcisela iidosi zakho zekamva.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

Ukuba i-Aimovig iyasebenza ekuthinteleni iintlungu zentloko yakho, wena nogqirha wakho ninokuthatha isigqibo sokuqhubeka nonyango nge-Aimovig ixesha elide.

Ezinye iindlela zeAimovig

Amanye amachiza ayafumaneka ukunceda ukuthintela intloko ebuhlungu. Abanye banokukusebenzela ngcono kunabanye. Ukuba unomdla wokuzama unyango ngaphandle kwe-Aimovig, thetha nogqirha wakho ukuze ufunde ngakumbi ngamanye amachiza anokukusebenzela.

Imizekelo yamanye amayeza avunyiweyo yi-FDA ukuthintela iintloko zentloko ebandakanya:

• ezinye i-peptide ezinxulumene noluhlobo lwe-calcitonin (CGRP):
• fremanezumab-vrfm (Ajovy)
• galcanezumab-gnlm (Ubume)
• amayeza athile okubanjwa, anje ngala:
• i-divalproex sodium (iDepakote)
• itopiramate (iTopamax, iTrokendi XR)
• i-neurotoxin onabotulinumtoxinA (Botox)
• i-beta-blocker propranolol (Inderal, Inderal LA)

Amanye amayeza asetyenziswa ngaphandle kwelebheli ukukhusela iintlungu zentloko. La mayeza aquka:

• ezinye i-anti-depressants, ezinje nge-amitriptyline okanye venlafaxine (Effexor XR)
• amanye amayeza okubamba, njenge-valproate sodium
• ezinye ii-beta-blockers, ezinje nge-metoprolol (Lopressor, Toprol XL) okanye i-atenolol (Tenormin)

Abachasi be-CGRP

I-Aimovig yinxalenye yodidi olutsha lwamachiza abizwa ngokuba yi-calcitonin enxulumene nopept peptide (CGRP) antagonists. I-Aimovig yamkelwe yi-FDA kwi-2018 ukukhusela iintlungu zentloko. Abanye ababini abachasene ne-CGRP ababizwa ngokuba yi-Ajovy kunye ne-Emgality nabo bavunyelwe kutsha nje. Iyeza lesine kweli klasi (eptinezumab) kulindeleke ukuba livunywe kungekudala.

Indlela abasebenza ngayo

Abachasene ne-CGRP abachaphazelekayo basebenza ngeendlela ezifanayo zokuthintela iintloko zentloko.

I-CGRP yiprotein emzimbeni wakho edityaniswe nokudumba kunye ne-vasodilation (ukwandiswa kwemithambo yegazi) kwingqondo. Oku kudumba kunye ne-vasodilation kunokubangela iintlungu ezivela kwintloko ebuhlungu. Ukwenza ezi ziphumo, i-CGRP kufuneka ibophe (incamathele) kwii-receptors zayo, eziziziza ezikwezinye iiseli zengqondo yakho.

I-Ajovy kunye ne-Emgality zombini ziyasebenza ngokuzibophelela kwi-CGRP uqobo. Ngenxa yoko, i-CGRP ayinakubopha kwii-receptors zayo. Ngokungafaniyo namanye amachiza amabini akweli klasi, i-Aimovig isebenza ngokubophelela kwii-receptors zeseli zobuchopho. Oku kuthintela i-CGRP ekwenzeni oku.

Ngokuthintela i-CGRP ekusebenzisaneni ne-receptor yayo, zontathu iziyobisi zinceda ukuyeka ukudumba kunye ne-vasodilation. Oku kunokukunceda ukukhusela i-migraine intloko.

Icala ngecala

Ishati engezantsi ithelekisa ulwazi olusisiseko malunga neziyobisi ezintathu ezivunyiweyo ze-FDA kule klasi ezisetyenziselwa ukuthintela iintloko zentloko. Ukufunda ngakumbi ngendlela i-Aimovig ethelekiswa ngayo nezinye iziyobisi, jonga eli candelo lilandelayo ("Aimovig vs. other drug").

Amaxabiso anokuhluka ngokuxhomekeka kwindawo okuyo, ikhemesti esetyenzisiweyo, i-inshurensi yakho, kunye neenkqubo zoncedo lomenzi.

I-Aimovig vs. nezinye iziyobisi

Usenokuzibuza ukuba i-Aimovig ithelekisa njani namanye amayeza anikwe ukusetyenziswa okufanayo. Apha ngezantsi kukho uthelekiso phakathi kweAimovig kunye namayeza aliqela.

I-Aimovig vs. Ajovy

I-Aimovig iqulethe ichiza i-erenumab, eyi-monoclonal antibody. I-Ajovy iqulethe ichiza i-fremanezumab, ekwangumzimba omzimba omnye. Iintsholongwane zeMonoclonal ngamayeza enziwe elebhu. La machiza avela kwiiseli zomzimba zokuzikhusela. Basebenza ngokuthintela umsebenzi weeproteni ezithile emzimbeni wakho.

I-Aimovig kunye ne-Ajovy bobabini bayeke umsebenzi weprotein ebizwa ngokuba yi-calcitonin enxulumene ne-peptide (CGRP). I-CGRP ibangela ukudumba kunye ne-vasodilation (ukwandiswa kwemithambo yegazi) kwingqondo, enokubangela iintlungu zentloko. Ukuthintela i-CGRP kunceda ukuthintela iintloko zentloko.

Sebenzisa

I-Aimovig kunye ne-Ajovy bobabini bavunyelwe yi-FDA ukuthintela iintloko zentloko kubantu abadala.

Iifom kunye nolawulo

I-Aimovig kunye ne-Ajovy bobabini beza kwifom yenaliti elawulwa phantsi kolusu lwakho (subcutaneous). Ungazinika inaliti ngokwakho ekhaya. Omabini la machiza anokuzifaka ngokwakho kwiindawo ezithile, ezinje:

• isisu sakho
• umphambili wamathanga akho
• umva weengalo zakho ezingasentla

I-Aimovig ibonelelwa njengedosi enye ye-autoinjector ekhethiweyo. Ihlala inikwa njenge-70-mg injection kanye ngenyanga. Nangona kunjalo, abanye abantu bamiselwe idosi ephezulu ye-140 mg inyanga nganye.

U-Ajovy unikezelwa njengesirinji yethamo elinye eligcwalisiweyo. Inokunikezwa ngenaliti enye ye-225 mg kanye ngenyanga. Okanye inokunikezelwa njenaliti ezintathu ezingama-225 mg kanye qho kwiinyanga ezintathu.

