Yintoni insulinoma, iimpawu eziphambili kunye nonyango

Umxholo

• Iimpawu eziphambili
• Uxilongo lwenziwa njani
• Izinketho zonyango
• 1. Utyando
• 2. Amayeza e-Hormonal kunye nabalawuli be-insulin
• 3. Unyango ngamayeza
• 4. Ukuncipha kunye nokuthanjiswa komzimba
• Izizathu ezinokubangela

I-Insulinoma, ekwabizwa ngokuba yi-islet cell tumor, luhlobo lwethumba kwi-pancreas, enobungozi okanye enobungozi, evelisa i-insulin egqithileyo, ebangela ukuba i-glucose yegazi yehle, ivelise i-hypoglycemia. Iimpawu ezibangelwa sesi sifo sinokuba nesiyezi, ukudideka engqondweni, ukungcangcazela kunye notshintsho kwiimvakalelo kwaye zenzeka ngenxa yokuhanjiswa kweglucose kwigazi.

Ukuchongwa kwe-insulinoma kwenziwa ngugqirha we-endocrinologist okanye i-oncologist kuvavanyo lwegazi, njengokuzila ukutya kwe-glucose kunye nokuvavanywa kwe-imaging, enokubalwa njenge-tomography, imaging resonance imaging okanye ukuskena kwezilwanyana zasekhaya, kwaye olona nyango lululo luqhaqho, amayeza amayeza kunye nolawulo lwegazi amanqanaba eswekile, kunye ne-chemotherapy, i-ablation okanye i-embolization.

Iimpawu eziphambili

I-Insulinoma luhlobo lwethumba elikwipancreas eliguqula amanqanaba eglucose egazi kwaye, ke, iimpawu eziphambili zihambelana nokunciphisa iswekile yegazi, ebizwa ngokuba yi-hypoglycemia, enje:

• Ukuphazamiseka okanye umbono ophindwe kabini;
• Ukudideka kwengqondo;
• Isiyezi;
• Ukuziva ubuthathaka;
• Ukucaphuka kakhulu;
• Imood iyatshintsha;
• Ukufa;
• Ukubila okugqithisileyo.

Kwiimeko ezinzima kakhulu, xa i-insulinoma ihambele phambili kwaye ichaphazela amanye amalungu omzimba, afana nesibindi, ingqondo kunye nezintso, iimpawu ezinjengokubanjwa, ukonyuka kwentliziyo, ukulahleka kwengqondo, ukuphelelwa ngamandla kunye ne-jaundice. Funda kabanzi malunga ne-jaundice kunye nendlela yokuyichonga.

Uxilongo lwenziwa njani

Ukuchongwa kwe-insulinoma kwenziwa kuvavanyo lwegazi, ekufuneka lwenziwe kwisisu esingenalutho, ukufumana inani leswekile kunye ne-insulin egazini kwaye, ngokubanzi, amaxabiso eswekile aphantsi kwaye amanqanaba e-insulin aphezulu. Jonga ukuba uvavanyo lokutya kweglucose lwenziwa njani kunye namaxabiso aqhelekileyo ekubhekiswa kuwo.

Ukufumana indawo ngqo, ubungakanani kunye nohlobo lwethumba kwi-pancreas kunye nokujonga ukuba i-insulinoma isasazekile na kwamanye amalungu omzimba, iimvavanyo zokucinga ezinje ngecomputer tomography, imaging resonance imaging okanye isilwanyana esiboniswe kwisilwanyana siboniswa yi-endocrinologist okanye oncologist.

Kwezinye iimeko, ugqirha unokuyalela ezinye iimvavanyo ukuba zincedise ukuxilongwa kwaye wazi ubungakanani besisu esinjenge-endoscopy, esetyenziselwa ukujonga ukuba ngaba eli thumba lifikile na ngaphakathi esiswini okanye emathunjini, nakwi-arteriography, echonga ukuhamba kwegazi kwi-pancreas.

