Uvavanyo lwe-Antineutrophil Cytoplasmic Antibodies (ANCA)

Umxholo

• Yintoni uvavanyo lwe-antineutrophil cytoplasmic antibodies (ANCA)?
• Isetyenziselwa ntoni?
• Kutheni ndifuna uvavanyo lwe-ANCA?
• Kwenzeka ntoni ngexesha lovavanyo lwe-ANCA?
• Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?
• Ngaba bukhona ubungozi kuvavanyo?
• Zithetha ntoni iziphumo?
• Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lwe-ANCA?
• Izalathiso

Yintoni uvavanyo lwe-antineutrophil cytoplasmic antibodies (ANCA)?

Olu vavanyo lujonga i-antineutrophil cytoplasmic antibodies (ANCA) egazini lakho. Ii-antibodies ziiproteni ezenziwa ngamajoni akho omzimba ukulwa izinto zangaphandle ezinjengeentsholongwane kunye neebhaktiriya. Kodwa ii-ANCAs zihlasela iiseli ezisempilweni ezaziwa ngokuba zii-neutrophils (uhlobo lweseli emhlophe yegazi) ngempazamo. Oku kunokukhokelela kwisifo esaziwa ngokuba yi-autoimmune vasculitis. Ukuzimela kwe-vasculitis kubangela ukuvuvukala kunye nokuvuvukala kwemithambo yegazi.

Imithambo yegazi ithwala igazi lisuka entliziyweni yakho liye kumalungu akho, izicwili kunye nezinye iinkqubo, emva koko ubuye kwakhona. Iindidi zemithambo yegazi zibandakanya imithambo yegazi, imithambo, kunye nemithanjana yegazi. Ukudumba kwimithambo yegazi kunokubangela iingxaki zempilo. Iingxaki ziyahluka ngokuxhomekeka ekubeni yeyiphi na imithambo yegazi kunye neenkqubo zomzimba ezichaphazelekayo.

Zimbini iintlobo eziphambili ze-ANCA. Iithagethi nganye zijolise kwiprotheni ethile ngaphakathi kweeseli ezimhlophe zegazi:

• I-PANCA, ejolise kwiprotein ebizwa ngokuba yi-MPO (myeloperoxidase)
• I-cANCA, ejolise kwiprotein ebizwa ngokuba yi-PR3 (proteinase 3)

Uvavanyo lunokubonisa ukuba ngaba unalo olunye okanye zombini iintlobo zeentsholongwane. Oku kunokunceda umboneleli wakho wokhathalelo lwempilo afumanise kwaye anyange isifo sakho.

Amanye amagama: Iintsholongwane ze-ANCA, i-cANCA pANCA, i-cytoplasmic neutrophil antibodies, i-serum, i-anticytoplasmic autoantibodies

Isetyenziselwa ntoni?

Uvavanyo lwe-ANCA luhlala lusetyenziselwa ukufumanisa ukuba ngaba unohlobo lwe-vasculitis ezenzekelayo. Kukho iintlobo ezahlukeneyo zokuphazamiseka. Zonke zibangela ukudumba nokudumba kwemithambo yegazi, kodwa uhlobo ngalunye luchaphazela imithambo yegazi eyahlukeneyo kunye namalungu omzimba. Iindidi ze-vasculitis ezizimeleyo zibandakanya:

• IGranulomatosis kunye ne-polyangiitis (GPA), ngaphambili sasibizwa ngokuba sisifo sika-Wegener. Ihlala ichaphazela imiphunga, izintso kunye neesinuses.
• Microscopic polyangiitis (MPA). Esi sifo sinokuchaphazela amalungu amaninzi emzimbeni, kubandakanya imiphunga, izintso, inkqubo yeemvakalelo kunye nolusu.
• I-granulomatosis ye-Eosinophilic kunye ne-polyangiitis (EGPA), eyayibizwa ngokuba yiChurg-Strauss syndrome. Esi sifo sihlala sichaphazela ulusu kunye nemiphunga. Ihlala ibangela isifuba.
• I-Polyarteritis nodosa (PAN). Esi sifo sihlala sichaphazela intliziyo, izintso, ulusu kunye nenkqubo ye-nervous system.

Uvavanyo lwe-ANCA lunokusetyenziselwa ukubeka esweni unyango lwezi ngxaki.

Kutheni ndifuna uvavanyo lwe-ANCA?

Umboneleli wakho wokhathalelo lwempilo unokuyalela uvavanyo lwe-ANCA ukuba uneempawu ze-autoimmune vasculitis. Iimpawu zibandakanya:

• Ifiva
• Ukudinwa
• Ukuhla ukusinda
• Imisipha kunye / okanye amalungu adibeneyo

Iimpawu zakho zinokuchaphazela elinye okanye amanye amalungu athile emzimbeni wakho. Izitho ezichaphazeleka ngokuxhaphakileyo kunye neempawu ezibangela zibandakanya:

• Amehlo
  • Ubomvu
  • Umbono omfiliba
  • Ukuphulukana nombono
• Iindlebe
  • Ukukhala ezindlebeni (tinnitus)
  • Ukuphulukana nokuva
• Sinuses
  • Iintlungu zesinus
  • Impumlo enemifinya
  • Impumlo iyopha
• Ulusu
  • Rashes
  • Izilonda okanye izilonda, uhlobo lwesifo esinzulu esicothayo ukuphola kunye / okanye ukugcina ukubuya
• Amaphaphu
  • Khohlela
  • Ingxaki yokuphefumla
  • Iintlungu zesifuba
• Izintso
  • Igazi kumchamo
  • Umchamo wegwebu, obangelwa yiprotein kumchamo
• Inkqubo yovalo
  • Ukuba ndindisholo nokubetha kwiindawo ezahlukeneyo zomzimba

Kwenzeka ntoni ngexesha lovavanyo lwe-ANCA?