Iziphumo kunye neengozi

Umsebenzi we-Aimovig kunye no-Ajovy ngeendlela ezifanayo kwaye babangela iziphumo ebezingalindelekanga ezifanayo. Iziphumo eziqhelekileyo kunye nezibi ezichaphazela la machiza zingezantsi.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeAimovig, ngeAjovy, okanye ngamachiza omabini (xa ethathwe ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeAimovig:
• ukuqhina
• izihlunu okanye izihlunu
• usulelo oluphezulu lokuphefumula (njengokubanda okuqhelekileyo okanye usulelo lwe-sinus)
• Iimpawu ezinjengomkhuhlane
• umqolo obuhlungu
• Inokwenzeka ngo-Ajovy:
• akukho ziphumo ebezingalindelekanga eziqhelekileyo
• Inokwenzeka kunye neAimovig kunye neAjovy:
• Ukuphendula kwendawo yenaliti njengentlungu, ukuqaqamba, okanye ubomvu

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezinzulu zeAimovig kunye neAjovy ziyeza elibi kakhulu. Ukuphendula okunjalo akuqhelekanga, kodwa kunokwenzeka. (Ngolwazi oluthe kratya, jonga "i-Allergic reaction" phantsi kwe "Iziphumo ebezingalindelekanga ze-Aimovig" ngasentla).

Ukuphendula komzimba

Kuvavanyo lweklinikhi olwenzelwe i-Aimovig kunye ne-Ajovy, bambalwa abantu ababenendlela yokuzikhusela kwizifo. Impendulo yabangela ukuba imizimba yabo ivelise izilwa-buhlungu ngokuchasene namayeza.

Ii-antibodies ziiproteni ezenziwe ngamajoni omzimba ukulwa izinto zangaphandle emzimbeni wakho. Umzimba wakho unokukhulisa ii-antibodies kuyo nayiphi na into yangaphandle, kubandakanya ne-monoclonal antibodies. Ukuba umzimba wakho wenza ii-antibodies ku-Aimovig okanye kwi-Ajovy, iyeza alinakuphinda lisebenze kuwe.

Kwezilingo zeklinikhi zeAimovig, ngaphezulu kweepesenti ze-6 zabantu abavelise izilwa-buhlungu kwichiza. Kwizifundo eziqhubekayo zeklinikhi, bambalwa abantu abangaphantsi kwipesenti ezi-2 zabantu abaye benza ii-antibodies ku-Ajovy.

Ngenxa yokuba i-Aimovig kunye ne-Ajovy zivunyiwe ngo-2018, kusekutsha kakhulu ukuba ungaziqheleka kangakanani ezi ziphumo kwaye zingayichaphazela njani indlela abantu abazisebenzisa ngayo ezi ziyobisi kwixa elizayo.

Ukusebenza ngempumelelo

I-Aimovig kunye ne-Ajovy bobabini basebenzayo ekukhuseleni iintloko zentloko, kodwa khange bathelekiswe ngokuthe ngqo kwizilingo zonyango.

Nangona kunjalo, izikhokelo zonyango lwe-migraine zicebisa ukuba ichiza linokukhetha kubantu abathile. Oku kubandakanya abantu:

• azikwazi ukunciphisa iintsuku zabo zenyanga ze-migraine ngokwaneleyo kunye namanye amayeza
• ayikwazi ukunyamezela amanye amayeza ngenxa yeempembelelo zecala okanye ukusebenzisana kweziyobisi

I-episodic migraine

Izifundo ezahlukileyo zika-Aimovig kunye no-Ajovy zibonise ukusebenza ngokuthintela i-episodic migraine headaches.

• Kwizifundo zeklinikhi ze-Aimovig, malunga neepesenti ezingama-40 zabantu abane-episodic migraine abafumene i-70 mg yeyeza inyanga nenyanga banciphisa iintsuku zabo zemigraine ngesiqingatha ngaphezulu kweenyanga ezintandathu. Ukufikelela kwiipesenti ezingama-50 zabantu abafumene i-140 mg baneziphumo ezifanayo.
• Kwisifundo seklinikhi sika-Ajovy, malunga neepesenti ezingama-48 zabantu abane-episodic migraine abafumene unyango lwenyanga kunye neziyobisi banciphisa iintsuku zabo ze-migraine ubuncinci ngaphezulu kweenyanga ezintathu. Malunga neepesenti ezingama-44 zabantu abafumene iAjovy rhoqo kwiinyanga ezintathu babeneziphumo ezifanayo.

Imigraine engapheliyo

Izifundo ezahlukileyo zika-Aimovig no-Ajovy zikwabonisa ukusebenza ngokuthintela iintlungu ezingapheliyo zentloko.

• Kuphononongo lweenyanga ezintathu lwekliniki ye-Aimovig, malunga neepesenti ezingama-40 zabantu abane-migraine engapheliyo abafumana i-70 mg okanye i-140 mg yeyeza rhoqo ngenyanga babe nesiqingatha seentsuku zemigraine okanye ezimbalwa.
• Kwisifundo seenyanga ezintathu se-Ajovy, phantse iipesenti ezingama-41 zabantu abane-migraine engapheliyo abafumana unyango lwenyanga nge-Ajovy banesiqingatha seentsuku ze-migraine emva konyango okanye bambalwa. Kubantu abafumene i-Ajovy qho kwiinyanga ezintathu, malunga neepesenti ezingama-37 babe neziphumo ezifanayo.

Iindleko

I-Aimovig kunye ne-Ajovy omabini la magama anegama lophawu. Akukho zifom zohlobo oluthile zeziyobisi ezikhoyo. Amayeza egama leBrand ngokubanzi abiza ngaphezulu kweefom zohlobo oluqhelekileyo.

Ngokusekwe kuqikelelo oluvela kwi-GoodRx.com, iAimovig kunye neAjovy zibiza ixabiso elifanayo. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi, indawo okuyo, nakwikhemesti oyisebenzisayo. Ixabiso lakho le-Aimovig liya kuxhomekeka kwidosi yakho.

I-Aimovig vs. iBotox

I-Aimovig iqulethe i-antioclonal antibody ebizwa ngokuba yi-erenumab. I-anti-monoclonal antibody luhlobo lwamachiza akhutshwe kwilebhu. La machiza enziwe ngeeseli zomzimba. I-Aimovig isebenza ukukhusela i-migraine yentloko ngokubhloka umsebenzi weprotein ethile enokubangela.

I-Botox iqulethe ichiza onabotulinumtoxinA. Eli chiza leliklasi lamayeza abizwa ngokuba zii-neurotoxin. IBotox isebenza ngokukhubaza okwethutyana izihlunu ezitofelwe kuyo. Esi siphumo sithintela imiqondiso yeentlungu kwiimisipha ekubeni zisebenze.Kucingelwa ukuba le nkqubo inceda ukuthintela iintlungu zentloko ngaphambi kokuba ziqale.

Sebenzisa

I-Aimovig yamkelwe yi-FDA ukuthintela i-episodic okanye engapheliyo migraine yentloko kubantu abadala.

I-Botox i-FDA-ivunyiwe ukukhusela i-migraine engapheliyo kubantu abadala. IBotox ikwavunyiwe ukunyanga ezinye iimeko, ezinje:

• Umlomo wesibeleko (intamo ejijekileyo)
• ukukhululeka kwenkophe
• isinyi kakhulu
• Ukuxhamla kwemisipha
• ukubila okugqithisileyo

Iifom kunye nolawulo

I-Aimovig iza njengethamo elinye le-autoinjector ekhethiweyo. Inikwa njengenaliti phantsi kolusu lwakho (subcutaneous) onokuzinika yona ekhaya. Inikwa ngethamo le-70 mg okanye i-140 mg ngenyanga.

