Umbhali: Robert Simon
Umhla Wokudalwa: 24 Isilimela 2021
Hlaziya Umhla: 7 Eyokwindla 2025
Anonim
Cinqair (reslizumab)- Asthma- by Saro Arakelians, PharmD- Episode # 123
Ividiyo: Cinqair (reslizumab)- Asthma- by Saro Arakelians, PharmD- Episode # 123

Umxholo

Yintoni iCinqair?

ICinqair ligama lonyango elichaza igama likagqirha. Isetyenziselwa ukunyanga isifo se-asthma esiqatha kubantu abadala. Ngolu hlobo lwesifo se-asthma esiqatha, unamazinga aphezulu eeosinophil (uhlobo lweseli emhlophe yegazi). Uyakuthatha iCinqair ukongeza kwezinye iziyobisi zesifuba. ICinqair ayisetyenziselwa ukunyanga i-asthma flare-ups.

ICinqair iqulethe i-reslizumab, eluhlobo lwechiza elibizwa ngokuba yi-biologic. I-Biologics yenziwe kwiiseli hayi kwimichiza.

ICinqair yinxalenye yodidi lweziyobisi ekuthiwa yi-interleukin-5 antagonist monoclonal antibodies (IgG4 kappa). Iklasi yeziyobisi liqela lamayeza asebenza ngendlela efanayo.

Umboneleli wezempilo uya kukunika iCinqair njenge-intravenous (IV) ukumnika kwi-ofisi kagqirha wakho okanye eklinikhi. Le yinaliti emthanjeni otyibilika kancinci ekuhambeni kwexesha. ICinqair infusions ihlala ithatha imizuzu engama-20 ukuya kwengama-50.

Ukusebenza ngempumelelo

I-Cinqair ifunyenwe iyasebenza kunyango lwe-asthma eosinophilic.


Kwizifundo ezibini zeklinikhi, i-62% kunye ne-75% yabantu abafumene iCinqair yesifo se-asthma esinamandla asinayo i-asthma flare-up. Kodwa kuphela i-46% kunye ne-55% yabantu abathathe indawo ye-placebo (akukho nyango) bengenayo i-asthma flare-up. Bonke abantu baphathwe ngeCinqair okanye nge-placebo iiveki ezingama-52. Uninzi lwabantu lwaluthatha i-corticosteroids kunye ne-beta-agonists ngexesha lokufunda.

ICinqair generic okanye i-biosimilar

ICinqair ifumaneka kuphela njengeyeza elinegama lophawu. Iqulethe isiyobisi esisebenzayo se-reslizumab.

ICinqair ayifumaneki okwangoku kwifom ye-biosimilar.

I-biosimilar liyeza elifana negama lophawu lweziyobisi. Iyeza elenziwa lafana nalawo aveliswe ngumenzi, kwelinye icala, liyikopi ngqo yegama lesiyobisi. I-Biosimilars isekwe kumachiza e-biologic, awenziwe ngamalungu ezinto eziphilayo. Iijenerikhi zisekwe kunyango oluqhelekileyo olwenziwe kwiikhemikhali.

I-Biosimilars kunye ne-genics zombini zikhuselekile kwaye zisebenza njengesiyobisi segama elenziwe ukuba likope. Kananjalo bathanda ukuxabisa imali encinci kunamayeza egama loshicilelo.


Iindleko zeCinqair

Njengawo onke amayeza, indleko zeCinqair ziyahluka. Umboneleli wezempilo uya kukunika iyeza njenge-intravenous (IV) ukumnika kwi-ofisi kagqirha wakho okanye eklinikhi. Iindleko ozihlawulela ukumnika kwakho ziya kuxhomekeka kwisicwangciso sakho seinshurensi nalapho ufumana unyango lwakho. ICinqair ayifumaneki ukuba uyithenge kwikhemesti yasekuhlaleni.

Uncedo lwezezimali kunye neinshurensi

Ukuba ufuna inkxaso yemali ukuhlawulela iCinqair, okanye ukuba ufuna uncedo lokuqonda i-inshurensi yakho, uncedo luyafumaneka.

I-Teva Respiratory, LLC, umenzi weCinqair, ubonelela ngeTeva Support Solutions. Ngolwazi oluthe kratya kunye nokufumanisa ukuba uyakufanelekela na ukuxhaswa, tsalela umnxeba ku-844-838-2211 okanye undwendwele iwebhusayithi yenkqubo.

Iziphumo ebezingalindelekanga zeCinqair

ICinqair inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa kusasazwa iCinqair. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga ezinokubakho zeCinqair, thetha nogqirha wakho okanye usokhemesti. Banokukunika iingcebiso malunga nendlela yokujongana nayo nayiphi na imiphumela emibi enokuthi ikhathaze.


Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo zeCinqair ziintlungu ze-oropharyngeal. Le yintlungu kwinxalenye yomqala wakho esemva komlomo wakho. Kwizifundo zeklinikhi, i-2.6% yabantu abathathe iCinqair banentlungu ye-oropharyngeal. Oku kwafaniswa ne-2.2% yabantu abathathe i-placebo (akukho nyango).

Intlungu ye-Oropharyngeal inokuhamba kwiintsuku ezimbalwa okanye kwiiveki ezimbalwa. Ukuba iintlungu zinzima okanye azihambi, thetha nogqirha wakho okanye usokhemesti. Banokucebisa ngonyango ukukunceda uzive ungcono.

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezimandundu ezivela eCinqair aziqhelekanga, kodwa zinokwenzeka. Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya oku kulandelayo:

  • I-Anaphylaxis * (uhlobo lweempendulo ezinzima). Iimpawu zingabandakanya:
    • ingxaki yokuphefumla, kubandakanya ukukhwehlela kunye nokuvutha
    • ingxaki yokuginya
    • ukudumba ebusweni bakho, emlonyeni, okanye emqaleni
    • ukubetha kancinci
    • ukutshitshiswa kwe-anaphylactic (ukwehla ngesiquphe koxinzelelo lwegazi kunye nengxaki yokuphefumla)
    • irhashalala
    • ukurhawuzelela ulusu
    • intetho engacacanga
    • isisu (isisu) iintlungu
    • isicaphucaphu
    • ukudideka
    • ixhala
  • Umhlaza. Iimpawu zingabandakanya:
    • Utshintsho emzimbeni wakho (umbala owahlukileyo, ubume, ukudumba, okanye izigaqa esifubeni sakho, isinyi, isilonda, okanye ulusu)
    • intloko ebuhlungu
    • ukuxhuzula
    • umbono okanye ingxaki yokuva
    • jonga kwicala elinye lobuso bakho
    • ukopha okanye ukugruzuka
    • ukukhohlela
    • utshintsho kumdla wokutya
    • ukudinwa (ukunqongophala kwamandla)
    • ifiva
    • ukudumba okanye amaqhuma
    • ukutyeba okanye ukwehla kobunzima

Iinkcukacha zesiphumo

Unokuzibuza ukuba zenzeka kangaphi ezinye iziphumo ebezingalindelekanga ngeli chiza. Nazi ezinye iinkcukacha kwiziphumo ebezingalindelekanga ezinokubangelwa leli chiza.