Izinketho zonyango

I-insulinoma luhlobo lwethumba kwi-pancreas, enokuba yingozi okanye ibe yingozi, ekhokelela kutshintsho kumanqanaba eswekile yegazi, kwaye ukuba inyangwa kwangoko iyanyangeka. Unyango lolu hlobo lwesifo luboniswa yi-oncologist kwaye luxhomekeke kwindawo, ubungakanani kunye nenqanaba le-tumor, nakubukho be-metastases, kwaye kunokucetyiswa:

1. Utyando

Utyando lolona hlobo lonyango lufanelekileyo lwe-insulinoma, nangona kunjalo, ukuba ithumba elikwipancreas likhulu kakhulu, lisasazeke kwamanye amalungu omzimba okanye umntu akaphilanga, ugqirha usenokungacebisi ukwenza utyando. Ukuba utyando lwenziwa, isigulana sinokufuna ukusebenzisa idreyini, ebizwa ngokuba yipenrose, ukuphelisa ulwelo oluqokelelwe ngexesha lotyando. Bona ngakumbi indlela yokunyamekela idreyini emva kotyando.

2. Amayeza e-Hormonal kunye nabalawuli be-insulin

Amanye amayeza anokusetyenziselwa ukunyanga i-insulinoma, enje ngamachiza anciphisa okanye acothise imveliso yehomoni eyenza ukuba ithumba likhule, njenge-somatostatin analogue, ebizwa ngokuba yi-octreotide kunye ne-lanreotide.

Amanye amachiza aboniswe kunyango lwesi sifo sisisombululo esinceda ukunciphisa amanqanaba e-insulin egazini, ukunqanda ukwehla kakhulu kweswekile. Ukongeza, ukutya okuneswekile eninzi kunokwenziwa ukuze amanqanaba eswekile aqheleke ngakumbi.

3. Unyango ngamayeza

I-Chemotherapy icetyiswa yi-oncologist ukunyanga i-insulinoma nge-metastasis kwaye inokusetyenziswa kwamachiza emthanjeni ukwenzela ukutshabalalisa iiseli ezingaqhelekanga, ezikhokelela ekukhuleni kwethumba, kunye nenani leeseshoni kunye nohlobo lweziyobisi esetyenzisiweyo sixhomekeke kwiimpawu zesifo, ezinje ngobungakanani kunye nendawo esihlala kuyo.

Nangona kunjalo, amachiza asetyenziswa kakhulu ekupheliseni iiseli ze-insulinoma yi-doxorubicin, i-fluorouracil, i-temozolomide, i-cisplatin kunye ne-etoposide. La machiza ahlala elawulwa kwi-serum, ngokusebenzisa i-catheter esemthanjeni kwaye, kwezinye iimeko, ngaphezulu kwesinye kunokusetyenziswa, kuxhomekeke kumgaqo olungiselelwe ngugqirha.

4. Ukuncipha kunye nokuthanjiswa komzimba

I-Radiofrequency ablation luhlobo lonyango olusebenzisa ubushushu, oluveliswa ngamaza erediyo, ukubulala iiseli ze-insulinoma ezigulayo kwaye kufanelekile ukunyanga amathumba amancinci angasasazeki kwamanye amalungu omzimba.

Njengakwisiqalo, ukuqiniswa kwemithambo yinkqubo ekhuselekileyo kunye nehlaselayo encinci, ekhuthazwa yi-oncologist ukunyanga i-insulinomas encinci kwaye ibandakanya ukusetyenziswa kolwelo oluthile, nge-catheter, ukuthintela ukuhamba kwegazi kwi-tumor, ukunceda ukuphelisa iiseli ezigulayo. .

Izizathu ezinokubangela

Izizathu ezichanekileyo ze-insulinoma azikachazwa ngokupheleleyo, kodwa zihlala zikhula ngakumbi kwabasetyhini kunamadoda, kubantu abaphakathi kweminyaka engama-40 nama-60 ubudala kwaye banezifo zofuzo ezinje ngohlobo 1 lwe-neurofibromatosis okanye isifo sephepha. Funda ngakumbi malunga ne-tuberous sclerosis kunye nendlela inyangwa ngayo.

Ukongeza, ukuba nezinye izifo ezinje nge-endocrine neoplasia, ebangela ukukhula okungaqhelekanga kweeseli kwinkqubo ye-endocrine, kunye ne-Von Hippel-Lindau syndrome, efunyanwa njengelifa kwaye ikhokelela ekubonakaleni kwama-cysts emzimbeni wonke, kunokunyusa amathuba okubonakala njenge-insulinoma .