I-Biologics kunye ne-PsA: Zithini izinto onokukhetha kuzo?

Umxholo

• Yintoni i-biologics?
• I-biologics isetyenziswa njani ukunyanga i-PsA?
• Zeziphi iindlela zam zokunyanga i-PsA nge-biologic?
• I-TNF-alpha inhibitors
• IL-12, IL-23, kunye ne-IL-17 inhibitors
• T-iseli inhibitors
• I-JAK kinase inhibitor
• Ngaba i-biologics ikhuselekile kuye wonke umntu one-PsA?
• Zithini iziphumo zokuthatha i-biologic?
• Ukuthatha

Ushwankathelo

I-Psoriatic arthritis, okanye i-PsA, ibangela ukudumba, ukuqina, kunye nentlungu edibeneyo. Akukho lunyango lwe-PsA, kodwa utshintsho kwindlela yokuphila kunye namayeza anokunceda ukulawula iimpawu.

Amayeza aqhelekileyo asetyenziswa zii-nonsteroidal anti-inflammatory drug (NSAIDs), isifo esiguqula amachiza e-antirheumatic (DMARDs), kunye ne-biologics.

I-Biologics ayiyonto intsha, kodwa inikezela ngonyango oluthe kratya ngoku kunakuqala. Izikhokelo ezitsha zincoma la machiza njengenye yeendlela zokuqala zonyango kwi-PsA.

Yintoni i-biologics?

Amayeza emveli aqukethe izinto zokwenziwa. Zenziwe ngeekhemikhali ezingafumaneki kwindalo.

Amachiza aqhelekileyo abantu abawaziyo kunye nabathembayo ayenziwa kwindawo yaselebhu evela kwizinto ezingezozobugcisa. I-Aspirin, umzekelo, yayimodareyithwa emva kwento kwi-willow bark, kodwa ngoku yenziwe ngezinto zokwenziwa.

Ngakolunye uhlangothi, i-Biologics yenziwe ngamacandelo ebhayoloji. Izazinzulu zisebenzisa iiseli ezipheleleyo, ii-enzymes, ii-antibodies, kunye nezinye izinto ukwenza iyeza elinomsebenzi othile.

Amathuba sele ubonakalisiwe kubuchwephesha bezonyango obenziwe kwizinto ezifumaneka kwindalo. Ukuba ukhe wanaso isitofu sokugonya okanye wafumana utofelo-gazi, uye wafumana unyango olwenziwe ngokusekwe kwizinto eziphilayo.

Kuba i-biologics ichane ngakumbi xa ujolise iiseli, kwaye ulingisa iimolekyuli ezifumaneka ngokwendalo emzimbeni, zihlala zisebenza ngakumbi. Baneziphumo ebezingalindelekanga ezimbalwa kunamachiza enziwe ngemichiza.

I-biologics isetyenziswa njani ukunyanga i-PsA?

Ukudumba ngesiqhelo kubangela ukudumba, ukuqina, kunye nentlungu edibeneyo echaza iPSA. I-Biologics esetyenziselwa ukunyanga i-PsA ijolise ngqo kwiindlela ezahlukeneyo emzimbeni ezenza ukudumba. Oku kwahlukile kumachiza emveli, ajolise kumanqanaba amaninzi kwinkqubo yomzimba yokuzikhusela.

Ngokuxhomekeka kwiimpawu zakho ze-psoriatic arthritis kunye nembali yonyango, ugqirha wakho unokucebisa enye yeebhayoloji ezininzi zoncedo.

Zeziphi iindlela zam zokunyanga i-PsA nge-biologic?

Kukho iindlela ezininzi zokunyanga i-PsA yakho nge-biologic. La mayeza angadityaniswa adityaniswe ngugqirha wakho ngokubhekisele kwindlela asebenza ngayo ngokunxulumene nenkqubo yomzimba yokuzikhusela.

I-TNF-alpha inhibitors

I-tumor necrosis factor-alpha (TNF-alpha) yiprotein ekhokelela kukudumba. Abantu abane-PsA banamanani agqithisileyo e-TNF-alpha kulusu lwabo okanye kumalungu abo.

La machiza mahlanu enzelwe ukuvimba le protein:

• ICimzia (i-certolizumab pegol)
• I-Enbrel (etanercept)
• Humira (adalimumab)
• I-Remicade (infliximab)
• ISimponi (golimumab)

Basebenza ngokumisa ukukhula okugqithileyo kweeseli zolusu kunye nokudumba okungakhokelela ekonakaleni kwezicwili ezidibeneyo.