I-Aimovig inokujova kwiindawo ezithile zomzimba. Zezi:

• isisu sakho
• umphambili wamathanga akho
• umva weengalo zakho ezingasentla

IBotox inikwa kuphela kwiofisi kagqirha. Ingene ngesirinji kwisihlunu (intramuscular), ngesiqhelo kwiiveki ezili-12. Iindawo eziqhelekileyo zenaliti zibandakanya:

• ibunzi lakho
• umva wentamo yakho namagxa
• ngentla nakufutshane neendlebe zakho
• kufutshane neenwele zakho emazantsi entamo yakho

Ugqirha wakho uya kukunika inaliti ezincinci ezingama-31 kwezi ndawo kwindawo nganye.

Iziphumo kunye neengozi

I-Aimovig kunye neBotox zombini zisetyenziselwa ukuthintela iintloko zentloko, kodwa zisebenza ngeendlela ezahlukeneyo. Ke ngoko, baneziphumo ebezingalindelekanga ezifanayo kwaye ezinye zahlukile.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho nge-Aimovig, kunye neBotox, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeAimovig:
• ukuqhina
• izihlunu zemithambo
• izihlunu
• umqolo obuhlungu
• usulelo oluphezulu lokuphefumula (njengokubanda okuqhelekileyo okanye usulelo lwe-sinus)
• Ngaba kunokwenzeka ngeBotox:
• intloko ebuhlungu okanye ukwanda kwemigraine
• ijwabu leso
• ukukhubazeka kwezihlunu zobuso
• intlungu yentamo
• ukuqina kwemisipha
• iintlungu zemisipha kunye nobuthathaka
• Inokwenzeka kunye neAimovig kunye neBotox:
• iimpendulo zesiza senaliti
• Iimpawu ezinjengomkhuhlane

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho nge-Aimovig, kunye neBotox, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeAimovig:
• zimbalwa iziphumo ebezingalindelekanga ezimandundu
• Ngaba kunokwenzeka ngeBotox:
• ukusasazeka kokukhubazeka kwimisipha ekufutshane
• ingxaki yokuginya nokuphefumla
• usulelo olubi
• Inokwenzeka kunye neAimovig kunye neBotox:
• iimpendulo ezibi kakhulu

I-Botox inesilumkiso esibhokisi esivela kwi-FDA malunga nokusasazeka kokukhubazeka kwiimisipha ezikufuphi kulandela inaliti. Isilumkiso sebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

Ukusebenza ngempumelelo

Imeko ekuphela kwayo yokuba zombini iAimovig kunye neBotox zisetyenziselwa ukuthintela iintlungu ezingapheliyo zentloko.

Izikhokelo zonyango zincoma i-Aimovig njengenketho kubantu abangenako ukunciphisa inani leentsuku ze-migraine ngokwaneleyo kunye nezinye iziyobisi. Kukwacetyiswa nabantu abangakwaziyo ukuthatha amanye amayeza ngenxa yeziphumo ebezingalindelekanga okanye ukuhlangana kweziyobisi.

I-Botox icetyiswa yiAmerican Academy of Neurology njengokhetho kunyango kubantu abane-migraine engapheliyo.

Ukusebenza kwala machiza akuzange kuthelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Nangona kunjalo, kwizifundo ezahlukileyo, i-Aimovig kunye neBotox bobabini bafeze iziphumo ezifanelekileyo ekuthinteleni iintlungu ezingapheliyo zentloko.

• Kwisifundo seklinikhi se-Aimovig, malunga neepesenti ezingama-40 zabantu abane-migraine engapheliyo abafumana i-70 mg okanye i-140 mg babe nesiqingatha seentsuku zemigraine okanye ezimbalwa emva kweenyanga ezintathu.
• Kwizifundo zeklinikhi zabantu abane-migraine engapheliyo, iBotox inciphise inani leentsuku zentloko ukuya kuthi ga kwiintsuku ezingama-9.2 ngokomndilili ngenyanga, ngaphezulu kweeveki ezingama-24. Kwesinye isifundo, malunga neepesenti ezingama-47 zabantu banciphise inani labo leentsuku zentloko ubuncinane ngesiqingatha.

Iindleko

I-Aimovig kunye neBotox zombini amayeza anegama lophawu. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza.

Ngokutsho koqikelelo oluvela kwi-GoodRx.com, iBotox ibiza ixabiso eliphantsi kuneAimovig. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza lixhomekeke kwidosi yakho, isicwangciso seinshurensi, indawo okuyo, nakwikhemesti oyisebenzisayo.

I-Aimovig ngokuchasene nobuGcisa

I-Aimovig iqulethe i-antioclonal antibody ebizwa ngokuba yi-erenumab. Ubume obuqulethe i-anti-monoclonal antibody ebizwa ngokuba yi-galcanezumab. I-anti-monoclonal antibody luhlobo lwamachiza akhutshwe kwilebhu. La machiza enziwe ngeeseli zomzimba. Basebenza ngokuthintela umsebenzi weeproteni ezithile emzimbeni wakho.

I-Aimovig kunye ne-Emgality zombini zibhloka umsebenzi weprotein emzimbeni wakho obizwa ngokuba yi-calcitonin enxulumene ne-peptide (CGRP). I-CGRP ibangela ukudumba kunye ne-vasodilation (ukwandiswa kwemithambo yegazi) kwingqondo, enokubangela iintlungu zentloko. Ngokuthintela umsebenzi we-CGRP, la machiza anceda ukuyeka ukudumba kunye ne-vasodilation. Oku kunceda ukukhusela i-migraine intloko.

Sebenzisa

I-Aimovig kunye ne-Emgality zombini zivunyelwe yi-FDA ukuthintela iintloko zentloko kubantu abadala.

Iifom kunye nolawulo

I-Aimovig inikezelwa kwidosi enye ye-autoinjector ekhethiweyo. Ubume bunikezelwa kwidosi enye yesirinji kunye nepeni enye yedosi. Omabini la machiza anikezwe ngenaliti yangaphantsi (inaliti phantsi kolusu). Ungazinika inaliti ngokwakho ekhaya kanye ngenyanga.

Omabini la machiza anokufakwa ngaphakathi kolusu kwiindawo ezithile emzimbeni wakho. Zezi:

• isisu sakho
• umphambili wamathanga akho
• umva weengalo zakho ezingasentla

Ubundlobongela bunokufakwa ngaphakathi kolusu lweempundu zakho.

I-Aimovig imiselwe njenge-70-mg okanye i-140-mg yenaliti yenyanga. Ubundlobongela bumiselwe njenge-120-mg yenaliti yenyanga.