Ingcali yokhathalelo lwempilo iyakuthatha isampulu yegazi kumthambo engalweni yakho, isebenzisa inaliti encinci. Emva kokuba inaliti ifakiwe, inani elincinci legazi liya kuqokelelwa kwityhubhu yovavanyo okanye igutyana. Unokuziva uluma kancinci xa inaliti ingena okanye iphuma. Oku kuhlala kuthatha imizuzu engaphantsi kwesihlanu.

Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?

Awudingi naluphi na ulungiselelo olukhethekileyo lovavanyo lwe-ANCA.

Ngaba bukhona ubungozi kuvavanyo?

Mncinci kakhulu umngcipheko wokuvavanywa kwegazi. Unokuba nentlungu encinci okanye ukrakra kwindawo apho inaliti yafakwa khona, kodwa uninzi lweempawu zihamba ngokukhawuleza.

Zithetha ntoni iziphumo?

Ukuba iziphumo zakho bezingalunganga, oko kuthetha ukuba iimpawu zakho mhlawumbi azikho ngenxa ye-vasculitis yokuzimela.

Ukuba iziphumo zakho bezintle, oko kunokuthetha ukuba une-autoimmune vasculitis. Ingabonisa nokuba ngaba ii-canan okanye ii-pANCA zafunyanwa. Oku kunokunceda ekuchongeni ukuba loluphi uhlobo lwe-vasculitis onayo.

Kungakhathaliseki ukuba uluphi uhlobo lwe-antibodies olufunyenweyo, unokufuna uvavanyo olongezelelweyo, olubizwa ngokuba yi-biopsy, ukuqinisekisa ukuxilongwa. I-biopsy yinkqubo esusa isampulu encinci yeethishu okanye iiseli zovavanyo. Umboneleli wakho wezempilo unokuyalela iimvavanyo ezingaphezulu ukulinganisa isixa se-ANCA egazini lakho.

Ukuba okwangoku unyangelwa i-autoimmune vasculitis, iziphumo zakho zingabonisa ukuba ngaba unyango lwakho luyasebenza.

Ukuba unemibuzo malunga neziphumo zakho, thetha nomboneleli wakho wezempilo.

Funda ngakumbi malunga novavanyo lwelabhoratri, uluhlu lweereferensi, kunye neziphumo zokuqonda.

Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lwe-ANCA?

Ukuba iziphumo zakho ze-ANCA zibonisa ukuba une-autoimmune vasculitis, kukho iindlela zokunyanga nokulawula imeko. Unyango lunokubandakanya amayeza, unyango olususa i-ANCAs okwethutyana egazini lakho, kunye / okanye utyando.

Izalathiso

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2. I-Allina yezeMpilo [kwi-Intanethi]. IMinneapolis: Impilo ka-Allina; Imilinganiselo ye-P-ANCA; [icatshulwe ngo-2019 ngoMeyi 3]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://account.allinahealth.org/library/content/49/150470
3. Iklinikhi yaseCleveland [kwi-Intanethi]. Cleveland (OH): Iiklinikhi yaseCleveland; c2019. Izilonda zomlenze neenyawo; [icatshulwe ngo-2019 ngoMeyi 3]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://my.clevelandclinic.org/health/diseases/17169-leg-and-foot-ulcers
4. Uvavanyo lweLebhu kwi-Intanethi [kwi-Intanethi]. IWashington DC: Umbutho waseMelika weKlinikhi yeKhemistry; c2001–2019. Iintsholongwane ze-ANCA / MPO / PR3; [ihlaziywe ngo-2019 ngoMatshi 29; ikhankanywe 2019 ngoMeyi 3]; [malunga nezikrini ezi-2]. Ifumaneka kwi: https://labtestsonline.org/tests/ancampopr3-antibodies
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8. Iilebhu zeMayo Clinic [kwi-Intanethi]. Isiseko seMayo seMfundo yezoNyango noPhando; c1995–2019. I-ID yovavanyo: ANCA: IiCytoplasmic Neutrophil Antibodies, iSerum: Iiklinikhi kunye nokutolika; [icatshulwe ngo-2019 ngoMeyi 3]; [malunga nezikrini ezi-4]. Ifumaneka kwi: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9441
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Ulwazi olukule ndawo akufuneki lusetyenziswe endaweni yonyango okanye iingcebiso. Nxibelelana nomboneleli wezempilo ukuba unemibuzo malunga nempilo yakho.