Ukuphendula ngokuchaseneyo

Njengoninzi lweziyobisi, abanye abantu banokuphendula emva kokufumana iCinqair. Iimpawu zokuphendula kancinci kunokubandakanya:

  • irhashalala
  • ukucheba
  • ukucoca (ukufudumala nokubomvu kwesikhumba sakho)

Akwaziwa ukuba bangaphi abantu abaphuhlise ukusabela okungafunekiyo emva kokuba befumene iCinqair.

Impendulo eyingozi kakhulu inqabile kodwa inokwenzeka. Ibizwa ngokuba yi-anaphylaxis (jonga ngezantsi).

I-Anaphylaxis

Ngelixa sifumana iCinqair, abanye abantu banokuphuhlisa imeko enqabileyo yokungezwani komzimba ebizwa ngokuba yi-anaphylaxis. Le mpendulo inzima kwaye inokusongela ubomi. Kwizifundo zeklinikhi, i-0.3% yabantu abafumene iCinqair bakhulisa i-anaphylaxis.

Amajoni akho omzimba anceda ukukhusela umzimba wakho kwizinto ezinokubangela izifo. Kodwa ngamanye amaxesha umzimba wakho uyabhideka kwaye ulwe nezinto ezingabangeli zifo. Abanye abantu, amajoni abo omzimba ahlasela izithako eCinqair. Oku kunokukhokelela kwi-anaphylaxis.

Iimpawu ze-anaphylaxis zingabandakanya:

  • ukudumba phantsi kolusu lwakho, ikakhulu kwiinkophe zakho, imilebe, izandla, okanye iinyawo
  • ukudumba kolwimi lwakho, umlomo, okanye umqala
  • ingxaki yokuphefumla

I-Anaphylaxis inokwenzeka kanye emva kwedosi yakho yesibini yeCinqair, ke ngoko kubalulekile ukuba impendulo ilawulwe kwangoko.

Kungenxa yesi sizathu le nto umboneleli wakho wezempilo eza kukubeka esweni iiyure ezininzi emva kokuba ufumene iCinqair. Ukuba uhlakulela iimpawu ze-anaphylaxis, umboneleli wakho wezempilo uya kukunyanga kwangoko. Baya kukwazisa ugqirha wakho.

Ukuba ugqirha wakho ufuna uyeke ukusebenzisa iCinqair, banokucebisa ngamanye amayeza.

Ukuphendula kwe-Anaphylactic ngamanye amaxesha kunokubangela i-biphasic anaphylaxis. Olu hlaselo lwesibini lwe-anaphylaxis. I-Biphasic anaphylaxis inokwenzeka kwiiyure ukuya kwiintsuku ezimbalwa emva kohlaselo lokuqala. Ukuba unayo impendulo ye-anaphylactic, umboneleli wakho wezempilo unokufuna ukukujonga ngakumbi. Baza kufuna ukuqinisekisa ukuba awuphuhlisi i-biphasic anaphylaxis.

Iimpawu ze-biphasic anaphylaxis zinokubandakanya:

  • Ulusu olurhawuzayo, olubomvu, okanye olunemingxunya (irchy)
  • ubuso nobulwimi budumbile
  • ingxaki yokuphefumla
  • isisu (isisu) iintlungu
  • ukugabha
  • urhudo
  • uxinzelelo lwegazi oluphantsi
  • ukulahleka kwengqondo (ukuphelelwa amandla)
  • ukutshitshiswa kwe-anaphylactic (ukwehla ngesiquphe koxinzelelo lwegazi kunye nengxaki yokuphefumla)

Ukuba awukho kwiziko lokhathalelo lwempilo kwaye ucinga ukuba une-anaphylactic okanye i-biphasic reaction kwiCinqair, tsalela umnxeba ku-911 ngoko nangoko. Emva kokuba impendulo iphathwe, yazisa ugqirha wakho. Banokucebisa ngesiyobisi se-asthma esahlukileyo.

Umhlaza

Amayeza athile anokubangela ukuba iiseli zakho ziqhubeke nokukhula ngokobungakanani okanye inani kwaye zibe ngumhlaza. Ngamanye amaxesha ezi seli zomhlaza zihambela kwizicubu kwiindawo ezahlukeneyo zomzimba wakho. Ezi zihlunu zibizwa ngokuba ngamathumba.

Kwizifundo zeklinikhi, i-0.6% yabantu abafumene iCinqair bakhula amathumba abumba kwiindawo ezahlukeneyo zomzimba. Uninzi lwabantu kwafunyaniswa ukuba banamathumba kwisithuba seenyanga ezintandathu zedosi yabo yokuqala yeCinqair. Oku kwafaniswa ne-0.3% yabantu abathathe i-placebo (akukho nyango).

Ukuba uqaphela naziphi na iimpawu zamathumba ezingahambiyo, xelela ugqirha wakho. (Jonga "Iziphumo ebezingalindelekanga ezimandundu" apha ngasentla ukuze ufumane uluhlu lweempawu.) Unokufuna iimvavanyo ukunceda ugqirha wakho afumanise ngakumbi malunga namathumba. Ugqirha wakho unokucebisa iyeza lesifuba esahlukileyo.

Umthamo weCinqair

Idosi yeCinqair emiselwe ngugqirha wakho iya kuxhomekeka kubunzima bakho.

Olu lwazi lulandelayo luchaza iidosi eziqhelekileyo ezisetyenziswayo okanye ezicetyiswayo. Nangona kunjalo, umboneleli wakho wezempilo unokukunika eyahlukileyo ukuba uyalelwa ngugqirha wakho ukuba enze njalo. Ugqirha wakho uya kumisela eyona idosi ilungele iimfuno zakho.

Iifom zamachiza kunye namandla

ICinqair iza nge-10-mL vial. Ibhotile nganye ine-100 mg ye-reslizumab. Umboneleli wakho wezempilo uya kukunika esi sisombululo njengokufakwa ngaphakathi (IV) kokufakwa ngaphakathi. Le yinaliti emthanjeni otyibilika kancinci ekuhambeni kwexesha. ICinqair infusions ihlala ithatha imizuzu engama-20 ukuya kwengama-50.

Isisombululo se-asthma

ICinqair imiselwe kumthamo we-3 mg / kg, kanye kwiiveki ezine.

Isixa seCinqair osifumeneyo siyakuxhomekeka kubungakanani obulinganisileyo. Umzekelo, i-150-lb. indoda inobunzima obumalunga ne-68 kg. Ukuba ugqirha wakhe umisela i-3 mg / kg yeCinqair kube kanye kwiiveki ezine, idosi yeCinqair iya kuba yi-204 mg ngokufakwa (68 x 3 = 204).

Kuthekani ukuba ndiphose idosi?

Ukuba uphoswa lidinga lokufumana iCinqair, tsalela umnikezeli wakho wezempilo ngokukhawuleza. Banokucwangcisa idinga elitsha kwaye bahlengahlengise ixesha lolunye utyelelo xa kufuneka njalo.

Ingcinga efanelekileyo yokubhala ishedyuli yonyango kwikhalenda. Unokuseta isikhumbuzi kwifowuni yakho ukuze ungaphoswa kukuqeshwa.