Iziphumo kunye neengozi

I-Aimovig kunye ne-Emgality ngamachiza afanayo enza ukuba kubekho iziphumo ebezingalindelekanga ezifanayo nezibi. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho nge-Aimovig, nge-Emgality, okanye ngamachiza omabini (xa ethathwe ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeAimovig:
• ukuqhina
• izihlunu zemithambo
• izihlunu zemisipha
• Iimpawu ezinjengomkhuhlane
• Inokwenzeka nge-Emgality:
• umqala obuhkungu
• Inokwenzeka kunye neAimovig kunye ne-Emgality:
• iimpendulo zesiza senaliti
• umqolo obuhlungu
• usulelo oluphezulu lokuphefumula (njengokubanda okuqhelekileyo okanye usulelo lwe-sinus)

Iziphumo ebezingalindelekanga ezimandundu

Ukusabela okungafunekiyo komzimba yinto enqabileyo enefuthe elibi kwi-Aimovig kunye ne-Emgality. (Ngolwazi oluthe kratya, jonga "i-Allergic reaction" phantsi kwe "Iziphumo ebezingalindelekanga ze-Aimovig" ngasentla).

Ukuphendula komzimba

Kuvavanyo lweklinikhi kwichiza ngalinye, bambalwa abantu ababenokuphendula komzimba kwi-Aimovig kunye ne-Emgality. Ngolu hlobo lokuphendula, amajoni omzimba avelise izilwa-buhlungu ezichasene neziyobisi.

Ii-antibodies ziiproteni kumzimba wakho zokulwa ezilwa nezinto zangaphandle emzimbeni wakho. Umzimba wakho unokwenza ii-antibodies kuyo nayiphi na into yangaphandle, kubandakanya ne-monoclonal antibodies ezinje ngeAimovig kunye ne-Emgality.

Ukuba umzimba wakho uvelisa izilwa-buhlungu kwelinye lala machiza, kunokwenzeka ukuba iyeza alinakuphinda lisebenze ukunqanda ukuba uqaqanjelwe yintloko.

Kwizifundo zeklinikhi zeAimovig, ngaphezulu kweepesenti ze-6 zabantu abathatha ichiza elenza izilwa-buhlungu kuyo. Kwaye kwizifundo zeklinikhi ze-Emgality, phantse iipesenti ezintlanu zabantu bavelise ii-antibodies kwi-Emgality.

Ngenxa yokuba i-Aimovig kunye ne-Emgality zivunyiwe kwi-2018, kusekutsha kakhulu ukwazi ukuba bangaphi abantu abanokuba nalo olu hlobo lokuphendula. Kusekuqaleni kakhulu ukuba ingayichaphazela njani indlela abantu abawasebenzisa ngayo la machiza kwixa elizayo.

Ukusebenza ngempumelelo

I-Aimovig kunye ne-Emgality khange ithelekiswe kwizifundo zeklinikhi, kodwa zombini ziyasebenza ekuthinteleni iintlungu zentloko.

Isikhokelo sonyango sicebisa i-Aimovig kunye ne-Emgality njengezinto ezinokwenziwa ngabantu abane-episodic okanye engapheliyo migraine:

• Awunakho ukuthatha amanye amayeza ngenxa yeziphumo ebezingalindelekanga okanye ukuhlangana kweziyobisi
• ayikwazi ukunciphisa inani labo leentsuku zenyanga ze-migraine ngokwaneleyo kunye namanye amayeza

I-episodic migraine

Izifundo ezahlukileyo ze-Aimovig kunye ne-Emgality zibonise ukuba omabini la mayeza ayasebenza ekuthinteleni i-episodic migraine headaches:

• Kwizifundo zeklinikhi ze-Aimovig, ukuya kuthi ga kwiipesenti ezingama-50 zabantu abane-episodic migraine abafumene i-140 mg yeyeza behlisa iintsuku zabo ze-migraine ubuncinci ngesiqingatha seenyanga ezintandathu. Malunga neepesenti ezingama-40 zabantu abafumene i-70 mg babone iziphumo ezifanayo.
• Kwizifundo zeklinikhi ze-Emgality zabantu abane-episodic migraine, malunga neepesenti ze-60 zabantu banciphise inani labo leentsuku ze-migraine ubuncinci ubuncinci ngaphezulu kweenyanga ezintandathu zonyango lwe-Emgality. Ukufikelela kwiipesenti ezili-16 zazingenasifo se-migraine emva kweenyanga ezintandathu zonyango.

Imigraine engapheliyo

Izifundo ezahlukileyo ze-Aimovig kunye ne-Emgality zibonise ukuba omabini la mayeza ayasebenza ekuthinteleni iintlungu ezingapheliyo zentloko:

• Kuphononongo lweenyanga ezintathu lweklinikhi yabantu abane-migraine engapheliyo, malunga neepesenti ezingama-40 zabantu abathathe i-70 mg okanye i-140 mg ye-Aimovig babe nesiqingatha seentsuku ezininzi ze-migraine okanye bambalwa ngonyango.
• Kwisifundo seenyanga ezintathu sonyango lwabantu abane-migraine engapheliyo, phantse iipesenti ezingama-30 zabantu abathathe i-Emgality kwiinyanga ezintathu babenesiqingatha seentsuku ze-migraine okanye bambalwa ngonyango.

Iindleko

I-Aimovig kunye ne-Emgality zombini zinegama lonyango. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza. Amachiza anegama lebrendi ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo evela kwi-GoodRx.com, i-Aimovig kunye ne-Emgality zibiza phantse isixa esifanayo. Elona xabiso ubuya kulihlawula ngalo naliphi na ichiza lixhomekeke kwidosi yakho, isicwangciso seinshurensi, indawo okuyo, nakwikhemesti oyisebenzisayo.

I-Aimovig vs.Topamax

I-Aimovig iqulethe i-antioclonal antibody ebizwa ngokuba yi-erenumab. I-antioclonal antibody luhlobo lweziyobisi eziphuhliswe kwiiseli zomzimba. Iziyobisi zolu hlobo zenziwe kwilebhu. I-Aimovig inceda ekuthinteleni intloko ebuhlungu be-migraine ngokumisa umsebenzi weeproteni ezithile ezizibangelayo.

I-Topamax iqulethe i-topiramate, uhlobo lweziyobisi ezisetyenziselwa ukunyanga ukuxhuzula. Akuqondwa kakuhle ukuba iTopamax isebenza njani ukuthintela iintloko zentloko. Kucingelwa ukuba ichiza liyancipha kwiiseli zemithambo-luvo ezingaphaya kwengqondo ezinokubangela iintlungu zentloko.

Sebenzisa

Zombini i-Aimovig kunye ne-Topamax zivunyiwe yi-FDA ukuthintela iintloko zentloko. I-Aimovig ivunyiwe ukuba isetyenziswe kubantu abadala, ngelixa i-Topamax ivunyiwe ukuba isetyenziswe kubantu abadala kunye nabantwana abaneminyaka eli-12 nangaphezulu.

I-Topamax nayo ivunyiwe ukuba inyange isifo sokuwa.

Iifom kunye nolawulo

I-Aimovig iza ngethamo elinye le-autoinjector ekhethiweyo. Inikwa njengenaliti phantsi kolusu lwakho (subcutaneous) ozinika lona ekhaya kanye ngenyanga. Umthamo oqhelekileyo ngowama-70 mg, kodwa abanye abantu banokuxhamla kwithamo le-140-mg.

