Colchicine (Colchis): yintoni, yintoni eyenzelwe kunye nendlela yokusebenzisa

Umxholo

• Yenzelwe ntoni
• Kusetyenziswa kwanjani
• 1. Umchasi
• 2. Isifo sikaPeyronie
• Colchicine kunyango lwe-COVID-19
• Ngubani ongafanele asebenzise
• Iziphumo ebezingalindelekanga ezinokwenzeka

I-Colchicine lunyango lokuchasana olusetyenziswa ngokubanzi ukunyanga nokukhusela uhlaselo olubi lwe-gout. Ukongeza, inokusetyenziselwa ukunyanga iimeko zesifo esinganyangekiyo, umkhuhlane we-Mediterranean okanye xa usebenzisa iziyobisi eziphantsi kwe-uric acid.

Eli yeza linokuthengwa ezikhemesti, generic okanye igama lorhwebo Colchis, iipakethe zeepilisi ezingama-20 okanye ezingama-30, xa kunikwa amayeza.

Yenzelwe ntoni

IColchicine lunyango olusetyenziselwa ukunyanga uhlaselo olubi lwe-gout kunye nokuthintela uhlaselo olubi kubantu abane-gouty arthritis engapheliyo.

Fumanisa ukuba yintoni sifo, yintoni ebangela kunye neempawu ezinokuvela.

Ukongeza, unyango ngala mayeza lunokuboniswa kwisifo sikaPeyronie, uMkhuhlane woSapho kwiMeditera kunye nakwiimeko zescleroderma, i-polyarthritis ehambelana nesarcoidosis kunye ne-psoriasis.

Kusetyenziswa kwanjani

Uhlobo lokusetyenziswa kwe-colchicine luyehluka ngokokubonisa kwayo, nangona kunjalo, kuyo nayiphi na imeko kubalulekile ukunqanda ukufunxa i-colchicine kunye nejusi yeziqhamo, njengoko esi siqhamo sinokuthintela ukupheliswa kwamayeza, sandise umngcipheko wobunzima kunye neziphumo ezibambekayo.

1. Umchasi

Ukuthintela uhlaselo lwe-gout, idosi ekhuthazwayo yipilisi enye ye-0.5 mg, ukuya kathathu ngemini, ngomlomo. Izigulana ezenziwa utyando kufuneka zithathe ipilisi enye kathathu ngemini, rhoqo emva kweeyure eziyi-8, ngomlomo, kwiintsuku ezi-3 ngaphambili kunye neentsuku ezi-3 emva kongenelelo.

Ukufumana isiqabu kuhlaselo olubi lwe-gout, idosi yokuqala kufuneka ibe yi-0.5 mg ukuya kwi-1.5 mg elandelwa yithebhulethi enye ngamanqanaba eeyure ezi-1, okanye iiyure ezi-2, kude kufike isiqabu seentlungu okanye isicaphucaphu, ukugabha okanye urhudo. Idosi akufuneki inyuswe ngaphandle kokhokelo lukagqirha, nokuba iimpawu aziphucuki.

Izigulana ezinganyangekiyo zinokuqhubeka nonyango ngethamo lokugcina iipilisi ezi-2 ngosuku, zonke iiyure ezili-12, ukuya kuthi ga kwiinyanga ezintathu, ngokokubona kukagqirha.

Elona dose liphezulu lifikelelweyo alifanelanga ukudlula i-7 mg yonke imihla.

2. Isifo sikaPeyronie

Unyango kufuneka luqaliswe nge-0.5 mg ukuya kwi-1.0 mg yonke imihla, ilawulwa ngeedosi enye ukuya kwezimbini, ezinokunyuswa ziye kuthi ga kwi-2 mg ngosuku, zilawulwe ngeedosi ezimbini ukuya kwezintathu.

Colchicine kunyango lwe-COVID-19

Ngokwengxelo yokuqala ekhutshwe liziko lentliziyo laseMontreal ^[1], I-colchicine ibonise iziphumo ezilungileyo kunyango lwezigulana ezine-COVID-19. Ngokwabaphandi, eli chiza libonakala ngathi liyalinciphisa inani lokulaliswa esibhedlele kunye nokusweleka, xa unyango luqalwa kwakamsinya emva kokuxilongwa.

Nangona kunjalo, kusafuneka ukuba zonke iziphumo zolu phononongo zaziwe kwaye zihlalutywe luluntu lwenzululwazi, kwaye kuyacetyiswa ukuba kuqhutyekwe nophando ngesiyobisi, ngakumbi kuba sisiyobisi esinokubangela iziphumo ebezingalindelekanga ezimbi xa Ayisetyenziswanga kwidosi echanekileyo kwaye iphantsi kweliso likagqirha.

Ngubani ongafanele asebenzise

Esi sixhobo akufuneki sisetyenziswe kubantu abanezigulo ze-aleji kuwo nawaphi na amacandelo akhoyo kwifomula, abantu abafumana i-dialysis okanye abantu abanesifo esibuhlungu samathumbu, i-hematological, isibindi, izintso okanye isifo sentliziyo.

Ukongeza, akufuneki isetyenziswe nakubantwana, abasetyhini abakhulelweyo okanye abasetyhini abancancisayo.

Iziphumo ebezingalindelekanga ezinokwenzeka

Iziphumo eziqhelekileyo ezinokubakho ngokusetyenziswa kweli nyango kukugabha, isicaphucaphu, ukudinwa, intloko ebuhlungu, igawuthi, iintlantsi, iintlungu esiswini kunye nentlungu kwingqula nakwipharynx. Esinye isiphumo esibaluleke kakhulu sisifo sorhudo, ekufuneka ukuba sivele, kufuneka sixelwe kwangoko kugqirha, njengoko ibonisa ukuba unyango kufuneka lunqunyanyiswe.

Ukongeza, nangona kunqabile, ukulahleka kweenwele, uxinzelelo lomqolo, dermatitis, utshintsho kwi-coagulation kunye nesibindi, ukungahambelani komzimba, ukonyuka kwe-creatine phosphokinase, ukunganyamezelani kwe-lactose, iintlungu zemisipha, ukunciphisa isidoda, imfusa, ukutshabalalisa iiseli zemisipha kunye ne-neuromuscular enetyhefu isifo.