Ngaba kuya kufuneka ndisebenzise eli chiza ixesha elide?

ICinqair yenzelwe ukuba isetyenziswe njengonyango lwexesha elide kwi-asthma ye-eosinophilic. Ukuba wena nogqirha wakho nibona ukuba iCinqair ikhuselekile kwaye iyasebenza kuwe, uya kuyisebenzisa ixesha elide.

ICinqair yesifuba

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anjengeCinqair ukunyanga iimeko ezithile. ICinqair ivunyiwe ukuba inyange isifo se-asthma esiqatha kubantu abadala. Iyeza alivunyelwanga ukunyanga ezinye iintlobo zesifo sombefu. Kwakhona, iCinqair ayivunyelwanga ukunyanga i-asthma flare-ups.

Uya kuthatha iCinqair ukongeza kunyango lwakho lwesifuba.

Kwisifundo seklinikhi, iCinqair yanikwa abantu abangama-245 abane-asthma ye-eosinophilic eqatha kwiiveki ezingama-52. Kweli qela, i-62% yabantu babengenayo i-asthma flare-up ngelo xesha. Oku kwafaniswa ne-46% yabantu abafumene i-placebo (akukho lunyango). Kulabo banesifo se-asthma:

  • Abantu abafumene iCinqair babenama-50% asezantsi amaqondo okuqhambuka kunyaka omnye kunabantu abafumene i-placebo.
  • Abantu abafumene iCinqair banenqanaba eliphantsi le-55% lokuphazamiseka okufuna ukusetyenziswa kwe-corticosteroids kunabantu abafumene i-placebo.
  • Abantu abafumene iCinqair bane-34% yenqanaba elisezantsi lokuqaqanjelwa kukukhokelela ekuhlaleni esibhedlele kunabantu abafumene i-placebo.

Kwesinye isifundo seklinikhi, iCinqair yanikwa abantu abangama-232 abane-asthma ye-eosinophilic eqatha kwiiveki ezingama-52. Kweli qela, i-75% yabantu babengenayo i-asthma flare-up ngelo xesha. Oku kwafaniswa ne-55% yabantu abafumene i-placebo (akukho nyango). Kulabo banesifo se-asthma:

  • Abantu abafumene iCinqair babenama-59% asezantsi amaqondo okuqhambuka kunabantu abafumene i-placebo.
  • Abantu abafumene iCinqair babenama-61% asezantsi amaqondo e-flare-ups awayefuna ii-corticosteroids kunabantu abafumene i-placebo.
  • Abantu abafumene iCinqair babenama-31% asezantsi amaqondo okuqhambuka akhokelela ekuhlaleni esibhedlele kunabantu abafumene i-placebo.

Ukusetyenziswa kweCinqair kunye nezinye iziyobisi

Wenzelwe ukuba usebenzise iCinqair kunye namayeza akho esifuba sombefu. Imizekelo yamachiza anokusetyenziswa kunye neCinqair ukunyanga isifo se-asthma esomeleleyo kubandakanya:

  • Inhaled kunye ne-corticosteroids yomlomo. Eyona nto isetyenziswa rhoqo kwisifo sombefu esibuhlungu kubandakanya:
    • I-beclomethasone dipropionate (Qvar Redihaler)
    • I-budesonide (iPulmicort Flexhaler)
    • iciclesonide (Alvesco)
    • i-fluticasone propionate (iArmonAir RespiClick, iArnuity Ellipta, iFlovent Diskus, iFlovent HFA)
    • I-mometasone furoate (Asmanex HFA, Asmanex Twisthaler)
    • i-prednisone (iRayos)
  • I-beta-adrenergic bronchodilators. Eyona nto isetyenziswa rhoqo kwisifo sombefu esibuhlungu kubandakanya:
    • isalmeterol (iSerevent)
    • formoterol (Foradil)
    • Ialbuterol (ProAir HFA, ProAir RespiClick, Proventil HFA, Ventolin HFA)
    • levalbuterol (Xopenex, Xopenex HFA)
  • Iitshintshi zendlela yeLeukotriene. Eyona nto isetyenziswa rhoqo kwisifo sombefu esibuhlungu kubandakanya:
    • imontelukast (Singulair)
    • zafirlukast (Ukuchaneka)
    • zileuton (Zyflo)
  • I-Muscarinic blockers, uhlobo lwe-anticholinergic. Eyona nto isetyenziswa rhoqo kwisifo sombefu esibuhlungu kubandakanya:
    • itiotropium bromide (iSpiriva Respimat)
    • ipratropium
  • Ithiophylline

Uninzi lwala machiza luza njengemveliso yokudibanisa. Umzekelo, Symbicort (budesonide kunye formoterol) kunye neAdvair Diskus (fluticasone kunye nesalmeterol).

Olunye uhlobo lwamayeza oya kuthi ugcine ulisebenzisa kunye neCinqair sisixhobo sokuhlangula. Nangona iCinqair isebenza ukunceda ukuthintela i-asthma flare-ups, usenokuhlaselwa sisifo sombefu. Xa oku kusenzeka, kuyakufuneka usebenzise i-inhaler yokuhlangula ukulawula isifuba sakho kwangoko. Qiniseka ukuba uyayiphatha inhaler yakho yohlangulo ngamaxesha onke.

Ukuba usebenzisa iCinqair, sukuyeka ukuthatha amanye amayeza esifuba ngaphandle kokuba ugqirha wakho ukuxelele. Kwaye ukuba unemibuzo malunga nenani leziyobisi ozithathayo, buza ugqirha wakho.

Ezinye iindlela zecinqair

Amanye amachiza akhoyo anokunyanga isifuba esinamandla se-eosinophilic asthma. Abanye banokukulungela ngcono kunabanye. Ukuba unomdla wokufumana enye iCinqair, thetha nogqirha wakho. Banokukuxelela ngamanye amayeza anokukusebenzela.

Imizekelo yezinye iziyobisi ezingasetyenziselwa ukunyanga i-asthma ye-eosinophilic asthma ibandakanya:

  • mepolizumab (iNucala)
  • ibenralizumab (Fasenra)
  • i-omalizumab (iXolair)
  • dupilumab (Iphindwe kabini)

ICinqair vs Nucala

Unokuzibuza ukuba iCinqair ithelekiswa njani namanye amayeza amiselwe ukusetyenziswa okufanayo. Apha sijonga indlela iCinqair neNucala ifana ngayo kwaye yahlukile.

Sebenzisa

Ulawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) luvumile zombini iCinqair kunye neNucala ukunyanga isifuba se-eosinophilic esibi kubantu abadala. U-Nucala uvunyiwe ukuba aphathe i-asthma eosinophilic eqinile kubantwana abaneminyaka eli-12 ukuya kwe-18 ubudala. Omabini la mayeza asetyenziswa kunye namanye amayeza esi sifo.

Ukongeza, iNucala ivunyiwe ukuba inyange isifo esinqabileyo esibizwa ngokuba yi-eosinophilic granulomatosis kunye ne-polyangiitis (EGPA). Esi sifo sikwabizwa ngokuba yi-Churg-Strauss syndrome, kwaye sibangela ukuba imithambo yegazi yakho idumbe (idumbe).