I-Topamax iza njengephilisi yomlomo okanye ithebhulethi yomlomo. Idosi yesiqhelo yi-50 mg ethathwa kabini yonke imihla. Kuxhomekeke kwingcebiso kagqirha wakho, ungaqala kumthamo osezantsi kwaye uwonyuse kumthamo oqhelekileyo kwiinyanga ezimbalwa.

Iziphumo kunye neengozi

I-Aimovig kunye ne-Topamax basebenza ngeendlela ezahlukeneyo emzimbeni kwaye ke baneziphumo ebezingalindelekanga ezahlukeneyo. Ezinye zeziphumo ebezingalindelekanga ezibi nezibi zamachiza omabini zingezantsi. Uluhlu olungezantsi alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeAimovig, kunye neTopamax, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeAimovig:
• iimpendulo zesiza senaliti
• umqolo obuhlungu
• ukuqhina
• izihlunu zemithambo
• ukudumba kwezihlunu
• Iimpawu ezinjengomkhuhlane
• Inokwenzeka ngeTopamax:
• umqala obuhkungu
• ukudinwa
• I-paresthesia (imvakalelo "yezikhonkwane neenaliti")
• isicaphucaphu
• urhudo
• ukuhla ukusinda
• Ukuphelelwa ngumdla wokutya
• ingxaki yokujonga
• Inokwenzeka kunye neAimovig kunye neTopamax:
• usulelo lokuphefumula (njengokubanda okuqhelekileyo okanye usulelo lwe-sinus)

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeAimovig, kunye neTopamax, okanye zombini iziyobisi (xa zithathwa ngokwahlukeneyo).

• Ngaba kunokwenzeka ngeAimovig:
• zimbalwa iziphumo ebezingalindelekanga ezimandundu
• Inokwenzeka ngeTopamax:
• iingxaki zombono, kubandakanya i-glaucoma
• ukunciphisa ukubila (ukungakwazi ukulawula ubushushu bomzimba)
• metabolic acidosis
• Iingcinga nezenzo zokuzibulala
• iingxaki zokucinga ezinje ngokudideka kunye nemicimbi yememori
• ukudakumba
• i-encephalopathy (isifo sengqondo)
• amatye ezintso
• ukonyuka kokuxhuzula xa ichiza limisiwe ngesiquphe (xa ichiza lisetyenziselwa unyango lokubanjwa)
• Inokwenzeka kunye neAimovig kunye neTopamax:
• iimpendulo ezibi kakhulu

Ukusebenza ngempumelelo

Injongo kuphela i-Aimovig kunye ne-Topamax zivunyelwe yi-FDA kukuthintela migraine.

Izikhokelo zonyango zincoma i-Aimovig njengenketho yokukhusela i-episodic okanye engapheliyo yintloko yentloko kubantu:

• Awunakho ukuthatha amanye amayeza ngenxa yeziphumo ebezingalindelekanga okanye ukuhlangana kweziyobisi
• ayinakunciphisa inani labo lokuqaqanjelwa yintloko rhoqo ngenyanga namanye amayeza

Izikhokelo zonyango zincoma i-Topiramate njengendlela yokukhusela i-episodic migraine headaches.

Izifundo zonyango azikathelekisi ngokuthe ngqo ukusebenza kwala machiza mabini ekuthinteleni iintlungu zentloko. Kodwa amayeza afundwe ngokwahlukeneyo.

I-episodic migraine

Izifundo ezahlukileyo zeAimovig kunye neTopamax zibonise ukuba omabini la machiza ayasebenza ekuthinteleni i-episodic migraine headaches:

• Kwizifundo zeklinikhi ze-Aimovig, ukuya kuthi ga kwiipesenti ezingama-50 zabantu abane-episodic migraine abafumene i-140 mg banqumle iintsuku zabo ze-migraine ubuncinci ngaphezulu kweenyanga ezintandathu zonyango. Malunga neepesenti ezingama-40 zabantu abafumene i-70 mg babone iziphumo ezifanayo.
• Kwizifundo zeklinikhi zabantu abane-episodic migraine abathathe i-Topamax, abo baneminyaka eyi-12 ubudala nangaphezulu babeneentloko ezimbini zentloko ye-migraine inyanga nenyanga. Abantwana abaneminyaka eyi-12 ukuya kwi-17 ene-episodic migraine babeneentloko ezimbalwa zentloko ye-migraine inyanga nenyanga.

Imigraine engapheliyo

Izifundo ezahlukileyo zamachiza zibonise ukuba zombini iAimovig kunye neTopamax zazisebenza ngokuthintela iintlungu ezingapheliyo zentloko:

• Kuphononongo lweenyanga ezintathu lwekliniki ye-Aimovig, malunga neepesenti ezingama-40 zabantu abaneentloko ezingapheliyo zemigraine ezifumene i-70 mg okanye i-140 mg ineentsuku ezinesiqingatha okanye ezininzi emva konyango.
• Kwisifundo esijonge kwiziphumo zolingo oluninzi lweklinikhi lufumanise ukuba kubantu abane-migraine engapheliyo, i-Topamax inciphise inani le-migraine okanye iintloko malunga nesihlanu ukuya kwasithoba inyanga nganye.

Iindleko

I-Aimovig kunye neTopamax zombini amayeza anegama lophawu. Amayeza egama leBrand ahlala exabisa ngaphezu kwamayeza enziwe afana nalawo enziwa ngumenzi. I-Aimovig ayifumaneki kwifom yohlobo oluqhelekileyo, kodwa i-Topamax iza njenge-generic ebizwa ngokuba yi-topiramate.

Ngokutsho koqikelelo oluvela kwi-GoodRx.com, i-Topamax inokubiza ngaphezulu okanye ngaphantsi kwe-Aimovig, kuxhomekeke kwidosi yakho. Kwaye i-topiramate, uhlobo oluqhelekileyo lwe-Topamax, luya kubiza ngaphantsi kwe-Topamax okanye i-Aimovig.

Elona xabiso ubuya kulihlawula ngalo naliphi na kula machiza lixhomekeke kwidosi yakho, isicwangciso sakho seinshurensi, indawo okuyo, kunye nekhemesti oyisebenzisayo.

I-Aimovig kunye notywala

Akukho nxibelelwano phakathi kwe-Aimovig kunye notywala.

Okwangoku, abanye abantu banokuziva ngathi ichiza alisebenzi kangako xa besela utywala ngelixa bethatha i-Aimovig. Kungenxa yokuba utywala bunokubangela ukuba abantu abaninzi babe nemigraine. Nokuba isixa esincinci sotywala sinokubangela ukuba i-migraine kubo.

Kuya kufuneka uphephe iziselo ezinesiselo esinxilisayo ukuba ufumanisa ukuba utywala bubangela iintlungu ezibuhlungu okanye iintloko eziqaqambayo rhoqo.

