Ukuzenzekelayo: Into ekufuneka uyazi

Umxholo

• Zeziphi izibonelelo zokuzenzekelayo?
• Ukutshintsha kokutya okunokunyusa ukuzimela
• Umgca wezantsi

Yintoni i-autophagy?

I-Autophagy yindlela yomzimba yokucoca iiseli ezonakalisiweyo, ukuze kuvuselelwe iiseli ezintsha, ezisempilweni, ngokuka-Priya Khorana, PhD, kwimfundo yesondlo evela kwiYunivesithi yaseColumbia.

"Ukuzenzekelayo" kuthetha ukuzimela kunye ne "phagy" kuthetha ukutya. Ke intsingiselo yokoqobo yokutya ngokuzenzekelayo "kukutya ngokwakho."

Ikwabizwa ngokuba "kukutya ngokwakho." Ngelixa oko kunokuba ngathi yinto ongafuniyo ukuba yenzeke emzimbeni wakho, iluncedo kwimpilo yakho iphela.

Kungenxa yokuba i-autophagy yindlela yokulondolozwa yokuzikhusela apho umzimba ungasusa iiseli ezingasebenziyo kwaye uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uphinde uzilungise, ngokutsho kwe-cardiologist eqinisekisiweyo yebhodi, uGqirha Luiza Petre.

UPetre ucacisa ukuba injongo ye-autophagy kukususa ukungcola kunye nokuzilawula ngokwakho ukuze usebenze ngokugqibeleleyo.

“Iyaphinda-tshintsha kwaye icoca ngaxeshanye, njengokucofa iqhosha lokuseta kwakhona emzimbeni wakho. Kwaye ikhuthaza ukusinda kunye nokulungiswa njengempendulo koxinzelelo olwahlukeneyo kunye neetyhefu eziqokelelwe kwiiseli zethu, utshilo.

Zeziphi izibonelelo zokuzenzekelayo?

Ezona zibonelelo ziphambili zokuzenzekelayo zibonakala ziza ngohlobo lwemigaqo-nkqubo echasene nokwaluphala. Ngapha koko, uPetre uthi yaziwa njengeyona ndlela yomzimba yokujika iwashi umva kunye nokwenza iiseli ezincinci.

U-Khorana uthi xa iiseli zethu zixinezelekile, ukunyuka kwe-autophagy kuyonyuswa ukuze kusikhusele, oku kunceda ukwandisa ixesha lokuphila kwakho.

Ukongeza, ugqirha wezidlo obhalisiweyo, uScott Keatley, i-RD, i-CDN, uthi ngamaxesha endlala, i-autophagy igcina umzimba uhamba ngokwaphula izinto zeselfowuni kwaye uphinde uzisebenzise kwiinkqubo eziyimfuneko.

"Ewe oku kufuna amandla kwaye akunakuqhubeka ngonaphakade, kodwa kusinika ixesha elininzi lokufumana isondlo," wongeza.

Kwinqanaba leselula, uPetre uthi izibonelelo zokuzenzekelayo zibandakanya:

• ukususa iiprotheni ezinobuthi kwiiseli ezinxulumene nezifo ezingenayo i-neurodeergenerative, ezifana ne-Parkinson kunye ne-Alzheimer's
• Ukuphinda kusetyenziswe kwakhona iiprotein zentsalela
• ukubonelela ngamandla kunye neebhloko zokwakha iiseli ezinokuthi zixhamle kulungiso
• kwinqanaba elikhulu, ikhuthaza ukuhlaziywa ngokutsha kunye neeseli ezinempilo

I-Autophagy ifumana ingqwalaselo enkulu ngendima enokuthi iyidlale ekuthinteleni okanye ekunyangeni umhlaza, nawo.

"I-Autophagy iyancipha njengoko sikhula, ke oku kuthetha ukuba iiseli ezingasasebenziyo okanye ezinokuthi zenze ingozi zivunyelwe ukuba zande, eyi-MO yeeseli zomhlaza," ucacisa uKeatley.

Ngelixa zonke iicancer ziqala kuhlobo oluthile lweeseli ezinesiphene, uPetre uthi umzimba kufuneka uziqaphele kwaye uzisuse ezo seli, zihlala zisebenzisa iinkqubo zokuzenzekelayo. Kungenxa yoko abanye abaphandi bejonga ukuba kungenzeka ukuba ukuzenzekelayo kunganciphisa umngcipheko womhlaza.