Zombini iCinqair kunye neNucala zikudidi lweziyobisi ezibizwa ngokuba zii-interleukin-5 antagonist monoclonal antibodies. Iklasi yeziyobisi liqela lamayeza asebenza ngendlela efanayo.

Iifom zeziyobisi kunye nolawulo

ICinqair iqulethe isiyobisi esisebenzayo se-reslizumab. I-Nucala iqulethe i-mepolizumab esebenzayo.

ICinqair iza ngeebhotile. Umboneleli wakho wezempilo uya kukunika isisombululo njenge-injection kwi-vein yakho (ukumnika ukungena ngaphakathi). ICinqair infusions ihlala ithatha imizuzu engama-20 ukuya kwengama-50.

UNucala uza ngeendlela ezintathu ezahlukeneyo:

  • Ibhotile yedosi enye yomgubo. Umboneleli wakho wezempilo uya kuxuba umgubo ngamanzi angenazintsholongwane. Emva koko baya kukunika isisombululo njengenaliti phantsi kolusu lwakho (inaliti yangaphantsi).
  • Ipeni enye yediski yokufaka i-autoinjector. Umboneleli wakho wezempilo uya kuqala akufundise ukuba usisebenzisa njani usiba. Emva koko unokuzifaka inaliti phantsi kolusu lwakho.
  • Idosi enye yesirinji ekhethiweyo. Umboneleli wakho wezempilo uya kuqala akufundise ukuba ungayisebenzisa njani isirinji. Emva koko unokuzifaka inaliti phantsi kolusu lwakho.

ICinqair imiselwe kumthamo we-3 mg / kg, kanye kwiiveki ezine. Inani leziyobisi ozifumanayo liya kuxhomekeka kubungakanani obulinganisileyo.

Umlinganiselo ophakanyisiweyo weNucala we-asthma yi-100 mg, kanye emva kweeveki ezine.

Iziphumo kunye neengozi

ICinqair kunye neNucala bobabini bakudidi olunye lweziyobisi, ke zisebenza ngendlela efanayo. La mayeza mabini anokubangela ukwahluka kakhulu okanye iziphumo ezifanayo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeCinqair okanye ngeNucala.

  • Inokwenzeka ngeCinqair:
    • Intlungu ye-oropharyngeal (iintlungu kwinxalenye yomqala wakho esemva komlomo wakho)
  • Inokwenzeka ngeNucala:
    • intloko ebuhlungu
    • umqolo obuhlungu
    • ukudinwa (ukunqongophala kwamandla)
    • ukusabela kolusu kwindawo yenaliti, kubandakanya iintlungu, ukuba bomvu, ukudumba, ukurhawuzelela, imvakalelo evuthayo

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeCinqair, kunye neNucala, okanye zombini iziyobisi (xa zinikwe ngokwahlukeneyo).

  • Inokwenzeka ngeCinqair:
    • amathumba
  • Inokwenzeka ngeNucala:
    • Usulelo lwe-herpes zoster (i-shingles)
  • Inokwenzeka kunye neCinqair kunye neNucala:
    • iimpendulo ezibi, kubandakanya i-anaphylaxis

Ukusebenza ngempumelelo

ICinqair kunye neNucala zombini zisetyenziselwa ukunyanga isifo se-asthma esibi.

La machiza awathelekiswanga ngokuthe ngqo kwizifundo zeklinikhi, kodwa uphononongo lwezifundo lufumanise zombini iCinqair kunye neNucala ukuba isebenze ekunciphiseni inani le-asthma flare-ups.

Iindleko

ICinqair kunye neNucala bobabini abasebenzisa iziyobisi. Okwangoku azikho iintlobo zebhayosimilar zeziyobisi.

I-biosimilar liyeza elifana negama lophawu lweziyobisi. Iyeza elenziwa lafana nalawo aveliswe ngumenzi, kwelinye icala, liyikopi ngqo yegama lesiyobisi. I-Biosimilars isekwe kumachiza e-biologic, awenziwe ngamalungu ezinto eziphilayo. Iijenerikhi zisekwe kunyango oluqhelekileyo olwenziwe kwiikhemikhali. I-Biosimilars kunye ne-genics zombini zikhuselekile kwaye zisebenza njengesiyobisi segama abazama ukukopa. Kananjalo bathanda ukuxabisa imali encinci kunamayeza egama loshicilelo.

Ngokutsho koqikelelo kwi-WellRx.com, iCinqair ngokubanzi ixabisa ngaphantsi kweNucala. Ixabiso langempela oza kulihlawula naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi nakwindawo okuyo.

ICinqair vs Fasenra

Ukongeza kwiNucala (ngasentla), iFasenra lelinye iyeza elinokusetyenziswa okufanayo nokweCinqair. Apha sijonga indlela iCinqair kunye neFasenra ezifanayo kunye ezahlukeneyo.

Sebenzisa

Ulawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) luvumile zombini iCinqair kunye neFasenra ukunyanga isifuba se-eosinophilic asthma kubantu abadala. I-Fasenra ikwavunyiwe ukuba inyange isifo se-asthma esibi kubantwana abaneminyaka eli-12 ukuya kweli-18. Omabini la machiza asetyenziswa kunye namanye amayeza esi sifo.

Zombini iCinqair kunye neFasenra zikudidi lweziyobisi ezibizwa ngokuba zii-interleukin-5 antagonist monoclonal antibodies. Iklasi yeziyobisi liqela lamayeza asebenza ngendlela efanayo.

Iifom zeziyobisi kunye nolawulo

ICinqair iqulethe isiyobisi esisebenzayo se-reslizumab. I-Fasenra iqulethe iziyobisi ezisebenzayo ze-benralizumab.

ICinqair iza ngebhotile. Umboneleli wakho wezempilo uya kukunika isisombululo njenge-injection kwi-vein yakho (ukumnika ukungena ngaphakathi). ICinqair infusions ihlala ithatha imizuzu engama-20 ukuya kwengama-50.

UFasenra uza kwisirinji ekhethiweyo. Umboneleli wezempilo uya kukunika iyeza njengelitofu phantsi kolusu lwakho (inaliti yangaphantsi).

ICinqair imiselwe kumthamo we-3 mg / kg, kanye kwiiveki ezine. Inani leziyobisi ozifumanayo liya kuxhomekeka kubungakanani obulinganisileyo.

Kwiidosi zakho zokuqala ezintathu zeFasenra, uya kufumana i-30 mg kanye kwiiveki ezine. Emva koko, uya kufumana i-30 mg yeFasenra kanye kwiiveki ezisibhozo.

Iziphumo kunye neengozi

ICinqair kunye neFasenra bobabini bakudidi olunye lweziyobisi, ke zisebenza ngendlela efanayo. La mayeza mabini anokubangela ukwahluka kakhulu okanye iziphumo ebezingalindelekanga ezifanayo. Apha ngezantsi kunemizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeCinqair okanye ngeFasenra.