Unxibelelwano lwe-Aimovig

Amachiza amaninzi anokusebenzisana namanye amayeza. Iziphumo ezahlukeneyo zinokubangelwa kukunxibelelana okungafaniyo. Umzekelo, ezinye iindlela zokunxibelelana zinokuphazamisa ukusebenza kakuhle kwesiyobisi, ngelixa ezinye zinokubangela iziphumo ebezingalindelekanga ezingakumbi.

I-Aimovig ayinalo ngokubanzi ukusebenzisana kweziyobisi. Kungenxa yendlela i-Aimovig eqhutywa ngayo emzimbeni wakho.

Indlela i-Aimovig eyenziwe ngayo

Amachiza amaninzi, amayeza, kunye nezongezo zenziwe umzimba (zenziwa) zii enzymes kwisibindi sakho. Kodwa amachiza e-monoclonal antibody, anje ngeAimovig, aqhelekanga ukusetyenzwa esibindini. Endaweni yoko, olu hlobo lweziyobisi lwenziwa ngaphakathi kwezinye iiseli emzimbeni wakho.

Ngenxa yokuba i-Aimovig ingacutshungulwa esibindini njengezinye iziyobisi ezininzi, ngokubanzi ayisebenzisani nezinye iziyobisi.

Ukuba unayo nayiphi na inkxalabo malunga nokudibanisa i-Aimovig kunye namanye amayeza onokuthi uthathe, thetha nogqirha wakho. Kwaye qiniseka ukubaxelela malunga nawo onke amayeza, i-counter-counter, kunye namanye amayeza owathathayo. Kuya kufuneka ubaxelele malunga nawo nawaphi na amayeza, iivithamini, kunye nezongezelelo zesondlo ozisebenzisayo.

Imiyalelo malunga nendlela yokuthatha iAimovig

I-Aimovig iza njengenaliti enikezwe phantsi kwesikhumba (sangaphantsi). Uzifaka ekhaya inaliti kanye ngenyanga. Ngethuba lokuqala ufumana iyeza lika-Aimovig, umboneleli wakho wezempilo uya kuchaza ukuba ungazinika njani inaliti.

I-Aimovig iza idosi enye (70 mg) ye-autoinjector. I-autoinjector nganye inedosi enye kuphela kwaye isetyenziselwa ukuba isetyenziswe kube kanye emva koko ilahlwe kude. (Ukuba ugqirha wakho umisela i-140 mg ngenyanga, uya kusebenzisa ii-autoinjectors ezimbini inyanga nganye.)

Apha ngezantsi kunolwazi ngendlela yokusebenzisa isirinji ekhethiweyo. Ukufumana ezinye iinkcukacha, ividiyo, kunye nemifanekiso yemiyalelo yenaliti, jonga iwebhusayithi yomenzi.

Ungayifaka njani inaliti

Ugqirha wakho uya kumisela i-70 mg kanye ngenyanga okanye i-140 mg kanye ngenyanga. Ukuba umiselwe i-70 mg ngenyanga, uya kuzitofa inaliti enye. Ukuba umiselwe i-140 mg ngenyanga, uya kuzinika iinaliti ezimbini ezahlukeneyo, enye emva kwenye.

Ukulungiselela ukujova

• Thatha iAimovig autoinjector yakho kwifriji kwimizuzu engama-30 ngaphambi kokuba ucwangcise ukwenza inaliti yakho. Oku kuyakuvumela ichiza ukuba lifudumale kubushushu begumbi. Shiya ikepusi kwisixhobo se-autoinjector de ube ukulungele ukutofa ichiza.
• Sukuzama ukufudumeza i-autoinjector ngokukhawuleza ngokuyihambisa ngemicrowave okanye ngokuhambisa amanzi ashushu ngaphezulu kwayo. Kwakhona, sukushukumisa i-autoinjector. Ukwenza ezi zinto kunokwenza ukuba i-Aimovig ikhuseleke kancinci kwaye isebenze.
• Ukuba ngempazamo ulahle i-autoinjector, ungayisebenzisi. Izinto ezincinci ze-autoinjector zinokwaphuka ngaphakathi, nokuba awunakubona monakalo.
• Ngelixa ulinde i-Aimovig ukuba ize kubushushu begumbi, fumana ezinye izinto oza kuzifuna. Oku kubandakanya:
• ukosula utywala
• iibhola zekotoni okanye i-gauze
• iibhandeji zokubambelela
• Isikhongozelo sokulahla ubukrelekrele
• Jonga i-autoinjector kwaye uqiniseke ukuba amayeza akabonakali enamafu. Kufanele ukuba ayinambala ngombala omthubi kakhulu ngombala. Ukuba ijongeka imdaka, kunamafu, okanye inamaqhekeza aqinileyo kulwelo, sukuyisebenzisa. Ukuba kufuneka, nxibelelana nogqirha wakho malunga nokufumana entsha. Jonga kwakhona umhla wokuphelelwa kwayo kwisixhobo ukuqinisekisa ukuba ichiza aliphelanga.
• Emva kokuhlamba izandla zakho ngesepha namanzi, khetha indawo yenaliti. I-Aimovig inokujova kwezi ndawo:
• isisu sakho (ubuncinci ii-intshi ezimbini kude nesisu sakho)
• umphambili wamathanga akho (ubuncinci ii-intshi ezimbini ngaphezulu kwedolo lakho okanye ii-intshi ezimbini ezantsi kwe-groin yakho)
• umva weengalo zakho ezingasentla (ukuba omnye umntu ukutofa inaliti)
• Sebenzisa ukosula utywala ukucoca indawo oceba ukuyifaka. Vumela utywala bume ngokupheleleyo ngaphambi kokuba utofe iyeza.
• Musa ukufaka iAimovig kwindawo yesikhumba etyumkileyo, enzima, ebomvu, okanye ethambileyo.

Sebenzisa i-autoinjector

1. Tsala ikepusi emhlophe ngqo kwi-autoinjector. Sukwenza oku ngaphezulu kwemizuzu emihlanu ngaphambi kokuba uyisebenzise.
2. Yolula okanye ucofe indawo yesikhumba apho uceba ukujoba khona iziyobisi. Yenza indawo eqinileyo yolusu malunga nee-intshi ezimbini ububanzi ngenaliti yakho.
3. Beka i-autoinjector kulusu lwakho kwi-90-degree angle. Cinezela ngokuqinileyo ulusu lwakho ukuya kude.
4. Cinezela iqhosha lokuqala elimfusa ngaphezulu kwe-autoinjector de uve ucofa.
5. Khupha iqhosha lokuqala elimfusa kodwa qhubeka ubambe i-autoinjector ezantsi kulusu lwakho ide ifestile kwi-autoinjector ijike ibe tyheli. Unokuva okanye uve ngathi "ucofa". Oku kungathatha imizuzwana eli-15. Kubalulekile ukwenza eli nyathelo ukuqinisekisa ukuba ufumana idosi iphela.
6. Susa i-autoinjector kulusu lwakho kwaye uyilahle kwisitya sakho sokulahla esibi.
7. Ukuba kukho naliphi na igazi kwindawo yenaliti, cofa ibhola yomqhaphu okanye igalikhi kulusu, kodwa musa ukurabha. Sebenzisa ibhandeji lokuncamathelisa xa kufuneka njalo.
8. Ukuba idosi yakho iyi-140 mg ngenyanga, phinda la manyathelo nge-autoinjector yesibini. Sukusebenzisa indawo yenaliti efanayo neyokuqala.