Ngelixa kungekho bungqina bobunzululwazi bokuxhasa oku, uPetre uthi abanye bacebisa ukuba iiseli zomhlaza ezininzi zinokususwa ngokuzikhulula.

Ucacisa ngale ndlela: “Ukwazi nokutshabalalisa izinto ezingahambanga kakuhle nokubangela ukuba zilungiswe kunegalelo ekunciphiseni umhlaza.”

Abaphandi bakholelwa ukuba izifundo ezitsha ziya kukhokelela kwingqondo eya kuthi ibancede bajolise kwi-autophagy njengonyango lomhlaza.

Ukutshintsha kokutya okunokunyusa ukuzimela

Khumbula ukuba ukuzilawula ngokuzenzekelayo kuthetha "ukuzitya." Ke, iyavakala into yokuba ukutya okukhawulezileyo kunye nokutya kwe-ketogenic kuyaziwa ukuba kubangele ukuzenzekelayo.

"Ukuzila ukutya [yeyona] nto ibangela ukuba umntu asebenze ngokuzenzekelayo," ucacisa watsho uPetre.

"I-Ketosis, ukutya okunamafutha amaninzi kunye ne-carbs ephantsi kuzisa izibonelelo ezifanayo zokuzila ukutya ngaphandle kokuzila ukutya, njengendlela emfutshane yokwenza utshintsho olufanayo olufanelekileyo," uyongeza. "Ngokungawongameli umzimba ngomthwalo wangaphandle, unika umzimba ithuba lokujonga impilo kunye nokulungisa."

Kwindlela yokutya yeketo, ufumana malunga neepesenti ezingama-75 zeekhalori zakho zemihla ngemihla kumanqatha, kunye neepesenti ezintlanu ukuya kwezili-10 zeekhalori zakho ezivela kwiikhabhohbhayithi.

Olu tshintsho kwimithombo yeekhalori lubangela ukuba umzimba wakho uguqule iindlela zayo zemetabolism. Iya kuqala ukusebenzisa amanqatha amafutha endaweni yeswekile evela kwiicarbohydrate.

Ukuphendula kolu thintelo, umzimba wakho uya kuqala ukuvelisa imizimba ye-ketone enezinto ezininzi zokukhusela. U-Khorana uthi uphononongo lubonisa ukuba i-ketosis nayo inokubangela indlala ebangelwa yindlala, enemisebenzi yothintelo.

"Amanqanaba asezantsi eswekile avela kwizidlo zombini kwaye adityaniswa ne-insulin esezantsi kunye namazinga aphezulu eglucagon," ucacisa uPetre. Kwaye inqanaba le-glucagon lelona liqala ukuzenzekelayo.

"Xa umzimba uphantsi kwiswekile ngokuzila ukutya okanye nge-ketosis, kuzisa uxinzelelo oluqinisekileyo oluvusa indlela yokulungisa ukusinda," uyongeza.

Indawo engeyo yokutya enokuthi nayo idlale indima ekuphembeleleni ukuzilawula komzimba kukuzilolonga. Ngokutsho kwesinye isilwanyana, ukuzilolonga emzimbeni kunokubangela ukuba amalungu omzimba azenzele ngokwamalungu ayinxalenye yenkqubo yokulawula ukutya.

Oku kunokubandakanya izihlunu, isibindi, ipancreas, kunye nezicubu zeadipose.

Umgca wezantsi

I-Autophagy iya kuqhubeka nokufumana ingqalelo njengoko abaphandi beqhuba izifundo ezininzi kwifuthe elinalo kwimpilo yethu.

Okwangoku, iingcali zezempilo kunye nezempilo ezinje ngeKhorana zikhomba kwinto yokuba kusekuninzi ekufuneka sikwenzile malunga nokuzimela kunye nendlela yokukhuthaza ngcono.

Kodwa ukuba unomdla wokuzama ukukhuthaza ukuzenzekelayo emzimbeni wakho, ucebisa ukuba uqale ngokudibanisa ukuzila nokuzilolonga rhoqo kwisiqhelo sakho.

Nangona kunjalo, kufuneka udibane nogqirha wakho ukuba uthatha nawaphi na amayeza, ukhulelwe, uncelise, okanye unqwenela ukukhulelwa, okanye unesifo esinganyangekiyo, njengesifo sentliziyo okanye isifo seswekile.

U-Khorana uyalumkisa ukuba awukhuthazwa ukuba uzila ukutya ukuba ungawela kulo naluphi na udidi olungentla.