  • Inokwenzeka ngeCinqair:
    • Intlungu ye-oropharyngeal (iintlungu kwinxalenye yomqala wakho esemva komlomo wakho)
  • Ngaba kunokwenzeka ngeFasenra:
    • intloko ebuhlungu
    • umqala obuhkungu

Iziphumo ebezingalindelekanga ezimandundu

Olu luhlu lunemizekelo yeziphumo ebezingalindelekanga ezinokubakho ngeCinqair, kunye neFasenra, okanye zombini iziyobisi (xa zinikwe ngokukodwa).

  • Inokwenzeka ngeCinqair:
    • amathumba
  • Ngaba kunokwenzeka ngeFasenra:
    • zimbalwa iziphumo ebezingalindelekanga eziqhelekileyo
  • Inokwenzeka kunye neCinqair kunye neFasenra:
    • iimpendulo ezibi, kubandakanya i-anaphylaxis

Ukusebenza ngempumelelo

ICinqair kunye neFasenra zombini zisetyenziselwa ukunyanga isifo se-asthma esibi.

La machiza khange athelekiswe ngokuthe ngqo kwizifundo zeklinikhi. Kodwa uphononongo lwezifundo lufumanise ukuba iCinqair isebenze ngakumbi ekuthinteleni i-asthma flare-ups kuneFasenra.

Iindleko

ICinqair kunye neFasenra zozibini iziyobisi ezinamagama. Okwangoku azikho iintlobo zebhayosimilar zeziyobisi.

I-biosimilar liyeza elifana negama lophawu lweziyobisi. Iyeza elenziwa lafana nalawo aveliswe ngumenzi, kwelinye icala, liyikopi ngqo yegama lesiyobisi. I-Biosimilars isekwe kumachiza e-biologic, awenziwe ngamalungu ezinto eziphilayo. Iijenerikhi zisekwe kunyango oluqhelekileyo olwenziwe kwiikhemikhali. I-Biosimilars kunye ne-genics zombini zikhuselekile kwaye zisebenza njengesiyobisi segama abazama ukukopa. Kananjalo bathanda ukuxabisa imali encinci kunamayeza egama loshicilelo.

Ngokwengqikelelo kwi-WellRx.com, iCinqair ngokubanzi ixabisa ngaphantsi kweFasenra. Elona xabiso uzakuhlawula ngalo naliphi na ichiza liya kuxhomekeka kwisicwangciso sakho seinshurensi nakwindawo okuyo.

ICinqair kunye notywala

Akukho nxibelelwano lwaziwayo phakathi kweCinqair kunye notywala ngeli xesha. Kodwa abanye abantu abane-asthma banokuphuhlisa i-flare-ups ngelixa besela utywala okanye emva kokuba besele utywala. Iwayini, i-cider, kunye nobhiya kunokwenzeka ukuba zibangele ezi zinto ziphazamisayo kunezinye iziselo ezinxilisayo.

Ukuba une-asthma flare-up ngelixa usela utywala, yeka ukusela utywala kwangoko. Yazisa ugqirha wakho malunga ne-flare-up ngexesha lotyelelo lwakho olulandelayo.

Thetha nogqirha wakho malunga nokuba ungasela kangakanani kunye nohlobo luni lotywala. Banokukuxelela ukuba kukhuseleke kangakanani ukusela ngexesha lonyango lwakho.

Ukudibana kweCinqair

Akukho kunxibelelana kwaziwayo phakathi kweCinqair kunye namanye amayeza, amayeza, izongezo, okanye ukutya. Kodwa ezinye zezi zinokunyusa ithuba lakho lokuba nesifo sombefu. Umzekelo, okunye ukutya okanye iziyobisi ezibangelwa kukwalana neziyobisi kunokubangela ukuvela kwesifuba.

Ukuba unayo nayiphi na into yokutya okanye yeziyobisi, xelela ugqirha wakho. Khankanya naziphi na iziyobisi, amayeza esintu, okanye izongezo ozithathayo. Ugqirha wakho unokucebisa uhlengahlengiso kwindlela otya ngayo, amayeza, okanye indlela ophila ngayo xa kufuneka njalo.

ICinqair inikwa njani

Umboneleli wezempilo uya kukunika iCinqair njenge-intravenous (IV) ukumnika kwi-ofisi kagqirha wakho okanye eklinikhi. Le yinaliti emthanjeni otyibilika kancinci ekuhambeni kwexesha.

Okokuqala, umboneleli wakho wezempilo uya kubeka inaliti komnye wemithambo yakho. Emva koko baya kudibanisa ibhegi equle iCinqair kwinaliti. Iyeza liya kuhamba ukusuka kwingxowa iye emzimbeni wakho. Oku kuya kuthatha malunga nemizuzu engama-20 ukuya kwengama-50.

Emva kokuba ufumene idosi yakho, umboneleli wakho wezempilo unokukujonga ukuze ubone ukuba uyayiphula na i-anaphylaxis. * Olu luhlobo lwempendulo ebukhali. (Ngeempawu ezinokubakho, jonga icandelo leCinqair icala). I-Anaphylaxis inokwenzeka emva kwayo nayiphi na idosi yeCinqair. Ke umboneleli wakho wezempilo unokukubeka esweni nokuba sele ufumene iCinqair ngaphambili.

Uyifumana nini iCinqair

ICinqair ihlala inikwa kube kanye kwiiveki ezine. Wena kunye nogqirha wakho unokuxoxa ngexesha elifanelekileyo lomhla ukuze ufumane ukumnika.

Ingcinga efanelekileyo yokubhala ishedyuli yonyango kwikhalenda. Unokuseta isikhumbuzi kwifowuni yakho ukuze ungaphoswa kukuqeshwa.

Isebenza njani iCinqair

Isifo sombefu yimeko apho iindlela zomoya ezikhokelela kwimiphunga yakho zidumbile (zidumbile). Imisipha ejikeleze i-airways iyacinywa, ethintela umoya ekuhambeni kuyo. Ngenxa yoko, ioksijini ayinakufikelela egazini lakho.

Nge-asthma enzima, iimpawu zinokuba zibi ngakumbi kune-asthma yesiqhelo. Kwaye ngamanye amaxesha iziyobisi ezinceda ukunyanga isifuba asisebenzi kwisifuba esiqatha. Ke ukuba une-asthma ebukhali, unokufuna amayeza ongezelelweyo.

Olunye uhlobo lwesifo se-asthma esiqatha sisifo se-asthma esibi. Ngolu hlobo lwesifuba, unamazinga aphezulu eeosinophil egazini lakho. I-Eosinophil luhlobo oluthile lweeseli ezimhlophe zegazi. (Iiseli ezimhlophe zegazi ziiseli ezivela kumajoni akho omzimba, ezinceda ukukhusela kwizifo.) Ukunyuka kwamanani eeosinophil kuzisa ukudumba kwindlela yakho yomoya nasemiphungeni. Oku kubangela iimpawu zakho zesifuba.

Wenza ntoni uCinqair?

Inani leeosinophil egazini lakho lixhomekeke kwizinto ezininzi. Into ebaluleke kakhulu inento yokwenza neprotein ebizwa ngokuba yi-interleukin-5 (IL-5). I-IL-5 ivumela ii-eosinophil ukuba zikhule kwaye zihambe ziye egazini lakho.