IL-12, IL-23, kunye ne-IL-17 inhibitors

I-Interleukin-12, i-interleukin-17, kunye ne-interleukin-23 ziiproteni ezahlukeneyo ezinxulumene nokudumba. Iibhayoloji ezintlanu ezikhoyo ziya kuphazamisa umsebenzi okanye i-receptor ehambelana nazo.

La mayeza enzelwe ukuthintela ukudumba:

• UStelara (ustekinumab): IL-12/23
• ICosentyx (secukinumab): IL-17
• I-Taltz (ixekizumab): IL-17
• USiliq (brodalumab): IL-17
• I-Tremfya (guselkumab): IL-23

T-iseli inhibitors

Kubantu abane-arthritis, iiseli ze-T-lymphocyte, okanye ii-T-seli, zenziwa zasebenza, ezinokuthi zikhokelele ekwandeni kwezi seli. Abanye abantu abane-arthritis baya kuphuhlisa i-T-cell engaphezulu.

Ezi ziiseli zomzimba, esizidingayo sonke. Kodwa ngobuninzi, bavelisa imichiza ekhokelela kumonakalo odibeneyo, iintlungu kunye nokudumba.

I-Orencia (abatacept) liyeza elichaphazela iiseli ze-T. I-Orencia ayinciphisi inani leeseli ze-T, kodwa iyayeka ukukhutshwa kwemichiza ebangela iimpawu ngokuthintela ukwenziwa kwe-T-cell.

I-JAK kinase inhibitor

I-Xeljanz (tofacitinib) lelinye iyeza elamkelweyo kwi-PsA. Yi-JAK kinase inhibitor, ebhekisa kwimolekyuli encinci ethintela indlela ebandakanyeka ekuphenduleni kwenkqubo yomzimba yokuzikhusela.

Eli yeza alingobuchwephesha bezobuchwephesha, kodwa ugqirha wakho angathetha nawe ngalo. Ihlala iqokelelwe kunye ne-biologics kwiingxoxo malunga neearhente ezijolise ngakumbi kwi-autoimmunity.

Ngaba i-biologics ikhuselekile kuye wonke umntu one-PsA?

I-Biologics iyacetyiswa kwabo baphila ngokuphakathi ukuya kwi-PsA ebukhali. Kodwa abanye abantu abagqatswa kwi-biologics.

Kungenxa yokuba iziphumo ebezingalindelekanga zamachiza zinokwenza ingozi engaphezulu kunokulunga. Abantu abanamajoni omzimba abuthathaka okanye izifo ezisebenzayo akufuneki bathathe i-biologics ye-PsA yabo. La machiza acinezela amajoni omzimba kwaye anokungakhuseleki ukuba awakho sele enengxaki ngandlela thile.

Iindleko kunye nokuphuma epokothweni kwe-biologics nako kunokuba ngumqobo kwabanye abantu.

Zithini iziphumo zokuthatha i-biologic?

I-biology nganye ye-PsA yahlukile. Ngamnye uneziphumo ebezingalindelekanga ezinokubakho. Nangona kunjalo, kukwakho ukufana kule klasi yeziyobisi. Iziphumo ebezingalindelekanga ezixhaphakileyo kuzo zonke i-biologics ngumngcipheko okhulayo wosulelo olungaqhelekanga, okanye olungenelelayo.

Ukuba wena nogqirha ugqibe ukuzama le khosi yonyango nge-biologic, unokufumana iimpawu ezinje ngomkhuhlane okanye usulelo lokuphefumla. Kuba i-biologics inikwa ngenaliti okanye nge-IV, unokufumana ukungonwabi apho inaliti ibeka khona ulusu lwakho.

I-Biologics inokukhokelela kwiziphumo ebezingalindelekanga ezibi kakhulu, ezinje ngokuphazamiseka kwegazi okanye umhlaza. Ngezi zizathu, licebo elihle ukukhulisa ubudlelwane obuluqilima nogqirha wakho. Ngokudibeneyo, unokuthatha isigqibo sokuba ngaba unyango lwe-biologic lolona nyango lwe-psoriatic arthritis yakho.

Ukuthatha

I-Biologics yazise unyango ekujoliswe kulo kwabo baphila ngokuphakathi ukuya kwi-PsA ebukhali. Ayizizo zonke izinto ezintsha, kodwa ngoku zithathwa njengonyango lodidi lokuqala lokunyanga i-PsA.