Ixesha

I-Aimovig kufuneka ithathwe kube kanye ngenyanga. Ingathathwa nanini na emini.

Ukuba uphosa idosi, thatha iAimovig ngokukhawuleza nje ukuba ukhumbule. Idosi elandelayo kufuneka ibe yinyanga enye emva kokuba uyithathileyo. Sebenzisa isixhobo sokukhumbuza amayeza kunokukunceda ukhumbule ukuthatha iAimovig kwishedyuli.

Ukuthatha i-Aimovig ngokutya

I-Aimovig ingathathwa kunye okanye ngaphandle kokutya.

Ukugcina

I-Aimovig kufuneka igcinwe kwifriji. Ingathathwa ngaphandle kwefriji kodwa kufuneka isetyenziswe ngaphakathi kweentsuku ezisixhenxe. Musa ukuyibuyisela kwifriji xa sele ikhutshiwe yaziswa kubushushu begumbi.

Musa ukumisa umkhenkce kwiAimovig. Kwakhona, yigcine kwiphakheji yayo yoqobo ukuyikhusela ekukhanyeni.

Isebenza njani iAimovig

I-Aimovig sisiyobisi esibizwa ngokuba yi-monoclonal antibody. Olu hlobo lweziyobisi lwenziwa kwilebhu evela kwiiproteni zamajoni omzimba. I-Aimovig isebenza ngokumisa umsebenzi weprotein emzimbeni wakho obizwa ngokuba yi-calcitonin peptide enxulumene nofuzo (CGRP). I-CGRP inokubangela ukudumba kunye ne-vasodilation (ukwandiswa kwemithambo yegazi) kwingqondo yakho.

Ukudumba kunye ne-vasodilation eziswe yi-CGRP sesona sizathu sinokubangela iintlungu zentloko. Ngapha koko, xa i-migraine iqala ukwenzeka, abantu banamanqanaba aphezulu e-CGRP kwigazi labo. I-Aimovig inceda ukuthintela i-migraine ngokumisa umsebenzi we-CGRP.

Ngelixa uninzi lwamayeza lusebenza ngokuchaphazela izinto ezininzi emzimbeni wakho, ii-antibodies ze-monoclonal ezinje ngeAimovig zisebenza kwiprotein enye kuphela emzimbeni. Ngenxa yoku, i-Aimovig inokubangela ukuhlangana okumbalwa kweziyobisi kunye neziphumo ebezingalindelekanga. Oku kungenza ukuba ibe lukhetho olulungileyo lonyango kubantu abangakwaziyo ukuthatha amanye amayeza ngenxa yeziphumo ebezingalindelekanga okanye unxibelelwano.

I-Aimovig isenokuba yindlela efanelekileyo yokonyango kubantu abangakhange bafumane elinye iyeza elinokunciphisa iintsuku zabo ze-migraine ngokwaneleyo.

Kuthatha ixesha elingakanani ukusebenza?

Emva kokuba uqale ukuthatha i-Aimovig, kungathatha iiveki ezimbalwa ukubona ukuphuculwa kwentloko yakho ye-migraine. I-Aimovig inokuthi iqale ukusebenza emva kweenyanga ezininzi.

Abantu abaninzi abathathe i-Aimovig ngexesha lovavanyo lweklinikhi babeneentsuku ezimbalwa zemigraine kwinyanga enye yokuqala kwesiyobisi. Abantu babeneentsuku ezimbalwa zemigraine emva kokuqhubeka nonyango kwiinyanga ezininzi.

I-Aimovig kunye nokukhulelwa

Akukhange kubekho zifundo zaneleyo zenziweyo zokwazi ukuba i-Aimovig ikhuselekile na ngexesha lokukhulelwa. Izifundo zezilwanyana azibonisanga mngcipheko ekukhulelweni xa uAimovig wanikwa umntu okhulelweyo. Nangona kunjalo, izifundo zezilwanyana azihlali ziqikelela ukuba iziyobisi ziya kukhuseleka ebantwini.

Ukuba ukhulelwe okanye ucinga ukukhulelwa, thetha nogqirha wakho ukuze ubone ukuba iAimovig ikulungele na. Kuya kufuneka ulinde de ungasakhulelwa ukuze usebenzise iAimovig.

I-Aimovig kunye nokuncancisa

Ayaziwa ukuba i-Aimovig idlula kubisi lwebele. Ke ngoko, akucaci ukuba i-Aimovig ikhuselekile ukuyisebenzisa ngelixa uncancisa.

Ukuba ucinga unyango nge-Aimovig ngelixa uncancisa umntwana wakho, thetha nogqirha wakho malunga nezibonelelo kunye neengozi. Kuya kufuneka uyeke ukuncancisa ukuba uqala ukuthatha i-Aimovig.

Imibuzo eqhelekileyo malunga neAimovig

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neAimovig.

Ngaba ukumisa i-Aimovig kubangela ukurhoxa?

Khange kubekho ngxelo ngeziphumo zokurhoxa emva kokumisa i-Aimovig. Nangona kunjalo, i-Aimovig yayisandula ukuvunywa yi-FDA, ngo-2018. Inani labantu abake basebenzise kwaye bayekisa unyango lwe-Aimovig lusenomda.

Ngaba iAimovig yi-biologic?

Ewe. I-Aimovig yi-monoclonal antibody, eluhlobo lwe-biologic. I-biologic sisiyobisi esenziwe kwizinto zebhayoloji, endaweni yeekhemikhali.

Ngenxa yokuba zinxibelelana neeseli ezithile zomzimba kunye neeproteni, i-biologics efana ne-Aimovig icingelwa ukuba ineziphumo ebezingalindelekanga ezimbalwa xa kuthelekiswa neziyobisi ezichaphazela uluhlu olubanzi lweenkqubo zomzimba, njengamanye amachiza e-migraine.

Ngaba unokusebenzisa iAimovig ukunyanga i-migraine?

Hayi. I-Aimovig isetyenziselwa kuphela ukuthintela intloko ebuhlungu ngaphambi kokuba iqale. Ayizukusebenza ukunyanga i-migraine esele iqalile.

Ngaba iAimovig iyayinyanga imigraine?

Hayi, i-Aimovig ayizukuyinyanga i-migraine. Akukho mayeza akhoyo ngoku anyanga i-migraine.

U-Aimovig wahluke njani kwezinye iziyobisi ze-migraine?

I-Aimovig yahlukile kuninzi lwamanye amachiza e-migraine kuba yayiyeyona nyango yokuqala evunyiweyo ye-FDA eyenziwe ngokukodwa ukuthintela iintlungu zentloko. I-Aimovig yinxalenye yodidi olutsha lwamachiza abizwa ngokuba yi-calcitonin enxulumene nopept peptide (CGRP) antagonists.