ICinqair inamathele kwi-IL-5. Ngokudibanisa nayo, iCinqair iyeka i-IL-5 ekusebenzeni. ICinqair inceda ukukhusela i-IL-5 ekuvumeleni ii-eosinophil zikhule kwaye zihambe ziye egazini lakho. Ukuba ii-eosinophil azikwazi ukufikelela kwigazi lakho, azinako ukufikelela kwimiphunga yakho. Ke ii-eosinophils azikwazi ukubangela ukudumba kwiindlela zakho zomoya kunye nemiphunga.

Kuthatha ixesha elingakanani ukusebenza?

Emva kwedosi yakho yokuqala yeCinqair, kunokuthatha ukuya kuthi ga kwiiveki ezine ukuba iimpawu zakho zesifuba ziyeke.

ICinqair ifikelela egazini lakho ngalo mzuzu unikwe lona. Iyeza lihamba ligazi lakho ukuya kwiiseli zakho ngoko nangoko. Xa iCinqair ifikelela kwiiseli zakho, incamathela kwi-IL-5 kwaye iyiyeke isebenze kwangoko.

Kodwa nje ukuba i-IL-5 iyeke ukusebenza, kuya kubakho amanqanaba aphezulu eeosinophil egazini lakho. ICinqair iyakunceda ukuthintela eli xabiso ukuba linganyuki. Iyeza liza kunceda ukunciphisa inani le-eosinophils, kodwa oku ngekhe kwenzeke kwangoko.

Kungathatha ukuya kwiiveki ezine ukwehlisa inani leeosinophil egazini lakho. Iimpawu zakho zesifuba zinokuthatha ukuya kuthi ga kwiiveki ezine ukuba zinyamalale emva kwedosi yakho yokuqala yeCinqair. Nje ukuba iimpawu zakho zihambe, ngekhe baphinde babuye nje ukuba uqhubeka ufumana iCinqair.

ICinqair kunye nokukhulelwa

Akonelanga kwizifundo zeklinikhi ezenziweyo ebantwini ukungqina ukuba iCinqair ikhuselekile ukusetyenziswa ngexesha lokukhulelwa. Kodwa kuyaziwa ukuba iCinqair ihamba nge-placenta kwaye ifikelela emntwaneni. I-placenta lilungu elikhula esibelekweni sakho ngelixa ukhulelwe.

Uphononongo kwizilwanyana lubonisa ukuba akukho ziphumo zibi ziya kwenzeka emntwaneni. Kodwa izifundo zezilwanyana azisoloko zibonisa okwenzekayo ebantwini.

Ukuba uthatha iCinqair kwaye ukhulelwe okanye ufuna ukukhulelwa, thetha nogqirha wakho. Banokukunceda uthathe isigqibo sokuba ngaba iCinqair okanye elinye iyeza lesifuba lilungele wena.

ICinqair kunye nokuncancisa

Akukho zifundo zeklinikhi ebantwini ezingqina ukuba kukhuselekile na ukuncancisa ngelixa uthatha iCinqair. Kodwa izifundo zabantu zibonisa ukuba iiproteni ezifanayo nezo ziseCinqair zikhona kubisi lwebele lomntu. Kwakhona, kwizifundo zezilwanyana, iCinqair yafunyanwa kubisi lwebele loomama. Ke kulindeleke ukuba iCinqair ifumaneke kubisi lwebele lomntu, nayo. Ayaziwa ukuba oku kuya kumchaphazela njani umntwana.

Ukuba ufuna ukuncancisa ngelixa ufumana iCinqair, xelela ugqirha wakho. Banokuthetha ngezinto ezilungileyo nezingalunganga kunye nawe.

Imibuzo eqhelekileyo malunga neCinqair

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neCinqair.

Ngaba iCinqair sisiyobisi sebhayoloji?

Ewe. ICinqair luhlobo lweziyobisi olubizwa ngokuba yi-biologic, olwenziwe kwizinto eziphilayo. Amayeza rhoqo, kwelinye icala, ayenziwa kwiikhemikhali.

ICinqair ikwi-anti-monoclonal antibody. Olu luhlobo lwebhayoloji enxibelelana nenkqubo yomzimba wakho yokuzikhusela. (Amajoni akho omzimba anceda ekukhuseleni umzimba wakho kwizifo.) Amachiza omzimba omzimba onjengeCinqair ancamathele kwiiproteni kumajoni akho omzimba. Xa iCinqair incamathele kwezi proteni, iyabayeka ekubangeleni ukudumba (ukudumba) kunye nezinye iimpawu zesifo sombefu.

Kutheni le nto iCinqair ingezi njenge-inhaler okanye ipilisi?

Umzimba wakho awunakho ukwenza iCinqair kwi-inhaler okanye kwifom yeepilisi, ngoko ichiza alinakukwazi ukunceda ukunyanga isifuba.

ICinqair luhlobo lweziyobisi ze-biologic ezaziwa njenge-monoclonal antibody. (Ngolwazi oluthe kratya malunga ne-biologics, jonga "Ngaba iCinqair sisiyobisi se-biologic?" Ngasentla.) Amachiza omzimba omzimba omnye ziiproteni ezinkulu. Ukuba uthatha la mayeza njengeepilisi, aya ngqo ngqo kwisisu nasemathumbu akho. Apho, iiasidi kunye nezinye iiproteni ezincinci ziya kuthi zichithe ii-antibodies ze-monoclonal. Ngenxa yokuba ii-antibodies ze-monoclonal zohlulwe zaziiziqwenga ezincinci, azisasebenzi kunyango lwesifuba. Ke ngoko kwifom yeepilisi, olu hlobo lweziyobisi alunakusebenza kakuhle.

Awunako ukuphefumla ii-antibodies ezininzi ze-monoclonal nokuba. Ukuba ukwenzile, iiproteni emiphungeni yakho ziyakwaphula ichiza elirholiswe kwangoko. Lincinci kakhulu iyeza elinokuyenza egazini nakwiiseli zakho. Oku kuya kunciphisa ukusebenza kakuhle kwesiyobisi emzimbeni wakho.

Eyona ndlela yokuthatha ii-antibody ze-monoclonal, kubandakanya neCinqair, kukungena ngaphakathi (IV) kokufakwa ngaphakathi. (Le yinaliti emthanjeni otyibilike kancinci ixesha elingaphezulu.) Kule fomu, amayeza aya ngqo egazini lakho. Akukho asidi okanye iiprotein ziya kuyaphula iyeza phantsi iiveki ezimbalwa. Ke amayeza anokuhamba ngegazi lakho kwaye asebenze kwiindawo zomzimba wakho eziyifunayo.

Kutheni ndingenakufumana iCinqair kwikhemesti?

Ekuphela kwendlela yokufumana iCinqair ngugqirha wakho. Umboneleli wezempilo uya kukunika iCinqair njenge-intravenous (IV) ukumnika kwi-ofisi kagqirha wakho okanye eklinikhi. Le yinaliti emthanjeni otyibilika kancinci ekuhambeni kwexesha. Ke ngekhe uthenge iCinqair kwikhemesti kwaye uzithathele yona.

Ngaba abantwana bangasebenzisa iCinqair?

Hayi. Ulawulo lokutya kunye neziyobisi (i-FDA) yamkele kuphela iCinqair yokunyanga abantu abadala. Izifundo zonyango ziye zavavanya ukusetyenziswa kweCinqair kubantwana abaneminyaka eli-12 ukuya kweli-18. Kodwa iziphumo azibonisanga ukuba ichiza lisebenza kakuhle kwaye likhuselekile ngokwaneleyo ukuba lingasetyenziswa ebantwaneni.

Ukuba umntwana wakho unesifo se-asthma esiqatha, thetha nogqirha wakhe. Banokucebisa amayeza ngaphandle kweCinqair anokunceda ukunyanga umntwana wakho.

Ndiza kusafuna ukuthatha i-corticosteroid kunye neCinqair?

Okunokwenzeka. Awenzelwe ukuba uthathe iCinqair ngokwakho. Kuya kufuneka usebenzise ichiza kunye namayeza akho esifo se-asthma, anokubandakanya i-corticosteroid.

ICinqair inceda kuphela ukunciphisa isifuba se-eosinophilic asthma. Olu luhlobo lwesifuba esibangelwa ngamanqanaba aphezulu eeosinophil (uhlobo lweseli emhlophe yegazi) egazini lakho.

NjengoCinqair, i-corticosteroids isebenza ngokunciphisa ukudumba (ukudumba) kwimiphunga yakho. Nangona kunjalo, ii-corticosteroids zinciphisa ukudumba ngeendlela ezahlukeneyo. Abantu abaninzi abane-asthma ebukhali badinga iCinqair kunye ne-corticosteroid yokunceda ukulawula isifo sombefu. Ke ngoko, ugqirha wakho unokukunika amayeza omabini. Ungayeki ukuthatha i-corticosteroid ngaphandle kokuba ugqirha akuxelele.

Ndiza kusafuna ukufumana inhaler yokuhlangula nam?

Ewe.Kuya kufuneka uphathe inhaler yokuhlangula ukuba ufumana iCinqair.

Nangona iCinqair inceda ukuphatha isifo se-asthma se-eosinophilic ixesha elide, usenokubanakho ukuphazamiseka. Kwaye iCinqair ayisebenzi ngokukhawuleza ngokwaneleyo ukuba inyange iimpawu zesifo sombefu ngesiquphe.

Ukuba awukwazi ukulawula iimpawu ze-asthma flare-up kwangoko, banokuba mandundu. Ke eyona ndlela yokufumana isibambo kubo kukusebenzisa inhaler yokuhlangula. Esi sixhobo siza kunceda ukunciphisa iimpawu zakho ze-asthma.

Gcina ukhumbule ukuba kuya kufuneka uthathe amanye amayeza akho e-asthma, kubandakanya iCinqair.

Izikhuselo zeCinqair

Eli chiza liza nezilumkiso ezininzi.

Isilumkiso se-FDA: Anaphylaxis

Eli chiza linesilumkiso esibhokisiweyo. Esi sisilumkiso esibi kakhulu esivela kuLawulo lokutya kunye noLawulo lweziyobisi (FDA). Isilumkiso esibhokisi silumkisa oogqirha nabantu malunga neziphumo zeziyobisi ezinokuba yingozi.

Impendulo ebukhali ebizwa ngokuba yi-anaphylaxis inokwenzeka emva kokufumana iCinqair. Iyeza linikwa ngumboneleli wezempilo, ke baya kujonga indlela umzimba wakho osabela ngayo kwiCinqair. Banokunyanga i-anaphylaxis ngokukhawuleza ukuba uyayiphuhlisa.

Ezinye izilumkiso

Ngaphambi kokuba uthathe iCinqair, thetha nogqirha wakho malunga nembali yakho yezempilo. ICinqair isenokungakulungeli ukuba uneemeko ezithile zonyango. Oku kubandakanya:

Usulelo lweHelminth

ICinqair isenokungakulungeli ukuba unesifo se-helminth (usulelo lwe-parasitic olubangelwa ziintshulube). Ugqirha wakho uya kudinga ukunyanga usulelo ngaphambi kokuba uqale ukusebenzisa iCinqair.

Ukuba ufumana usulelo lwe-helminth ngelixa usebenzisa iCinqair, ugqirha wakho unokulumisa unyango lwakho. Banokukunika amayeza okususa isifo. Nje ukuba usulelo lumnke, ugqirha wakho usenokuqalisa ukufumana iCinqair kwakhona.

Gcina engqondweni iimpawu zosulelo lwe-helminth ukuze wazi ukuba ujonge ntoni. Iimpawu zingabandakanya urhudo, iintlungu esiswini sakho, ukungondleki kunye nobuthathaka.

Ukukhulelwa

Akonelanga kwizifundo zeklinikhi ezenziweyo ebantwini ukungqina ukuba iCinqair ikhuselekile ukusetyenziswa ngexesha lokukhulelwa. Ukufunda ngakumbi, jonga icandelo le "Cinqair kunye nokukhulelwa" apha ngasentla.

Phawula: Ngolwazi oluthe kratya malunga neziphumo ezinokubakho zeCinqair, jonga icandelo leCinqair elineziphumo ezingasentla.

Ulwazi lobungcali lweCinqair

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Iimpawu

ICinqair ibonakalisiwe kunyango lwe-asthma ebukhali. Ukuvunywa kwesiyobisi kulungiselelwe ukusetyenziswa kwaso njengonyango olongezelelekileyo kunyango lwesifo sombefu. ICinqair akufuneki ithathe indawo yonyango lwangoku oluchazwe kwizigulana, kubandakanya nokusetyenziswa kwee-corticosteroids.

Ukuvunywa kweCinqair kunyango lwabantu abane-eosinophilic phenotype. Iyeza akufuneki lilawulwe kubantu abane-phenotypes ezahlukeneyo. Kwaye ayifanelanga ukuba ilawulwe kunyango lwezinye izifo ezinxulumene ne-eosinophilic.

Kwakhona, iCinqair ayiboniswanga ukunyanga ii-bronchospasms ezibi okanye imeko ye-asthmaticus. Ukusetyenziswa kwesiyobisi ukukhupha iimpawu akuzange kuhlolisiswe ngexesha lezifundo zeklinikhi.

Ukusetyenziswa kweCinqair kufanele kugcinelwe abantu abadala kuneminyaka eyi-18. Ayinalo imvume yokutya kunye noLawulo lweziyobisi (FDA) kubantu abancinci kunelo xesha.

Indlela yokusebenza

Indlela echanekileyo yokusebenza kweCinqair ayikacaciswa ngokupheleleyo okwangoku. Kodwa kukholelwa ukuba isebenza ngendlela ye-interleukin-5 (IL-5).

ICinqair yintsholongwane ye-IgG4-kappa monoclonal antibody ebopha kwi-IL-5. Ukudityaniswa kunokudityaniswa rhoqo kwe-picomolar eyi-81 (pM). Ngokuzibophelela kwi-IL-5, iCinqair ichasene ne-IL-5 kwaye inqanda umsebenzi wayo webhayoloji. Oku kwenzeka ngenxa yokuba iCinqair ithintela i-IL-5 ekubeni ibopheleke kwi-IL-5 receptor ekhoyo kumgangatho weselula weeosinophils.