Uninzi lwamanye amachiza asetyenziselwa ukukhusela i-migraine entloko eneneni ayenzelwe ezinye izizathu, njengokunyanga ukuxhuzula, uxinzelelo lwegazi oluphezulu, okanye uxinzelelo. Uninzi lwezi ziyobisi zisetyenziselwa ngaphandle kwelebheli ukukhusela iintlungu zentloko.

Ukuba ngenaliti yenyanga kwenza iAimovig yahluke kuninzi lwamachiza othintelo lwe-migraine. Uninzi lwala machiza luza njengamacwecwe okanye iipilisi. IBotox lelinye ichiza eliza njengenaliti. Nangona kunjalo, kufuneka inikezwe kwiofisi kagqirha kube kanye kwiinyanga ezintathu. Ungazinika inaliti zeAimovig ekhaya.

Kwaye ngokungafaniyo nezinye iziyobisi zokuthintela i-migraine, i-Aimovig yi-monoclonal antibody. Olu luhlobo lonyango olwenziwe kwilebhu. Yenziwe ngamaseli omzimba.

Amachiza omzimba omonoclonal aphulwe ngaphakathi kwiiseli ezahlukeneyo zomzimba. Amanye amachiza othintelo lwe-migraine aphulwe sisibindi. Ngenxa yalo mahluko, ii-antibodies ze-monoclonal ezinje nge-Aimovig zihlala zinokunxibelelana okumbalwa kweziyobisi kunamanye amayeza asetyenziselwa ukuthintela iintlungu zentloko.

Ukuba ndithatha i-Aimovig, ndingayeka ukuthatha amanye amayeza am okuthintela?

Kusenokwenzeka. Umzimba womntu ngamnye uya kuphendula kwi-Aimovig ngokwahlukileyo. Ukuba i-Aimovig inciphisa inani le-migraine entloko onayo, unokukwazi ukuyeka ukuthatha amanye amayeza othintelo. Kodwa xa uqala unyango, ugqirha wakho uya kuncoma ukuba uqale ukuthatha i-Aimovig kunye namanye amayeza okukhusela.

Emva kokuba uthathe i-Aimovig iinyanga ezimbini ukuya kwezintathu, ugqirha wakho uya kuthetha nawe malunga nokuba lisebenza kanjani na iyeza. Wena nogqirha wakho ninokuthetha ngokuyeka amanye amayeza eniwathintelayo okanye ninciphise idosi yala machiza.

Libanda elingaphezulu kwe-Aimovig

Ukujova iidosi ezininzi ze-Aimovig kunokunyusa umngcipheko wokuphendula kwendawo yenaliti. Ukuba uxabisa okanye u-hypersensitive ku-Aimovig okanye kwi-latex (isithako kwiphakheji ye-Aimovig), unokuba semngciphekweni wokuphendula okunzulu.

Iimpawu libanda

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• Intlungu ebuhlungu, ukurhawuzelela, okanye ubomvu kwindawo ekufuphi nenaliti
• ukugungxula
• urhwebo
• i-angioedema (ukudumba phantsi kolusu)
• ukudumba kolwimi, umqala, okanye umlomo
• ingxaki yokuphefumla

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe kakhulu eli chiza, biza ugqirha wakho okanye ufune isikhokelo kuMbutho waseMelika wamaZiko oLawulo lweTyhefu e800-222-1222 okanye ngesixhobo sabo se-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Izilumkiso zeAimovig

Ngaphambi kokuba uthathe i-Aimovig, thetha nogqirha wakho malunga nembali yakho yezempilo. I-Aimovig isenokungakulungeli ukuba uneemeko ezithile zonyango. Oku kubandakanya:

• I-latex yokungezwani komzimba. I-Aimovig autoinjector iqulethe uhlobo lweerabha efanayo nelatex. Oku kunokubangela ukusabela kubantu abangadibaniyo ne-latex. Ukuba unembali yokuphendula ngokuqatha kwiimveliso eziqukethe i-latex, i-Aimovig isenokungabi lonyango olufanelekileyo kuwe.

Ukupheliswa kweAimovig kunye nokugcinwa

Xa iAimovig ikhutshwa ekhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile esebhotileni. Lo mhla uqhele ukuba ngunyaka omnye ukusukela kumhla wokukhutshwa kwamayeza.

Injongo yale mihla yokuphelelwa lixesha kukuqinisekisa ukusebenza kweyeza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha.

Kuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya nokuba ligcinwa njani kwaye liphi iyeza.

I-Aimovig autoinjector ekhethiweyo kufuneka igcinwe kwifriji. Ingagcinwa ngaphandle kwefriji kangangeentsuku ezisixhenxe. Musa ukubuyela kwifriji xa sele ifikelele kubushushu begumbi.

Musa ukushukumisa okanye ubambe umkhenkce weAimovig autoinjector. Kwaye gcina i-autoinjector kwiphakheji yoqobo ukuyikhusela ekukhanyeni.

Ukuba awusebenzisanga iyeza elidlulileyo kumhla wokuphelelwa kwalo, thetha nosokhemesti wakho malunga nokuba unganako na ukuyisebenzisa.

Ulwazi lobungcali lweAimovig

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Indlela yokusebenza

I-Aimovig (erenumab) yintsholongwane yomntu ebambelela kwi-calcitonin enxulumene ne-peptide (CGRP) receptor kwaye ithintela i-CGRP ligand ekusebenzeni kwe-receptor.

I-Pharmacokinetics kunye ne-metabolism

I-Aimovig ilawulwa rhoqo ngenyanga kwaye ifikelela kugxininiso lwaseburhulumenteni emva kweedosi ezintathu. Ubuninzi boxinzelelo kufikelelwa kwiintsuku ezintandathu. I-Metabolism ayenzeki ngeendlela ze-cytochrome P450.

Ukubopha kwi-CGRP kuyahlalisa kwaye kuqhuba ukupheliswa koxinzelelo olusezantsi. Kwindawo eziphezulu, iAimovig isuswa ngeendlela ezingafaniyo zeproteolytic. Ukuphazamiseka kwe-renal okanye i-hepatic kulindeleke ukuba kuchaphazele iipropathi ze-pharmacokinetic.

Ukungqinelana

Akukho zichasene nokusetyenziswa kweAimovig.

Ukugcina

I-Aimovig ye-autoinjector ekhethiweyo kufuneka igcinwe kwifriji kubushushu obuphakathi kwe-36⁰F kunye ne-46⁰F (2⁰C kunye ne-8⁰C). Inokususwa kwisikhenkcisi kwaye igcinwe kubushushu begumbi (ukuya kuthi ga kwi-77⁰F, okanye i-25⁰C) kangangeentsuku ezisi-7.

Gcina iAimovig kwiipakethe zokuqala ukuyikhusela ekukhanyeni. Musa ukuyibuyisela kwifriji xa sele ifikile kubushushu begumbi. Sukuma ngumkhenkce okanye ugungqise iAimovig autoinjector.

Iphepha elichazayo ukuba awusenanto oyifunayo: Iindaba zezoNyango namhlanje zenze zonke iinzame zokuqinisekisa ukuba zonke iinkcukacha zichanekile, zibanzi kwaye zihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.