I-IL-5 yeyona cytokine ibaluleke kakhulu ekukhuleni, umahluko, ukugaywa kwabantu, ukusebenza, kunye nokusinda kweeosinophil. Ukungabikho kokunxibelelana phakathi kwe-IL-5 kunye ne-eosinophils kuthintela i-IL-5 ekubeni nezi zenzo zeselfowuni kwii-eosinophil. Ke umjikelezo weselfowuni kunye nemisebenzi yebhayoloji iba sesichengeni. I-Eosinophil iyeke ukusebenza ngokufanelekileyo kwaye ife.

Kubantu abane-eosinophil prototype yesifo se-asthma esomeleleyo, ii-eosinophil zibalulekile kwisifo. I-Eosinophils ibangela ukudumba okungapheliyo emiphungeni, ekhokelela kwisifo sombefu esinganyangekiyo. Ngokunciphisa inani kunye nokusebenza kweeosinophils, iCinqair inciphisa ukudumba emiphungeni. Isifo sombefu esinamandla silawulwa okwethutyana.

Iiseli ezincinci, ii-macrophage, i-neutrophils kunye ne-lymphocyte nazo zinokutshisa imiphunga. Ukongeza, ii-eicosanoids, i-histamine, ii-cytokines, kunye ne-leukotrienes zinokubangela oku kudumba. Ayaziwa ukuba iCinqair isebenza kwezi seli kunye nabalamli ukulawula ukudumba emiphungeni.

I-Pharmacokinetics kunye ne-metabolism

ICinqair ifezekisa ukuqaqamba kwayo ekupheleni kwexesha lokumiliselwa. Ulawulo oluninzi lweCinqair lukhokelela kuqokelelo lwalo kwi-serum ye-1.5- ukuya kwi-1.9. Ukugxilwa kwe-serum kuyehla kwigophe le-biphasic. Oku kugxila akuguquki kubukho be-anti-Cinqair antibodies.

Nje ukuba ilawulwe, iCinqair inexabiso lokuhanjiswa kweelitha ezi-5. Oku kuthetha ukuba amaxabiso aphezulu eCinqair awanakufikelela kwizicubu ze-extravascular.

Njengakwii-antibody ezininzi ze-monoclonal, iCinqair ihlupheka ngokuthotywa kwe-enzymatic. Iiproteymic enzymes ziguqula zibe ziipeptides ezincinci kunye neeamino acid. Ukugqitywa kweproteolysis yeCinqair kuthatha ixesha. Isiqingatha-sobomi bayo malunga neentsuku ezingama-24. Kwakhona, inqanaba lokususwa kwayo limalunga ne-7 yeemililitha ngeyure (mL / hr). Ukucoca ekujolise kuko ekujoliswe kuko kwiCinqair akunakulindeleka ukuba kwenzeke. Kungenxa yokuba ibophelela kwi-interleukin-5 (IL-5), eyi-cytokine enyibilikayo.

Izifundo ze-Pharmacokinetics zeCinqair ziyafana kakhulu phakathi kwabantu bobudala obahlukeneyo, isini, okanye ubuhlanga. Umahluko phakathi kwabantu uphakathi kwe-20% ukuya kwi-30% yoxinzelelo oluphezulu kunye nokuvezwa ngokubanzi.

Izifundo ze-Pharmacokinetics azibonisi mahluko ubalulekileyo phakathi kwabantu abanesiqhelo kunye nokunyusa okuthembekileyo kokuvavanywa kokusebenza kwesibindi. Umsebenzi oqhelekileyo ubandakanya amanqanaba e-bilirubin kunye ne-aspirate aminotransferase engaphantsi okanye elingana nomda ophezulu oqhelekileyo (ULN). Uvavanyo olwandisiweyo lomsebenzi lubandakanya amanqanaba e-bilirubin ngaphezulu kwe-ULN kwaye ingaphantsi okanye ilingane ne-1.5-phinda i-ULN. Inokubandakanya amanqanaba e-aspartate aminotransferase ephezulu kune-ULN.

Kwakhona, izifundo ze-pharmacokinetics zibonisa ukuba akukho mahluko phakathi kwabantu abanomsebenzi oqhelekileyo okanye ongalunganga we-renal. Umsebenzi oqhelekileyo we-renal uthetha i-glomerular filtration rate (eGFR) engaphezulu okanye elingana ne-90 mL ngomzuzu nge-1.73 yemitha nganye. (ml / min / 1.73 m2). Ukusebenza okuthobekileyo kunye nokulinganisela kwezintso kuthetha ukuba kuqikelelwe i-eGFR phakathi kwe-60 ukuya kwi-89 mL / min / 1.73 m2 kunye ne-30 ukuya kwi-59 mL / min / 1.73 m2, ngokulandelelana.

Ukungqinelana

ICinqair iyaphikiswa kubantu esele bevelise ubuntununtunu bayo nayiphi na into esebenzayo okanye engasebenziyo yeCinqair.

Hypersensitivity inokwenzeka kanye emva kolawulo lweCinqair. Kodwa kwezinye iimeko, kunokwenzeka ngaphakathi kweeyure ezimbalwa emva kolawulo lweziyobisi. Ukubeka iliso kwizigulana emva kolawulo lweCinqair kubalulekile ukuqaphela ukukhula kweempendulo zehypersensitivity.

Hypersensitivity sisifo samalungu amaninzi esinokubangela i-anaphylaxis kunye nokufa kukothuka kwe-anaphylactic. Zonke izigulana ezine-hypersensitivity to Cinqair kufuneka ziphazamise unyango ngokukhawuleza. Kule meko, iimpawu zonyango lwe-hypersensitivity kufuneka ziphathwe. Ezi zigulana akufuneki ziphinde zifumane unyango lweCinqair kwakhona.

Thetha kwizigulana zakho malunga neempawu ze-hypersensitivity kunye ne-anaphylaxis. Baxelele ukuba babize i-911 ngokukhawuleza ukuba bacinga ukuba banazo ezi meko. Kwakhona, baxelele ukuba bazise ababoneleli babo bezempilo ukuba bafumana i-hypersensitivity okanye i-anaphylaxis yokuchaza kwakhona indlela yonyango.

Ukugcina

ICinqair kufuneka ifrijiwe phakathi kwe-36 ° F ukuya kwi-46 ° F (2 ° C ukuya kwi-8 ° C). Kubalulekile ukuba ichiza alingabi ngumkhenkce okanye lishukunyiswe. Kubalulekile ukugcina iCinqair kwiphakheji yayo yentsusa kude kube kusetyenziswa. Oku kuya kukhusela ichiza ekonakaleni kokukhanya.

Iphepha elichazayo ukuba awusenanto oyifunayo: Iindaba zezoNyango namhlanje zenze zonke iinzame zokuqinisekisa ukuba zonke iinkcukacha zichanekile, zibanzi kwaye zihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.

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